Dante Labs Atlas

Genes, variants and traits, and how they connect.

Point to or tap a trait to see the traits it shares the most genes with, then choose a second to compare the two.

A reference to the human genome: every gene's page, the variants ClinVar classifies as disease-causing, and the traits the Human Phenotype Ontology links to genes. It describes the research, never anyone's own genome.

Body systems

Arcs join each trait to the 3 traits it shares the largest part of its genes with; the heavier the arc, the larger the share.
The larger a trait, the more genes HPO links to it.

Links from the Human Phenotype Ontology, release 2026-09-01.

How genes and traits connect

Each disc is one of the 24 traits linked to the most genes, in the colour of its body system, and each point a gene in which one of them is seen most often. Together, an arc joins two traits that share genes; with the genes, an arc joins a gene to a trait wherever the Human Phenotype Ontology links them.

Traits that share the most genes

The pairs among the 24 traits in the globe with the largest share of genes in common: the genes linked to both, out of the genes linked to either. Every gene HPO links to each trait counts, not only those the globe draws.

Traits	Genes in common	Share	Most often seen with both
Global developmental delayEpilepsy	1 252 1 252 genes in common	51%	MECP2 POMT2 ARX
Global developmental delayIntellectual disability	1 179 1 179 genes in common	50%	FGFR3 CEP290 MKS1
Global developmental delayLow muscle tone	1 084 1 084 genes in common	46%	ALDH18A1 LARGE1 POMT2
EpilepsyIntellectual disability	1 073 1 073 genes in common	45%	ARX SLC2A1 BRAF
Global developmental delayAbnormally small head	989 989 genes in common	44%	POMT1 POMT2 ARX
EpilepsyLow muscle tone	983 983 genes in common	42%	FKTN PEX10 PEX12
Intellectual disabilityLow muscle tone	925 925 genes in common	41%	AHI1 ALDH18A1 CEP290
Wide-set eyesLow-set ears	483 483 genes in common	40%	FLNA BRAF ATP6V0A2
Intellectual disabilityAbnormally small head	837 837 genes in common	39%	ARX POMT1 ERCC6
Short statureAbnormally small head	742 742 genes in common	38%	ERCC4 RAB3GAP1 RNU4ATAC
Little lower jawHigh palate	440 440 genes in common	38%	MED12 PIEZO2 RECQL4
Intellectual disabilityShort stature	815 815 genes in common	37%	BRAF FLNA PNPLA6
EpilepsyAbnormally small head	840 840 genes in common	37%	TGIF1 ARX POMT2
Wide-set eyesLittle lower jaw	461 461 genes in common	37%	FLNA FLNB MYH3
Global developmental delayShort stature	871 871 genes in common	36%	ALDH18A1 DVL1 PPP3CA
Little lower jawLow-set ears	435 435 genes in common	36%	FLNA MYH3 SATB2
Low muscle toneAbnormally small head	740 740 genes in common	35%	POMT2 RAB3GAP2 ATP5F1A
Wide-set eyesHigh palate	433 433 genes in common	35%	FGFR2 RECQL4 CDH11
Intellectual disabilityCross-eyed	701 701 genes in common	35%	CREBBP EP300 CC2D2A
Global developmental delayCross-eyed	763 763 genes in common	34%	CC2D2A INPP5E NALCN

Traits in the globe

Genes in the globe

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