Požymis
Early onset of puberty
Klinikinis pavadinimas: Precocious puberty
The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys.
Santrauka
- Taip pat vadinama
- Early puberty
- Kūno sistema
- Abnormality of the endocrine system
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
Read the genes linked to Early onset of puberty, and the rest of your genome, with one test.
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Įsigyti savo Genome Test156 genų susiję su Early onset of puberty
Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Early onset of puberty. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| EPG5ectopic P-granules 5 autophagy tethering factor | Visada | 1 ligoje |
| FEM1Bfem-1 homolog B | Visada | 1 ligoje |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Visada | 1 ligoje |
| KDM2Blysine demethylase 2B | Visada | 1 ligoje |
| DLK1delta like non-canonical Notch ligand 1 | Labai dažnai (80–99%) | 3 ligose |
| GNASGNAS complex locus | Labai dažnai (80–99%) | 2 ligose |
| HYMAIhydatidiform mole associated and imprinted | Labai dažnai (80–99%) | 1 ligoje |
| LHCGRluteinizing hormone/choriogonadotropin receptor | Labai dažnai (80–99%) | 1 ligoje |
| LMNAlamin A/C | Labai dažnai (80–99%) | 1 ligoje |
| MEG3maternally expressed 3 | Labai dažnai (80–99%) | 3 ligose |
| PLAGL1PLAG1 like zinc finger 1 | Labai dažnai (80–99%) | 1 ligoje |
| RTL1retrotransposon Gag like 1 | Labai dažnai (80–99%) | 3 ligose |
| ASXL3ASXL transcriptional regulator 3 | Dažnai (30–79%) | 1 ligoje |
| CDONcell adhesion associated, oncogene regulated | Dažnai (30–79%) | 1 ligoje |
| CRIPTOcripto, EGF-CFC family member | Dažnai (30–79%) | 1 ligoje |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Dažnai (30–79%) | 1 ligoje |
| DISP1dispatched RND transporter family member 1 | Dažnai (30–79%) | 1 ligoje |
| DLL1delta like canonical Notch ligand 1 | Dažnai (30–79%) | 1 ligoje |
| FGF8fibroblast growth factor 8 | Dažnai (30–79%) | 1 ligoje |
| FOXH1forkhead box H1 | Dažnai (30–79%) | 1 ligoje |
| FREM1FRAS1 related extracellular matrix 1 | Dažnai (30–79%) | 1 ligoje |
| GAS1growth arrest specific 1 | Dažnai (30–79%) | 1 ligoje |
| GLI2GLI family zinc finger 2 | Dažnai (30–79%) | 1 ligoje |
| HNRNPRheterogeneous nuclear ribonucleoprotein R | Dažnai (30–79%) | 1 ligoje |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Dažnai (30–79%) | 1 ligoje |
| NODALnodal growth differentiation factor | Dažnai (30–79%) | 1 ligoje |
| PIGFphosphatidylinositol glycan anchor biosynthesis class F | Dažnai (30–79%) | 1 ligoje |
| PTCH1patched 1 | Dažnai (30–79%) | 1 ligoje |
| SHHsonic hedgehog signaling molecule | Dažnai (30–79%) | 1 ligoje |
| SIX3SIX homeobox 3 | Dažnai (30–79%) | 1 ligoje |
| STILSTIL centriolar assembly protein | Dažnai (30–79%) | 1 ligoje |
| TFE3transcription factor binding to IGHM enhancer 3 | Dažnai (30–79%) | 1 ligoje |
| TGIF1TGFB induced factor homeobox 1 | Dažnai (30–79%) | 1 ligoje |
| ZIC2Zic family zinc finger 2 | Dažnai (30–79%) | 1 ligoje |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Kartais (5–29%) | 1 ligoje |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Kartais (5–29%) | 1 ligoje |
| CLIP2CAP-Gly domain containing linker protein 2 | Kartais (5–29%) | 1 ligoje |
| CNTNAP2contactin associated protein 2 | Kartais (5–29%) | 1 ligoje |
| CTSHcathepsin H | Kartais (5–29%) | 1 ligoje |
| DDX3XDEAD-box helicase 3 X-linked | Kartais (5–29%) | 2 ligose |
Rodyti dar 116 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Kartais (5–29%) | 1 ligoje |
| EIF4Heukaryotic translation initiation factor 4H | Kartais (5–29%) | 1 ligoje |
| ELNelastin | Kartais (5–29%) | 1 ligoje |
| EXT2exostosin glycosyltransferase 2 | Kartais (5–29%) | 1 ligoje |
| FBXO22F-box protein 22 | Kartais (5–29%) | 1 ligoje |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Kartais (5–29%) | 1 ligoje |
| GLI3GLI family zinc finger 3 | Kartais (5–29%) | 2 ligose |
| GRB10growth factor receptor bound protein 10 | Kartais (5–29%) | 1 ligoje |
| GTF2Igeneral transcription factor IIi | Kartais (5–29%) | 1 ligoje |
| GTF2IRD1GTF2I repeat domain containing 1 | Kartais (5–29%) | 1 ligoje |
| GTF2IRD2GTF2I repeat domain containing 2 | Kartais (5–29%) | 1 ligoje |
| H4C5H4 clustered histone 5 | Kartais (5–29%) | 1 ligoje |
| H6PDhexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase | Kartais (5–29%) | 2 ligose |
| HCRThypocretin neuropeptide precursor | Kartais (5–29%) | 1 ligoje |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Kartais (5–29%) | 1 ligoje |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Kartais (5–29%) | 1 ligoje |
| HRASHRas proto-oncogene, GTPase | Kartais (5–29%) | 3 ligose |
| HSD11B1hydroxysteroid 11-beta dehydrogenase 1 | Kartais (5–29%) | 1 ligoje |
| INSRinsulin receptor | Kartais (5–29%) | 3 ligose |
| KDM6Alysine demethylase 6A | Kartais (5–29%) | 1 ligoje |
| KMT2Blysine methyltransferase 2B | Kartais (5–29%) | 1 ligoje |
| KMT2Dlysine methyltransferase 2D | Kartais (5–29%) | 1 ligoje |
| KRASKRas proto-oncogene, GTPase | Kartais (5–29%) | 1 ligoje |
| LIMK1LIM domain kinase 1 | Kartais (5–29%) | 1 ligoje |
| MAB21L2mab-21 like 2 | Kartais (5–29%) | 1 ligoje |
| MAGEL2MAGE family member L2 | Kartais (5–29%) | 5 ligose |
| MC2Rmelanocortin 2 receptor | Kartais (5–29%) | 1 ligoje |
| METTL27methyltransferase like 27 | Kartais (5–29%) | 1 ligoje |
| MIA3MIA SH3 domain ER export factor 3 | Kartais (5–29%) | 1 ligoje |
| MOGmyelin oligodendrocyte glycoprotein | Kartais (5–29%) | 1 ligoje |
| MRAPmelanocortin 2 receptor accessory protein | Kartais (5–29%) | 1 ligoje |
| MSL3MSL complex subunit 3 | Kartais (5–29%) | 1 ligoje |
| NCF1neutrophil cytosolic factor 1 | Kartais (5–29%) | 1 ligoje |
| NFIXnuclear factor I X | Kartais (5–29%) | 1 ligoje |
| NNTnicotinamide nucleotide transhydrogenase | Kartais (5–29%) | 2 ligose |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Kartais (5–29%) | 1 ligoje |
| NRASNRAS proto-oncogene, GTPase | Kartais (5–29%) | 1 ligoje |
| P2RY11purinergic receptor P2Y11 | Kartais (5–29%) | 1 ligoje |
| PCNTpericentrin | Kartais (5–29%) | 2 ligose |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Kartais (5–29%) | 1 ligoje |
| PLAAT3phospholipase A and acyltransferase 3 | Kartais (5–29%) | 1 ligoje |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Kartais (5–29%) | 1 ligoje |
| RAI1retinoic acid induced 1 | Kartais (5–29%) | 1 ligoje |
| RFC2replication factor C subunit 2 | Kartais (5–29%) | 1 ligoje |
| SIM1SIM bHLH transcription factor 1 | Kartais (5–29%) | 1 ligoje |
| SLC35A2solute carrier family 35 member A2 | Kartais (5–29%) | 1 ligoje |
| SMAD4SMAD family member 4 | Kartais (5–29%) | 1 ligoje |
| SOX6SRY-box transcription factor 6 | Kartais (5–29%) | 1 ligoje |
| SPENspen family transcriptional repressor | Kartais (5–29%) | 1 ligoje |
| SRCAPSnf2 related CREBBP activator protein | Kartais (5–29%) | 1 ligoje |
| STARsteroidogenic acute regulatory protein | Kartais (5–29%) | 1 ligoje |
| STX1Asyntaxin 1A | Kartais (5–29%) | 1 ligoje |
| TBL2transducin beta like 2 | Kartais (5–29%) | 1 ligoje |
| TMEM270transmembrane protein 270 | Kartais (5–29%) | 1 ligoje |
| TNFSF4TNF superfamily member 4 | Kartais (5–29%) | 1 ligoje |
| TNRC6Btrinucleotide repeat containing adaptor 6B | Kartais (5–29%) | 1 ligoje |
| TONSLtonsoku like, DNA repair protein | Kartais (5–29%) | 1 ligoje |
| TXNRD2thioredoxin reductase 2 | Kartais (5–29%) | 1 ligoje |
| VPS37DVPS37D subunit of ESCRT-I | Kartais (5–29%) | 1 ligoje |
| ZNF365zinc finger protein 365 | Kartais (5–29%) | 1 ligoje |
| ZNF526zinc finger protein 526 | Kartais (5–29%) | 1 ligoje |
| ARXaristaless related homeobox | Retai (1–4 %) | 1 ligoje |
| CACNA1Ecalcium voltage-gated channel subunit alpha1 E | Retai (1–4 %) | 1 ligoje |
| CASKcalcium/calmodulin dependent serine protein kinase | Retai (1–4 %) | 1 ligoje |
| CDKL5cyclin dependent kinase like 5 | Retai (1–4 %) | 1 ligoje |
| DMXL2Dmx like 2 | Retai (1–4 %) | 1 ligoje |
| EHMT1euchromatic histone lysine methyltransferase 1 | Retai (1–4 %) | 1 ligoje |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Retai (1–4 %) | 1 ligoje |
| GNAO1G protein subunit alpha o1 | Retai (1–4 %) | 1 ligoje |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Retai (1–4 %) | 1 ligoje |
| GRM7glutamate metabotropic receptor 7 | Retai (1–4 %) | 1 ligoje |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Retai (1–4 %) | 1 ligoje |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Retai (1–4 %) | 1 ligoje |
| KCNT1potassium sodium-activated channel subfamily T member 1 | Retai (1–4 %) | 1 ligoje |
| KMT2Clysine methyltransferase 2C | Retai (1–4 %) | 1 ligoje |
| LGI1leucine rich glioma inactivated 1 | Retai (1–4 %) | 1 ligoje |
| NDNnecdin, MAGE family member | Retai (1–4 %) | 3 ligose |
| NEUROD2neuronal differentiation 2 | Retai (1–4 %) | 1 ligoje |
| NF1neurofibromin 1 | Retai (1–4 %) | 1 ligoje |
| OCA2OCA2 melanosomal transmembrane protein | Retai (1–4 %) | 3 ligose |
| PDE11Aphosphodiesterase 11A | Retai (1–4 %) | 1 ligoje |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Retai (1–4 %) | 1 ligoje |
| PIGPphosphatidylinositol glycan anchor biosynthesis class P | Retai (1–4 %) | 1 ligoje |
| PIGQphosphatidylinositol glycan anchor biosynthesis class Q | Retai (1–4 %) | 1 ligoje |
| PLCB1phospholipase C beta 1 | Retai (1–4 %) | 1 ligoje |
| PNKPpolynucleotide kinase 3'-phosphatase | Retai (1–4 %) | 1 ligoje |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Retai (1–4 %) | 1 ligoje |
| RHOBTB2Rho related BTB domain containing 2 | Retai (1–4 %) | 1 ligoje |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Retai (1–4 %) | 1 ligoje |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Retai (1–4 %) | 1 ligoje |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Retai (1–4 %) | 2 ligose |
| SIK1salt inducible kinase 1 | Retai (1–4 %) | 1 ligoje |
| SLC12A5solute carrier family 12 member 5 | Retai (1–4 %) | 1 ligoje |
| SLC25A22solute carrier family 25 member 22 | Retai (1–4 %) | 2 ligose |
| SLC32A1solute carrier family 32 member 1 | Retai (1–4 %) | 1 ligoje |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Retai (1–4 %) | 3 ligose |
| TBC1D24TBC1 domain family member 24 | Retai (1–4 %) | 1 ligoje |
| TRIM8tripartite motif containing 8 | Retai (1–4 %) | 1 ligoje |
| CPLX1complexin 1 | Neužfiksuota | 1 ligoje |
| CTBP1C-terminal binding protein 1 | Neužfiksuota | 1 ligoje |
| DHCR77-dehydrocholesterol reductase | Neužfiksuota | 1 ligoje |
| FGFRL1fibroblast growth factor receptor like 1 | Neužfiksuota | 1 ligoje |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Neužfiksuota | 1 ligoje |
| IFNGinterferon gamma | Neužfiksuota | 1 ligoje |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Neužfiksuota | 1 ligoje |
| MKRN3makorin ring finger protein 3 | Neužfiksuota | 1 ligoje |
| NPAP1nuclear pore associated protein 1 | Neužfiksuota | 1 ligoje |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Neužfiksuota | 1 ligoje |
| NSD2nuclear receptor binding SET domain protein 2 | Neužfiksuota | 1 ligoje |
| PWAR1Prader Willi/Angelman region RNA 1 | Neužfiksuota | 1 ligoje |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Neužfiksuota | 1 ligoje |
| RAB23RAB23, member RAS oncogene family | Neužfiksuota | 1 ligoje |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Neužfiksuota | 1 ligoje |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Neužfiksuota | 1 ligoje |
| TSC1TSC complex subunit 1 | Neužfiksuota | 1 ligoje |
| TSC2TSC complex subunit 2 | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
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- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
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