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Özellik
Parkinsonism
Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.
Özet
- Vücut sistemi
- Abnormality of the nervous system
AtlasKimlere Yardımcı OluyoruzBilimimizÜrünlerSonuçlar
Giriş YapSorGenomunuzu dizileyin↗
Bu sayfanın veri olarak görünümü
Veriyi JSON olarak okumak için sayfa adresinin sonuna .json ekleyin veya application/json isteyin.
library(jsonlite)
url <- "https://dantelabs.com/traits/parkinsonism.json"
page <- fromJSON(url)
page$trait$nameParkinsonismHP:0001300
AtlasKimlere Yardımcı OluyoruzBilimimizÜrünlerSonuçlar
Giriş YapSorGenomunuzu dizileyin↗
Parkinsonism ile bağlantılı genleri ve genomunuzun geri kalanını tek bir testle okuyun.
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Genome Test'imi al62 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Parkinson DiseaseReads 12 of these genesFBXO7GBA1LRRK2PLA2G6PRKNSNCAAbout this report →
- Inherited Neurodegenerative DisordersReads 56 of these genesCLN3CSF1RDCTN1FMR1PLA2G6POLGAbout this report →
- Amyotrophic Lateral Sclerosis (ALS)Reads 15 of these genesDCTN1CHCHD10FUSSQSTM1TARDBPTBK1About this report →
- Basal Ganglia CalcificationReads 7 of these genesJAM2NAA60MYORGPDGFBPDGFRBSLC20A2About this report →
Show 58 more reports
- Neurodegeneration with Brain Iron Accumulation (NBIA)Reads 8 of these genesPLA2G6ATP13A2COASYC19orf12PANK2WDR45About this report →
- Frontotemporal DementiaReads 9 of these genesPSEN1CHCHD10MAPTSQSTM1TBK1VCPAbout this report →
- Alzheimer diseaseReads 5 of these genesAPPPSEN1PSEN2TREM2APOEAbout this report →
- BH4 Deficiency & Monoamine Neurotransmitter DisordersReads 6 of these genesSLC18A2GCH1THDNAJC12PCBD1PTSAbout this report →
- Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)Reads 9 of these genesATP1A3PPP2R2BSTUB1TBPAFG3L2ATXN2About this report →
- Dystonia, Myotonia, Paroxysmal DyskinesiaReads 9 of these genesNR4A2SLC18A2SLC6A3WARS2ATP1A3GCH1About this report →
- Hereditary Manganese Transporter DisordersReads 2 of these genesSLC39A14SLC30A10About this report →
- Cerebral Amyloid AngiopathyReads 2 of these genesCST3APPAbout this report →
- Neuroacanthocytosis and Huntington Disease PhenocopiesReads 2 of these genesVPS13AJPH3About this report →
- Neuronal Ceroid LipofuscinosisReads 4 of these genesCLN3ATP13A2GRNDNAJC5About this report →
- Rare Hereditary Peripheral NeuropathiesReads 16 of these genesDCTN1MPV17PLA2G6POLGCHCHD10COQ2About this report →
- Epilepsy (Full Panel)Reads 14 of these genesATP6AP2RNU2-2SYNJ1ATP1A3GABRA1GABRG2About this report →
- Adult-Onset Leukodystrophies (CSF1R, LMNB1, Nasu-Hakola)Reads 2 of these genesCSF1RTREM2About this report →
- 22q11.2 Deletion SyndromeReads 1 of these genesTBX1About this report →
- Brain Abnormalities, Neurodegeneration and Dysosteosclerosis (BANDDOS)Reads 1 of these genesCSF1RAbout this report →
- Cerebrotendinous XanthomatosisReads 1 of these genesCYP27A1About this report →
- Chediak-Higashi syndromeReads 1 of these genesLYSTAbout this report →
- Christianson SyndromeReads 1 of these genesSLC9A6About this report →
- Dopamine Transporter Deficiency SyndromeReads 1 of these genesSLC6A3About this report →
- Dravet SyndromeReads 1 of these genesSCN1AAbout this report →
- Fragile X SyndromeReads 1 of these genesFMR1About this report →
- Gaucher DiseaseReads 1 of these genesGBA1About this report →
- Genetic Prion Disease (incl. Fatal Familial Insomnia)Reads 1 of these genesPRNPAbout this report →
