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Gene

POLR1A

RNA polymerase I subunit A

Summary

Cytogenetic location
2p11.2
Coordinates
Chromosome 2: 86,020,216–86,105,886 (GRCh38)
Exons
34 exons across 85.7 kb
Protein
1,720 amino acids
Also known as
DKFZP586M0122, FLJ21915, RPO1-4, RPA1, RPA190
MANE Select transcript
ENST00000263857.11NM_015425.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads POLR1A yet. The test sequences your whole genome, so your data includes it all the same.

How POLR1A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where POLR1A sits. POLR1A and 17 genes near it on chromosome 2, from 85,563,051 to 86,563,050.Chromosome 22p11.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.385.6 Mb85.8 Mb86 Mb86.2 Mb86.4 MbVAMP8: 85,561,562–85,582,032, forward strandVAMP5: 85,584,397–85,593,421, forward strandRNF181: 85,595,620–85,598,589, forward strandRNF181TMEM150A: 85,598,547–85,603,201, reverse strandTMEM150AUSP39: 85,602,856–85,657,710, forward strandUSP39C2orf68: 85,605,254–85,612,066, reverse strandC2orf68SFTPB: 85,655,154–85,668,741, reverse strandSFTPBGNLY: 85,685,175–85,698,854, forward strandGNLYATOH8: 85,751,344–85,794,266, forward strandATOH8ST3GAL5: 85,837,120–85,905,199, reverse strandST3GAL5POLR1A: 86,020,216–86,105,886, reverse strandPOLR1APTCD3: 86,106,223–86,142,157, forward strandPTCD3IMMT: 86,142,798–86,195,631, reverse strandIMMTMRPL35: 86,199,355–86,222,540, forward strandMRPL35REEP1: 86,210,522–86,338,083, reverse strandREEP1KDM3A: 86,440,647–86,492,716, forward strandKDM3ACHMP3: 86,502,688–86,563,507, reverse strandCHMP3RNF103-CHMP3: 86,505,668–86,721,122, reverse strandRNF103-CHMP3Diagram of POLR1A: 34 exons on the reverse strand of chromosome 2Exon 30: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 34: 86,020,216–86,027,523, 7,308 basesExon 33: 86,027,885–86,028,049, 165 basesExon 32: 86,028,594–86,028,711, 118 basesExon 31: 86,030,196–86,030,396, 201 basesExon 30: 86,031,330–86,031,635, 306 basesExon 29: 86,032,272–86,032,382, 111 basesExon 28: 86,033,661–86,033,787, 127 basesExon 27: 86,038,700–86,038,857, 158 basesExon 26: 86,039,327–86,039,462, 136 basesExon 25: 86,040,392–86,040,559, 168 basesExon 24: 86,041,889–86,042,103, 215 basesExon 23: 86,042,974–86,043,195, 222 basesExon 22: 86,044,139–86,044,304, 166 basesExon 21: 86,045,278–86,045,360, 83 basesExon 20: 86,045,617–86,045,769, 153 basesExon 19: 86,047,165–86,047,263, 99 basesExon 18: 86,048,884–86,049,042, 159 basesExon 17: 86,049,160–86,049,242, 83 basesExon 16: 86,052,817–86,053,000, 184 basesExon 15: 86,054,140–86,054,289, 150 basesExon 14: 86,065,274–86,065,465, 192 basesExon 13: 86,070,018–86,070,272, 255 basesExon 12: 86,075,030–86,075,260, 231 basesExon 11: 86,077,859–86,077,981, 123 basesExon 10: 86,078,114–86,078,284, 171 basesExon 9: 86,080,816–86,080,978, 163 basesExon 8: 86,081,601–86,081,706, 106 basesExon 7: 86,083,082–86,083,168, 87 basesExon 6: 86,088,566–86,088,669, 104 basesExon 5: 86,088,785–86,088,870, 86 basesExon 4: 86,089,822–86,089,929, 108 basesExon 3: 86,098,611–86,098,760, 150 basesExon 2: 86,099,968–86,100,172, 205 basesExon 1: 86,105,700–86,105,886, 187 bases343025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.5 kb of the gene's 85.7 kb; 5,163 of those bases code for the protein.

How a genome test reads POLR1A

5

positions in POLR1A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 85.7 kb of POLR1A, introns included, not only the 12.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). POLR1A gene: RNA polymerase I subunit A. Retrieved 17 October 2026, from https://dantelabs.com/genes/polr1a

Vancouver

Dante Labs. POLR1A gene: RNA polymerase I subunit A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/polr1a

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