Trait
Itching
Clinical name: Pruritus
Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus.
Summary
- Also called
- Itchy skin, Skin itching
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
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Get my Genome Test155 genes linked to Itching
Changes in these genes cause rare conditions in which Itching is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB11ATP binding cassette subfamily B member 11 | Always | In 4 conditions |
| ABCB4ATP binding cassette subfamily B member 4 | Always | In 3 conditions |
| AMOTL1angiomotin like 1 | Always | In 1 condition |
| ATP8B1ATPase phospholipid transporting 8B1 | Always | In 5 conditions |
| CCDC47coiled-coil domain containing 47 | Always | In 1 condition |
| CDSNcorneodesmosin | Always | In 2 conditions |
| CLDN1claudin 1 | Always | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Always | In 3 conditions |
| CST3cystatin C | Always | In 1 condition |
| DSG4desmoglein 4 | Always | In 1 condition |
| FLG2filaggrin 2 | Always | In 1 condition |
| MIA3MIA SH3 domain ER export factor 3 | Always | In 1 condition |
| OSMRoncostatin M receptor | Always | In 1 condition |
| PERPp53 apoptosis effector related to PMP22 | Always | In 1 condition |
| PLCG2phospholipase C gamma 2 | Always | In 1 condition |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| PLECplectin | Always | In 1 condition |
| SLC27A4solute carrier family 27 member 4 | Always | In 1 condition |
| ST14ST14 transmembrane serine protease matriptase | Always | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Always | In 1 condition |
| USP53ubiquitin specific peptidase 53 | Always | In 1 condition |
| VIPAS39VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog | Always | In 1 condition |
| VPS33BVPS33B late endosome and lysosome associated | Always | In 1 condition |
| ABCA12ATP binding cassette subfamily A member 12 | Very often (80–99%) | In 2 conditions |
| ALOX12Barachidonate 12-lipoxygenase, 12R type | Very often (80–99%) | In 2 conditions |
| ALOXE3arachidonate epidermal lipoxygenase 3 | Very often (80–99%) | In 2 conditions |
| ASPRV1aspartic peptidase retroviral like 1 | Very often (80–99%) | In 2 conditions |
| ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | Very often (80–99%) | In 2 conditions |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| CD28CD28 molecule | Very often (80–99%) | In 2 conditions |
| CERS3ceramide synthase 3 | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 2 conditions |
| CYP4F22cytochrome P450 family 4 subfamily F member 22 | Very often (80–99%) | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Very often (80–99%) | In 1 condition |
| FECHferrochelatase | Very often (80–99%) | In 2 conditions |
| KITKIT proto-oncogene, receptor tyrosine kinase | Very often (80–99%) | In 3 conditions |
| KRT14keratin 14 | Very often (80–99%) | In 3 conditions |
| KRT5keratin 5 | Very often (80–99%) | In 5 conditions |
| LBRlamin B receptor | Very often (80–99%) | In 2 conditions |
| LIPNlipase family member N | Very often (80–99%) | In 1 condition |
Show 115 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| NIPAL4NIPA like domain containing 4 | Very often (80–99%) | In 2 conditions |
| NLRP3NLR family pyrin domain containing 3 | Very often (80–99%) | In 1 condition |
| NR1H4nuclear receptor subfamily 1 group H member 4 | Very often (80–99%) | In 1 condition |
| PEPDpeptidase D | Very often (80–99%) | In 1 condition |
| PNPLA1patatin like domain 1, omega-hydroxyceramide transacylase | Very often (80–99%) | In 1 condition |
| SDR9C7short chain dehydrogenase/reductase family 9C member 7 | Very often (80–99%) | In 2 conditions |
| SPINK5serine peptidase inhibitor Kazal type 5 | Very often (80–99%) | In 2 conditions |
| STAT3signal transducer and activator of transcription 3 | Very often (80–99%) | In 1 condition |
| SULT2B1sulfotransferase family 2B member 1 | Very often (80–99%) | In 3 conditions |
| TGM1transglutaminase 1 | Very often (80–99%) | In 2 conditions |
| TNFRSF1BTNF receptor superfamily member 1B | Very often (80–99%) | In 2 conditions |
| ADAadenosine deaminase | Often (30–79%) | In 1 condition |
| ALDH3A2aldehyde dehydrogenase 3 family member A2 | Often (30–79%) | In 1 condition |
| AQP5aquaporin 5 | Often (30–79%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 2 conditions |
| BRCA1BRCA1 DNA repair associated | Often (30–79%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Often (30–79%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Often (30–79%) | In 1 condition |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CHD7chromodomain helicase DNA binding protein 7 | Often (30–79%) | In 1 condition |
| CST6cystatin E/M | Often (30–79%) | In 1 condition |
| DCDC2doublecortin domain containing 2 | Often (30–79%) | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Often (30–79%) | In 1 condition |
| EPAS1endothelial PAS domain protein 1 | Often (30–79%) | In 1 condition |
| EPORerythropoietin receptor | Often (30–79%) | In 1 condition |
| FHfumarate hydratase | Often (30–79%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Often (30–79%) | In 1 condition |
| HLA-DRAmajor histocompatibility complex, class II, DR alpha | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| IL12Ainterleukin 12A | Often (30–79%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Often (30–79%) | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Often (30–79%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| JAK2Janus kinase 2 | Often (30–79%) | In 2 conditions |
| KIF12kinesin family member 12 | Often (30–79%) | In 1 condition |
| KRT10keratin 10 | Often (30–79%) | In 1 condition |
| LRP1LDL receptor related protein 1 | Often (30–79%) | In 2 conditions |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| MED12mediator complex subunit 12 | Often (30–79%) | In 1 condition |
| MMEL1membrane metalloendopeptidase like 1 | Often (30–79%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Often (30–79%) | In 1 condition |
| MVKmevalonate kinase | Often (30–79%) | In 2 conditions |
| MYO5Bmyosin VB | Often (30–79%) | In 2 conditions |
| NUDCD3NudC domain containing 3 | Often (30–79%) | In 1 condition |
| PMVKphosphomevalonate kinase | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| POU2AF1POU class 2 homeobox associating factor 1 | Often (30–79%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Often (30–79%) | In 1 condition |
| PTPN3protein tyrosine phosphatase non-receptor type 3 | Often (30–79%) | In 1 condition |
| RAG1recombination activating 1 | Often (30–79%) | In 1 condition |
| RAG2recombination activating 2 | Often (30–79%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Often (30–79%) | In 1 condition |
| ROS1ROS proto-oncogene 1, receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SCN10Asodium voltage-gated channel alpha subunit 10 | Often (30–79%) | In 1 condition |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Often (30–79%) | In 2 conditions |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Often (30–79%) | In 2 conditions |
| SPIBSpi-B transcription factor | Often (30–79%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Often (30–79%) | In 2 conditions |
| STX3syntaxin 3 | Often (30–79%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Often (30–79%) | In 2 conditions |
| THPOthrombopoietin | Often (30–79%) | In 1 condition |
| TNFSF15TNF superfamily member 15 | Often (30–79%) | In 1 condition |
| TNPO3transportin 3 | Often (30–79%) | In 1 condition |
| UNC45Aunc-45 myosin chaperone A | Often (30–79%) | In 1 condition |
| WDR83OSWD repeat domain 83 opposite strand | Often (30–79%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| CASTcalpastatin | Sometimes (5–29%) | In 1 condition |
| CLEC7AC-type lectin domain containing 7A | Sometimes (5–29%) | In 1 condition |
| DSPdesmoplakin | Sometimes (5–29%) | In 1 condition |
| FDPSfarnesyl diphosphate synthase | Sometimes (5–29%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Sometimes (5–29%) | In 1 condition |
| GPNMBglycoprotein nmb | Sometimes (5–29%) | In 1 condition |
| GPR35G protein-coupled receptor 35 | Sometimes (5–29%) | In 1 condition |
| GSNgelsolin | Sometimes (5–29%) | In 1 condition |
| HSD3B7hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | Sometimes (5–29%) | In 1 condition |
| IL17Finterleukin 17F | Sometimes (5–29%) | In 1 condition |
| IL17RAinterleukin 17 receptor A | Sometimes (5–29%) | In 1 condition |
| IL17RCinterleukin 17 receptor C | Sometimes (5–29%) | In 1 condition |
| KRT74keratin 74 | Sometimes (5–29%) | In 1 condition |
| LIPAlipase A, lysosomal acid type | Sometimes (5–29%) | In 1 condition |
| MST1macrophage stimulating 1 | Sometimes (5–29%) | In 1 condition |
| MVDmevalonate diphosphate decarboxylase | Sometimes (5–29%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin | Sometimes (5–29%) | In 1 condition |
| PKP1plakophilin 1 | Sometimes (5–29%) | In 1 condition |
| POFUT1protein O-fucosyltransferase 1 | Sometimes (5–29%) | In 1 condition |
| POGLUT1protein O-glucosyltransferase 1 | Sometimes (5–29%) | In 2 conditions |
| PPP1R13Lprotein phosphatase 1 regulatory subunit 13 like | Sometimes (5–29%) | In 1 condition |
| PSENENpresenilin enhancer, gamma-secretase subunit | Sometimes (5–29%) | In 1 condition |
| RAF1Raf-1 proto-oncogene, serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| SEMA4Dsemaphorin 4D | Sometimes (5–29%) | In 1 condition |
| SLC17A9solute carrier family 17 member 9 | Sometimes (5–29%) | In 1 condition |
| SOX5SRY-box transcription factor 5 | Sometimes (5–29%) | In 1 condition |
| TCF4transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TRAF3IP2TRAF3 interacting protein 2 | Sometimes (5–29%) | In 1 condition |
| ZEB2zinc finger E-box binding homeobox 2 | Sometimes (5–29%) | In 1 condition |
| ZFYVE19zinc finger FYVE-type containing 19 | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Rarely (1–4%) | In 1 condition |
| GATA1GATA binding protein 1 | Rarely (1–4%) | In 1 condition |
| LDHAlactate dehydrogenase A | Rarely (1–4%) | In 1 condition |
| URODuroporphyrinogen decarboxylase | Rarely (1–4%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Rarely (1–4%) | In 1 condition |
| IL31RAinterleukin 31 receptor A | Not recorded | In 1 condition |
| KLK11kallikrein related peptidase 11 | Not recorded | In 1 condition |
| PDGFRAplatelet derived growth factor receptor alpha | Not recorded | In 1 condition |
| SLCO1B1solute carrier organic anion transporter family member 1B1 | Not recorded | In 1 condition |
| SLCO1B3solute carrier organic anion transporter family member 1B3 | Not recorded | In 1 condition |
| TJP2tight junction protein 2 | Not recorded | In 1 condition |
| TRPM4transient receptor potential cation channel subfamily M member 4 | Not recorded | In 1 condition |
| XPNPEP2X-prolyl aminopeptidase 2 | Not recorded | In 1 condition |
| ZNF341zinc finger protein 341 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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