Požymis
Bleeding tendency
Klinikinis pavadinimas: Abnormal bleeding
An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
Santrauka
- Taip pat vadinama
- Bleeding diathesis, Hemorrhagic diathesis
- Kūno sistema
- Abnormality of blood and blood-forming tissues
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
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Įsigyti savo Genome Test140 genų susiję su Bleeding tendency
Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Bleeding tendency. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| ALG13ALG13 UDP-N-acetylglucosaminyltransferase subunit | Visada | 1 ligoje |
| F13A1coagulation factor XIII A chain | Visada | 1 ligoje |
| F13Bcoagulation factor XIII B chain | Visada | 1 ligoje |
| FGAfibrinogen alpha chain | Visada | 4 ligose |
| FGBfibrinogen beta chain | Visada | 4 ligose |
| FGGfibrinogen gamma chain | Visada | 4 ligose |
| FYB1FYN binding protein 1 | Visada | 1 ligoje |
| GALEUDP-galactose-4-epimerase | Visada | 1 ligoje |
| GFI1Bgrowth factor independent 1B transcriptional repressor | Visada | 1 ligoje |
| HPS3HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 | Visada | 1 ligoje |
| HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 | Visada | 1 ligoje |
| ITGB3integrin subunit beta 3 | Visada | 3 ligose |
| PRKACGprotein kinase cAMP-activated catalytic subunit gamma | Visada | 1 ligoje |
| PTPRJprotein tyrosine phosphatase receptor type J | Visada | 1 ligoje |
| ARF1ARF GTPase 1 | Labai dažnai (80–99%) | 1 ligoje |
| ARFGEF2ARF guanine nucleotide exchange factor 2 | Labai dažnai (80–99%) | 1 ligoje |
| BMPR1Abone morphogenetic protein receptor type 1A | Labai dažnai (80–99%) | 3 ligose |
| CHST14carbohydrate sulfotransferase 14 | Labai dažnai (80–99%) | 1 ligoje |
| DSEdermatan sulfate epimerase | Labai dažnai (80–99%) | 1 ligoje |
| ENGendoglin | Labai dažnai (80–99%) | 1 ligoje |
| ERMARDER membrane associated RNA degradation | Labai dažnai (80–99%) | 1 ligoje |
| F11coagulation factor XI | Labai dažnai (80–99%) | 2 ligose |
| F8coagulation factor VIII | Labai dažnai (80–99%) | 2 ligose |
| FLNAfilamin A | Labai dažnai (80–99%) | 1 ligoje |
| GATA1GATA binding protein 1 | Labai dažnai (80–99%) | 2 ligose |
| GP1BAglycoprotein Ib platelet subunit alpha | Labai dažnai (80–99%) | 3 ligose |
| GP1BBglycoprotein Ib platelet subunit beta | Labai dažnai (80–99%) | 3 ligose |
| GP9glycoprotein IX platelet | Labai dažnai (80–99%) | 2 ligose |
| GREM1gremlin 1, DAN family BMP antagonist | Labai dažnai (80–99%) | 1 ligoje |
| JAK2Janus kinase 2 | Labai dažnai (80–99%) | 3 ligose |
| MAP1Bmicrotubule associated protein 1B | Labai dažnai (80–99%) | 1 ligoje |
| MPLMPL proto-oncogene, thrombopoietin receptor | Labai dažnai (80–99%) | 3 ligose |
| NBEAL2neurobeachin like 2 | Labai dažnai (80–99%) | 2 ligose |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Labai dažnai (80–99%) | 1 ligoje |
| SLC35A1solute carrier family 35 member A1 | Labai dažnai (80–99%) | 1 ligoje |
| SMAD4SMAD family member 4 | Labai dažnai (80–99%) | 1 ligoje |
| THPOthrombopoietin | Labai dažnai (80–99%) | 2 ligose |
| TMTC3transmembrane O-mannosyltransferase targeting cadherins 3 | Labai dažnai (80–99%) | 1 ligoje |
| ATRXATRX chromatin remodeler | Dažnai (30–79%) | 1 ligoje |
| BCORBCL6 corepressor | Dažnai (30–79%) | 1 ligoje |
Rodyti dar 100 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Dažnai (30–79%) | 2 ligose |
| CALRcalreticulin | Dažnai (30–79%) | 2 ligose |
| CASP10caspase 10 | Dažnai (30–79%) | 1 ligoje |
| CBLCbl proto-oncogene | Dažnai (30–79%) | 1 ligoje |
| CD109CD109 molecule | Dažnai (30–79%) | 1 ligoje |
| F2coagulation factor II, thrombin | Dažnai (30–79%) | 1 ligoje |
