Trait
Early onset of puberty
Clinical name: Precocious puberty
The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys.
Summary
- Also called
- Early puberty
- Body system
- Abnormality of the endocrine system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Early onset of puberty, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test156 genes linked to Early onset of puberty
Changes in these genes cause rare conditions in which Early onset of puberty is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EPG5ectopic P-granules 5 autophagy tethering factor | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Very often (80–99%) | In 3 conditions |
| GNASGNAS complex locus | Very often (80–99%) | In 2 conditions |
| HYMAIhydatidiform mole associated and imprinted | Very often (80–99%) | In 1 condition |
| LHCGRluteinizing hormone/choriogonadotropin receptor | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| MEG3maternally expressed 3 | Very often (80–99%) | In 3 conditions |
| PLAGL1PLAG1 like zinc finger 1 | Very often (80–99%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Very often (80–99%) | In 3 conditions |
| ASXL3ASXL transcriptional regulator 3 | Often (30–79%) | In 1 condition |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 1 condition |
| CRIPTOcripto, EGF-CFC family member | Often (30–79%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Often (30–79%) | In 1 condition |
| DISP1dispatched RND transporter family member 1 | Often (30–79%) | In 1 condition |
| DLL1delta like canonical Notch ligand 1 | Often (30–79%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 1 condition |
| FOXH1forkhead box H1 | Often (30–79%) | In 1 condition |
| FREM1FRAS1 related extracellular matrix 1 | Often (30–79%) | In 1 condition |
| GAS1growth arrest specific 1 | Often (30–79%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 1 condition |
| HNRNPRheterogeneous nuclear ribonucleoprotein R | Often (30–79%) | In 1 condition |
| IQSEC2IQ motif and Sec7 domain ArfGEF 2 | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 1 condition |
| PIGFphosphatidylinositol glycan anchor biosynthesis class F | Often (30–79%) | In 1 condition |
| PTCH1patched 1 | Often (30–79%) | In 1 condition |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 1 condition |
| SIX3SIX homeobox 3 | Often (30–79%) | In 1 condition |
| STILSTIL centriolar assembly protein | Often (30–79%) | In 1 condition |
| TFE3transcription factor binding to IGHM enhancer 3 | Often (30–79%) | In 1 condition |
| TGIF1TGFB induced factor homeobox 1 | Often (30–79%) | In 1 condition |
| ZIC2Zic family zinc finger 2 | Often (30–79%) | In 1 condition |
| BAZ1Bbromodomain adjacent to zinc finger domain 1B | Sometimes (5–29%) | In 1 condition |
| BUD23BUD23 rRNA methyltransferase and ribosome maturation factor | Sometimes (5–29%) | In 1 condition |
| CLIP2CAP-Gly domain containing linker protein 2 | Sometimes (5–29%) | In 1 condition |
| CNTNAP2contactin associated protein 2 | Sometimes (5–29%) | In 1 condition |
| CTSHcathepsin H | Sometimes (5–29%) | In 1 condition |
| DDX3XDEAD-box helicase 3 X-linked | Sometimes (5–29%) | In 2 conditions |
Show 116 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| DNAJC30DnaJ heat shock protein family (Hsp40) member C30 | Sometimes (5–29%) | In 1 condition |
| EIF4Heukaryotic translation initiation factor 4H | Sometimes (5–29%) | In 1 condition |
| ELNelastin | Sometimes (5–29%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| FBXO22F-box protein 22 | Sometimes (5–29%) | In 1 condition |
| FKBP6FKBP prolyl isomerase family member 6 (inactive) | Sometimes (5–29%) | In 1 condition |
| GLI3GLI family zinc finger 3 | Sometimes (5–29%) | In 2 conditions |
| GRB10growth factor receptor bound protein 10 | Sometimes (5–29%) | In 1 condition |
| GTF2Igeneral transcription factor IIi | Sometimes (5–29%) | In 1 condition |
| GTF2IRD1GTF2I repeat domain containing 1 | Sometimes (5–29%) | In 1 condition |
| GTF2IRD2GTF2I repeat domain containing 2 | Sometimes (5–29%) | In 1 condition |
| H4C5H4 clustered histone 5 | Sometimes (5–29%) | In 1 condition |
| H6PDhexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase | Sometimes (5–29%) | In 2 conditions |
| HCRThypocretin neuropeptide precursor | Sometimes (5–29%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Sometimes (5–29%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 3 conditions |
| HSD11B1hydroxysteroid 11-beta dehydrogenase 1 | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 3 conditions |
| KDM6Alysine demethylase 6A | Sometimes (5–29%) | In 1 condition |
| KMT2Blysine methyltransferase 2B | Sometimes (5–29%) | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| LIMK1LIM domain kinase 1 | Sometimes (5–29%) | In 1 condition |
| MAB21L2mab-21 like 2 | Sometimes (5–29%) | In 1 condition |
| MAGEL2MAGE family member L2 | Sometimes (5–29%) | In 5 conditions |
| MC2Rmelanocortin 2 receptor | Sometimes (5–29%) | In 1 condition |
| METTL27methyltransferase like 27 | Sometimes (5–29%) | In 1 condition |
| MIA3MIA SH3 domain ER export factor 3 | Sometimes (5–29%) | In 1 condition |
| MOGmyelin oligodendrocyte glycoprotein | Sometimes (5–29%) | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Sometimes (5–29%) | In 1 condition |
| MSL3MSL complex subunit 3 | Sometimes (5–29%) | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Sometimes (5–29%) | In 1 condition |
