AtlasKam padedameMūsų mokslasProduktaiRezultatai
PrisijungtiKlaustiSekvenuokite savo genomą↗
Požymis
Increased lactate in body
Klinikinis pavadinimas: Lactic acidosis
An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids.
Santrauka
- Taip pat vadinama
- Hyperlacticacidemia, Lactic acidemia, Lacticacidemia, Lacticacidosis
- Kūno sistema
- Laboratory abnormality
AtlasKam padedameMūsų mokslasProduktaiRezultatai
PrisijungtiKlaustiSekvenuokite savo genomą↗
Ši puslapis kaip duomenys
Norėdami perskaityti jį kaip JSON, pridėkite .json prie puslapio adreso arba nurodykite application/json.
library(jsonlite)
url <- "https://dantelabs.com/traits/lactic-acidosis.json"
page <- fromJSON(url)
page$trait$nameIncreased lactate in bodyHP:0003128
AtlasKam padedameMūsų mokslasProduktaiRezultatai
PrisijungtiKlaustiSekvenuokite savo genomą↗
Vienu tyrimu sužinokite genus, susijusius su Increased lactate in body, ir kitą jūsų genomo dalį.
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Įsigyti savo Genome Test202 genų susiję su Increased lactate in body
Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Increased lactate in body. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| ACAD9acyl-CoA dehydrogenase family member 9 | Visada | 2 ligose |
| AGKacylglycerol kinase | Visada | 2 ligose |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Visada | 2 ligose |
| BOLA3bolA family member 3 | Visada | 1 ligoje |
| COA6cytochrome c oxidase assembly factor 6 | Visada | 1 ligoje |
| COQ9coenzyme Q9 | Visada | 1 ligoje |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Visada | 2 ligose |
| COX15cytochrome c oxidase assembly factor COX15 | Visada | 2 ligose |
| COX6B1cytochrome c oxidase subunit 6B1 | Visada | 2 ligose |
| COX8Acytochrome c oxidase subunit 8A | Visada | 1 ligoje |
| COXFA4cytochrome c oxidase associated subunit FA4 | Visada | 1 ligoje |
| CYC1cytochrome c1 | Visada | 1 ligoje |
| DGUOKdeoxyguanosine kinase | Visada | 1 ligoje |
| DNM1Ldynamin 1L | Visada | 1 ligoje |
| EARS2glutamyl-tRNA synthetase 2, mitochondrial | Visada | 1 ligoje |
| EEFSECeukaryotic elongation factor, selenocysteine-tRNA specific | Visada | 1 ligoje |
| ETHE1ETHE1 persulfide dioxygenase | Visada | 2 ligose |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Visada | 1 ligoje |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Visada | 1 ligoje |
| FBXL4F-box and leucine rich repeat protein 4 | Visada | 1 ligoje |
| FDX2ferredoxin 2 | Visada | 1 ligoje |
| FOXRED1FAD dependent oxidoreductase domain containing 1 | Visada | 2 ligose |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Visada | 1 ligoje |
| GATBglutamyl-tRNA amidotransferase subunit B | Visada | 1 ligoje |
| GATCglutamyl-tRNA amidotransferase subunit C | Visada | 1 ligoje |
| GTPBP3GTP binding protein 3, mitochondrial | Visada | 2 ligose |
| HLCSholocarboxylase synthetase | Visada | 1 ligoje |
| IBA57iron-sulfur cluster assembly factor IBA57 | Visada | 2 ligose |
| LARS2leucyl-tRNA synthetase 2, mitochondrial | Visada | 1 ligoje |
| LIASlipoic acid synthetase | Visada | 1 ligoje |
| LRPPRCleucine rich pentatricopeptide repeat containing | Visada | 2 ligose |
| LYRM4LYR motif containing 4 | Visada | 1 ligoje |
| LYRM7LYR motif containing 7 | Visada | 1 ligoje |
| MARS1methionyl-tRNA synthetase 1 | Visada | 1 ligoje |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Visada | 1 ligoje |
| MIPEPmitochondrial intermediate peptidase | Visada | 1 ligoje |
| MRPS14mitochondrial ribosomal protein S14 | Visada | 1 ligoje |
| MRPS16mitochondrial ribosomal protein S16 | Visada | 1 ligoje |
| MRPS22mitochondrial ribosomal protein S22 | Visada | 1 ligoje |
| MRPS34mitochondrial ribosomal protein S34 | Visada | 1 ligoje |
Rodyti dar 162 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Visada | 1 ligoje |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Visada | 3 ligose |
| MTO1mitochondrial tRNA translation optimization 1 | Visada | 2 ligose |
| NDUFA10NADH:ubiquinone oxidoreductase subunit A10 | Visada | 1 ligoje |
