Požymis
Recurrent middle ear infection
Klinikinis pavadinimas: Recurrent otitis media
Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media.
Santrauka
- Taip pat vadinama
- Frequent otitis media, Multiple episodes of otitis media, Otitis media, recurrent, Recurrent episodes of otitis media, Susceptibility to otitis media
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
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Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Recurrent middle ear infection. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| ADA2adenosine deaminase 2 | Visada | 1 ligoje |
| AMOTL1angiomotin like 1 | Visada | 1 ligoje |
| AP3B1adaptor related protein complex 3 subunit beta 1 | Visada | 1 ligoje |
| ATXN7L3ataxin 7 like 3 | Visada | 1 ligoje |
| BLNKB cell linker | Visada | 1 ligoje |
| CCDC47coiled-coil domain containing 47 | Visada | 1 ligoje |
| CD19CD19 molecule | Visada | 2 ligose |
| CD3ECD3 epsilon subunit of T-cell receptor complex | Visada | 1 ligoje |
| CD3GCD3 gamma subunit of T-cell receptor complex | Visada | 1 ligoje |
| CD4CD4 molecule | Visada | 1 ligoje |
| CD40LGCD40 ligand | Visada | 1 ligoje |
| CD79ACD79a molecule | Visada | 1 ligoje |
| CD79BCD79b molecule | Visada | 1 ligoje |
| CEBPECCAAT enhancer binding protein epsilon | Visada | 1 ligoje |
| CFAP52cilia and flagella associated protein 52 | Visada | 1 ligoje |
| CORO1Acoronin 1A | Visada | 1 ligoje |
| CR2complement C3d receptor 2 | Visada | 1 ligoje |
| DNAH11dynein axonemal heavy chain 11 | Visada | 2 ligose |
| DNAH5dynein axonemal heavy chain 5 | Visada | 2 ligose |
| DNAI2dynein axonemal intermediate chain 2 | Visada | 2 ligose |
| DRC1dynein regulatory complex subunit 1 | Visada | 2 ligose |
| DRC2dynein regulatory complex subunit 2 | Visada | 2 ligose |
| DYRK1Adual specificity tyrosine phosphorylation regulated kinase 1A | Visada | 1 ligoje |
| FCGR3AFc gamma receptor IIIa | Visada | 1 ligoje |
| FEM1Bfem-1 homolog B | Visada | 1 ligoje |
| FLT3LGfms related receptor tyrosine kinase 3 ligand | Visada | 1 ligoje |
| HEPHL1hephaestin like 1 | Visada | 1 ligoje |
| HYAL1hyaluronidase 1 | Visada | 1 ligoje |
| HYDINHYDIN axonemal central pair apparatus protein | Visada | 2 ligose |
| ICOSinducible T cell costimulator | Visada | 2 ligose |
| ICOSLGinducible T cell costimulator ligand | Visada | 1 ligoje |
| IDUAalpha-L-iduronidase | Visada | 1 ligoje |
| IGLL1immunoglobulin lambda like polypeptide 1 | Visada | 1 ligoje |
| IKZF2IKAROS family zinc finger 2 | Visada | 2 ligose |
| IL17RAinterleukin 17 receptor A | Visada | 1 ligoje |
| IL21Rinterleukin 21 receptor | Visada | 1 ligoje |
| IL6STinterleukin 6 cytokine family signal transducer | Visada | 1 ligoje |
| IL7Rinterleukin 7 receptor | Visada | 1 ligoje |
