Træk
Hyperkeratosis
Hyperkeratosis is a histopathological term defining a thickened stratum corneum and may be present in many different skin conditions, with many possible overlaps. Hyperkeratosis refers to the increased thickness of the stratum corneum, the outer layer of the skin. Hyperkeratosis is subclassified as orthokeratotic or parakeratotic. Orthokeratotic hyperkeratosis refers to the thickening of the keratin layer with preserved keratinocyte maturation, while parakeratotic hyperkeratosis shows retained nuclei as a sign of delayed maturation of keratinocytes.
Resumé
- Også kaldet
- Epidermal hyperkeratosis
- Kropssystem
- Abnormality of the integument
ReferencegenomGRCh38hg38
Positioner på gen- og variantsider følger dette valg i denne browser.
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Bestil min Genome Test148 gener knyttet til Hyperkeratosis
Ændringer i disse gener forårsager sjældne tilstande, hvor Hyperkeratosis ses. De fleste med dette træk har ingen af disse tilstande, og et gen på denne liste siger intet om nogens eget genom.
| Gen | Hvor ofte det ses | Tilstande |
|---|---|---|
| ADAM10ADAM metallopeptidase domain 10 | Altid | I 1 tilstand |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Altid | I 2 tilstande |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Altid | I 3 tilstande |
| CASTcalpastatin | Altid | I 1 tilstand |
| CERS3ceramide synthase 3 | Altid | I 1 tilstand |
| DCLRE1CDNA cross-link repair 1C | Altid | I 1 tilstand |
| DSPdesmoplakin | Altid | I 1 tilstand |
| ELOVL1ELOVL fatty acid elongase 1 | Altid | I 1 tilstand |
| EXPH5exophilin 5 | Altid | I 1 tilstand |
| GJA1gap junction protein alpha 1 | Altid | I 3 tilstande |
| GJB2gap junction protein beta 2 | Altid | I 4 tilstande |
| GLSglutaminase | Altid | I 1 tilstand |
| IL1RNinterleukin 1 receptor antagonist | Altid | I 1 tilstand |
| JUPjunction plakoglobin | Altid | I 1 tilstand |
| KDSR3-ketodihydrosphingosine reductase | Altid | I 2 tilstande |
| KRT10keratin 10 | Altid | I 3 tilstande |
| KRT83keratin 83 | Altid | I 1 tilstand |
| LIPNlipase family member N | Altid | I 2 tilstande |
| LORICRINloricrin cornified envelope precursor protein | Altid | I 2 tilstande |
| MAD1L1mitotic arrest deficient 1 like 1 | Altid | I 1 tilstand |
| MAP2K1mitogen-activated protein kinase kinase 1 | Altid | I 3 tilstande |
| NDC1NDC1 transmembrane nucleoporin | Altid | I 1 tilstand |
| NSDHLNAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL | Altid | I 2 tilstande |
| OSBPL2oxysterol binding protein like 2 | Altid | I 1 tilstand |
| PERPp53 apoptosis effector related to PMP22 | Altid | I 1 tilstand |
| PPOXprotoporphyrinogen oxidase | Altid | I 1 tilstand |
| RAG1recombination activating 1 | Altid | I 1 tilstand |
| RAG2recombination activating 2 | Altid | I 1 tilstand |
| RIGIRNA sensor RIG-I | Altid | I 1 tilstand |
| SPINK5serine peptidase inhibitor Kazal type 5 | Altid | I 2 tilstande |
| SULT2B1sulfotransferase family 2B member 1 | Altid | I 2 tilstande |
| TRPS1transcriptional repressor GATA binding 1 | Altid | I 1 tilstand |
| VEGFCvascular endothelial growth factor C | Altid | I 1 tilstand |
| WNT10AWnt family member 10A | Altid | I 1 tilstand |