| NDUFA11NADH:ubiquinone oxidoreductase subunit A11 | Visada | 2 ligose |
| NDUFAF1NADH:ubiquinone oxidoreductase complex assembly factor 1 | Visada | 2 ligose |
| NDUFAF5NADH:ubiquinone oxidoreductase complex assembly factor 5 | Visada | 2 ligose |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Visada | 1 ligoje |
| NDUFAF8NADH:ubiquinone oxidoreductase complex assembly factor 8 | Visada | 2 ligose |
| NDUFB10NADH:ubiquinone oxidoreductase subunit B10 | Visada | 2 ligose |
| NDUFB3NADH:ubiquinone oxidoreductase subunit B3 | Visada | 2 ligose |
| NDUFB7NADH:ubiquinone oxidoreductase subunit B7 | Visada | 1 ligoje |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Visada | 2 ligose |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Visada | 2 ligose |
| NDUFS6NADH:ubiquinone oxidoreductase subunit S6 | Visada | 2 ligose |
| NDUFV2NADH:ubiquinone oxidoreductase core subunit V2 | Visada | 2 ligose |
| NFU1NFU1 iron-sulfur cluster scaffold | Visada | 2 ligose |
| NSUN3NOP2/Sun RNA methyltransferase 3 | Visada | 1 ligoje |
| PCpyruvate carboxylase | Visada | 1 ligoje |
| PCK1phosphoenolpyruvate carboxykinase 1 | Visada | 2 ligose |
| PDHA1pyruvate dehydrogenase E1 subunit alpha 1 | Visada | 2 ligose |
| PDHBpyruvate dehydrogenase E1 subunit beta | Visada | 2 ligose |
| PDP1pyruvate dehydrogenase phosphatase catalytic subunit 1 | Visada | 2 ligose |
| PET100PET100 cytochrome c oxidase chaperone | Visada | 1 ligoje |
| PNPLA8patatin like domain 8, phospholipase A2 | Visada | 1 ligoje |
| QRSL1glutaminyl-tRNA amidotransferase subunit QRSL1 | Visada | 1 ligoje |
| RFC4replication factor C subunit 4 | Visada | 1 ligoje |
| RMND1required for meiotic nuclear division 1 homolog | Visada | 1 ligoje |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Visada | 2 ligose |
| SCO1synthesis of cytochrome C oxidase 1 | Visada | 1 ligoje |
| SCO2synthesis of cytochrome C oxidase 2 | Visada | 2 ligose |
| SDHDsuccinate dehydrogenase complex subunit D | Visada | 1 ligoje |
| SFXN4sideroflexin 4 | Visada | 1 ligoje |
| SLC25A19solute carrier family 25 member 19 | Visada | 1 ligoje |
| SLC25A4solute carrier family 25 member 4 | Visada | 2 ligose |
| SLC25A42solute carrier family 25 member 42 | Visada | 1 ligoje |
| SLC37A4solute carrier family 37 member 4 | Visada | 3 ligose |
| SLC52A1solute carrier family 52 member 1 | Visada | 1 ligoje |
| SQORsulfide quinone oxidoreductase | Visada | 1 ligoje |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Visada | 2 ligose |
| SURF1SURF1 cytochrome c oxidase assembly factor | Visada | 1 ligoje |
| TACO1translational activator of cytochrome c oxidase I | Visada | 1 ligoje |
| TMEM70transmembrane protein 70 | Visada | 1 ligoje |
| TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit | Visada | 1 ligoje |
| TRMT5tRNA methyltransferase 5 | Visada | 1 ligoje |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Visada | 1 ligoje |
| UQCC3ubiquinol-cytochrome c reductase complex assembly factor 3 | Visada | 1 ligoje |
| UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | Visada | 1 ligoje |
| VARS2valyl-tRNA synthetase 2, mitochondrial | Visada | 1 ligoje |
| YARS2tyrosyl-tRNA synthetase 2 | Visada | 2 ligose |
| DLDdihydrolipoamide dehydrogenase | Labai dažnai (80–99%) | 2 ligose |
| FBP1fructose-bisphosphatase 1 | Labai dažnai (80–99%) | 1 ligoje |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Labai dažnai (80–99%) | 3 ligose |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Labai dažnai (80–99%) | 1 ligoje |
| MPV17mitochondrial inner membrane protein MPV17 | Labai dažnai (80–99%) | 1 ligoje |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Labai dažnai (80–99%) | 2 ligose |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Labai dažnai (80–99%) | 2 ligose |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Labai dažnai (80–99%) | 2 ligose |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Labai dažnai (80–99%) | 3 ligose |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Labai dažnai (80–99%) | 1 ligoje |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Labai dažnai (80–99%) | 1 ligoje |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Labai dažnai (80–99%) | 1 ligoje |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Labai dažnai (80–99%) | 2 ligose |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Labai dažnai (80–99%) | 2 ligose |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Labai dažnai (80–99%) | 2 ligose |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Labai dažnai (80–99%) | 2 ligose |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Labai dažnai (80–99%) | 2 ligose |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Labai dažnai (80–99%) | 2 ligose |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Labai dažnai (80–99%) | 2 ligose |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Labai dažnai (80–99%) | 2 ligose |
| NDUFA1NADH:ubiquinone oxidoreductase subunit A1 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Labai dažnai (80–99%) | 2 ligose |
| NDUFA9NADH:ubiquinone oxidoreductase subunit A9 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFAF3NADH:ubiquinone oxidoreductase complex assembly factor 3 | Labai dažnai (80–99%) | 2 ligose |
| NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFB9NADH:ubiquinone oxidoreductase subunit B9 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFS1NADH:ubiquinone oxidoreductase core subunit S1 | Labai dažnai (80–99%) | 2 ligose |
| NDUFS3NADH:ubiquinone oxidoreductase core subunit S3 | Labai dažnai (80–99%) | 2 ligose |
| NDUFS7NADH:ubiquinone oxidoreductase core subunit S7 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFS8NADH:ubiquinone oxidoreductase core subunit S8 | Labai dažnai (80–99%) | 1 ligoje |
| NDUFV1NADH:ubiquinone oxidoreductase core subunit V1 | Labai dažnai (80–99%) | 1 ligoje |
| NUBPLNUBP iron-sulfur cluster assembly factor, mitochondrial | Labai dažnai (80–99%) | 1 ligoje |
| PUS1pseudouridine synthase 1 | Labai dažnai (80–99%) | 2 ligose |
| SERAC1serine active site containing 1 | Labai dažnai (80–99%) | 2 ligose |
| SLC25A13solute carrier family 25 member 13 | Labai dažnai (80–99%) | 1 ligoje |
| SLC25A3solute carrier family 25 member 3 | Labai dažnai (80–99%) | 2 ligose |
| TANGO2transport and golgi organization 2 homolog | Labai dažnai (80–99%) | 2 ligose |
| TIMMDC1translocase of inner mitochondrial membrane domain containing 1 | Labai dažnai (80–99%) | 1 ligoje |
| TKFCtriokinase and FMN cyclase | Labai dažnai (80–99%) | 2 ligose |
| TMEM126Btransmembrane protein 126B | Labai dažnai (80–99%) | 2 ligose |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Dažnai (30–79%) | 1 ligoje |
| ATP5F1AATP synthase F1 subunit alpha | Dažnai (30–79%) | 2 ligose |
| ATP5F1DATP synthase F1 subunit delta | Dažnai (30–79%) | 2 ligose |
| ATP5F1EATP synthase F1 subunit epsilon | Dažnai (30–79%) | 2 ligose |
| ATP5MKATP synthase membrane subunit k | Dažnai (30–79%) | 1 ligoje |
| ATP5POATP synthase peripheral stalk subunit OSCP | Dažnai (30–79%) | 1 ligoje |
| ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 | Dažnai (30–79%) | 1 ligoje |
| C1QBPcomplement C1q binding protein | Dažnai (30–79%) | 1 ligoje |
| CAMKMTcalmodulin-lysine N-methyltransferase | Dažnai (30–79%) | 1 ligoje |
| COA8cytochrome c oxidase assembly factor 8 | Dažnai (30–79%) | 1 ligoje |
| DAP3death associated protein 3 | Dažnai (30–79%) | 1 ligoje |
| ELAC2elaC ribonuclease Z 2 | Dažnai (30–79%) | 1 ligoje |
| GFERgrowth factor, augmenter of liver regeneration | Dažnai (30–79%) | 1 ligoje |
| GFM1G elongation factor mitochondrial 1 | Dažnai (30–79%) | 1 ligoje |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Dažnai (30–79%) | 1 ligoje |
| IVDisovaleryl-CoA dehydrogenase | Dažnai (30–79%) | 1 ligoje |
| LIG3DNA ligase 3 | Dažnai (30–79%) | 1 ligoje |
| LIPT2lipoyl(octanoyl) transferase 2 | Dažnai (30–79%) | 1 ligoje |
| LONP1lon peptidase 1, mitochondrial | Dažnai (30–79%) | 1 ligoje |
