Požymis
Itching
Klinikinis pavadinimas: Pruritus
Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
Santrauka
- Taip pat vadinama
- Itchy skin, Skin itching
- Kūno sistema
- Abnormality of the integument
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
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Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Itching. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| ABCB11ATP binding cassette subfamily B member 11 | Visada | 4 ligose |
| ABCB4ATP binding cassette subfamily B member 4 | Visada | 3 ligose |
| AMOTL1angiomotin like 1 | Visada | 1 ligoje |
| ATP8B1ATPase phospholipid transporting 8B1 | Visada | 5 ligose |
| CCDC47coiled-coil domain containing 47 | Visada | 1 ligoje |
| CDSNcorneodesmosin | Visada | 2 ligose |
| CLDN1claudin 1 | Visada | 1 ligoje |
| COL7A1collagen type VII alpha 1 chain | Visada | 3 ligose |
| CST3cystatin C | Visada | 1 ligoje |
| DSG4desmoglein 4 | Visada | 1 ligoje |
| FLG2filaggrin 2 | Visada | 1 ligoje |
| MIA3MIA SH3 domain ER export factor 3 | Visada | 1 ligoje |
| OSMRoncostatin M receptor | Visada | 1 ligoje |
| PERPp53 apoptosis effector related to PMP22 | Visada | 1 ligoje |
| PLCG2phospholipase C gamma 2 | Visada | 1 ligoje |
| PLD4phospholipase D family member 4 | Visada | 1 ligoje |
| PLECplectin | Visada | 1 ligoje |
| SLC27A4solute carrier family 27 member 4 | Visada | 1 ligoje |
| ST14ST14 transmembrane serine protease matriptase | Visada | 1 ligoje |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Visada | 1 ligoje |
| USP53ubiquitin specific peptidase 53 | Visada | 1 ligoje |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Visada | 1 ligoje |
| VPS33BVPS33B late endosome and lysosome associated | Visada | 1 ligoje |
| ABCA12ATP binding cassette subfamily A member 12 | Labai dažnai (80–99%) | 2 ligose |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Labai dažnai (80–99%) | 2 ligose |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Labai dažnai (80–99%) | 2 ligose |
| ASPRV1aspartic peptidase retroviral like 1 | Labai dažnai (80–99%) | 2 ligose |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Labai dažnai (80–99%) | 2 ligose |
| ATP7BATPase copper transporting beta | Labai dažnai (80–99%) | 1 ligoje |
| CD28CD28 molecule | Labai dažnai (80–99%) | 2 ligose |
| CERS3ceramide synthase 3 | Labai dažnai (80–99%) | 1 ligoje |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Labai dažnai (80–99%) | 2 ligose |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Labai dažnai (80–99%) | 1 ligoje |
| DNASE1L3deoxyribonuclease 1L3 | Labai dažnai (80–99%) | 1 ligoje |
| FECHferrochelatase | Labai dažnai (80–99%) | 2 ligose |
| KITKIT proto-oncogene, receptor tyrosine kinase | Labai dažnai (80–99%) | 3 ligose |
| KRT14keratin 14 | Labai dažnai (80–99%) | 3 ligose |
| KRT5keratin 5 | Labai dažnai (80–99%) | 5 ligose |
| LBRlamin B receptor | Labai dažnai (80–99%) | 2 ligose |
| LIPNlipase family member N | Labai dažnai (80–99%) | 1 ligoje |
Rodyti dar 115 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| NIPAL4NIPA like domain containing 4 | Labai dažnai (80–99%) | 2 ligose |
| NLRP3NLR family pyrin domain containing 3 | Labai dažnai (80–99%) | 1 ligoje |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Labai dažnai (80–99%) | 1 ligoje |
| PEPDpeptidase D | Labai dažnai (80–99%) | 1 ligoje |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Labai dažnai (80–99%) | 1 ligoje |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Labai dažnai (80–99%) | 2 ligose |
| SPINK5serine peptidase inhibitor Kazal type 5 | Labai dažnai (80–99%) | 2 ligose |
| STAT3signal transducer and activator of transcription 3 | Labai dažnai (80–99%) | 1 ligoje |