| ABCA12ATP binding cassette subfamily A member 12 | Meget ofte (80–99 %) | I 2 tilstande |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Meget ofte (80–99 %) | I 1 tilstand |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Meget ofte (80–99 %) | I 2 tilstande |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Meget ofte (80–99 %) | I 3 tilstande |
| AP1B1adaptor related protein complex 1 subunit beta 1 | Meget ofte (80–99 %) | I 1 tilstand |
| AP1S1adaptor related protein complex 1 subunit sigma 1 | Meget ofte (80–99 %) | I 1 tilstand |
Vis 108 gener mere
| Gen | Hvor ofte det ses | Tilstande |
|---|---|---|
| ASPRV1aspartic peptidase retroviral like 1 | Meget ofte (80–99 %) | I 2 tilstande |
| ATP2C1ATPase secretory pathway Ca2+ transporting 1 | Meget ofte (80–99 %) | I 1 tilstand |
| CLEC7AC-type lectin domain containing 7A | Meget ofte (80–99 %) | I 1 tilstand |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Meget ofte (80–99 %) | I 1 tilstand |
| FLGfilaggrin | Meget ofte (80–99 %) | I 1 tilstand |
| GJB3gap junction protein beta 3 | Meget ofte (80–99 %) | I 1 tilstand |
| GJB4gap junction protein beta 4 | Meget ofte (80–99 %) | I 1 tilstand |
| GLAgalactosidase alpha | Meget ofte (80–99 %) | I 1 tilstand |
| HLA-Bmajor histocompatibility complex, class I, B | Meget ofte (80–99 %) | I 1 tilstand |
| HRASHRas proto-oncogene, GTPase | Meget ofte (80–99 %) | I 1 tilstand |
| IL17Finterleukin 17F | Meget ofte (80–99 %) | I 1 tilstand |
| IL17RAinterleukin 17 receptor A | Meget ofte (80–99 %) | I 1 tilstand |
| IL17RCinterleukin 17 receptor C | Meget ofte (80–99 %) | I 1 tilstand |
| INSRinsulin receptor | Meget ofte (80–99 %) | I 3 tilstande |
| KRT1keratin 1 | Meget ofte (80–99 %) | I 3 tilstande |
| KRT14keratin 14 | Meget ofte (80–99 %) | I 2 tilstande |
| KRT16keratin 16 | Meget ofte (80–99 %) | I 1 tilstand |
| KRT5keratin 5 | Meget ofte (80–99 %) | I 3 tilstande |
| KRT9keratin 9 | Meget ofte (80–99 %) | I 1 tilstand |
| LMNAlamin A/C | Meget ofte (80–99 %) | I 2 tilstande |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Meget ofte (80–99 %) | I 1 tilstand |
| MVKmevalonate kinase | Meget ofte (80–99 %) | I 1 tilstand |
| NAGAalpha-N-acetylgalactosaminidase | Meget ofte (80–99 %) | I 3 tilstande |
| NEU1neuraminidase 1 | Meget ofte (80–99 %) | I 1 tilstand |
| NIPAL4NIPA like domain containing 4 | Meget ofte (80–99 %) | I 2 tilstande |
| PEPDpeptidase D | Meget ofte (80–99 %) | I 1 tilstand |
| PMVKphosphomevalonate kinase | Meget ofte (80–99 %) | I 1 tilstand |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Meget ofte (80–99 %) | I 2 tilstande |
| STSsteroid sulfatase | Meget ofte (80–99 %) | I 2 tilstande |
| TATtyrosine aminotransferase | Meget ofte (80–99 %) | I 1 tilstand |
| TGM1transglutaminase 1 | Meget ofte (80–99 %) | I 1 tilstand |
| TP63tumor protein p63 | Meget ofte (80–99 %) | I 2 tilstande |
| TRAF3IP2TRAF3 interacting protein 2 | Meget ofte (80–99 %) | I 1 tilstand |
| ZMPSTE24zinc metallopeptidase STE24 | Meget ofte (80–99 %) | I 2 tilstande |
| ANAPC1anaphase promoting complex subunit 1 | Ofte (30–79 %) | I 1 tilstand |
| ATL1atlastin GTPase 1 | Ofte (30–79 %) | I 1 tilstand |
| ATL3atlastin GTPase 3 | Ofte (30–79 %) | I 2 tilstande |
| CDSNcorneodesmosin | Ofte (30–79 %) | I 1 tilstand |
| COG6component of oligomeric golgi complex 6 | Ofte (30–79 %) | I 1 tilstand |
| DDB2damage specific DNA binding protein 2 | Ofte (30–79 %) | I 1 tilstand |
| ECM1extracellular matrix protein 1 | Ofte (30–79 %) | I 2 tilstande |
| ELOVL4ELOVL fatty acid elongase 4 | Ofte (30–79 %) | I 2 tilstande |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Ofte (30–79 %) | I 2 tilstande |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Ofte (30–79 %) | I 1 tilstand |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Ofte (30–79 %) | I 1 tilstand |
| ERCC5ERCC excision repair 5, endonuclease | Ofte (30–79 %) | I 1 tilstand |
| FLT4fms related receptor tyrosine kinase 4 | Ofte (30–79 %) | I 1 tilstand |
| KRASKRas proto-oncogene, GTPase | Ofte (30–79 %) | I 2 tilstande |
| KRT74keratin 74 | Ofte (30–79 %) | I 1 tilstand |
| LZTR1leucine zipper like post translational regulator 1 | Ofte (30–79 %) | I 2 tilstande |
| MAP2K2mitogen-activated protein kinase kinase 2 | Ofte (30–79 %) | I 2 tilstande |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Ofte (30–79 %) | I 3 tilstande |
| POFUT1protein O-fucosyltransferase 1 | Ofte (30–79 %) | I 1 tilstand |
| POGLUT1protein O-glucosyltransferase 1 | Ofte (30–79 %) | I 1 tilstand |
| PSENENpresenilin enhancer, gamma-secretase subunit | Ofte (30–79 %) | I 1 tilstand |
| SHOC2SHOC2 leucine rich repeat scaffold protein | Ofte (30–79 %) | I 1 tilstand |
| SPTLC1serine palmitoyltransferase long chain base subunit 1 | Ofte (30–79 %) | I 1 tilstand |
| SPTLC2serine palmitoyltransferase long chain base subunit 2 | Ofte (30–79 %) | I 1 tilstand |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Ofte (30–79 %) | I 1 tilstand |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Ofte (30–79 %) | I 1 tilstand |
| VPS33BVPS33B late endosome and lysosome associated | Ofte (30–79 %) | I 1 tilstand |
| WRNWRN RecQ like helicase | Ofte (30–79 %) | I 1 tilstand |
| XPAXPA, DNA damage recognition and repair factor | Ofte (30–79 %) | I 1 tilstand |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Ofte (30–79 %) | I 1 tilstand |
| AHSGalpha 2-HS glycoprotein | Nogle gange (5–29 %) | I 1 tilstand |
| CD28CD28 molecule | Nogle gange (5–29 %) | I 1 tilstand |
| CDH3cadherin 3 | Nogle gange (5–29 %) | I 1 tilstand |
| COL12A1collagen type XII alpha 1 chain | Nogle gange (5–29 %) | I 1 tilstand |
| COL6A1collagen type VI alpha 1 chain | Nogle gange (5–29 %) | I 1 tilstand |
| COL6A2collagen type VI alpha 2 chain | Nogle gange (5–29 %) | I 1 tilstand |
| COL6A3collagen type VI alpha 3 chain | Nogle gange (5–29 %) | I 1 tilstand |
| COL7A1collagen type VII alpha 1 chain | Nogle gange (5–29 %) | I 2 tilstande |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Nogle gange (5–29 %) | I 1 tilstand |
| DIP2BDIP2 acetate--CoA ligase B (putative) | Nogle gange (5–29 %) | I 1 tilstand |
| DKC1dyskerin pseudouridine synthase 1 | Nogle gange (5–29 %) | I 1 tilstand |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Nogle gange (5–29 %) | I 1 tilstand |
| DOLKdolichol kinase | Nogle gange (5–29 %) | I 1 tilstand |
| ELMO2engulfment and cell motility 2 | Nogle gange (5–29 %) | I 1 tilstand |
| ERMARDER membrane associated RNA degradation | Nogle gange (5–29 %) | I 1 tilstand |
| FERMT1FERM domain containing kindlin 1 | Nogle gange (5–29 %) | I 1 tilstand |
| GMPPAGDP-mannose pyrophosphorylase A | Nogle gange (5–29 %) | I 1 tilstand |
| HDAC6histone deacetylase 6 | Nogle gange (5–29 %) | I 1 tilstand |
