Trait
Dementia
A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior.
Summary
- Also called
- Dementia, progressive, Progressive dementia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Dementia, and the rest of your genome, with one test.
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Get my Genome Test195 genes linked to Dementia
Changes in these genes cause rare conditions in which Dementia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AARS1alanyl-tRNA synthetase 1 | Always | In 1 condition |
| ABCB7ATP binding cassette subfamily B member 7 | Always | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Always | In 4 conditions |
| CERS1ceramide synthase 1 | Always | In 1 condition |
| CTSFcathepsin F | Always | In 1 condition |
| CYLDCYLD lysine 63 deubiquitinase | Always | In 1 condition |
| DNAJC5DnaJ heat shock protein family (Hsp40) member C5 | Always | In 1 condition |
| GBA2glucosylceramidase beta 2 | Always | In 2 conditions |
| GPRC5BG protein-coupled receptor class C group 5 member B | Always | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Always | In 1 condition |
| PRNPprion protein (Kanno blood group) | Always | In 9 conditions |
| SPG21SPG21 abhydrolase domain containing, maspardin | Always | In 2 conditions |
| TBPTATA-box binding protein | Always | In 2 conditions |
| TREM2triggering receptor expressed on myeloid cells 2 | Always | In 5 conditions |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Always | In 1 condition |
| VPS13Cvacuolar protein sorting 13 homolog C | Always | In 2 conditions |
| WDR45WD repeat domain 45 | Always | In 2 conditions |
| APPamyloid beta precursor protein | Very often (80–99%) | In 7 conditions |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Very often (80–99%) | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Very often (80–99%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Very often (80–99%) | In 1 condition |
| FMR1fragile X messenger ribonucleoprotein 1 | Very often (80–99%) | In 2 conditions |
| HTRA1HtrA serine peptidase 1 | Very often (80–99%) | In 3 conditions |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Very often (80–99%) | In 2 conditions |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Very often (80–99%) | In 2 conditions |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Very often (80–99%) | In 2 conditions |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Very often (80–99%) | In 2 conditions |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Very often (80–99%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Very often (80–99%) | In 2 conditions |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Very often (80–99%) | In 2 conditions |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Very often (80–99%) | In 2 conditions |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Very often (80–99%) | In 2 conditions |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Very often (80–99%) | In 3 conditions |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Very often (80–99%) | In 2 conditions |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Very often (80–99%) | In 2 conditions |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Very often (80–99%) | In 2 conditions |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Very often (80–99%) | In 2 conditions |
| PSEN1presenilin 1 | Very often (80–99%) | In 4 conditions |
| PSEN2presenilin 2 | Very often (80–99%) | In 3 conditions |
| ROGDIrogdi atypical leucine zipper | Very often (80–99%) | In 2 conditions |
Show 155 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SLC13A5solute carrier family 13 member 5 | Very often (80–99%) | In 1 condition |
| SORL1sortilin related receptor 1 | Very often (80–99%) | In 1 condition |
| TOMM40translocase of outer mitochondrial membrane 40 | Very often (80–99%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Very often (80–99%) | In 2 conditions |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| APOEapolipoprotein E | Often (30–79%) | In 3 conditions |
| ARSAarylsulfatase A | Often (30–79%) | In 1 condition |
| ATN1atrophin 1 | Often (30–79%) | In 2 conditions |
| ATXN2ataxin 2 | Often (30–79%) | In 3 conditions |
| CBLIFcobalamin binding intrinsic factor | Often (30–79%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Often (30–79%) | In 1 condition |
| CLN6CLN6 transmembrane ER protein | Often (30–79%) | In 1 condition |
| CMPK2cytidine/uridine monophosphate kinase 2 | Often (30–79%) | In 1 condition |
| CSTBcystatin B | Often (30–79%) | In 2 conditions |
| DNMT1DNA methyltransferase 1 | Often (30–79%) | In 2 conditions |
| EPG5ectopic P-granules 5 autophagy tethering factor | Often (30–79%) | In 1 condition |
| EPM2AEPM2A glucan phosphatase, laforin | Often (30–79%) | In 2 conditions |
| GBA1glucosylceramidase beta 1 | Often (30–79%) | In 5 conditions |
| GRNgranulin precursor | Often (30–79%) | In 1 condition |
| HTThuntingtin | Often (30–79%) | In 2 conditions |
| JAM2junctional adhesion molecule 2 | Often (30–79%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Often (30–79%) | In 5 conditions |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Often (30–79%) | In 2 conditions |
| MYORGmyogenesis regulating glycosidase | Often (30–79%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Often (30–79%) | In 1 condition |
| NDUFA1NADH:ubiquinone oxidoreductase subunit A1 | Often (30–79%) | In 1 condition |
| NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1 | Often (30–79%) | In 2 conditions |
| NOTCH2NLCnotch 2 N-terminal like C | Often (30–79%) | In 2 conditions |
| NOTCH3notch receptor 3 | Often (30–79%) | In 2 conditions |
| PANK2pantothenate kinase 2 | Often (30–79%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Often (30–79%) | In 2 conditions |
| PDGFRBplatelet derived growth factor receptor beta | Often (30–79%) | In 2 conditions |
| PSAPprosaposin | Often (30–79%) | In 1 condition |
| RNF216ring finger protein 216 | Often (30–79%) | In 2 conditions |
| RRP12ribosomal RNA processing 12 homolog | Often (30–79%) | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Often (30–79%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Often (30–79%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Often (30–79%) | In 1 condition |
| TRPM7transient receptor potential cation channel subfamily M member 7 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 2 conditions |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Often (30–79%) | In 2 conditions |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Sometimes (5–29%) | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Sometimes (5–29%) | In 2 conditions |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Sometimes (5–29%) | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Sometimes (5–29%) | In 1 condition |
| CLN8CLN8 transmembrane ER and ERGIC protein | Sometimes (5–29%) | In 1 condition |
| COL4A1collagen type IV alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| DCTN1dynactin subunit 1 | Sometimes (5–29%) | In 1 condition |
| DGUOKdeoxyguanosine kinase | Sometimes (5–29%) | In 2 conditions |
| DLATdihydrolipoamide S-acetyltransferase | Sometimes (5–29%) | In 1 condition |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Sometimes (5–29%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sometimes (5–29%) | In 1 condition |
| FBXO7F-box protein 7 | Sometimes (5–29%) | In 1 condition |
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Sometimes (5–29%) | In 1 condition |
| GCDHglutaryl-CoA dehydrogenase | Sometimes (5–29%) | In 1 condition |
| HTRA2HtrA serine peptidase 2 | Sometimes (5–29%) | In 1 condition |
| JPH3junctophilin 3 | Sometimes (5–29%) | In 2 conditions |
| KCTD7potassium channel tetramerization domain containing 7 | Sometimes (5–29%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Sometimes (5–29%) | In 3 conditions |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 1 condition |
| MATR3matrin 3 | Sometimes (5–29%) | In 2 conditions |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Sometimes (5–29%) | In 1 condition |
| PARK7Parkinsonism associated deglycase | Sometimes (5–29%) | In 1 condition |
| PINK1PTEN induced kinase 1 | Sometimes (5–29%) | In 2 conditions |
| PNPLA6patatin like domain 6, lysophospholipase | Sometimes (5–29%) | In 1 condition |
| PODXLpodocalyxin like | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 3 conditions |
| PPP2R2Bprotein phosphatase 2 regulatory subunit Bbeta | Sometimes (5–29%) | In 2 conditions |
| PRICKLE1prickle planar cell polarity protein 1 | Sometimes (5–29%) | In 1 condition |
| PRKNparkin RBR E3 ubiquitin protein ligase | Sometimes (5–29%) | In 1 condition |
| RAB39BRAB39B, member RAS oncogene family | Sometimes (5–29%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Sometimes (5–29%) | In 2 conditions |
| SCARB2scavenger receptor class B member 2 | Sometimes (5–29%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| SNCAsynuclein alpha | Sometimes (5–29%) | In 6 conditions |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| SYNJ1synaptojanin 1 | Sometimes (5–29%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Sometimes (5–29%) | In 1 condition |
| TUBA4Atubulin alpha 4a | Sometimes (5–29%) | In 1 condition |
| TUBB4Atubulin beta 4A class IVa | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 2 conditions |