| SULT2B1sulfotransferase family 2B member 1 | Labai dažnai (80–99%) | 3 ligose |
| TGM1transglutaminase 1 | Labai dažnai (80–99%) | 2 ligose |
| TNFRSF1BTNF receptor superfamily member 1B | Labai dažnai (80–99%) | 2 ligose |
| ADAadenosine deaminase | Dažnai (30–79%) | 1 ligoje |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Dažnai (30–79%) | 1 ligoje |
| AQP5aquaporin 5 | Dažnai (30–79%) | 1 ligoje |
| ASXL1ASXL transcriptional regulator 1 | Dažnai (30–79%) | 2 ligose |
| BRCA1BRCA1 DNA repair associated | Dažnai (30–79%) | 1 ligoje |
| BRCA2BRCA2 DNA repair associated | Dažnai (30–79%) | 1 ligoje |
| CARD14caspase recruitment domain family member 14 | Dažnai (30–79%) | 1 ligoje |
| CBLCbl proto-oncogene | Dažnai (30–79%) | 1 ligoje |
| CHD7chromodomain helicase DNA binding protein 7 | Dažnai (30–79%) | 1 ligoje |
| CST6cystatin E/M | Dažnai (30–79%) | 1 ligoje |
| DCDC2doublecortin domain containing 2 | Dažnai (30–79%) | 1 ligoje |
| DCLRE1CDNA cross-link repair 1C | Dažnai (30–79%) | 1 ligoje |
| EPAS1endothelial PAS domain protein 1 | Dažnai (30–79%) | 1 ligoje |
| EPORerythropoietin receptor | Dažnai (30–79%) | 1 ligoje |
| FHfumarate hydratase | Dažnai (30–79%) | 1 ligoje |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Dažnai (30–79%) | 1 ligoje |
| HLA-DRAmajor histocompatibility complex, class II, DR alpha | Dažnai (30–79%) | 1 ligoje |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Dažnai (30–79%) | 1 ligoje |
| IL12Ainterleukin 12A | Dažnai (30–79%) | 1 ligoje |
| IL12RB1interleukin 12 receptor subunit beta 1 | Dažnai (30–79%) | 1 ligoje |
| IL2RGinterleukin 2 receptor subunit gamma | Dažnai (30–79%) | 1 ligoje |
| IL7Rinterleukin 7 receptor | Dažnai (30–79%) | 1 ligoje |
| IRF5interferon regulatory factor 5 | Dažnai (30–79%) | 1 ligoje |
| JAK2Janus kinase 2 | Dažnai (30–79%) | 2 ligose |
| KIF12kinesin family member 12 | Dažnai (30–79%) | 1 ligoje |
| KRT10keratin 10 | Dažnai (30–79%) | 1 ligoje |
| LRP1LDL receptor related protein 1 | Dažnai (30–79%) | 2 ligose |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Dažnai (30–79%) | 1 ligoje |
| MED12mediator complex subunit 12 | Dažnai (30–79%) | 1 ligoje |
| MMEL1membrane metalloendopeptidase like 1 | Dažnai (30–79%) | 1 ligoje |
| MPLMPL proto-oncogene, thrombopoietin receptor | Dažnai (30–79%) | 1 ligoje |
| MVKmevalonate kinase | Dažnai (30–79%) | 2 ligose |
| MYO5Bmyosin VB | Dažnai (30–79%) | 2 ligose |
| NUDCD3NudC domain containing 3 | Dažnai (30–79%) | 1 ligoje |
| PMVKphosphomevalonate kinase | Dažnai (30–79%) | 1 ligoje |
| PORCNporcupine O-acyltransferase | Dažnai (30–79%) | 1 ligoje |
| POU2AF1POU class 2 homeobox associating factor 1 | Dažnai (30–79%) | 1 ligoje |
| PSMB10proteasome 20S subunit beta 10 | Dažnai (30–79%) | 1 ligoje |
| PTPN3protein tyrosine phosphatase non-receptor type 3 | Dažnai (30–79%) | 1 ligoje |
| RAG1recombination activating 1 | Dažnai (30–79%) | 1 ligoje |
| RAG2recombination activating 2 | Dažnai (30–79%) | 1 ligoje |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Dažnai (30–79%) | 1 ligoje |
| ROS1ROS proto-oncogene 1, receptor tyrosine kinase | Dažnai (30–79%) | 1 ligoje |
| RUNX1RUNX family transcription factor 1 | Dažnai (30–79%) | 1 ligoje |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Dažnai (30–79%) | 1 ligoje |
| SCN10Asodium voltage-gated channel alpha subunit 10 | Dažnai (30–79%) | 1 ligoje |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Dažnai (30–79%) | 2 ligose |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Dažnai (30–79%) | 2 ligose |
| SPIBSpi-B transcription factor | Dažnai (30–79%) | 1 ligoje |
| SRSF2serine and arginine rich splicing factor 2 | Dažnai (30–79%) | 2 ligose |
| STX3syntaxin 3 | Dažnai (30–79%) | 1 ligoje |