| MRPS7mitochondrial ribosomal protein S7 | Dažnai (30–79%) | 1 ligoje |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Dažnai (30–79%) | 1 ligoje |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Dažnai (30–79%) | 1 ligoje |
| NDUFA8NADH:ubiquinone oxidoreductase subunit A8 | Dažnai (30–79%) | 1 ligoje |
| PCK2phosphoenolpyruvate carboxykinase 2, mitochondrial | Dažnai (30–79%) | 1 ligoje |
| PDHXpyruvate dehydrogenase complex component X | Dažnai (30–79%) | 2 ligose |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Dažnai (30–79%) | 2 ligose |
| POLGDNA polymerase gamma, catalytic subunit | Dažnai (30–79%) | 2 ligose |
| PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent 1B | Dažnai (30–79%) | 1 ligoje |
| PREPLprolyl endopeptidase like | Dažnai (30–79%) | 1 ligoje |
| SLC3A1solute carrier family 3 member 1 | Dažnai (30–79%) | 1 ligoje |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Dažnai (30–79%) | 1 ligoje |
| TPK1thiamin pyrophosphokinase 1 | Dažnai (30–79%) | 1 ligoje |
| TRNT1tRNA nucleotidyl transferase 1 | Dažnai (30–79%) | 1 ligoje |
| TYMPthymidine phosphorylase | Dažnai (30–79%) | 2 ligose |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Dažnai (30–79%) | 2 ligose |
| COQ8Acoenzyme Q8A | Kartais (5–29%) | 2 ligose |
| HADHhydroxyacyl-CoA dehydrogenase | Kartais (5–29%) | 1 ligoje |
| PMPCApeptidase, mitochondrial processing subunit alpha | Kartais (5–29%) | 1 ligoje |
| RYR1ryanodine receptor 1 | Kartais (5–29%) | 1 ligoje |
| USP18ubiquitin specific peptidase 18 | Kartais (5–29%) | 1 ligoje |
| ALDH7A1aldehyde dehydrogenase 7 family member A1 | Retai (1–4 %) | 1 ligoje |
| FHfumarate hydratase | Retai (1–4 %) | 2 ligose |
| MT-CYBmitochondrially encoded cytochrome b | Retai (1–4 %) | 2 ligose |
| PHKBphosphorylase kinase regulatory subunit beta | Retai (1–4 %) | 1 ligoje |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Retai (1–4 %) | 2 ligose |
| PLPBPpyridoxal phosphate binding protein | Retai (1–4 %) | 1 ligoje |
| ALDOBaldolase, fructose-bisphosphate B | Neužfiksuota | 1 ligoje |
| APTXaprataxin | Neužfiksuota | 1 ligoje |
| BCKDHAbranched chain keto acid dehydrogenase E1 subunit alpha | Neužfiksuota | 1 ligoje |
| CA5Acarbonic anhydrase 5A | Neužfiksuota | 1 ligoje |
| COQ2coenzyme Q2, polyprenyltransferase | Neužfiksuota | 1 ligoje |
| DLATdihydrolipoamide S-acetyltransferase | Neužfiksuota | 1 ligoje |
| ISCUiron-sulfur cluster assembly enzyme | Neužfiksuota | 1 ligoje |
| LARS1leucyl-tRNA synthetase 1 | Neužfiksuota | 1 ligoje |
| LIPT1lipoyltransferase 1 | Neužfiksuota | 1 ligoje |
| MLYCDmalonyl-CoA decarboxylase | Neužfiksuota | 1 ligoje |
| MPC1mitochondrial pyruvate carrier 1 | Neužfiksuota | 1 ligoje |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Neužfiksuota | 1 ligoje |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Neužfiksuota | 1 ligoje |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Neužfiksuota | 1 ligoje |
| MT-TTmitochondrially encoded tRNA-Thr (ACN) | Neužfiksuota | 1 ligoje |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Neužfiksuota | 1 ligoje |
| NAXENAD(P)HX epimerase | Neužfiksuota | 1 ligoje |
| PCCApropionyl-CoA carboxylase subunit alpha | Neužfiksuota | 1 ligoje |
| PCCBpropionyl-CoA carboxylase subunit beta | Neužfiksuota | 1 ligoje |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Neužfiksuota | 1 ligoje |
| TK2thymidine kinase 2 | Neužfiksuota | 1 ligoje |
| TRMUtRNA mitochondrial 2-thiouridylase | Neužfiksuota | 1 ligoje |
| TSFMTs translation elongation factor, mitochondrial | Neužfiksuota | 1 ligoje |
| TUFMTu translation elongation factor, mitochondrial | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
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- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.17-8666dff2.
AtlasKam padedameMūsų mokslasProduktaiRezultatai
PrisijungtiKlaustiSekvenuokite savo genomą↗
Vienas testas. Atsakymai visam gyvenimui.
Nuo 449 $Nemokamas pristatymas · Rezultatai per 6–8 savaites