| ITGB6integrin subunit beta 6 | Nogle gange (5–29 %) | I 1 tilstand |
| LSSlanosterol synthase | Nogle gange (5–29 %) | I 1 tilstand |
| MDFICMyoD family inhibitor domain containing | Nogle gange (5–29 %) | I 1 tilstand |
| PDGFRBplatelet derived growth factor receptor beta | Nogle gange (5–29 %) | I 1 tilstand |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Nogle gange (5–29 %) | I 1 tilstand |
| RIT1Ras like without CAAX 1 | Nogle gange (5–29 %) | I 1 tilstand |
| TNFRSF1BTNF receptor superfamily member 1B | Nogle gange (5–29 %) | I 1 tilstand |
| TYRtyrosinase | Nogle gange (5–29 %) | I 1 tilstand |
| AKT1AKT serine/threonine kinase 1 | Ikke registreret | I 1 tilstand |
| CARD14caspase recruitment domain family member 14 | Ikke registreret | I 1 tilstand |
| CSTAcystatin A | Ikke registreret | I 1 tilstand |
| ENPP1ectonucleotide pyrophosphatase/phosphodiesterase 1 | Ikke registreret | I 1 tilstand |
| GBA1glucosylceramidase beta 1 | Ikke registreret | I 1 tilstand |
| GRHL2grainyhead like transcription factor 2 | Ikke registreret | I 1 tilstand |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Ikke registreret | I 1 tilstand |
| KITLGKIT ligand | Ikke registreret | I 1 tilstand |
| KLK11kallikrein related peptidase 11 | Ikke registreret | I 1 tilstand |
| MPDU1mannose-P-dolichol utilization defect 1 | Ikke registreret | I 1 tilstand |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Ikke registreret | I 1 tilstand |
| POLA1DNA polymerase alpha 1, catalytic subunit | Ikke registreret | I 1 tilstand |
| RNU4ATACRNA, U4atac small nuclear | Ikke registreret | I 1 tilstand |
| SERPINB8serpin family B member 8 | Ikke registreret | I 1 tilstand |
| SOX18SRY-box transcription factor 18 | Ikke registreret | I 1 tilstand |
| SRD5A3steroid 5 alpha-reductase 3 | Ikke registreret | I 1 tilstand |
| ST14ST14 transmembrane serine protease matriptase | Ikke registreret | I 1 tilstand |
| ZNF750zinc finger protein 750 | Ikke registreret | I 1 tilstand |
Hvor hyppigt det ses hos personer med en af genets tilstande, den hyppigste værdi på tværs af dem, sådan som Human Phenotype Ontology registrerer det. Disse sider beskriver egenskaber og den forskning, der ligger bag dem. De er ikke en diagnose, og hvis du har spørgsmål om symptomer, bør du spørge en læge eller genetisk rådgiver.
Snævrere træk
- Follicular hyperkeratosis32 gener
- Hyperkeratotic papule17 gener
- Plantar hyperkeratosis17 gener
- Palmar hyperkeratosis12 gener
- Thickened, discolored skin under nail8 gener
- Generalized hyperkeratosis7 gener
- Orthokeratotic hyperkeratosis7 gener
- Cobblestone-like hyperkeratosis5 gener
- Linear arrays of macular hyperkeratoses in flexural areas5 gener
- Hyperparakeratosis4 gener
- Perifollicular hyperkeratosis2 gener
- Gingival hyperkeratosis1 gen
- Hyperkeratosis over edematous areas1 gen
- Hyperkeratosis with erythema1 gen
- Periorificial hyperkeratosis1 gen
- Streaks of hyperkeratosis along each finger onto the palm1 gen
- Subungual hyperkeratotic fragments1 gen
Bredere træk
Hvor oplysningerne kommer fra
- Human Phenotype Ontology, udgivelse 2026-09-01: egenskaben, dens navne, definition og de gener, der er knyttet til den. Læs mere på hpo.jax.org.
- Dataudgivelse 2026.10.16-c6eea6bf.
Én test. Svar for hele livet.
Fra 449 $Gratis forsendelse · Resultater på 6–8 uger