| TET2tet methylcytosine dioxygenase 2 | Dažnai (30–79%) | 2 ligose |
| THPOthrombopoietin | Dažnai (30–79%) | 1 ligoje |
| TNFSF15TNF superfamily member 15 | Dažnai (30–79%) | 1 ligoje |
| TNPO3transportin 3 | Dažnai (30–79%) | 1 ligoje |
| UNC45Aunc-45 myosin chaperone A | Dažnai (30–79%) | 1 ligoje |
| WDR83OSWD repeat domain 83 opposite strand | Dažnai (30–79%) | 1 ligoje |
| ALKALK receptor tyrosine kinase | Kartais (5–29%) | 1 ligoje |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Kartais (5–29%) | 1 ligoje |
| CASTcalpastatin | Kartais (5–29%) | 1 ligoje |
| CLEC7AC-type lectin domain containing 7A | Kartais (5–29%) | 1 ligoje |
| DSPdesmoplakin | Kartais (5–29%) | 1 ligoje |
| FDPSfarnesyl diphosphate synthase | Kartais (5–29%) | 1 ligoje |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Kartais (5–29%) | 1 ligoje |
| GPNMBglycoprotein nmb | Kartais (5–29%) | 1 ligoje |
| GPR35G protein-coupled receptor 35 | Kartais (5–29%) | 1 ligoje |
| GSNgelsolin | Kartais (5–29%) | 1 ligoje |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Kartais (5–29%) | 1 ligoje |
| IL17Finterleukin 17F | Kartais (5–29%) | 1 ligoje |
| IL17RAinterleukin 17 receptor A | Kartais (5–29%) | 1 ligoje |
| IL17RCinterleukin 17 receptor C | Kartais (5–29%) | 1 ligoje |
| KRT74keratin 74 | Kartais (5–29%) | 1 ligoje |
| LIPAlipase A, lysosomal acid type | Kartais (5–29%) | 1 ligoje |
| MST1macrophage stimulating 1 | Kartais (5–29%) | 1 ligoje |
| MVDmevalonate diphosphate decarboxylase | Kartais (5–29%) | 1 ligoje |
| NRASNRAS proto-oncogene, GTPase | Kartais (5–29%) | 1 ligoje |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Kartais (5–29%) | 1 ligoje |
| PKP1plakophilin 1 | Kartais (5–29%) | 1 ligoje |
| POFUT1protein O-fucosyltransferase 1 | Kartais (5–29%) | 1 ligoje |
| POGLUT1protein O-glucosyltransferase 1 | Kartais (5–29%) | 2 ligose |
| PPP1R13Lprotein phosphatase 1 regulatory subunit 13 like | Kartais (5–29%) | 1 ligoje |
| PSENENpresenilin enhancer, gamma-secretase subunit | Kartais (5–29%) | 1 ligoje |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Kartais (5–29%) | 1 ligoje |
| SEMA4Dsemaphorin 4D | Kartais (5–29%) | 1 ligoje |
| SLC17A9solute carrier family 17 member 9 | Kartais (5–29%) | 1 ligoje |
| SOX5SRY-box transcription factor 5 | Kartais (5–29%) | 1 ligoje |
| TCF4transcription factor 4 | Kartais (5–29%) | 1 ligoje |
| TRAF3IP2TRAF3 interacting protein 2 | Kartais (5–29%) | 1 ligoje |
| ZEB2zinc finger E-box binding homeobox 2 | Kartais (5–29%) | 1 ligoje |
| ZFYVE19zinc finger FYVE-type containing 19 | Kartais (5–29%) | 1 ligoje |
| CTNNB1catenin beta 1 | Retai (1–4 %) | 1 ligoje |
| GATA1GATA binding protein 1 | Retai (1–4 %) | 1 ligoje |
| LDHAlactate dehydrogenase A | Retai (1–4 %) | 1 ligoje |
| URODuroporphyrinogen decarboxylase | Retai (1–4 %) | 1 ligoje |
| UROSuroporphyrinogen III synthase | Retai (1–4 %) | 1 ligoje |
| IL31RAinterleukin 31 receptor A | Neužfiksuota | 1 ligoje |
| KLK11kallikrein related peptidase 11 | Neužfiksuota | 1 ligoje |
| PDGFRAplatelet derived growth factor receptor alpha | Neužfiksuota | 1 ligoje |
| SLCO1B1solute carrier organic anion transporter family member 1B1 | Neužfiksuota | 1 ligoje |
| SLCO1B3solute carrier organic anion transporter family member 1B3 | Neužfiksuota | 1 ligoje |
| TJP2tight junction protein 2 | Neužfiksuota | 1 ligoje |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Neužfiksuota | 1 ligoje |
| XPNPEP2X-prolyl aminopeptidase 2 | Neužfiksuota | 1 ligoje |
| ZNF341zinc finger protein 341 | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
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- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.16-c6eea6bf.
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