Traits

Traits linked to KRAS

KRas proto-oncogene, GTPase

The Human Phenotype Ontology links 386 traits to KRAS, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	Hvor ofte den forekommer
Benign eye tumor	Alltid
Broad neck	Alltid
Bulbous nose	Alltid
Coarse facial features	Alltid
Full lower lip	Alltid
Long philtrum	Alltid
Short nose	Alltid
Skin tag in front of the ear	Alltid
Sparse eyebrow	Alltid
Abnormal conjunctiva morphology	Svært ofte (80–99 %)
Abnormal eyelashes	Svært ofte (80–99 %)
Absent eyebrow	Svært ofte (80–99 %)
Adenoma sebaceum	Svært ofte (80–99 %)
Broad opening between the eyelids	Svært ofte (80–99 %)
Corners of eye widely separated	Svært ofte (80–99 %)
Cystic hygroma	Svært ofte (80–99 %)
Decreased width of the skull	Svært ofte (80–99 %)
Depressed nasal bridge	Svært ofte (80–99 %)
Downward slanting of the opening between the eyelids	Svært ofte (80–99 %)
Flattened bony protrusion above eyes	Svært ofte (80–99 %)
Frontal bossing	Svært ofte (80–99 %)
Full cheeks	Svært ofte (80–99 %)
High forehead	Svært ofte (80–99 %)
High palate	Svært ofte (80–99 %)
Little lower jaw	Svært ofte (80–99 %)
Long face	Svært ofte (80–99 %)
Midface retrusion	Svært ofte (80–99 %)
Nasal tip, upturned	Svært ofte (80–99 %)
Prominent back of the head	Svært ofte (80–99 %)
Relatively large head	Svært ofte (80–99 %)
Short neck	Svært ofte (80–99 %)
Sparse or absent eyebrows	Svært ofte (80–99 %)
Thickened skin folds of neck	Svært ofte (80–99 %)
Triangular face	Svært ofte (80–99 %)
Webbed neck	Svært ofte (80–99 %)
Abnormal nasolacrimal system morphology	Ofte (30–79 %)
Abnormality of the eyelid	Ofte (30–79 %)
Abnormality of the face	Ofte (30–79 %)
Abnormality of the skull	Ofte (30–79 %)
Asymmetry of the posterior head	Ofte (30–79 %)
Big calvaria	Ofte (30–79 %)
Cheekbone underdevelopment	Ofte (30–79 %)
Deep philtrum	Ofte (30–79 %)
Enlargement of craniofacial bones	Ofte (30–79 %)
Eye folds	Ofte (30–79 %)
Facial asymmetry	Ofte (30–79 %)
Full lips	Ofte (30–79 %)
Giant cell granuloma of mandible	Ofte (30–79 %)
Left unilambdoid synostosis	Ofte (30–79 %)
Long, narrow head	Ofte (30–79 %)
Low hairline at back of neck	Ofte (30–79 %)
Narrow forehead	Ofte (30–79 %)
Narrow opening between the eyelids	Ofte (30–79 %)
Palpebral thickening	Ofte (30–79 %)
Prominent forehead	Ofte (30–79 %)
Short opening between the eyelids	Ofte (30–79 %)
Sparse or absent eyelashes	Ofte (30–79 %)
Abnormal facial shape	Noen ganger (5–29 %)
Cancer of salivary gland	Noen ganger (5–29 %)
Cleft eyelid	Noen ganger (5–29 %)
Dandy-Walker malformation	Noen ganger (5–29 %)
Early closure of midline skull joint	Noen ganger (5–29 %)
Parietal bossing	Noen ganger (5–29 %)
Submucous cleft hard palate	Noen ganger (5–29 %)
Wide nasal bridge	Noen ganger (5–29 %)
Abnormal dentition	Ikke registrert
Abnormality of dental color	Ikke registrert
Abnormality of dental shape	Ikke registrert
Abnormality of head shape	Ikke registrert
Absent eyelashes	Ikke registrert
Bad bite	Ikke registrert
Broad forehead	Ikke registrert
Decreased size of nasal bridge	Ikke registrert
Open bite	Ikke registrert
Open mouth	Ikke registrert
Scaphocephaly	Ikke registrert

