Trait
Increased lactate in body
Clinical name: Lactic acidosis
An abnormal buildup of lactic acid in the body, leading to acidification of the blood and other bodily fluids.
Summary
- Also called
- Hyperlacticacidemia, Lactic acidemia, Lacticacidemia, Lacticacidosis
- Body system
- Laboratory abnormality
Reference genomeGRCh38hg38
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Read the genes linked to Increased lactate in body, and the rest of your genome, with one test.
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Get my Genome Test202 genes linked to Increased lactate in body
Changes in these genes cause rare conditions in which Increased lactate in body is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACAD9acyl-CoA dehydrogenase family member 9 | Always | In 2 conditions |
| AGKacylglycerol kinase | Always | In 2 conditions |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Always | In 2 conditions |
| BOLA3bolA family member 3 | Always | In 1 condition |
| COA6cytochrome c oxidase assembly factor 6 | Always | In 1 condition |
| COQ9coenzyme Q9 | Always | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Always | In 2 conditions |
| COX15cytochrome c oxidase assembly factor COX15 | Always | In 2 conditions |
| COX6B1cytochrome c oxidase subunit 6B1 | Always | In 2 conditions |
| COX8Acytochrome c oxidase subunit 8A | Always | In 1 condition |
| COXFA4cytochrome c oxidase associated subunit FA4 | Always | In 1 condition |
| CYC1cytochrome c1 | Always | In 1 condition |
| DGUOKdeoxyguanosine kinase | Always | In 1 condition |
| DNM1Ldynamin 1L | Always | In 1 condition |
| EARS2glutamyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| EEFSECeukaryotic elongation factor, selenocysteine-tRNA specific | Always | In 1 condition |
| ETHE1ETHE1 persulfide dioxygenase | Always | In 2 conditions |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Always | In 1 condition |
| FBXL4F-box and leucine rich repeat protein 4 | Always | In 1 condition |
| FDX2ferredoxin 2 | Always | In 1 condition |
| FOXRED1FAD dependent oxidoreductase domain containing 1 | Always | In 2 conditions |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Always | In 1 condition |
| GATBglutamyl-tRNA amidotransferase subunit B | Always | In 1 condition |
| GATCglutamyl-tRNA amidotransferase subunit C | Always | In 1 condition |
| GTPBP3GTP binding protein 3, mitochondrial | Always | In 2 conditions |
| HLCSholocarboxylase synthetase | Always | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Always | In 2 conditions |
| LARS2leucyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| LIASlipoic acid synthetase | Always | In 1 condition |
| LRPPRCleucine rich pentatricopeptide repeat containing | Always | In 2 conditions |
| LYRM4LYR motif containing 4 | Always | In 1 condition |
| LYRM7LYR motif containing 7 | Always | In 1 condition |
| MARS1methionyl-tRNA synthetase 1 | Always | In 1 condition |
| MICOS13mitochondrial contact site and cristae organizing system subunit 13 | Always | In 1 condition |
| MIPEPmitochondrial intermediate peptidase | Always | In 1 condition |
| MRPS14mitochondrial ribosomal protein S14 | Always | In 1 condition |
| MRPS16mitochondrial ribosomal protein S16 | Always | In 1 condition |
| MRPS22mitochondrial ribosomal protein S22 | Always | In 1 condition |
| MRPS34mitochondrial ribosomal protein S34 | Always | In 1 condition |
Show 162 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Always | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Always | In 3 conditions |
| MTO1mitochondrial tRNA translation optimization 1 | Always | In 2 conditions |
| NDUFA10NADH:ubiquinone oxidoreductase subunit A10 | Always | In 1 condition |
| NDUFA11NADH:ubiquinone oxidoreductase subunit A11 | Always | In 2 conditions |
| NDUFAF1NADH:ubiquinone oxidoreductase complex assembly factor 1 | Always | In 2 conditions |
| NDUFAF5NADH:ubiquinone oxidoreductase complex assembly factor 5 | Always | In 2 conditions |
| NDUFAF6NADH:ubiquinone oxidoreductase complex assembly factor 6 | Always | In 1 condition |
