Trait
Bleeding tendency
Clinical name: Abnormal bleeding
An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects.
Summary
- Also called
- Bleeding diathesis, Hemorrhagic diathesis
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test140 genes linked to Bleeding tendency
Changes in these genes cause rare conditions in which Bleeding tendency is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG13ALG13 UDP-N-acetylglucosaminyltransferase subunit | Always | In 1 condition |
| F13A1coagulation factor XIII A chain | Always | In 1 condition |
| F13Bcoagulation factor XIII B chain | Always | In 1 condition |
| FGAfibrinogen alpha chain | Always | In 4 conditions |
| FGBfibrinogen beta chain | Always | In 4 conditions |
| FGGfibrinogen gamma chain | Always | In 4 conditions |
| FYB1FYN binding protein 1 | Always | In 1 condition |
| GALEUDP-galactose-4-epimerase | Always | In 1 condition |
| GFI1Bgrowth factor independent 1B transcriptional repressor | Always | In 1 condition |
| HPS3HPS3 biogenesis of lysosomal organelles complex 2 subunit 1 | Always | In 1 condition |
| HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 | Always | In 1 condition |
| ITGB3integrin subunit beta 3 | Always | In 3 conditions |
| PRKACGprotein kinase cAMP-activated catalytic subunit gamma | Always | In 1 condition |
| PTPRJprotein tyrosine phosphatase receptor type J | Always | In 1 condition |
| ARF1ARF GTPase 1 | Very often (80–99%) | In 1 condition |
| ARFGEF2ARF guanine nucleotide exchange factor 2 | Very often (80–99%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Very often (80–99%) | In 3 conditions |
| CHST14carbohydrate sulfotransferase 14 | Very often (80–99%) | In 1 condition |
| DSEdermatan sulfate epimerase | Very often (80–99%) | In 1 condition |
| ENGendoglin | Very often (80–99%) | In 1 condition |
| ERMARDER membrane associated RNA degradation | Very often (80–99%) | In 1 condition |
| F11coagulation factor XI | Very often (80–99%) | In 2 conditions |
| F8coagulation factor VIII | Very often (80–99%) | In 2 conditions |
| FLNAfilamin A | Very often (80–99%) | In 1 condition |
| GATA1GATA binding protein 1 | Very often (80–99%) | In 2 conditions |
| GP1BAglycoprotein Ib platelet subunit alpha | Very often (80–99%) | In 3 conditions |
| GP1BBglycoprotein Ib platelet subunit beta | Very often (80–99%) | In 3 conditions |
| GP9glycoprotein IX platelet | Very often (80–99%) | In 2 conditions |
| GREM1gremlin 1, DAN family BMP antagonist | Very often (80–99%) | In 1 condition |
| JAK2Janus kinase 2 | Very often (80–99%) | In 3 conditions |
| MAP1Bmicrotubule associated protein 1B | Very often (80–99%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Very often (80–99%) | In 3 conditions |
| NBEAL2neurobeachin like 2 | Very often (80–99%) | In 2 conditions |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Very often (80–99%) | In 1 condition |
| SLC35A1solute carrier family 35 member A1 | Very often (80–99%) | In 1 condition |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 1 condition |
| THPOthrombopoietin | Very often (80–99%) | In 2 conditions |
| TMTC3transmembrane O-mannosyltransferase targeting cadherins 3 | Very often (80–99%) | In 1 condition |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Often (30–79%) | In 1 condition |
Show 100 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 2 conditions |
| CALRcalreticulin | Often (30–79%) | In 2 conditions |
| CASP10caspase 10 | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CD109CD109 molecule | Often (30–79%) | In 1 condition |
| F2coagulation factor II, thrombin | Often (30–79%) | In 1 condition |
| FASFas cell surface death receptor | Often (30–79%) | In 1 condition |
| FASLGFas ligand | Often (30–79%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Often (30–79%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Often (30–79%) | In 2 conditions |
| GGCXgamma-glutamyl carboxylase | Often (30–79%) | In 4 conditions |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Often (30–79%) | In 1 condition |
| ITGA2integrin subunit alpha 2 | Often (30–79%) | In 1 condition |
| ITGA2Bintegrin subunit alpha 2b | Often (30–79%) | In 2 conditions |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Often (30–79%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Often (30–79%) | In 1 condition |
| MRASmuscle RAS oncogene homolog | Often (30–79%) | In 1 condition |
| NABP1nucleic acid binding protein 1 | Often (30–79%) | In 1 condition |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Often (30–79%) | In 1 condition |
| PMLPML nuclear body scaffold | Often (30–79%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 1 condition |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Often (30–79%) | In 2 conditions |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| RARAretinoic acid receptor alpha | Often (30–79%) | In 1 condition |
| RASA2RAS p21 protein activator 2 | Often (30–79%) | In 1 condition |
| RFT1RFT1 glycolipid translocator homolog | Often (30–79%) | In 1 condition |
| RIT1Ras like without CAAX 1 | Often (30–79%) | In 1 condition |
| RRASRAS related | Often (30–79%) | In 1 condition |
| RRAS2RAS related 2 | Often (30–79%) | In 1 condition |
| SERPINF2serpin family F member 2 | Often (30–79%) | In 1 condition |
| SH2B3SH2B adaptor protein 3 | Often (30–79%) | In 1 condition |
| SLC7A7solute carrier family 7 member 7 | Often (30–79%) | In 1 condition |
| SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 | Often (30–79%) | In 2 conditions |
| SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 | Often (30–79%) | In 1 condition |
| SPRED2sprouty related EVH1 domain containing 2 | Often (30–79%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Often (30–79%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Often (30–79%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Often (30–79%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 4 conditions |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| VKORC1vitamin K epoxide reductase complex subunit 1 | Often (30–79%) | In 2 conditions |
| ZBTB16zinc finger and BTB domain containing 16 | Often (30–79%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| AMNamnion associated transmembrane protein | Sometimes (5–29%) | In 1 condition |
| B4GALT1beta-1,4-galactosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| CLPBClpB family mitochondrial disaggregase | Sometimes (5–29%) | In 1 condition |
| COG6component of oligomeric golgi complex 6 | Sometimes (5–29%) | In 1 condition |
| CUBNcubilin | Sometimes (5–29%) | In 1 condition |
| EPORerythropoietin receptor | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Sometimes (5–29%) | In 1 condition |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| LIN28Blin-28 RNA binding posttranscriptional regulator B | Sometimes (5–29%) | In 1 condition |
| LMO1LIM domain only 1 | Sometimes (5–29%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| MGAT2alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | Sometimes (5–29%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Sometimes (5–29%) | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Sometimes (5–29%) | In 1 condition |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Sometimes (5–29%) | In 1 condition |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| RPS14ribosomal protein S14 | Sometimes (5–29%) | In 1 condition |
| RYR1ryanodine receptor 1 | Sometimes (5–29%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Sometimes (5–29%) | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Sometimes (5–29%) | In 1 condition |
| SMAD2SMAD family member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD3SMAD family member 3 | Sometimes (5–29%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Sometimes (5–29%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Sometimes (5–29%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| URODuroporphyrinogen decarboxylase | Sometimes (5–29%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Sometimes (5–29%) | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Sometimes (5–29%) | In 1 condition |
| F12coagulation factor XII | Rarely (1–4%) | In 1 condition |
| MTTPmicrosomal triglyceride transfer protein | Rarely (1–4%) | In 1 condition |
| SF3B1splicing factor 3b subunit 1 | Rarely (1–4%) | In 1 condition |
| SLC25A13solute carrier family 25 member 13 | Rarely (1–4%) | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Rarely (1–4%) | In 1 condition |
| ABCG8ATP binding cassette subfamily G member 8 | Not recorded | In 1 condition |
| ANO6anoctamin 6 | Not recorded | In 1 condition |
| CD36CD36 molecule (CD36 blood group) | Not recorded | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Not recorded | In 1 condition |
| F5coagulation factor V | Not recorded | In 1 condition |
| F7coagulation factor VII | Not recorded | In 1 condition |
| FERMT3FERM domain containing kindlin 3 | Not recorded | In 1 condition |
| G6PC1glucose-6-phosphatase catalytic subunit 1 | Not recorded | In 1 condition |
| LMAN1lectin, mannose binding 1 | Not recorded | In 1 condition |
| MPImannose phosphate isomerase | Not recorded | In 1 condition |
| MYH9myosin heavy chain 9 | Not recorded | In 1 condition |
| P2RY12purinergic receptor P2Y12 | Not recorded | In 1 condition |
| PEX12peroxisomal biogenesis factor 12 | Not recorded | In 1 condition |
| SERPINE1serpin family E member 1 | Not recorded | In 1 condition |
| SRCSRC proto-oncogene, non-receptor tyrosine kinase | Not recorded | In 1 condition |
| STIM1stromal interaction molecule 1 | Not recorded | In 1 condition |
| VWFvon Willebrand factor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Bloody nose110 genes
- Bleeding gums61 genes
- Prolonged bleeding time48 genes
- Abnormally heavy bleeding during menstruation43 genes
- Oral cavity bleeding22 genes
- Bleeding below the skin15 genes
- Excessive bleeding after minor trauma15 genes
- Cephalohematoma13 genes
- Internal bleeding11 genes
- Abnormal umbilical stump bleeding10 genes
- Bleeding with minor or no trauma8 genes
- Prolonged bleeding following procedure7 genes
- Excessive bleeding from superficial cuts5 genes
- Abnormal vaginal bleeding2 genes
- Bleeding requiring red cell transfusion1 gene
- Excessive bleeding after a venipuncture1 gene
- Abnormal onset of bleeding
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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