Abnormality of the nervous system

Trait	Hvor ofte den forekommer
Decrease in size of the outer layer of the brain due to loss of brain cells	Alltid
Degeneration of cerebrum	Alltid
Global developmental delay	Alltid
Intellectual disability	Alltid
Intellectual disability, severe	Alltid
Severe global developmental delay	Alltid
Abnormal shape of nervous system	Svært ofte (80–99 %)
Abnormal speech pattern	Svært ofte (80–99 %)
Absent septum pellucidum	Svært ofte (80–99 %)
Absent/small cerebellum	Svært ofte (80–99 %)
Agenesis of corpus callosum	Svært ofte (80–99 %)
Difficulty articulating speech	Svært ofte (80–99 %)
Diminished deep tendon reflex	Svært ofte (80–99 %)
EEG abnormality	Svært ofte (80–99 %)
Epilepsy	Svært ofte (80–99 %)
Glioblastoma multiforme	Svært ofte (80–99 %)
Increased reflexes	Svært ofte (80–99 %)
Neurodevelopmental abnormality	Svært ofte (80–99 %)
Ventriculomegaly	Svært ofte (80–99 %)
Anxiety	Ofte (30–79 %)
Attention deficit	Ofte (30–79 %)
Autism	Ofte (30–79 %)
Behavioral abnormality	Ofte (30–79 %)
Cavity within brain	Ofte (30–79 %)
Chiari type I malformation	Ofte (30–79 %)
Depression	Ofte (30–79 %)
Difficulty finding words	Ofte (30–79 %)
Echoing another person's speech	Ofte (30–79 %)
Inability to speak	Ofte (30–79 %)
Irritability	Ofte (30–79 %)
Migraine	Ofte (30–79 %)
Motor delay	Ofte (30–79 %)
Neurodevelopmental delay	Ofte (30–79 %)
Rise in pressure inside skull	Ofte (30–79 %)
Subcortical cerebral atrophy	Ofte (30–79 %)
Abnormal gait	Noen ganger (5–29 %)
Abnormal pyramidal sign	Noen ganger (5–29 %)
Aplasia/Hypoplasia of the corpus callosum	Noen ganger (5–29 %)
Benign neoplasm of the central nervous system	Noen ganger (5–29 %)
Cancer of early nerve cells	Noen ganger (5–29 %)
Disorder of involuntary muscle movements	Noen ganger (5–29 %)
Disturbed sensory perception	Noen ganger (5–29 %)
Dysgraphia	Noen ganger (5–29 %)
Fluid-filled sac located in membrane surrounding brain or spinal cord	Noen ganger (5–29 %)
Hallucinations	Noen ganger (5–29 %)
Loss of developmental milestones	Noen ganger (5–29 %)
Memory impairment	Noen ganger (5–29 %)
Paralysis	Noen ganger (5–29 %)
Paralysis of all four limbs	Noen ganger (5–29 %)
Paralysis on one side of body	Noen ganger (5–29 %)
Paralysis or weakness of one side of body	Noen ganger (5–29 %)
Peripheral axonal neuropathy	Noen ganger (5–29 %)
Pins and needles feeling	Noen ganger (5–29 %)
Specific learning disability	Noen ganger (5–29 %)
Too much cerebrospinal fluid in the brain	Noen ganger (5–29 %)
Weakness of one side of body	Noen ganger (5–29 %)
Hemimegalencephaly	Ikke registrert
More active than typical	Ikke registrert
Tongue thrusting	Ikke registrert
Underdeveloped frontal lobe	Ikke registrert