| NDUFAF8NADH:ubiquinone oxidoreductase complex assembly factor 8 | Always | In 2 conditions |
| NDUFB10NADH:ubiquinone oxidoreductase subunit B10 | Always | In 2 conditions |
| NDUFB3NADH:ubiquinone oxidoreductase subunit B3 | Always | In 2 conditions |
| NDUFB7NADH:ubiquinone oxidoreductase subunit B7 | Always | In 1 condition |
| NDUFS2NADH:ubiquinone oxidoreductase core subunit S2 | Always | In 2 conditions |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Always | In 2 conditions |
| NDUFS6NADH:ubiquinone oxidoreductase subunit S6 | Always | In 2 conditions |
| NDUFV2NADH:ubiquinone oxidoreductase core subunit V2 | Always | In 2 conditions |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 2 conditions |
| NSUN3NOP2/Sun RNA methyltransferase 3 | Always | In 1 condition |
| PCpyruvate carboxylase | Always | In 1 condition |
| PCK1phosphoenolpyruvate carboxykinase 1 | Always | In 2 conditions |
| PDHA1pyruvate dehydrogenase E1 subunit alpha 1 | Always | In 2 conditions |
| PDHBpyruvate dehydrogenase E1 subunit beta | Always | In 2 conditions |
| PDP1pyruvate dehydrogenase phosphatase catalytic subunit 1 | Always | In 2 conditions |
| PET100PET100 cytochrome c oxidase chaperone | Always | In 1 condition |
| PNPLA8patatin like domain 8, phospholipase A2 | Always | In 1 condition |
| QRSL1glutaminyl-tRNA amidotransferase subunit QRSL1 | Always | In 1 condition |
| RFC4replication factor C subunit 4 | Always | In 1 condition |
| RMND1required for meiotic nuclear division 1 homolog | Always | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Always | In 2 conditions |
| SCO1synthesis of cytochrome C oxidase 1 | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 2 conditions |
| SDHDsuccinate dehydrogenase complex subunit D | Always | In 1 condition |
| SFXN4sideroflexin 4 | Always | In 1 condition |
| SLC25A19solute carrier family 25 member 19 | Always | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Always | In 2 conditions |
| SLC25A42solute carrier family 25 member 42 | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 3 conditions |
| SLC52A1solute carrier family 52 member 1 | Always | In 1 condition |
| SQORsulfide quinone oxidoreductase | Always | In 1 condition |
| SUCLG1succinate-CoA ligase GDP/ADP-forming subunit alpha | Always | In 2 conditions |
| SURF1SURF1 cytochrome c oxidase assembly factor | Always | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Always | In 1 condition |
| TMEM70transmembrane protein 70 | Always | In 1 condition |
| TRMT10CtRNA methyltransferase 10C, mitochondrial RNase P subunit | Always | In 1 condition |
| TRMT5tRNA methyltransferase 5 | Always | In 1 condition |
| UQCC2ubiquinol-cytochrome c reductase complex assembly factor 2 | Always | In 1 condition |
| UQCC3ubiquinol-cytochrome c reductase complex assembly factor 3 | Always | In 1 condition |
| UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | Always | In 1 condition |
| VARS2valyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| YARS2tyrosyl-tRNA synthetase 2 | Always | In 2 conditions |
| DLDdihydrolipoamide dehydrogenase | Very often (80–99%) | In 2 conditions |
| FBP1fructose-bisphosphatase 1 | Very often (80–99%) | In 1 condition |
| HSD17B10hydroxysteroid 17-beta dehydrogenase 10 | Very often (80–99%) | In 3 conditions |
| IARS2isoleucyl-tRNA synthetase 2, mitochondrial | Very often (80–99%) | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Very often (80–99%) | In 1 condition |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Very often (80–99%) | In 2 conditions |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Very often (80–99%) | In 2 conditions |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Very often (80–99%) | In 2 conditions |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Very often (80–99%) | In 3 conditions |
| MT-ND2mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 | Very often (80–99%) | In 1 condition |
