Tunnus
Hyperkeratosis
Hyperkeratosis is a histopathological term defining a thickened stratum corneum and may be present in many different skin conditions, with many possible overlaps. Hyperkeratosis refers to the increased thickness of the stratum corneum, the outer layer of the skin. Hyperkeratosis is subclassified as orthokeratotic or parakeratotic. Orthokeratotic hyperkeratosis refers to the thickening of the keratin layer with preserved keratinocyte maturation, while parakeratotic hyperkeratosis shows retained nuclei as a sign of delayed maturation of keratinocytes.
Kokkuvõte
- Teised nimetused
- Epidermal hyperkeratosis
- Kehasüsteem
- Abnormality of the integument
VõrdlusgenoomGRCh38hg38
Geeni- ja variandilehtede positsioonid järgivad seda valikut selles brauseris.
Read the genes linked to Hyperkeratosis, and the rest of your genome, with one test.
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Telli oma Genome Test148 geeni on seotud tunnusega Hyperkeratosis
Nende geenide muutused põhjustavad haruldasi haigusi, mille puhul esineb Hyperkeratosis. Enamikul selle tunnusega inimestest ei ole ühtegi neist haigustest. Selles loendis olev geen ei ütle midagi kellegi enda genoomi kohta.
| Geen | Kui sageli seda täheldatakse | Haigused |
|---|---|---|
| ADAM10ADAM metallopeptidase domain 10 | Alati | Esineb 1 haiguses |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Alati | Esineb 2 haiguses |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Alati | Esineb 3 haiguses |
| CASTcalpastatin | Alati | Esineb 1 haiguses |
| CERS3ceramide synthase 3 | Alati | Esineb 1 haiguses |
| DCLRE1CDNA cross-link repair 1C | Alati | Esineb 1 haiguses |
| DSPdesmoplakin | Alati | Esineb 1 haiguses |
| ELOVL1ELOVL fatty acid elongase 1 | Alati | Esineb 1 haiguses |
| EXPH5exophilin 5 | Alati | Esineb 1 haiguses |
| GJA1gap junction protein alpha 1 | Alati | Esineb 3 haiguses |
| GJB2gap junction protein beta 2 | Alati | Esineb 4 haiguses |
| GLSglutaminase | Alati | Esineb 1 haiguses |
| IL1RNinterleukin 1 receptor antagonist | Alati | Esineb 1 haiguses |
| JUPjunction plakoglobin | Alati | Esineb 1 haiguses |
| KDSR3-ketodihydrosphingosine reductase | Alati | Esineb 2 haiguses |
| KRT10keratin 10 | Alati | Esineb 3 haiguses |
| KRT83keratin 83 | Alati | Esineb 1 haiguses |
| LIPNlipase family member N | Alati | Esineb 2 haiguses |
| LORICRINloricrin cornified envelope precursor protein | Alati | Esineb 2 haiguses |
| MAD1L1mitotic arrest deficient 1 like 1 | Alati | Esineb 1 haiguses |
| MAP2K1mitogen-activated protein kinase kinase 1 | Alati | Esineb 3 haiguses |
| NDC1NDC1 transmembrane nucleoporin | Alati | Esineb 1 haiguses |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Alati | Esineb 2 haiguses |
| OSBPL2oxysterol binding protein like 2 | Alati | Esineb 1 haiguses |
| PERPp53 apoptosis effector related to PMP22 | Alati | Esineb 1 haiguses |
| PPOXprotoporphyrinogen oxidase | Alati | Esineb 1 haiguses |
| RAG1recombination activating 1 | Alati | Esineb 1 haiguses |
| RAG2recombination activating 2 | Alati | Esineb 1 haiguses |
| RIGIRNA sensor RIG-I | Alati | Esineb 1 haiguses |
| SPINK5serine peptidase inhibitor Kazal type 5 | Alati | Esineb 2 haiguses |
| SULT2B1sulfotransferase family 2B member 1 | Alati | Esineb 2 haiguses |
| TRPS1transcriptional repressor GATA binding 1 | Alati | Esineb 1 haiguses |
| VEGFCvascular endothelial growth factor C | Alati | Esineb 1 haiguses |
| WNT10AWnt family member 10A | Alati | Esineb 1 haiguses |