Abnormality of the integument

Trait	Hvor ofte den forekommer
Absence of part of skin at birth	Alltid
Few cafe-au-lait spots	Alltid
Hyperpigmented streaks	Alltid
Absent/small skin	Svært ofte (80–99 %)
Beauty mark	Svært ofte (80–99 %)
Brittle hair	Svært ofte (80–99 %)
Dry skin	Svært ofte (80–99 %)
Excessive sweating	Svært ofte (80–99 %)
Excessive wrinkled skin	Svært ofte (80–99 %)
Fine hair	Svært ofte (80–99 %)
Firm lump under the skin	Svært ofte (80–99 %)
Generalized hyperpigmentation	Svært ofte (80–99 %)
Hair loss	Svært ofte (80–99 %)
Skin cancer	Svært ofte (80–99 %)
Yellow bumps of fatty deposits on skin	Svært ofte (80–99 %)
Abnormal fingerprints	Ofte (30–79 %)
Abnormal hair quantity	Ofte (30–79 %)
Chicken skin	Ofte (30–79 %)
Coarse hair	Ofte (30–79 %)
Curly hair	Ofte (30–79 %)
Hyperelastic skin	Ofte (30–79 %)
Hyperkeratosis	Ofte (30–79 %)
Ichthyosis	Ofte (30–79 %)
Irregular hyperpigmentation	Ofte (30–79 %)
Liver spots	Ofte (30–79 %)
Multiple birthmarks	Ofte (30–79 %)
Patchy darkened skin	Ofte (30–79 %)
Poor fingernail formation	Ofte (30–79 %)
port-wine stain	Ofte (30–79 %)
Slow-growing hair	Ofte (30–79 %)
Sparse hair	Ofte (30–79 %)
Basal cell carcinoma	Noen ganger (5–29 %)
Loose redundant skin	Noen ganger (5–29 %)
Numerous moles	Noen ganger (5–29 %)
Epidermal nevus	Ikke registrert
Linear nevus sebaceous	Ikke registrert
Mole	Ikke registrert
Nevus sebaceous	Ikke registrert
Patchy lightened skin	Ikke registrert

Abnormality of the cardiovascular system

Trait	Hvor ofte den forekommer
Increased spleen size	Alltid
Abnormal cardiovascular system morphology	Svært ofte (80–99 %)
Abnormal EKG	Svært ofte (80–99 %)
Abnormal heart valve morphology	Svært ofte (80–99 %)
An opening in the wall separating the top two chambers of the heart	Svært ofte (80–99 %)
Collection of dilated blood vessels that forms mass	Svært ofte (80–99 %)
Narrowing of lung artery	Svært ofte (80–99 %)
Narrowing of pulmonic valve	Svært ofte (80–99 %)
Abnormal heart rate	Ofte (30–79 %)
Abnormal pulmonary valve morphology	Ofte (30–79 %)
Abnormality of the cardiovascular system	Ofte (30–79 %)
Abnormality of the lymphatic system	Ofte (30–79 %)
Abnormality of the spleen	Ofte (30–79 %)
Disease of the heart muscle	Ofte (30–79 %)
Enlarged and thickened heart muscle	Ofte (30–79 %)
Increased blood pressure in blood vessels of lungs	Ofte (30–79 %)
Mitral valve prolapse	Ofte (30–79 %)
Patent foramen ovale	Ofte (30–79 %)
Strawberry birthmark	Ofte (30–79 %)
Swollen lymph nodes	Ofte (30–79 %)
Tricuspid valve prolapse	Ofte (30–79 %)
Visceral angiomatosis	Ofte (30–79 %)
Abnormal aortic morphology	Noen ganger (5–29 %)
Cardiac diverticulum	Noen ganger (5–29 %)
Enlarged liver and spleen	Noen ganger (5–29 %)
Hole in heart wall separating two lower heart chambers	Noen ganger (5–29 %)
Interrupted aortic arch	Noen ganger (5–29 %)
Narrowing of aorta	Noen ganger (5–29 %)
Narrowing of aortic valve	Noen ganger (5–29 %)
Patent ductus arteriosus	Sjelden (1–4%)
Cerebral arteriovenous malformation	Ikke registrert
Mini stroke	Ikke registrert
Strawberry mark	Ikke registrert

Abnormality of the digestive system

Trait	Hvor ofte den forekommer
Feeding difficulties	Alltid
Pancreatic adenocarcinoma	Alltid
Abdominal pain	Svært ofte (80–99 %)
Absent/small abdominal wall muscles	Svært ofte (80–99 %)
Anorexia	Svært ofte (80–99 %)
Constipation	Svært ofte (80–99 %)
Feeding difficulties in infancy	Svært ofte (80–99 %)
Inability to properly digest food due to lack of pancreatic digestive enzymes	Svært ofte (80–99 %)
Malabsorption	Svært ofte (80–99 %)
Poor appetite	Svært ofte (80–99 %)
Colon cancer	Ofte (30–79 %)
Enlarged colon lacking nerve cells	Ofte (30–79 %)
Enlarged liver	Ofte (30–79 %)
Extrahepatic cholestasis	Ofte (30–79 %)
Functional intestinal obstruction	Ofte (30–79 %)
Gastrostomy tube feeding in infancy	Ofte (30–79 %)
Intestinal pseudo-obstruction	Ofte (30–79 %)
Jaundice	Ofte (30–79 %)
Nausea and vomiting	Ofte (30–79 %)
Rectal tumor	Ofte (30–79 %)
Stomach tumor	Ofte (30–79 %)
Abnormality of the gastrointestinal tract	Noen ganger (5–29 %)
Cancer of the pancreas	Noen ganger (5–29 %)
Functional abnormality of the gastrointestinal tract	Noen ganger (5–29 %)
Growths in inner lining of intestine	Noen ganger (5–29 %)
Hepatocellular carcinoma	Noen ganger (5–29 %)
Intermittent diarrhea	Noen ganger (5–29 %)
Liver cancer	Noen ganger (5–29 %)
Peritoneal abscess	Noen ganger (5–29 %)
Acid reflux	Ikke registrert
Bladder exstrophy	Ikke registrert
Stomach cancer	Ikke registrert
Vomiting	Ikke registrert

Abnormality of the musculoskeletal system

Trait	Hvor ofte den forekommer
Funnel chest	Alltid
Wide rib cage	Alltid
Back pain	Svært ofte (80–99 %)
Double-Jointed	Svært ofte (80–99 %)
Inability to make and keep healthy fat tissue	Svært ofte (80–99 %)
Low muscle tone	Svært ofte (80–99 %)
Multiple fatty lumps	Svært ofte (80–99 %)
Muscle weakness	Svært ofte (80–99 %)
Pigeon chest	Svært ofte (80–99 %)
Shield chest	Svært ofte (80–99 %)
Vertebral segmentation defect	Svært ofte (80–99 %)
Abnormal deposits of calcium in the brain	Ofte (30–79 %)
Bone cyst	Ofte (30–79 %)
Breakdown of bone	Ofte (30–79 %)
Delayed bone maturation	Ofte (30–79 %)
Generalized decreased muscle tone	Ofte (30–79 %)
Involuntary muscle stiffness, contraction, or spasm	Ofte (30–79 %)
Muscle stiffness	Ofte (30–79 %)
Rigidity	Ofte (30–79 %)
Scoliosis	Ofte (30–79 %)
Skeletal tumor	Ofte (30–79 %)
Spasticity and rigidity of muscles	Ofte (30–79 %)
Abnormal shape of cartilage	Noen ganger (5–29 %)
Abnormal skeletal development	Noen ganger (5–29 %)
Dysostosis multiplex	Noen ganger (5–29 %)
Flexed joint that cannot be straightened	Noen ganger (5–29 %)
Osteochondrosis	Noen ganger (5–29 %)
Osteopenia	Noen ganger (5–29 %)
Hypophosphatemic rickets	Ikke registrert
Kyphoscoliosis	Ikke registrert
Recurrent fractures	Ikke registrert

Abnormality of the eye

Trait	Hvor ofte den forekommer
Blue eyes	Alltid
Bulging eye	Alltid
Farsightedness	Alltid
Wide-set eyes	Alltid
Abnormality of the eye	Svært ofte (80–99 %)
Abnormality of vision	Svært ofte (80–99 %)
Abnormally small eyeball	Svært ofte (80–99 %)
Cat eye	Svært ofte (80–99 %)
Drooping upper eyelid	Svært ofte (80–99 %)
Noninflammatory retina disease	Svært ofte (80–99 %)
Chorioretinal atrophy	Ofte (30–79 %)
Close sighted	Ofte (30–79 %)
Corneal opacity	Ofte (30–79 %)
Cross-eyed	Ofte (30–79 %)
Involuntary, rapid, rhythmic eye movements	Ofte (30–79 %)
Amaurosis fugax	Noen ganger (5–29 %)
Astigmatism	Noen ganger (5–29 %)
Cerebral visual impairment	Noen ganger (5–29 %)
Eye muscle paralysis	Noen ganger (5–29 %)
Opacification of the corneal stroma	Noen ganger (5–29 %)
Optic atrophy	Noen ganger (5–29 %)
Partial loss of field of vision	Noen ganger (5–29 %)
Visual impairment	Noen ganger (5–29 %)
Anisometropia	Ikke registrert
Cornea of eye less than 10mm in diameter	Ikke registrert
Notched pupil	Ikke registrert
Oculomotor apraxia	Ikke registrert
Optic nerve dysplasia	Ikke registrert
Progressive loss of vision	Ikke registrert

Abnormality of the genitourinary system

Trait	Hvor ofte den forekommer
Abnormality of the reproductive system	Ofte (30–79 %)
Abnormality of the ureter	Ofte (30–79 %)
Undescended testes	Ofte (30–79 %)
Abnormality of the bladder	Noen ganger (5–29 %)
Abnormality of the penis	Noen ganger (5–29 %)
Dilatation of the renal pelvis	Noen ganger (5–29 %)
Endometrial carcinoma	Noen ganger (5–29 %)
Epispadias	Noen ganger (5–29 %)
Hydronephrosis	Noen ganger (5–29 %)
Hypospadias	Noen ganger (5–29 %)
Kidney cancer	Noen ganger (5–29 %)
Malignant genitourinary tract tumor	Noen ganger (5–29 %)
Ovarian cancer	Noen ganger (5–29 %)
Ovarian carcinoma	Noen ganger (5–29 %)
Urinary tract neoplasm	Noen ganger (5–29 %)
Bladder neoplasm	Ikke registrert
Horseshoe kidney	Ikke registrert
Transitional cell carcinoma of the bladder	Ikke registrert

Abnormality of limbs

Trait	Hvor ofte den forekommer
Curvature of little finger	Alltid
Back knee	Svært ofte (80–99 %)
Thickening of palms and soles	Svært ofte (80–99 %)
Abnormal morphology of ulna	Ofte (30–79 %)
Deep palm line	Ofte (30–79 %)
Outward turned elbows	Ofte (30–79 %)
Short fingers or toes	Ofte (30–79 %)
Short palm	Ofte (30–79 %)
Fused forearm bones	Noen ganger (5–29 %)
Knock knees	Noen ganger (5–29 %)
Abnormalities of the fingers	Ikke registrert
Abnormalities of the toes	Ikke registrert
Asymmetric overgrowth	Ikke registrert
Finger joint hyperextensibility	Ikke registrert
Left and right leg differ in length or width	Ikke registrert
Multiple plantar creases	Ikke registrert

Abnormality of the ear

Trait	Hvor ofte den forekommer
Thickened helices	Alltid
Ears rotated toward back of head	Svært ofte (80–99 %)
Low-set ears	Svært ofte (80–99 %)
Abnormality of the ear	Ofte (30–79 %)
Hearing impairment	Ofte (30–79 %)
Large earlobe	Ofte (30–79 %)
Large ears	Ofte (30–79 %)
Aplasia of the semicircular canal	Noen ganger (5–29 %)
Sensorineural hearing impairment	Noen ganger (5–29 %)
Earlobe crease	Ikke registrert

Abnormality of blood and blood-forming tissues

Trait	Hvor ofte den forekommer
Gastrointestinal bleeding	Svært ofte (80–99 %)
Abnormal platelet function	Ofte (30–79 %)
Abnormality of coagulation	Ofte (30–79 %)
Bleeding tendency	Ofte (30–79 %)
Blood tumor	Noen ganger (5–29 %)
Bruising susceptibility	Noen ganger (5–29 %)
Juvenile myelomonocytic leukemia	Noen ganger (5–29 %)
Acute myeloid leukemia	Ikke registrert

Growth abnormality

Trait	Hvor ofte den forekommer
Faltering weight	Svært ofte (80–99 %)
Faltering weight in infancy	Svært ofte (80–99 %)
Short stature	Svært ofte (80–99 %)
Uneven or disproportionate growth of one body part compared to another	Svært ofte (80–99 %)
Weight loss	Svært ofte (80–99 %)
Growth delay	Ofte (30–79 %)
Growth delay as children	Noen ganger (5–29 %)
General overgrowth	Ikke registrert

Abnormality of the endocrine system

Trait	Hvor ofte den forekommer
Hypogonadotropic hypogonadism	Svært ofte (80–99 %)
Pineal cyst	Ofte (30–79 %)
Delayed start of first period	Noen ganger (5–29 %)
Early onset of puberty	Noen ganger (5–29 %)
Neoplasm of the thyroid gland	Noen ganger (5–29 %)
Noncancerous tumor in pituitary gland	Noen ganger (5–29 %)

Abnormality of the respiratory system

Trait	Hvor ofte den forekommer
Laryngeal hypoplasia	Ofte (30–79 %)
Laryngeal carcinoma	Noen ganger (5–29 %)
Alveolar cell carcinoma	Ikke registrert
Lung adenocarcinoma	Ikke registrert
Non-small cell lung carcinoma	Ikke registrert

Laboratory abnormality

Trait	Hvor ofte den forekommer
Diabetes mellitus	Noen ganger (5–29 %)
High liver enzymes	Noen ganger (5–29 %)
High urine phosphate levels	Noen ganger (5–29 %)
Swelling caused by excess lymph fluid under skin	Noen ganger (5–29 %)
Increased level of L-fucose in urine	Ikke registrert

Abnormality of the breast

Trait	Hvor ofte den forekommer
Wide-spaced nipples	Svært ofte (80–99 %)
Breast cancer	Noen ganger (5–29 %)
Accessory nipple	Ikke registrert

Abnormality of prenatal development or birth

Trait	Hvor ofte den forekommer
High levels of amniotic fluid	Ofte (30–79 %)
Premature birth	Ofte (30–79 %)

Constitutional symptom

Trait	Hvor ofte den forekommer
Chronic fatigue	Svært ofte (80–99 %)
Fatigue	Svært ofte (80–99 %)

Abnormal tissue mass

Trait	Hvor ofte den forekommer
Cancer of skin pigment cells	Noen ganger (5–29 %)

Abnormality of the immune system

Trait	Hvor ofte den forekommer
Baby eczema	Ikke registrert

Hvor ofte dette forekommer hos personer med en av genets tilstander, oppgitt som den hyppigste forekomsten blant dem, slik Human Phenotype Ontology registrerer den. Disse sidene beskriver egenskaper og forskningen bak dem. De er ikke en diagnose, og om symptomer bør du spørre lege eller genetisk rådgiver.

Slik er informasjonen samlet

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KRAS and how often each is seen. Find out more at hpo.jax.org.

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