- GTP Cyclohydrolase 1 DeficiencyReads 1 of these genesGCH1About this report →
- KIF5A-Related Amyotrophic Lateral SclerosisReads 1 of these genesKIF5AAbout this report →
- Rett Syndrome and MECP2-Related DisordersReads 1 of these genesMECP2About this report →
- TNR-Related Neurodevelopmental Disorder with SpasticityReads 1 of these genesTNRAbout this report →
- UBTF-Related NeuroregressionReads 1 of these genesUBTFAbout this report →
- Lysosomal Storage DiseaseReads 7 of these genesCLN3GBA1AP5Z1CYP27A1GNEGRNAbout this report →
- Cerebral Arteriopathy with Subcortical Infarcts and LeukoencephalopathyReads 1 of these genesNOTCH3About this report →
- Hereditary FibromatosesReads 1 of these genesPDGFRBAbout this report →
- Charcot-Marie-Tooth DiseaseReads 6 of these genesDCTN1MPV17VCPSIGMAR1SORDSPG11About this report →
- Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)Reads 3 of these genesSCN9ASPTLC1SPTLC2About this report →
- Hereditary Spastic ParaplegiaReads 5 of these genesATP13A2AP5Z1ERLIN1KIF5ASPG11About this report →
- Hereditary AmyloidosisReads 2 of these genesCST3APPAbout this report →
- Familial Hemiplegic MigraineReads 1 of these genesSCN1AAbout this report →
- Spinal Muscular AtrophyReads 3 of these genesDCTN1CHCHD10SIGMAR1About this report →
- Hereditary Optic NeuropathyReads 2 of these genesATP1A3AFG3L2About this report →
- Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)Reads 4 of these genesSTUB1CYP27A1SYNE1TWNKAbout this report →
- Inherited ThrombocytopeniasReads 3 of these genesGNEGP1BBPLAUAbout this report →
- Familial Paget Disease of BoneReads 1 of these genesSQSTM1About this report →
- Hereditary Episodic AtaxiasReads 1 of these genesSCN2AAbout this report →
- Inherited Fibrinolytic DisordersReads 1 of these genesPLAUAbout this report →
- Inherited Iron Metabolism DisordersReads 1 of these genesCPAbout this report →
- Distal MyopathiesReads 2 of these genesVCPGNEAbout this report →
- Intellectual DisabilityReads 7 of these genesATP6AP2RAB39BPCDH19SCN2AHIVEP2JMJD1CAbout this report →
- Other Inherited LeukodystrophiesReads 4 of these genesCSF1RTREM2CYP27A1TMEM106BAbout this report →
- Primary Mitochondrial DiseaseReads 5 of these genesMPV17POLGCOQ2AFG3L2TWNKAbout this report →
- Inherited Platelet Function DisordersReads 1 of these genesGP1BBAbout this report →
- HyperlipidemiaReads 1 of these genesAPOEAbout this report →
- Female InfertilityReads 2 of these genesFMR1TWNKAbout this report →
- Homocystinuria & Cobalamin DisordersReads 1 of these genesCBSAbout this report →
- Pontocerebellar Hypoplasia (TSEN54 and MINPP1)Reads 1 of these genesCOASYAbout this report →
- Hereditary Congenital & Juvenile CataractReads 1 of these genesFTLAbout this report →
- Congenital Disorders of GlycosylationReads 2 of these genesATP6AP2GNEAbout this report →
- Pelizaeus-Merzbacher Disease & Hypomyelinating LeukodystrophiesReads 1 of these genesTMEM106BAbout this report →
- Dilated CardiomyopathyReads 1 of these genesSYNE1About this report →
- Other Inborn Errors of ImmunityReads 2 of these genesLYSTTBX1About this report →
Parkinsonism ile bağlantılı genleri ve genomunuzun geri kalanını tek bir testle okuyun.
$449'den başlayanÜcretsiz kargo · Sonuçlar 6–8 hafta içinde
Genome Test'imi alParkinsonism ile ilişkili 141 gen
Bu genlerdeki değişiklikler, Parkinsonism özelliğinin görüldüğü nadir durumlara yol açar. Bu özelliğe sahip çoğu kişide bu durumlardan hiçbiri yoktur; ayrıca bu listedeki bir gen, kimsenin kendi genomu hakkında bir şey söylemez.
| Gen | Ne sıklıkla görüldüğü | Durumlar |
|---|---|---|
| ATP6AP2ATPase H+ transporting accessory protein 2 | Her zaman | 2 durumda |
| CLN3CLN3 lysosomal/endosomal transmembrane protein, battenin | Her zaman | 1 durumda |
| CSF1Rcolony stimulating factor 1 receptor | Her zaman | 1 durumda |
| CST3cystatin C | Her zaman | 1 durumda |
| DCTN1dynactin subunit 1 | Her zaman | 2 durumda |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Her zaman | 1 durumda |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Her zaman | 2 durumda |
| FASTKD5FASTK mitochondrial RNA regulator 5 | Her zaman | 1 durumda |
| FBXO7F-box protein 7 | Her zaman | 2 durumda |
| FMR1fragile X messenger ribonucleoprotein 1 | Her zaman | 2 durumda |
| GBA1glucosylceramidase beta 1 | Her zaman | 4 durumda |
| GIGYF2GRB10 interacting GYF protein 2 | Her zaman | 1 durumda |
| LRRK2leucine rich repeat kinase 2 | Her zaman | 2 durumda |
| MPV17mitochondrial inner membrane protein MPV17 | Her zaman | 1 durumda |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Her zaman | 3 durumda |
| PLA2G6phospholipase A2 group VI | Her zaman | 1 durumda |
| POLGDNA polymerase gamma, catalytic subunit | Her zaman | 2 durumda |
| PRKNparkin RBR E3 ubiquitin protein ligase | Her zaman | 1 durumda |
| PTRHD1peptidyl-tRNA hydrolase domain containing 1 | Her zaman | 1 durumda |
| RAB32RAB32, member RAS oncogene family | Her zaman | 1 durumda |
| RAB39BRAB39B, member RAS oncogene family | Her zaman | 1 durumda |
| RNU2-2RNA, U2 small nuclear 2 | Her zaman | 1 durumda |
| SLC18A2solute carrier family 18 member A2 | Her zaman | 2 durumda |
| SLC9A6solute carrier family 9 member A6 | Her zaman | 1 durumda |
| SNCAsynuclein alpha | Her zaman | 5 durumda |
| SYNJ1synaptojanin 1 | Her zaman | 1 durumda |
| VPS35VPS35 retromer complex component | Her zaman | 2 durumda |
| APPamyloid beta precursor protein | Çok sık (%80–99) | 2 durumda |
| ATP13A2ATPase cation transporting 13A2 | Çok sık (%80–99) | 4 durumda |
| COASYCoenzyme A synthase | Çok sık (%80–99) | 1 durumda |
| PSEN1presenilin 1 | Çok sık (%80–99) | 3 durumda |
| PSEN2presenilin 2 | Çok sık (%80–99) | 1 durumda |
| SLC6A3solute carrier family 6 member 3 | Çok sık (%80–99) | 2 durumda |
| SORL1sortilin related receptor 1 | Çok sık (%80–99) | 1 durumda |
| TOMM40translocase of outer mitochondrial membrane 40 | Çok sık (%80–99) | 1 durumda |
| TREM2triggering receptor expressed on myeloid cells 2 | Çok sık (%80–99) | 2 durumda |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Çok sık (%80–99) | 2 durumda |
| ACBD6acyl-CoA binding domain containing 6 | Sık (%30–79) | 1 durumda |
| AOPEPaminopeptidase O (putative) | Sık (%30–79) | 1 durumda |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Sık (%30–79) | 2 durumda |
101 gen daha göster
| Gen | Ne sıklıkla görüldüğü | Durumlar |
|---|---|---|
| C19orf12chromosome 19 open reading frame 12 | Sık (%30–79) | 1 durumda |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Sık (%30–79) | 2 durumda |
| COQ2coenzyme Q2, polyprenyltransferase | Sık (%30–79) | 3 durumda |
| EIF2AK2eukaryotic translation initiation factor 2 alpha kinase 2 | Sık (%30–79) | 1 durumda |
| FUSFUS RNA binding protein | Sık (%30–79) | 2 durumda |
| GABRA1gamma-aminobutyric acid type A receptor subunit alpha1 | Sık (%30–79) | 1 durumda |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Sık (%30–79) | 1 durumda |
| GCH1GTP cyclohydrolase 1 | Sık (%30–79) | 1 durumda |
| IMPDH2inosine monophosphate dehydrogenase 2 | Sık (%30–79) | 1 durumda |
| JAM2junctional adhesion molecule 2 | Sık (%30–79) | 2 durumda |
| MAPTmicrotubule associated protein tau | Sık (%30–79) | 7 durumda |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sık (%30–79) | 2 durumda |
| PANK2pantothenate kinase 2 | Sık (%30–79) | 2 durumda |
| PCDH19protocadherin 19 | Sık (%30–79) | 1 durumda |
| PPP2R2Bprotein phosphatase 2 regulatory subunit Bbeta | Sık (%30–79) | 2 durumda |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Sık (%30–79) | 1 durumda |
| PRKRAprotein activator of interferon induced protein kinase EIF2AK2 | Sık (%30–79) | 2 durumda |
| PRNPprion protein (Kanno blood group) | Sık (%30–79) | 2 durumda |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sık (%30–79) | 1 durumda |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Sık (%30–79) | 1 durumda |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Sık (%30–79) | 1 durumda |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Sık (%30–79) | 1 durumda |
| SLC39A14solute carrier family 39 member 14 | Sık (%30–79) | 2 durumda |
| SQSTM1sequestosome 1 | Sık (%30–79) | 1 durumda |
| STUB1STIP1 homology and U-box containing protein 1 | Sık (%30–79) | 1 durumda |
| TARDBPTAR DNA binding protein | Sık (%30–79) | 2 durumda |
| TBK1TANK binding kinase 1 | Sık (%30–79) | 1 durumda |
| TBPTATA-box binding protein | Sık (%30–79) | 3 durumda |
| THtyrosine hydroxylase | Sık (%30–79) | 2 durumda |
| TSPOAP1TSPO associated protein 1 | Sık (%30–79) | 1 durumda |
| VCPvalosin containing protein | Sık (%30–79) | 3 durumda |
| VPS13Avacuolar protein sorting 13 homolog A | Sık (%30–79) | 2 durumda |
| WDR45WD repeat domain 45 | Sık (%30–79) | 2 durumda |
| AFG3L2AFG3 like matrix AAA peptidase subunit 2 | Bazen (%5–29) | 2 durumda |
| ALS2alsin Rho guanine nucleotide exchange factor ALS2 | Bazen (%5–29) | 1 durumda |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Bazen (%5–29) | 2 durumda |
| ARVCFARVCF delta catenin family member | Bazen (%5–29) | 1 durumda |
| ATXN2ataxin 2 | Bazen (%5–29) | 3 durumda |
| ATXN3ataxin 3 | Bazen (%5–29) | 2 durumda |
| CBScystathionine beta-synthase | Bazen (%5–29) | 1 durumda |
| CHMP2Bcharged multivesicular body protein 2B | Bazen (%5–29) | 1 durumda |
| COMTcatechol-O-methyltransferase | Bazen (%5–29) | 1 durumda |
| CPceruloplasmin | Bazen (%5–29) | 1 durumda |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Bazen (%5–29) | 1 durumda |
| DNAJC12DnaJ heat shock protein family (Hsp40) member C12 | Bazen (%5–29) | 1 durumda |
| ERLIN1ER lipid raft associated 1 | Bazen (%5–29) | 1 durumda |
| FTLferritin light chain | Bazen (%5–29) | 2 durumda |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Bazen (%5–29) | 1 durumda |
| GP1BBglycoprotein Ib platelet subunit beta | Bazen (%5–29) | 1 durumda |
| GRNgranulin precursor | Bazen (%5–29) | 2 durumda |
| HIRAhistone cell cycle regulator | Bazen (%5–29) | 1 durumda |
| HIVEP2HIVEP zinc finger 2 | Bazen (%5–29) | 1 durumda |
| JMJD1Cjumonji domain containing 1C | Bazen (%5–29) | 1 durumda |
| JPH3junctophilin 3 | Bazen (%5–29) | 1 durumda |
| KCNN2potassium calcium-activated channel subfamily N member 2 | Bazen (%5–29) | 1 durumda |
| KIF5Akinesin family member 5A | Bazen (%5–29) | 2 durumda |
| LYSTlysosomal trafficking regulator | Bazen (%5–29) | 1 durumda |
| MECP2methyl-CpG binding protein 2 | Bazen (%5–29) | 2 durumda |
| MYORGmyogenesis regulating glycosidase | Bazen (%5–29) | 2 durumda |
| NOTCH3notch receptor 3 | Bazen (%5–29) | 1 durumda |
| PDGFBplatelet derived growth factor subunit B | Bazen (%5–29) | 2 durumda |
| PDGFRBplatelet derived growth factor receptor beta | Bazen (%5–29) | 2 durumda |
| RREB1ras responsive element binding protein 1 | Bazen (%5–29) | 1 durumda |
| RRP12ribosomal RNA processing 12 homolog | Bazen (%5–29) | 1 durumda |
| SEC24CSEC24 homolog C, COPII component | Bazen (%5–29) | 1 durumda |
| SIGMAR1sigma receptor chaperone 1 | Bazen (%5–29) | 1 durumda |
| SLC20A2solute carrier family 20 member 2 | Bazen (%5–29) | 1 durumda |
| SORDsorbitol dehydrogenase | Bazen (%5–29) | 1 durumda |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Bazen (%5–29) | 2 durumda |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Bazen (%5–29) | 1 durumda |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Bazen (%5–29) | 1 durumda |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Bazen (%5–29) | 1 durumda |
| TBX1T-box transcription factor 1 | Bazen (%5–29) | 1 durumda |
| TMEM106Btransmembrane protein 106B | Bazen (%5–29) | 1 durumda |
| TRMT2BtRNA methyltransferase 2B | Bazen (%5–29) | 1 durumda |
| UBQLN2ubiquilin 2 | Bazen (%5–29) | 1 durumda |
| UBTFupstream binding transcription factor | Bazen (%5–29) | 1 durumda |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Bazen (%5–29) | 1 durumda |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Bazen (%5–29) | 2 durumda |
| ATN1atrophin 1 | Seyrek (%1–4) | 1 durumda |
| CATcatalase | Seyrek (%1–4) | 1 durumda |
| PCBD1pterin-4 alpha-carbinolamine dehydratase 1 | Seyrek (%1–4) | 1 durumda |
| SCARB2scavenger receptor class B member 2 | Seyrek (%1–4) | 1 durumda |
| TWNKtwinkle mtDNA helicase | Seyrek (%1–4) | 1 durumda |
| ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide | Kaydedilmedi | 1 durumda |
| APOEapolipoprotein E | Kaydedilmedi | 1 durumda |
| ATXN8OSATXN8 opposite strand lncRNA | Kaydedilmedi | 1 durumda |
| C9orf72C9orf72-SMCR8 complex subunit | Kaydedilmedi | 1 durumda |
| DNAJC5DnaJ heat shock protein family (Hsp40) member C5 | Kaydedilmedi | 1 durumda |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Kaydedilmedi | 1 durumda |
| MPOmyeloperoxidase | Kaydedilmedi | 1 durumda |
| MT-TTmitochondrially encoded tRNA-Thr (ACN) | Kaydedilmedi | 1 durumda |
| PDE10Aphosphodiesterase 10A | Kaydedilmedi | 1 durumda |
| PINK1PTEN induced kinase 1 | Kaydedilmedi | 1 durumda |
| PLAUplasminogen activator, urokinase | Kaydedilmedi | 1 durumda |
| PTS6-pyruvoyltetrahydropterin synthase | Kaydedilmedi | 1 durumda |
| SLC30A10solute carrier family 30 member 10 | Kaydedilmedi | 1 durumda |
| SNCAIPsynuclein alpha interacting protein | Kaydedilmedi | 1 durumda |
| SNCBsynuclein beta | Kaydedilmedi | 1 durumda |
| TMEM240transmembrane protein 240 | Kaydedilmedi | 1 durumda |
| TNRtenascin R | Kaydedilmedi | 1 durumda |
Bu özelliğin, genin ilişkili olduğu durumlardan birine sahip kişiler arasında ne sıklıkta görüldüğü; Human Phenotype Ontology'nin kaydettiği şekliyle, bunlar arasında en sık görülen oran. Bu sayfalar özellikleri ve bunların arkasındaki araştırmaları anlatır; tanı koymaz. Belirtiler hakkında bir doktora veya genetik danışmana başvurmanız gerekir.
Daha dar özellikler
Daha geniş özellikler
Bilgilerin kaynağı
- Human Phenotype Ontology, 2026-09-01 sürümü: özellik, adları, tanımı ve buna bağlı genler. Ayrıntılar için hpo.jax.org adresine bakın.
- Veri sürümü 2026.10.19-9814e911.
AtlasKimlere Yardımcı OluyoruzBilimimizÜrünlerSonuçlar
Giriş YapSorGenomunuzu dizileyin↗
From traits to your genome
Read the genes behind these traits in your own DNA.
The Genome Test sequences nearly all of your DNA, not a preset panel, so every gene on these pages is in your data. Premium adds 810+ physician-ready reports.
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