| FASFas cell surface death receptor | Dažnai (30–79%) | 1 ligoje |
| FASLGFas ligand | Dažnai (30–79%) | 1 ligoje |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Dažnai (30–79%) | 1 ligoje |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Dažnai (30–79%) | 2 ligose |
| GGCXgamma-glutamyl carboxylase | Dažnai (30–79%) | 4 ligose |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Dažnai (30–79%) | 1 ligoje |
| ITGA2integrin subunit alpha 2 | Dažnai (30–79%) | 1 ligoje |
| ITGA2Bintegrin subunit alpha 2b | Dažnai (30–79%) | 2 ligose |
| KRASKRas proto-oncogene, GTPase | Dažnai (30–79%) | 1 ligoje |
| LYSTlysosomal trafficking regulator | Dažnai (30–79%) | 1 ligoje |
| LZTR1leucine zipper like post translational regulator 1 | Dažnai (30–79%) | 1 ligoje |
| MRASmuscle RAS oncogene homolog | Dažnai (30–79%) | 1 ligoje |
| NABP1nucleic acid binding protein 1 | Dažnai (30–79%) | 1 ligoje |
| NPM1nucleophosmin 1 | Dažnai (30–79%) | 1 ligoje |
| NRASNRAS proto-oncogene, GTPase | Dažnai (30–79%) | 1 ligoje |
| NUMA1nuclear mitotic apparatus protein 1 | Dažnai (30–79%) | 1 ligoje |
| PMLPML nuclear body scaffold | Dažnai (30–79%) | 1 ligoje |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Dažnai (30–79%) | 1 ligoje |
| PTENphosphatase and tensin homolog | Dažnai (30–79%) | 1 ligoje |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Dažnai (30–79%) | 2 ligose |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Dažnai (30–79%) | 1 ligoje |
| RARAretinoic acid receptor alpha | Dažnai (30–79%) | 1 ligoje |
| RASA2RAS p21 protein activator 2 | Dažnai (30–79%) | 1 ligoje |
| RFT1RFT1 glycolipid translocator homolog | Dažnai (30–79%) | 1 ligoje |
| RIT1Ras like without CAAX 1 | Dažnai (30–79%) | 1 ligoje |
| RRASRAS related | Dažnai (30–79%) | 1 ligoje |
| RRAS2RAS related 2 | Dažnai (30–79%) | 1 ligoje |
| SERPINF2serpin family F member 2 | Dažnai (30–79%) | 1 ligoje |
| SH2B3SH2B adaptor protein 3 | Dažnai (30–79%) | 1 ligoje |
| SLC7A7solute carrier family 7 member 7 | Dažnai (30–79%) | 1 ligoje |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Dažnai (30–79%) | 2 ligose |
| SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 | Dažnai (30–79%) | 1 ligoje |
| SPRED2sprouty related EVH1 domain containing 2 | Dažnai (30–79%) | 1 ligoje |
| STAT3signal transducer and activator of transcription 3 | Dažnai (30–79%) | 1 ligoje |
| STAT5Bsignal transducer and activator of transcription 5B | Dažnai (30–79%) | 1 ligoje |
| TBL1XR1TBL1X/Y related 1 | Dažnai (30–79%) | 1 ligoje |
| TET2tet methylcytosine dioxygenase 2 | Dažnai (30–79%) | 4 ligose |
| TP53tumor protein p53 | Dažnai (30–79%) | 1 ligoje |
| VKORC1vitamin K epoxide reductase complex subunit 1 | Dažnai (30–79%) | 2 ligose |
| ZBTB16zinc finger and BTB domain containing 16 | Dažnai (30–79%) | 1 ligoje |
| ALKALK receptor tyrosine kinase | Kartais (5–29%) | 1 ligoje |
| AMNamnion associated transmembrane protein | Kartais (5–29%) | 1 ligoje |
| B4GALT1beta-1,4-galactosyltransferase 1 | Kartais (5–29%) | 1 ligoje |
| CLPBClpB family mitochondrial disaggregase | Kartais (5–29%) | 1 ligoje |
| COG6component of oligomeric golgi complex 6 | Kartais (5–29%) | 1 ligoje |
| CUBNcubilin | Kartais (5–29%) | 1 ligoje |
| EPORerythropoietin receptor | Kartais (5–29%) | 1 ligoje |
| GBA1glucosylceramidase beta 1 | Kartais (5–29%) | 1 ligoje |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Kartais (5–29%) | 1 ligoje |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Kartais (5–29%) | 1 ligoje |
| IPO8importin 8 | Kartais (5–29%) | 1 ligoje |
| LIN28Blin-28 RNA binding posttranscriptional regulator B | Kartais (5–29%) | 1 ligoje |
| LMO1LIM domain only 1 | Kartais (5–29%) | 1 ligoje |
| MAP2K1mitogen-activated protein kinase kinase 1 | Kartais (5–29%) | 1 ligoje |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Kartais (5–29%) | 1 ligoje |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Kartais (5–29%) | 1 ligoje |
| PHOX2Bpaired like homeobox 2B | Kartais (5–29%) | 1 ligoje |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Kartais (5–29%) | 1 ligoje |
| RASA1RAS p21 protein activator 1 | Kartais (5–29%) | 1 ligoje |
| RPS14ribosomal protein S14 | Kartais (5–29%) | 1 ligoje |
| RYR1ryanodine receptor 1 | Kartais (5–29%) | 1 ligoje |
| SCARB2scavenger receptor class B member 2 | Kartais (5–29%) | 1 ligoje |
| SLC37A4solute carrier family 37 member 4 | Kartais (5–29%) | 1 ligoje |
| SMAD2SMAD family member 2 | Kartais (5–29%) | 1 ligoje |
| SMAD3SMAD family member 3 | Kartais (5–29%) | 1 ligoje |
| TGFB2transforming growth factor beta 2 | Kartais (5–29%) | 1 ligoje |
| TGFB3transforming growth factor beta 3 | Kartais (5–29%) | 1 ligoje |
| TGFBR1transforming growth factor beta receptor 1 | Kartais (5–29%) | 1 ligoje |
| TGFBR2transforming growth factor beta receptor 2 | Kartais (5–29%) | 1 ligoje |
| URODuroporphyrinogen decarboxylase | Kartais (5–29%) | 1 ligoje |
| UROSuroporphyrinogen III synthase | Kartais (5–29%) | 1 ligoje |
| VPS33BVPS33B late endosome and lysosome associated | Kartais (5–29%) | 1 ligoje |
| F12coagulation factor XII | Retai (1–4 %) | 1 ligoje |
| MTTPmicrosomal triglyceride transfer protein | Retai (1–4 %) | 1 ligoje |
| SF3B1splicing factor 3b subunit 1 | Retai (1–4 %) | 1 ligoje |
| SLC25A13solute carrier family 25 member 13 | Retai (1–4 %) | 1 ligoje |
| SMPD1sphingomyelin phosphodiesterase 1 | Retai (1–4 %) | 1 ligoje |
| ABCG8ATP binding cassette subfamily G member 8 | Neužfiksuota | 1 ligoje |
| ANO6anoctamin 6 | Neužfiksuota | 1 ligoje |
| CD36CD36 molecule (CD36 blood group) | Neužfiksuota | 1 ligoje |
| CISD2CDGSH iron sulfur domain 2 | Neužfiksuota | 1 ligoje |
| F5coagulation factor V | Neužfiksuota | 1 ligoje |
| F7coagulation factor VII | Neužfiksuota | 1 ligoje |
| FERMT3FERM domain containing kindlin 3 | Neužfiksuota | 1 ligoje |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Neužfiksuota | 1 ligoje |
| LMAN1lectin, mannose binding 1 | Neužfiksuota | 1 ligoje |
| MPImannose phosphate isomerase | Neužfiksuota | 1 ligoje |
| MYH9myosin heavy chain 9 | Neužfiksuota | 1 ligoje |
| P2RY12purinergic receptor P2Y12 | Neužfiksuota | 1 ligoje |
| PEX12peroxisomal biogenesis factor 12 | Neužfiksuota | 1 ligoje |
| SERPINE1serpin family E member 1 | Neužfiksuota | 1 ligoje |
| SRCSRC proto-oncogene, non-receptor tyrosine kinase | Neužfiksuota | 1 ligoje |
| STIM1stromal interaction molecule 1 | Neužfiksuota | 1 ligoje |
| VWFvon Willebrand factor | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
Siauresni požymiai
- Bloody nose110 genų
- Bleeding gums61 genas
- Prolonged bleeding time48 genų
- Abnormally heavy bleeding during menstruation43 genų
- Oral cavity bleeding22 genų
- Bleeding below the skin15 genų
- Excessive bleeding after minor trauma15 genų
- Cephalohematoma13 genų
- Internal bleeding11 genų
- Abnormal umbilical stump bleeding10 genų
- Bleeding with minor or no trauma8 genų
- Prolonged bleeding following procedure7 genų
- Excessive bleeding from superficial cuts5 genų
- Abnormal vaginal bleeding2 genų
- Bleeding requiring red cell transfusion1 genas
- Excessive bleeding after a venipuncture1 genas
- Abnormal onset of bleeding
Platesni požymiai
Iš kur tai žinoma
- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.16-c6eea6bf.
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