| IRF4interferon regulatory factor 4 | Visada | 1 ligoje |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Visada | 1 ligoje |
Rodyti dar 202 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| JAK3Janus kinase 3 | Visada | 1 ligoje |
| LBRlamin B receptor | Visada | 1 ligoje |
| LIG1DNA ligase 1 | Visada | 1 ligoje |
| LRRC56leucine rich repeat containing 56 | Visada | 2 ligose |
| LRRC7leucine rich repeat containing 7 | Visada | 1 ligoje |
| MAGT1magnesium transporter 1 | Visada | 1 ligoje |
| NME5NME/NM23 family member 5 | Visada | 2 ligose |
| PAN2poly(A) specific ribonuclease subunit PAN2 | Visada | 1 ligoje |
| PDCD1programmed cell death 1 | Visada | 1 ligoje |
| PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | Visada | 1 ligoje |
| POLR1ARNA polymerase I subunit A | Visada | 1 ligoje |
| PRKCDprotein kinase C delta | Visada | 1 ligoje |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Visada | 2 ligose |
| RAC2Rac family small GTPase 2 | Visada | 1 ligoje |
| RSPH3radial spoke head 3 | Visada | 2 ligose |
| SEC61A1SEC61 translocon subunit alpha 1 | Visada | 2 ligose |
| SH3KBP1SH3 domain containing kinase binding protein 1 | Visada | 1 ligoje |
| SLC35C1solute carrier family 35 member C1 | Visada | 2 ligose |
| SLC37A4solute carrier family 37 member 4 | Visada | 1 ligoje |
| STK36serine/threonine kinase 36 | Visada | 2 ligose |
| TAF4TATA-box binding protein associated factor 4 | Visada | 1 ligoje |
| TFE3transcription factor binding to IGHM enhancer 3 | Visada | 1 ligoje |
| TNFRSF13BTNF receptor superfamily member 13B | Visada | 1 ligoje |
| TNFRSF13CTNF receptor superfamily member 13C | Visada | 1 ligoje |
| TOP2BDNA topoisomerase II beta | Visada | 1 ligoje |
| TPP2tripeptidyl peptidase 2 | Visada | 2 ligose |
| TRACT cell receptor alpha constant | Visada | 1 ligoje |
| WFDC2WAP four-disulfide core domain 2 | Visada | 1 ligoje |
| ZFPM2zinc finger protein, FOG family member 2 | Visada | 1 ligoje |
| CCDC40coiled-coil domain 40 molecular ruler complex subunit | Labai dažnai (80–99%) | 2 ligose |
| CDCA7cell division cycle associated 7 | Labai dažnai (80–99%) | 1 ligoje |
| DOCK8dedicator of cytokinesis 8 | Labai dažnai (80–99%) | 1 ligoje |
| EYA4EYA transcriptional coactivator and phosphatase 4 | Labai dažnai (80–99%) | 1 ligoje |
| NFKB2nuclear factor kappa B subunit 2 | Labai dažnai (80–99%) | 2 ligose |
| ODAD1outer dynein arm docking complex subunit 1 | Labai dažnai (80–99%) | 2 ligose |
| RAI1retinoic acid induced 1 | Labai dažnai (80–99%) | 1 ligoje |
| SPAG1sperm associated antigen 1 | Labai dažnai (80–99%) | 2 ligose |
| ADAadenosine deaminase | Dažnai (30–79%) | 1 ligoje |
| ARHGAP29Rho GTPase activating protein 29 | Dažnai (30–79%) | 1 ligoje |
| ARHGEF38Rho guanine nucleotide exchange factor 38 | Dažnai (30–79%) | 1 ligoje |
| BAP1BRCA1 associated deubiquitinase 1 | Dažnai (30–79%) | 1 ligoje |
| BMP4bone morphogenetic protein 4 | Dažnai (30–79%) | 1 ligoje |
| BPTFbromodomain PHD finger transcription factor | Dažnai (30–79%) | 1 ligoje |
| BRWD1bromodomain and WD repeat domain containing 1 | Dažnai (30–79%) | 1 ligoje |
| BTKBruton tyrosine kinase | Dažnai (30–79%) | 2 ligose |
| C1QBcomplement C1q B chain | Dažnai (30–79%) | 1 ligoje |
| CBLBCbl proto-oncogene B | Dažnai (30–79%) | 1 ligoje |
| CCDC39coiled-coil domain 39 molecular ruler complex subunit | Dažnai (30–79%) | 1 ligoje |
| CCNOcyclin O | Dažnai (30–79%) | 1 ligoje |
| CD28CD28 molecule | Dažnai (30–79%) | 1 ligoje |
| CDH1cadherin 1 | Dažnai (30–79%) | 1 ligoje |
| CFAP221cilia and flagella associated protein 221 | Dažnai (30–79%) | 1 ligoje |
| CFAP298cilia and flagella associated protein 298 | Dažnai (30–79%) | 2 ligose |
| CFAP300cilia and flagella associated protein 300 | Dažnai (30–79%) | 1 ligoje |
| CFAP74cilia and flagella associated protein 74 | Dažnai (30–79%) | 1 ligoje |
| CFIcomplement factor I | Dažnai (30–79%) | 1 ligoje |
| CLXNcalaxin | Dažnai (30–79%) | 1 ligoje |
| COBLL1cordon-bleu WH2 repeat protein like 1 | Dažnai (30–79%) | 1 ligoje |
| COL11A1collagen type XI alpha 1 chain | Dažnai (30–79%) | 1 ligoje |
| DAW1dynein assembly factor with WD repeats 1 | Dažnai (30–79%) | 2 ligose |
| DLG1discs large MAGUK scaffold protein 1 | Dažnai (30–79%) | 1 ligoje |
| DLX4distal-less homeobox 4 | Dažnai (30–79%) | 1 ligoje |
| DNAAF1dynein axonemal assembly factor 1 | Dažnai (30–79%) | 2 ligose |
| DNAAF11dynein axonemal assembly factor 11 | Dažnai (30–79%) | 2 ligose |
| DNAAF19dynein axonemal assembly factor 19 | Dažnai (30–79%) | 2 ligose |
| DNAAF2dynein axonemal assembly factor 2 | Dažnai (30–79%) | 1 ligoje |
| DNAAF3dynein axonemal assembly factor 3 | Dažnai (30–79%) | 1 ligoje |
| DNAAF4dynein axonemal assembly factor 4 | Dažnai (30–79%) | 2 ligose |
| DNAAF5dynein axonemal assembly factor 5 | Dažnai (30–79%) | 2 ligose |
| DNAAF6dynein axonemal assembly factor 6 | Dažnai (30–79%) | 1 ligoje |
| DNAH1dynein axonemal heavy chain 1 | Dažnai (30–79%) | 1 ligoje |
| DNAH7dynein axonemal heavy chain 7 | Dažnai (30–79%) | 1 ligoje |
| DNAH9dynein axonemal heavy chain 9 | Dažnai (30–79%) | 1 ligoje |
| DNAI1dynein axonemal intermediate chain 1 | Dažnai (30–79%) | 1 ligoje |
| DNAJB13DnaJ heat shock protein family (Hsp40) member B13 | Dažnai (30–79%) | 1 ligoje |
| DNAL1dynein axonemal light chain 1 | Dažnai (30–79%) | 1 ligoje |
| DPF2double PHD fingers 2 | Dažnai (30–79%) | 1 ligoje |
| DPP9dipeptidyl peptidase 9 | Dažnai (30–79%) | 1 ligoje |
| DRC4dynein regulatory complex subunit 4 | Dažnai (30–79%) | 2 ligose |
| ELNelastin | Dažnai (30–79%) | 1 ligoje |
| FGFR3fibroblast growth factor receptor 3 | Dažnai (30–79%) | 3 ligose |
| FOXJ1forkhead box J1 | Dažnai (30–79%) | 1 ligoje |