| MT-ND3mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 | Very often (80–99%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Very often (80–99%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Very often (80–99%) | In 2 conditions |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Very often (80–99%) | In 2 conditions |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Very often (80–99%) | In 2 conditions |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Very often (80–99%) | In 2 conditions |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Very often (80–99%) | In 2 conditions |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Very often (80–99%) | In 2 conditions |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Very often (80–99%) | In 2 conditions |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Very often (80–99%) | In 2 conditions |
| NDUFA1NADH:ubiquinone oxidoreductase subunit A1 | Very often (80–99%) | In 1 condition |
| NDUFA6NADH:ubiquinone oxidoreductase subunit A6 | Very often (80–99%) | In 2 conditions |
| NDUFA9NADH:ubiquinone oxidoreductase subunit A9 | Very often (80–99%) | In 1 condition |
| NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2 | Very often (80–99%) | In 1 condition |
| NDUFAF3NADH:ubiquinone oxidoreductase complex assembly factor 3 | Very often (80–99%) | In 2 conditions |
| NDUFAF4NADH:ubiquinone oxidoreductase complex assembly factor 4 | Very often (80–99%) | In 1 condition |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Very often (80–99%) | In 1 condition |
| NDUFB9NADH:ubiquinone oxidoreductase subunit B9 | Very often (80–99%) | In 1 condition |
| NDUFS1NADH:ubiquinone oxidoreductase core subunit S1 | Very often (80–99%) | In 2 conditions |
| NDUFS3NADH:ubiquinone oxidoreductase core subunit S3 | Very often (80–99%) | In 2 conditions |
| NDUFS7NADH:ubiquinone oxidoreductase core subunit S7 | Very often (80–99%) | In 1 condition |
| NDUFS8NADH:ubiquinone oxidoreductase core subunit S8 | Very often (80–99%) | In 1 condition |
| NDUFV1NADH:ubiquinone oxidoreductase core subunit V1 | Very often (80–99%) | In 1 condition |
| NUBPLNUBP iron-sulfur cluster assembly factor, mitochondrial | Very often (80–99%) | In 1 condition |
| PUS1pseudouridine synthase 1 | Very often (80–99%) | In 2 conditions |
| SERAC1serine active site containing 1 | Very often (80–99%) | In 2 conditions |
| SLC25A13solute carrier family 25 member 13 | Very often (80–99%) | In 1 condition |
| SLC25A3solute carrier family 25 member 3 | Very often (80–99%) | In 2 conditions |
| TANGO2transport and golgi organization 2 homolog | Very often (80–99%) | In 2 conditions |
| TIMMDC1translocase of inner mitochondrial membrane domain containing 1 | Very often (80–99%) | In 1 condition |
| TKFCtriokinase and FMN cyclase | Very often (80–99%) | In 2 conditions |
| TMEM126Btransmembrane protein 126B | Very often (80–99%) | In 2 conditions |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Often (30–79%) | In 2 conditions |
| ATP5F1DATP synthase F1 subunit delta | Often (30–79%) | In 2 conditions |
| ATP5F1EATP synthase F1 subunit epsilon | Often (30–79%) | In 2 conditions |
| ATP5MKATP synthase membrane subunit k | Often (30–79%) | In 1 condition |
| ATP5POATP synthase peripheral stalk subunit OSCP | Often (30–79%) | In 1 condition |
| ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 | Often (30–79%) | In 1 condition |
| C1QBPcomplement C1q binding protein | Often (30–79%) | In 1 condition |
| CAMKMTcalmodulin-lysine N-methyltransferase | Often (30–79%) | In 1 condition |
| COA8cytochrome c oxidase assembly factor 8 | Often (30–79%) | In 1 condition |
| DAP3death associated protein 3 | Often (30–79%) | In 1 condition |
| ELAC2elaC ribonuclease Z 2 | Often (30–79%) | In 1 condition |
| GFERgrowth factor, augmenter of liver regeneration | Often (30–79%) | In 1 condition |
| GFM1G elongation factor mitochondrial 1 | Often (30–79%) | In 1 condition |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Often (30–79%) | In 1 condition |
| IVDisovaleryl-CoA dehydrogenase | Often (30–79%) | In 1 condition |