| ABCA12ATP binding cassette subfamily A member 12 | Väga sageli (80–99%) | Esineb 2 haiguses |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Väga sageli (80–99%) | Esineb 1 haiguses |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Väga sageli (80–99%) | Esineb 2 haiguses |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Väga sageli (80–99%) | Esineb 3 haiguses |
| AP1B1adaptor related protein complex 1 subunit beta 1 | Väga sageli (80–99%) | Esineb 1 haiguses |
| AP1S1adaptor related protein complex 1 subunit sigma 1 | Väga sageli (80–99%) | Esineb 1 haiguses |
Näita veel 108 geeni
| Geen | Kui sageli seda täheldatakse | Haigused |
|---|---|---|
| ASPRV1aspartic peptidase retroviral like 1 | Väga sageli (80–99%) | Esineb 2 haiguses |
| ATP2C1ATPase secretory pathway Ca2+ transporting 1 | Väga sageli (80–99%) | Esineb 1 haiguses |
| CLEC7AC-type lectin domain containing 7A | Väga sageli (80–99%) | Esineb 1 haiguses |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Väga sageli (80–99%) | Esineb 1 haiguses |
| FLGfilaggrin | Väga sageli (80–99%) | Esineb 1 haiguses |
| GJB3gap junction protein beta 3 | Väga sageli (80–99%) | Esineb 1 haiguses |
| GJB4gap junction protein beta 4 | Väga sageli (80–99%) | Esineb 1 haiguses |
| GLAgalactosidase alpha | Väga sageli (80–99%) | Esineb 1 haiguses |
| HLA-Bmajor histocompatibility complex, class I, B | Väga sageli (80–99%) | Esineb 1 haiguses |
| HRASHRas proto-oncogene, GTPase | Väga sageli (80–99%) | Esineb 1 haiguses |
| IL17Finterleukin 17F | Väga sageli (80–99%) | Esineb 1 haiguses |
| IL17RAinterleukin 17 receptor A | Väga sageli (80–99%) | Esineb 1 haiguses |
| IL17RCinterleukin 17 receptor C | Väga sageli (80–99%) | Esineb 1 haiguses |
| INSRinsulin receptor | Väga sageli (80–99%) | Esineb 3 haiguses |
| KRT1keratin 1 | Väga sageli (80–99%) | Esineb 3 haiguses |
| KRT14keratin 14 | Väga sageli (80–99%) | Esineb 2 haiguses |
| KRT16keratin 16 | Väga sageli (80–99%) | Esineb 1 haiguses |
| KRT5keratin 5 | Väga sageli (80–99%) | Esineb 3 haiguses |
| KRT9keratin 9 | Väga sageli (80–99%) | Esineb 1 haiguses |
| LMNAlamin A/C | Väga sageli (80–99%) | Esineb 2 haiguses |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Väga sageli (80–99%) | Esineb 1 haiguses |
| MVKmevalonate kinase | Väga sageli (80–99%) | Esineb 1 haiguses |
| NAGAalpha-N-acetylgalactosaminidase | Väga sageli (80–99%) | Esineb 3 haiguses |
| NEU1neuraminidase 1 | Väga sageli (80–99%) | Esineb 1 haiguses |
| NIPAL4NIPA like domain containing 4 | Väga sageli (80–99%) | Esineb 2 haiguses |
| PEPDpeptidase D | Väga sageli (80–99%) | Esineb 1 haiguses |
| PMVKphosphomevalonate kinase | Väga sageli (80–99%) | Esineb 1 haiguses |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Väga sageli (80–99%) | Esineb 2 haiguses |
| STSsteroid sulfatase | Väga sageli (80–99%) | Esineb 2 haiguses |
| TATtyrosine aminotransferase | Väga sageli (80–99%) | Esineb 1 haiguses |
| TGM1transglutaminase 1 | Väga sageli (80–99%) | Esineb 1 haiguses |
| TP63tumor protein p63 | Väga sageli (80–99%) | Esineb 2 haiguses |
| TRAF3IP2TRAF3 interacting protein 2 | Väga sageli (80–99%) | Esineb 1 haiguses |
| ZMPSTE24zinc metallopeptidase STE24 | Väga sageli (80–99%) | Esineb 2 haiguses |
| ANAPC1anaphase promoting complex subunit 1 | Sageli (30–79%) | Esineb 1 haiguses |
| ATL1atlastin GTPase 1 | Sageli (30–79%) | Esineb 1 haiguses |
| ATL3atlastin GTPase 3 | Sageli (30–79%) | Esineb 2 haiguses |
| CDSNcorneodesmosin | Sageli (30–79%) | Esineb 1 haiguses |
| COG6component of oligomeric golgi complex 6 | Sageli (30–79%) | Esineb 1 haiguses |
| DDB2damage specific DNA binding protein 2 | Sageli (30–79%) | Esineb 1 haiguses |
| ECM1extracellular matrix protein 1 | Sageli (30–79%) | Esineb 2 haiguses |
| ELOVL4ELOVL fatty acid elongase 4 | Sageli (30–79%) | Esineb 2 haiguses |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sageli (30–79%) | Esineb 2 haiguses |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sageli (30–79%) | Esineb 1 haiguses |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Sageli (30–79%) | Esineb 1 haiguses |
| ERCC5ERCC excision repair 5, endonuclease | Sageli (30–79%) | Esineb 1 haiguses |
| FLT4fms related receptor tyrosine kinase 4 | Sageli (30–79%) | Esineb 1 haiguses |
| KRASKRas proto-oncogene, GTPase | Sageli (30–79%) | Esineb 2 haiguses |
| KRT74keratin 74 | Sageli (30–79%) | Esineb 1 haiguses |
| LZTR1leucine zipper like post translational regulator 1 | Sageli (30–79%) | Esineb 2 haiguses |
| MAP2K2mitogen-activated protein kinase kinase 2 | Sageli (30–79%) | Esineb 2 haiguses |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sageli (30–79%) | Esineb 3 haiguses |
| POFUT1protein O-fucosyltransferase 1 | Sageli (30–79%) | Esineb 1 haiguses |
| POGLUT1protein O-glucosyltransferase 1 | Sageli (30–79%) | Esineb 1 haiguses |
| PSENENpresenilin enhancer, gamma-secretase subunit | Sageli (30–79%) | Esineb 1 haiguses |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Sageli (30–79%) | Esineb 1 haiguses |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Sageli (30–79%) | Esineb 1 haiguses |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Sageli (30–79%) | Esineb 1 haiguses |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Sageli (30–79%) | Esineb 1 haiguses |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Sageli (30–79%) | Esineb 1 haiguses |
| VPS33BVPS33B late endosome and lysosome associated | Sageli (30–79%) | Esineb 1 haiguses |
| WRNWRN RecQ like helicase | Sageli (30–79%) | Esineb 1 haiguses |
| XPAXPA, DNA damage recognition and repair factor | Sageli (30–79%) | Esineb 1 haiguses |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Sageli (30–79%) | Esineb 1 haiguses |
| AHSGalpha 2-HS glycoprotein | Mõnikord (5–29%) | Esineb 1 haiguses |
| CD28CD28 molecule | Mõnikord (5–29%) | Esineb 1 haiguses |
| CDH3cadherin 3 | Mõnikord (5–29%) | Esineb 1 haiguses |
| COL12A1collagen type XII alpha 1 chain | Mõnikord (5–29%) | Esineb 1 haiguses |
| COL6A1collagen type VI alpha 1 chain | Mõnikord (5–29%) | Esineb 1 haiguses |
| COL6A2collagen type VI alpha 2 chain | Mõnikord (5–29%) | Esineb 1 haiguses |
| COL6A3collagen type VI alpha 3 chain | Mõnikord (5–29%) | Esineb 1 haiguses |
| COL7A1collagen type VII alpha 1 chain | Mõnikord (5–29%) | Esineb 2 haiguses |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Mõnikord (5–29%) | Esineb 1 haiguses |
| DIP2BDIP2 acetate--CoA ligase B (putative) | Mõnikord (5–29%) | Esineb 1 haiguses |
| DKC1dyskerin pseudouridine synthase 1 | Mõnikord (5–29%) | Esineb 1 haiguses |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Mõnikord (5–29%) | Esineb 1 haiguses |
| DOLKdolichol kinase | Mõnikord (5–29%) | Esineb 1 haiguses |
| ELMO2engulfment and cell motility 2 | Mõnikord (5–29%) | Esineb 1 haiguses |
| ERMARDER membrane associated RNA degradation | Mõnikord (5–29%) | Esineb 1 haiguses |
| FERMT1FERM domain containing kindlin 1 | Mõnikord (5–29%) | Esineb 1 haiguses |
| GMPPAGDP-mannose pyrophosphorylase A | Mõnikord (5–29%) | Esineb 1 haiguses |
| HDAC6histone deacetylase 6 | Mõnikord (5–29%) | Esineb 1 haiguses |
| ITGB6integrin subunit beta 6 | Mõnikord (5–29%) | Esineb 1 haiguses |
| LSSlanosterol synthase | Mõnikord (5–29%) | Esineb 1 haiguses |
| MDFICMyoD family inhibitor domain containing | Mõnikord (5–29%) | Esineb 1 haiguses |
| PDGFRBplatelet derived growth factor receptor beta | Mõnikord (5–29%) | Esineb 1 haiguses |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Mõnikord (5–29%) | Esineb 1 haiguses |
| RIT1Ras like without CAAX 1 | Mõnikord (5–29%) | Esineb 1 haiguses |
| TNFRSF1BTNF receptor superfamily member 1B | Mõnikord (5–29%) | Esineb 1 haiguses |
| TYRtyrosinase | Mõnikord (5–29%) | Esineb 1 haiguses |
| AKT1AKT serine/threonine kinase 1 | Pole registreeritud | Esineb 1 haiguses |
| CARD14caspase recruitment domain family member 14 | Pole registreeritud | Esineb 1 haiguses |
| CSTAcystatin A | Pole registreeritud | Esineb 1 haiguses |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Pole registreeritud | Esineb 1 haiguses |
| GBA1glucosylceramidase beta 1 | Pole registreeritud | Esineb 1 haiguses |
| GRHL2grainyhead like transcription factor 2 | Pole registreeritud | Esineb 1 haiguses |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Pole registreeritud | Esineb 1 haiguses |
| KITLGKIT ligand | Pole registreeritud | Esineb 1 haiguses |
| KLK11kallikrein related peptidase 11 | Pole registreeritud | Esineb 1 haiguses |
| MPDU1mannose-P-dolichol utilization defect 1 | Pole registreeritud | Esineb 1 haiguses |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Pole registreeritud | Esineb 1 haiguses |
| POLA1DNA polymerase alpha 1, catalytic subunit | Pole registreeritud | Esineb 1 haiguses |
| RNU4ATACRNA, U4atac small nuclear | Pole registreeritud | Esineb 1 haiguses |
| SERPINB8serpin family B member 8 | Pole registreeritud | Esineb 1 haiguses |
| SOX18SRY-box transcription factor 18 | Pole registreeritud | Esineb 1 haiguses |
| SRD5A3steroid 5 alpha-reductase 3 | Pole registreeritud | Esineb 1 haiguses |
| ST14ST14 transmembrane serine protease matriptase | Pole registreeritud | Esineb 1 haiguses |
| ZNF750zinc finger protein 750 | Pole registreeritud | Esineb 1 haiguses |
Kui sageli see esineb geenist tulenevate seisunditega inimeste seas, kõige sagedamini nende kõigi seas, nagu on märgitud Inimese fenotüübi ontoloogias. Need lehed kirjeldavad tunnuseid ja nende taga olevaid uuringuid; need ei ole diagnoos ning sümptomite kohta tuleks küsida arstilt või geneetilt nõustajalt.
Kitsamad tunnused
- Follicular hyperkeratosis32 geeni
- Hyperkeratotic papule17 geeni
- Plantar hyperkeratosis17 geeni
- Palmar hyperkeratosis12 geeni
- Thickened, discolored skin under nail8 geeni
- Generalized hyperkeratosis7 geeni
- Orthokeratotic hyperkeratosis7 geeni
- Cobblestone-like hyperkeratosis5 geeni
- Linear arrays of macular hyperkeratoses in flexural areas5 geeni
- Hyperparakeratosis4 geeni
- Perifollicular hyperkeratosis2 geeni
- Gingival hyperkeratosis1 geen
- Hyperkeratosis over edematous areas1 geen
- Hyperkeratosis with erythema1 geen
- Periorificial hyperkeratosis1 geen
- Streaks of hyperkeratosis along each finger onto the palm1 geen
- Subungual hyperkeratotic fragments1 geen
Laiemad tunnused
Allikas
- Inimese fenotüübi ontoloogia, versioon 2026-09-01: tunnus, selle nimetused, määratlus ja sellega seotud geenid. Lisateave leiab aadressilt hpo.jax.org.
- Andmeversioon 2026.10.16-c6eea6bf.
Üks test. Vastused kogu eluks.
Alates 449 $Tasuta kohaletoimetamine · Tulemused 6–8 nädala pärast