| FOXP1forkhead box P1 | Dažnai (30–79%) | 1 ligoje |
| FZD2frizzled class receptor 2 | Dažnai (30–79%) | 1 ligoje |
| GAS2L2growth arrest specific 2 like 2 | Dažnai (30–79%) | 2 ligose |
| GLRA2glycine receptor alpha 2 | Dažnai (30–79%) | 1 ligoje |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Dažnai (30–79%) | 2 ligose |
| GNSglucosamine (N-acetyl)-6-sulfatase | Dažnai (30–79%) | 1 ligoje |
| GUSBglucuronidase beta | Dažnai (30–79%) | 1 ligoje |
| H4C3H4 clustered histone 3 | Dažnai (30–79%) | 1 ligoje |
| IKBKBinhibitor of nuclear factor kappa B kinase subunit beta | Dažnai (30–79%) | 1 ligoje |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Dažnai (30–79%) | 1 ligoje |
| INSRinsulin receptor | Dažnai (30–79%) | 1 ligoje |
| IRF6interferon regulatory factor 6 | Dažnai (30–79%) | 1 ligoje |
| KDM6Alysine demethylase 6A | Dažnai (30–79%) | 2 ligose |
| KMT2Dlysine methyltransferase 2D | Dažnai (30–79%) | 1 ligoje |
| LRBALPS responsive beige-like anchor protein | Dažnai (30–79%) | 1 ligoje |
| MAP3K7mitogen-activated protein kinase kinase kinase 7 | Dažnai (30–79%) | 1 ligoje |
| MCIDASmulticiliate differentiation and DNA synthesis associated cell cycle protein | Dažnai (30–79%) | 1 ligoje |
| MGPmatrix Gla protein | Dažnai (30–79%) | 2 ligose |
| MLXIPLMLX interacting protein like | Dažnai (30–79%) | 1 ligoje |
| MSX1msh homeobox 1 | Dažnai (30–79%) | 1 ligoje |
| NECTIN1nectin cell adhesion molecule 1 | Dažnai (30–79%) | 1 ligoje |
| NEK10NIMA related kinase 10 | Dažnai (30–79%) | 1 ligoje |
| NFKBIANFKB inhibitor alpha | Dažnai (30–79%) | 1 ligoje |
| NME8NME/NM23 family member 8 | Dažnai (30–79%) | 1 ligoje |
| ODAD2outer dynein arm docking complex subunit 2 | Dažnai (30–79%) | 2 ligose |
| ODAD3outer dynein arm docking complex subunit 3 | Dažnai (30–79%) | 2 ligose |
| ODAD4outer dynein arm docking complex subunit 4 | Dažnai (30–79%) | 1 ligoje |
| OFD1OFD1 centriole and centriolar satellite protein | Dažnai (30–79%) | 1 ligoje |
| PDGFRAplatelet derived growth factor receptor alpha | Dažnai (30–79%) | 1 ligoje |
| POGZpogo transposable element derived with ZNF domain | Dažnai (30–79%) | 1 ligoje |
| POLR3ARNA polymerase III subunit A | Dažnai (30–79%) | 1 ligoje |
| PSMB8proteasome 20S subunit beta 8 | Dažnai (30–79%) | 1 ligoje |
| PTENphosphatase and tensin homolog | Dažnai (30–79%) | 1 ligoje |
| RAP1BRAP1B, member of RAS oncogene family | Dažnai (30–79%) | 1 ligoje |
| RELBRELB proto-oncogene, NF-kB subunit | Dažnai (30–79%) | 1 ligoje |
| RFX5regulatory factor X5 | Dažnai (30–79%) | 1 ligoje |
| RIC1RIC1 partner of RAB6A GEF complex | Dažnai (30–79%) | 1 ligoje |
| RNF2ring finger protein 2 | Dažnai (30–79%) | 1 ligoje |
| RNU4ATACRNA, U4atac small nuclear | Dažnai (30–79%) | 2 ligose |
| RPGRretinitis pigmentosa GTPase regulator | Dažnai (30–79%) | 1 ligoje |