| UCHL1ubiquitin C-terminal hydrolase L1 | Sometimes (5–29%) | In 1 condition |
| VPS13Avacuolar protein sorting 13 homolog A | Sometimes (5–29%) | In 1 condition |
| ZFYVE26zinc finger FYVE-type containing 26 | Sometimes (5–29%) | In 1 condition |
| ATRXATRX chromatin remodeler | Rarely (1–4%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Rarely (1–4%) | In 1 condition |
| CDH23cadherin related 23 | Rarely (1–4%) | In 1 condition |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Rarely (1–4%) | In 1 condition |
| DNM1Ldynamin 1L | Rarely (1–4%) | In 1 condition |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Rarely (1–4%) | In 1 condition |
| GIGYF2GRB10 interacting GYF protein 2 | Rarely (1–4%) | In 1 condition |
| LIG3DNA ligase 3 | Rarely (1–4%) | In 1 condition |
| LMNB1lamin B1 | Rarely (1–4%) | In 1 condition |
| MMACHCmetabolism of cobalamin associated C | Rarely (1–4%) | In 2 conditions |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Rarely (1–4%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Rarely (1–4%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Rarely (1–4%) | In 1 condition |
| PPIBpeptidylprolyl isomerase B | Rarely (1–4%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Rarely (1–4%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Rarely (1–4%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Rarely (1–4%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Rarely (1–4%) | In 1 condition |
| STARD7StAR related lipid transfer domain containing 7 | Rarely (1–4%) | In 1 condition |
| TP53tumor protein p53 | Rarely (1–4%) | In 1 condition |
| TYMPthymidine phosphorylase | Rarely (1–4%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Rarely (1–4%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Rarely (1–4%) | In 1 condition |
| VPS35VPS35 retromer complex component | Rarely (1–4%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Not recorded | In 1 condition |
| ATP7BATPase copper transporting beta | Not recorded | In 1 condition |
| ATXN10ataxin 10 | Not recorded | In 1 condition |
| ATXN3ataxin 3 | Not recorded | In 2 conditions |
| ATXN8OSATXN8 opposite strand lncRNA | Not recorded | In 1 condition |
| C19orf12chromosome 19 open reading frame 12 | Not recorded | In 1 condition |
| C9orf72C9orf72-SMCR8 complex subunit | Not recorded | In 1 condition |
| CFAP43cilia and flagella associated protein 43 | Not recorded | In 1 condition |
| CLN3CLN3 lysosomal/endosomal transmembrane protein, battenin | Not recorded | In 1 condition |
| CPceruloplasmin | Not recorded | In 1 condition |
| CPT1Ccarnitine palmitoyltransferase 1C | Not recorded | In 1 condition |
| CST3cystatin C | Not recorded | In 1 condition |
| CUBNcubilin | Not recorded | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Not recorded | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Not recorded | In 1 condition |
| FTLferritin light chain | Not recorded | In 1 condition |
| GM2Aganglioside GM2 activator | Not recorded | In 1 condition |
| HEXAhexosaminidase subunit alpha | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| IRF6interferon regulatory factor 6 | Not recorded | In 1 condition |
| ITM2Bintegral membrane protein 2B | Not recorded | In 2 conditions |
| MMEmembrane metalloendopeptidase | Not recorded | In 1 condition |
| MPOmyeloperoxidase | Not recorded | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Not recorded | In 1 condition |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Not recorded | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Not recorded | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Not recorded | In 1 condition |
| MT-TTmitochondrially encoded tRNA-Thr (ACN) | Not recorded | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Not recorded | In 1 condition |
| NDPnorrin cystine knot growth factor NDP | Not recorded | In 1 condition |
| NPC1NPC intracellular cholesterol transporter 1 | Not recorded | In 1 condition |
| NPC2NPC intracellular cholesterol transporter 2 | Not recorded | In 1 condition |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Not recorded | In 1 condition |
| PDE10Aphosphodiesterase 10A | Not recorded | In 1 condition |
| PLAUplasminogen activator, urokinase | Not recorded | In 1 condition |
| PRDM8PR/SET domain 8 | Not recorded | In 1 condition |
| PRDX1peroxiredoxin 1 | Not recorded | In 1 condition |
| SERPINI1serpin family I member 1 | Not recorded | In 1 condition |
| SNCAIPsynuclein alpha interacting protein | Not recorded | In 1 condition |
| SNCBsynuclein beta | Not recorded | In 1 condition |
| SPASTspastin | Not recorded | In 1 condition |
| TTRtransthyretin | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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