| LIG3DNA ligase 3 | Often (30–79%) | In 1 condition |
| LIPT2lipoyl(octanoyl) transferase 2 | Often (30–79%) | In 1 condition |
| LONP1lon peptidase 1, mitochondrial | Often (30–79%) | In 1 condition |
| MRPS7mitochondrial ribosomal protein S7 | Often (30–79%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Often (30–79%) | In 1 condition |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Often (30–79%) | In 1 condition |
| NDUFA8NADH:ubiquinone oxidoreductase subunit A8 | Often (30–79%) | In 1 condition |
| PCK2phosphoenolpyruvate carboxykinase 2, mitochondrial | Often (30–79%) | In 1 condition |
| PDHXpyruvate dehydrogenase complex component X | Often (30–79%) | In 2 conditions |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 2 conditions |
| PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent 1B | Often (30–79%) | In 1 condition |
| PREPLprolyl endopeptidase like | Often (30–79%) | In 1 condition |
| SLC3A1solute carrier family 3 member 1 | Often (30–79%) | In 1 condition |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Often (30–79%) | In 1 condition |
| TPK1thiamin pyrophosphokinase 1 | Often (30–79%) | In 1 condition |
| TRNT1tRNA nucleotidyl transferase 1 | Often (30–79%) | In 1 condition |
| TYMPthymidine phosphorylase | Often (30–79%) | In 2 conditions |
| WARS2tryptophanyl tRNA synthetase 2, mitochondrial | Often (30–79%) | In 2 conditions |
| COQ8Acoenzyme Q8A | Sometimes (5–29%) | In 2 conditions |
| HADHhydroxyacyl-CoA dehydrogenase | Sometimes (5–29%) | In 1 condition |
| PMPCApeptidase, mitochondrial processing subunit alpha | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| USP18ubiquitin specific peptidase 18 | Sometimes (5–29%) | In 1 condition |
| ALDH7A1aldehyde dehydrogenase 7 family member A1 | Rarely (1–4%) | In 1 condition |
| FHfumarate hydratase | Rarely (1–4%) | In 2 conditions |
| MT-CYBmitochondrially encoded cytochrome b | Rarely (1–4%) | In 2 conditions |
| PHKBphosphorylase kinase regulatory subunit beta | Rarely (1–4%) | In 1 condition |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Rarely (1–4%) | In 2 conditions |
| PLPBPpyridoxal phosphate binding protein | Rarely (1–4%) | In 1 condition |
| ALDOBaldolase, fructose-bisphosphate B | Not recorded | In 1 condition |
| APTXaprataxin | Not recorded | In 1 condition |
| BCKDHAbranched chain keto acid dehydrogenase E1 subunit alpha | Not recorded | In 1 condition |
| CA5Acarbonic anhydrase 5A | Not recorded | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Not recorded | In 1 condition |
| DLATdihydrolipoamide S-acetyltransferase | Not recorded | In 1 condition |
| ISCUiron-sulfur cluster assembly enzyme | Not recorded | In 1 condition |
| LARS1leucyl-tRNA synthetase 1 | Not recorded | In 1 condition |
| LIPT1lipoyltransferase 1 | Not recorded | In 1 condition |
| MLYCDmalonyl-CoA decarboxylase | Not recorded | In 1 condition |
| MPC1mitochondrial pyruvate carrier 1 | Not recorded | In 1 condition |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Not recorded | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Not recorded | In 1 condition |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Not recorded | In 1 condition |
| MT-TTmitochondrially encoded tRNA-Thr (ACN) | Not recorded | In 1 condition |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Not recorded | In 1 condition |
| NAXENAD(P)HX epimerase | Not recorded | In 1 condition |
| PCCApropionyl-CoA carboxylase subunit alpha | Not recorded | In 1 condition |
| PCCBpropionyl-CoA carboxylase subunit beta | Not recorded | In 1 condition |
| SUCLA2succinate-CoA ligase ADP-forming subunit beta | Not recorded | In 1 condition |
| TK2thymidine kinase 2 | Not recorded | In 1 condition |
| TRMUtRNA mitochondrial 2-thiouridylase | Not recorded | In 1 condition |
| TSFMTs translation elongation factor, mitochondrial | Not recorded | In 1 condition |
| TUFMTu translation elongation factor, mitochondrial | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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