| RSPH1radial spoke head component 1 | Dažnai (30–79%) | 2 ligose |
| RSPH4Aradial spoke head component 4A | Dažnai (30–79%) | 1 ligoje |
| RSPH9radial spoke head component 9 | Dažnai (30–79%) | 1 ligoje |
| SMARCD2SWI/SNF related BAF chromatin remodeling complex subunit D2 | Dažnai (30–79%) | 1 ligoje |
| SMG9SMG9 nonsense mediated mRNA decay factor | Dažnai (30–79%) | 1 ligoje |
| SPEF2sperm flagellar and cilia associated 2 | Dažnai (30–79%) | 1 ligoje |
| SPINK5serine peptidase inhibitor Kazal type 5 | Dažnai (30–79%) | 1 ligoje |
| STIM1stromal interaction molecule 1 | Dažnai (30–79%) | 1 ligoje |
| TBX1T-box transcription factor 1 | Dažnai (30–79%) | 1 ligoje |
| TCF3transcription factor 3 | Dažnai (30–79%) | 1 ligoje |
| THRBthyroid hormone receptor beta | Dažnai (30–79%) | 1 ligoje |
| TLR8toll like receptor 8 | Dažnai (30–79%) | 1 ligoje |
| TMCO1transmembrane and coiled-coil domains 1 | Dažnai (30–79%) | 1 ligoje |
| TP63tumor protein p63 | Dažnai (30–79%) | 2 ligose |
| TRAF3TNF receptor associated factor 3 | Dažnai (30–79%) | 1 ligoje |
| TTC12tetratricopeptide repeat domain 12 | Dažnai (30–79%) | 1 ligoje |
| UNC119unc-119 lipid binding chaperone | Dažnai (30–79%) | 1 ligoje |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Dažnai (30–79%) | 1 ligoje |
| WASWASP actin nucleation promoting factor | Dažnai (30–79%) | 1 ligoje |
| WDR26WD repeat domain 26 | Dažnai (30–79%) | 2 ligose |
| ZEB2zinc finger E-box binding homeobox 2 | Dažnai (30–79%) | 3 ligose |
| ZMYND10zinc finger MYND-type containing 10 | Dažnai (30–79%) | 2 ligose |
| ZNF341zinc finger protein 341 | Dažnai (30–79%) | 1 ligoje |
| ADAT3adenosine deaminase tRNA specific 3 | Kartais (5–29%) | 2 ligose |
| AGR2anterior gradient 2, protein disulphide isomerase family member | Kartais (5–29%) | 1 ligoje |
| AIREautoimmune regulator | Kartais (5–29%) | 1 ligoje |
| ANAPC1anaphase promoting complex subunit 1 | Kartais (5–29%) | 1 ligoje |
| CDC42BPBCDC42 binding protein kinase beta | Kartais (5–29%) | 1 ligoje |
| DDB1damage specific DNA binding protein 1 | Kartais (5–29%) | 1 ligoje |
| DLK1delta like non-canonical Notch ligand 1 | Kartais (5–29%) | 2 ligose |
| DOCK11dedicator of cytokinesis 11 | Kartais (5–29%) | 1 ligoje |
| DOCK2dedicator of cytokinesis 2 | Kartais (5–29%) | 1 ligoje |
| FBXO11F-box protein 11 | Kartais (5–29%) | 1 ligoje |
| FOCADfocadhesin | Kartais (5–29%) | 1 ligoje |
| GNB2G protein subunit beta 2 | Kartais (5–29%) | 1 ligoje |
| GRHL3grainyhead like transcription factor 3 | Kartais (5–29%) | 2 ligose |
| H4C5H4 clustered histone 5 | Kartais (5–29%) | 1 ligoje |
| IGHG2immunoglobulin heavy constant gamma 2 (G2m marker) | Kartais (5–29%) | 1 ligoje |
| IGHMimmunoglobulin heavy constant mu | Kartais (5–29%) | 1 ligoje |
| IGKCimmunoglobulin kappa constant | Kartais (5–29%) | 1 ligoje |
| KAT6Alysine acetyltransferase 6A | Kartais (5–29%) | 1 ligoje |
| KDM6Blysine demethylase 6B | Kartais (5–29%) | 1 ligoje |
| KIF15kinesin family member 15 | Kartais (5–29%) | 1 ligoje |
| KMT2Alysine methyltransferase 2A | Kartais (5–29%) | 1 ligoje |
| KMT5Blysine methyltransferase 5B | Kartais (5–29%) | 1 ligoje |
| MAPK1mitogen-activated protein kinase 1 | Kartais (5–29%) | 1 ligoje |
| MEG3maternally expressed 3 | Kartais (5–29%) | 2 ligose |
| MNS1meiosis specific nuclear structural 1 | Kartais (5–29%) | 1 ligoje |
| NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit | Kartais (5–29%) | 2 ligose |
| NBNnibrin | Kartais (5–29%) | 1 ligoje |
| PGM1phosphoglucomutase 1 | Kartais (5–29%) | 1 ligoje |
| PHIPPHIP subunit of CUL4-Ring ligase complex | Kartais (5–29%) | 1 ligoje |
| PLCG2phospholipase C gamma 2 | Kartais (5–29%) | 1 ligoje |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Kartais (5–29%) | 1 ligoje |
| RAC1Rac family small GTPase 1 | Kartais (5–29%) | 2 ligose |
| RNU4-2RNA, U4 small nuclear 2 | Kartais (5–29%) | 1 ligoje |
| RTL1retrotransposon Gag like 1 | Kartais (5–29%) | 2 ligose |
| SRCAPSnf2 related CREBBP activator protein | Kartais (5–29%) | 1 ligoje |
| SRYsex determining region Y | Kartais (5–29%) | 1 ligoje |
| SYKspleen associated tyrosine kinase | Kartais (5–29%) | 1 ligoje |
| TAOK1TAO kinase 1 | Kartais (5–29%) | 1 ligoje |
| TNRC6Btrinucleotide repeat containing adaptor 6B | Kartais (5–29%) | 1 ligoje |
| UBBubiquitin B | Kartais (5–29%) | 2 ligose |
| A2ML1alpha-2-macroglobulin like 1 | Neužfiksuota | 1 ligoje |
| ACP5acid phosphatase 5, tartrate resistant | Neužfiksuota | 1 ligoje |
| ATN1atrophin 1 | Neužfiksuota | 1 ligoje |
| BCORBCL6 corepressor | Neužfiksuota | 1 ligoje |
| CD3DCD3 delta subunit of T-cell receptor complex | Neužfiksuota | 1 ligoje |
| COL2A1collagen type II alpha 1 chain | Neužfiksuota | 1 ligoje |
| DHCR77-dehydrocholesterol reductase | Neužfiksuota | 1 ligoje |
| FLNAfilamin A | Neužfiksuota | 1 ligoje |
| IDSiduronate 2-sulfatase | Neužfiksuota | 1 ligoje |
| IL2RBinterleukin 2 receptor subunit beta | Neužfiksuota | 1 ligoje |
| IL6Rinterleukin 6 receptor | Neužfiksuota | 1 ligoje |
| JAGN1jagunal vesicle mediated transporter 1 | Neužfiksuota | 1 ligoje |
| NCKAP1LNCK associated protein 1 like | Neužfiksuota | 1 ligoje |
| PCYT1Aphosphate cytidylyltransferase 1A, choline | Neužfiksuota | 1 ligoje |
| RPL11ribosomal protein L11 | Neužfiksuota | 1 ligoje |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Neužfiksuota | 1 ligoje |
| SETD2SET domain containing 2, histone lysine methyltransferase | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
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- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.16-c6eea6bf.
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