| NFIXnuclear factor I X | Sometimes (5–29%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Sometimes (5–29%) | In 2 conditions |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Sometimes (5–29%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| P2RY11purinergic receptor P2Y11 | Sometimes (5–29%) | In 1 condition |
| PCNTpericentrin | Sometimes (5–29%) | In 2 conditions |
| PIGTphosphatidylinositol glycan anchor biosynthesis class T | Sometimes (5–29%) | In 1 condition |
| PLAAT3phospholipase A and acyltransferase 3 | Sometimes (5–29%) | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 1 condition |
| RFC2replication factor C subunit 2 | Sometimes (5–29%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SLC35A2solute carrier family 35 member A2 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| SOX6SRY-box transcription factor 6 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| SRCAPSnf2 related CREBBP activator protein | Sometimes (5–29%) | In 1 condition |
| STARsteroidogenic acute regulatory protein | Sometimes (5–29%) | In 1 condition |
| STX1Asyntaxin 1A | Sometimes (5–29%) | In 1 condition |
| TBL2transducin beta like 2 | Sometimes (5–29%) | In 1 condition |
| TMEM270transmembrane protein 270 | Sometimes (5–29%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Sometimes (5–29%) | In 1 condition |
| TNRC6Btrinucleotide repeat containing adaptor 6B | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Sometimes (5–29%) | In 1 condition |
| VPS37DVPS37D subunit of ESCRT-I | Sometimes (5–29%) | In 1 condition |
| ZNF365zinc finger protein 365 | Sometimes (5–29%) | In 1 condition |
| ZNF526zinc finger protein 526 | Sometimes (5–29%) | In 1 condition |
| ARXaristaless related homeobox | Rarely (1–4%) | In 1 condition |
| CACNA1Ecalcium voltage-gated channel subunit alpha1 E | Rarely (1–4%) | In 1 condition |
| CASKcalcium/calmodulin dependent serine protein kinase | Rarely (1–4%) | In 1 condition |
| CDKL5cyclin dependent kinase like 5 | Rarely (1–4%) | In 1 condition |
| DMXL2Dmx like 2 | Rarely (1–4%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Rarely (1–4%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Rarely (1–4%) | In 1 condition |
| GNAO1G protein subunit alpha o1 | Rarely (1–4%) | In 1 condition |
| GRIN1glutamate ionotropic receptor NMDA type subunit 1 | Rarely (1–4%) | In 1 condition |
| GRM7glutamate metabotropic receptor 7 | Rarely (1–4%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Rarely (1–4%) | In 1 condition |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Rarely (1–4%) | In 1 condition |
| KCNT1potassium sodium-activated channel subfamily T member 1 | Rarely (1–4%) | In 1 condition |
| KMT2Clysine methyltransferase 2C | Rarely (1–4%) | In 1 condition |
| LGI1leucine rich glioma inactivated 1 | Rarely (1–4%) | In 1 condition |
| NDNnecdin, MAGE family member | Rarely (1–4%) | In 3 conditions |
| NEUROD2neuronal differentiation 2 | Rarely (1–4%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Rarely (1–4%) | In 3 conditions |
| PDE11Aphosphodiesterase 11A | Rarely (1–4%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Rarely (1–4%) | In 1 condition |
| PIGPphosphatidylinositol glycan anchor biosynthesis class P | Rarely (1–4%) | In 1 condition |
| PIGQphosphatidylinositol glycan anchor biosynthesis class Q | Rarely (1–4%) | In 1 condition |
| PLCB1phospholipase C beta 1 | Rarely (1–4%) | In 1 condition |
| PNKPpolynucleotide kinase 3'-phosphatase | Rarely (1–4%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Rarely (1–4%) | In 1 condition |
| RHOBTB2Rho related BTB domain containing 2 | Rarely (1–4%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Rarely (1–4%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Rarely (1–4%) | In 1 condition |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Rarely (1–4%) | In 2 conditions |
| SIK1salt inducible kinase 1 | Rarely (1–4%) | In 1 condition |
| SLC12A5solute carrier family 12 member 5 | Rarely (1–4%) | In 1 condition |
| SLC25A22solute carrier family 25 member 22 | Rarely (1–4%) | In 2 conditions |
| SLC32A1solute carrier family 32 member 1 | Rarely (1–4%) | In 1 condition |
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Rarely (1–4%) | In 3 conditions |
| TBC1D24TBC1 domain family member 24 | Rarely (1–4%) | In 1 condition |
| TRIM8tripartite motif containing 8 | Rarely (1–4%) | In 1 condition |
| CPLX1complexin 1 | Not recorded | In 1 condition |
| CTBP1C-terminal binding protein 1 | Not recorded | In 1 condition |
| DHCR77-dehydrocholesterol reductase | Not recorded | In 1 condition |
| FGFRL1fibroblast growth factor receptor like 1 | Not recorded | In 1 condition |
| HERC2HECT and RLD domain containing E3 ubiquitin protein ligase 2 | Not recorded | In 1 condition |
| IFNGinterferon gamma | Not recorded | In 1 condition |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Not recorded | In 1 condition |
| MKRN3makorin ring finger protein 3 | Not recorded | In 1 condition |
| NPAP1nuclear pore associated protein 1 | Not recorded | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Not recorded | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Not recorded | In 1 condition |
| PWAR1Prader Willi/Angelman region RNA 1 | Not recorded | In 1 condition |
| PWRN1Prader-Willi region non-protein coding RNA 1 | Not recorded | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Not recorded | In 1 condition |
| SNORD115-1small nucleolar RNA, C/D box 115-1 | Not recorded | In 1 condition |
| SNORD116-1small nucleolar RNA, C/D box 116-1 | Not recorded | In 1 condition |
| TSC1TSC complex subunit 1 | Not recorded | In 1 condition |
| TSC2TSC complex subunit 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks