Požymis

Wide nose

Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae.

HPO HP:0000445

Taip pat vadinama: Broad nose, Increased breadth of nose, Increased nasal breadth, Increased nasal width, Increased width of nose
Kūno sistema: Abnormality of head or neck

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/wide-nose.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

Vienu tyrimu sužinokite genus, susijusius su Wide nose, ir kitą jūsų genomo dalį.

Nuo 449 $Nemokamas pristatymas · Rezultatai per 6–8 savaites

Įsigyti savo Genome Test

137 genų susiję su Wide nose

Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Wide nose. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.

Genas	Kaip dažnai pasireiškia	Ligos
ARID2AT-rich interaction domain 2	Visada	1 ligoje
CCNQcyclin Q	Visada	1 ligoje
CDH11cadherin 11	Visada	1 ligoje
CHD8chromodomain helicase DNA binding protein 8	Visada	1 ligoje
GPC4glypican 4	Visada	1 ligoje
GRIP1glutamate receptor interacting protein 1	Visada	1 ligoje
INTS11integrator complex subunit 11	Visada	1 ligoje
KDM2Blysine demethylase 2B	Visada	1 ligoje
KDM6Alysine demethylase 6A	Visada	1 ligoje
KDM6Blysine demethylase 6B	Visada	1 ligoje
KMT2Dlysine methyltransferase 2D	Visada	1 ligoje
LARP7La ribonucleoprotein 7, transcriptional regulator	Visada	2 ligose
LRRC7leucine rich repeat containing 7	Visada	1 ligoje
MOGSmannosyl-oligosaccharide glucosidase	Visada	2 ligose
PPFIA3PPFI scaffold protein A3	Visada	1 ligoje
PRRX1paired related homeobox 1	Visada	1 ligoje
SLC37A4solute carrier family 37 member 4	Visada	1 ligoje
SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1	Visada	1 ligoje
STAT3signal transducer and activator of transcription 3	Visada	1 ligoje
TAF4TATA-box binding protein associated factor 4	Visada	1 ligoje
UBR5ubiquitin protein ligase E3 component n-recognin 5	Visada	1 ligoje
VPS33AVPS33A core subunit of CORVET and HOPS complexes	Visada	1 ligoje
VPS53VPS53 subunit of GARP complex	Visada	1 ligoje
WLSWnt ligand secretion mediator	Visada	1 ligoje
ACTBactin beta	Labai dažnai (80–99%)	1 ligoje
ACTG1actin gamma 1	Labai dažnai (80–99%)	1 ligoje
AIPAHR interacting HSP90 co-chaperone	Labai dažnai (80–99%)	1 ligoje
CKAP2Lcytoskeleton associated protein 2L	Labai dažnai (80–99%)	1 ligoje
CLCF1cardiotrophin like cytokine factor 1	Labai dažnai (80–99%)	1 ligoje
CRLF1cytokine receptor like factor 1	Labai dažnai (80–99%)	2 ligose
DVL1dishevelled segment polarity protein 1	Labai dažnai (80–99%)	1 ligoje
DVL3dishevelled segment polarity protein 3	Labai dažnai (80–99%)	1 ligoje
ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2	Labai dažnai (80–99%)	1 ligoje
FZD2frizzled class receptor 2	Labai dažnai (80–99%)	1 ligoje
GPR101G protein-coupled receptor 101	Labai dažnai (80–99%)	1 ligoje
KAT6Blysine acetyltransferase 6B	Labai dažnai (80–99%)	2 ligose
MGPmatrix Gla protein	Labai dažnai (80–99%)	1 ligoje
PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1	Labai dažnai (80–99%)	1 ligoje
SEC23ASEC23 homolog A, COPII component	Labai dažnai (80–99%)	1 ligoje
TCTN3tectonic family member 3	Labai dažnai (80–99%)	1 ligoje

Rodyti dar 97 genų

Genas	Kaip dažnai pasireiškia	Ligos
TMCO1transmembrane and coiled-coil domains 1	Labai dažnai (80–99%)	2 ligose
TRIM37tripartite motif containing 37	Labai dažnai (80–99%)	1 ligoje
WNT5AWnt family member 5A	Labai dažnai (80–99%)	1 ligoje
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Labai dažnai (80–99%)	1 ligoje
ACBD6acyl-CoA binding domain containing 6	Dažnai (30–79%)	1 ligoje
ARID1AAT-rich interaction domain 1A	Dažnai (30–79%)	1 ligoje
ATP6V1B2ATPase H+ transporting V1 subunit B2	Dažnai (30–79%)	1 ligoje
CAMTA1calmodulin binding transcription activator 1	Dažnai (30–79%)	1 ligoje
COX7Bcytochrome c oxidase subunit 7B	Dažnai (30–79%)	1 ligoje
DPF2double PHD fingers 2	Dažnai (30–79%)	1 ligoje
DYNC2H1dynein cytoplasmic 2 heavy chain 1	Dažnai (30–79%)	1 ligoje
DYNC2I1dynein 2 intermediate chain 1	Dažnai (30–79%)	1 ligoje
DYNC2I2dynein 2 intermediate chain 2	Dažnai (30–79%)	1 ligoje
FHL1four and a half LIM domains 1	Dažnai (30–79%)	1 ligoje
GON4Lgon-4 like	Dažnai (30–79%)	1 ligoje
HCCSholocytochrome c synthase	Dažnai (30–79%)	1 ligoje
IFT80intraflagellar transport 80	Dažnai (30–79%)	1 ligoje
IL11RAinterleukin 11 receptor subunit alpha	Dažnai (30–79%)	1 ligoje
KATNB1katanin regulatory subunit B1	Dažnai (30–79%)	1 ligoje
KCNH1potassium voltage-gated channel subfamily H member 1	Dažnai (30–79%)	3 ligose
KCNN3potassium calcium-activated channel subfamily N member 3	Dažnai (30–79%)	1 ligoje
KICS2KICSTOR subunit 2	Dažnai (30–79%)	1 ligoje
MEGF8multiple EGF like domains 8	Dažnai (30–79%)	1 ligoje
NDE1nudE neurodevelopment protein 1	Dažnai (30–79%)	1 ligoje
NDUFB11NADH:ubiquinone oxidoreductase subunit B11	Dažnai (30–79%)	1 ligoje
NOTCH2notch receptor 2	Dažnai (30–79%)	2 ligose
OTUD6BOTU deubiquitinase 6B	Dažnai (30–79%)	1 ligoje
PHGDHphosphoglycerate dehydrogenase	Dažnai (30–79%)	1 ligoje
PORcytochrome p450 oxidoreductase	Dažnai (30–79%)	1 ligoje
POU4F1POU class 4 homeobox 1	Dažnai (30–79%)	1 ligoje
QRICH1glutamine rich 1	Dažnai (30–79%)	1 ligoje
RAB23RAB23, member RAS oncogene family	Dažnai (30–79%)	1 ligoje
RELNreelin	Dažnai (30–79%)	1 ligoje
RNF2ring finger protein 2	Dažnai (30–79%)	1 ligoje
RPS6KA3ribosomal protein S6 kinase A3	Dažnai (30–79%)	3 ligose
SETD1ASET domain containing 1A, histone lysine methyltransferase	Dažnai (30–79%)	1 ligoje
TRMT10AtRNA methyltransferase 10A	Dažnai (30–79%)	2 ligose
TWIST2twist family bHLH transcription factor 2	Dažnai (30–79%)	1 ligoje
WDR35WD repeat domain 35	Dažnai (30–79%)	1 ligoje
ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18	Kartais (5–29%)	1 ligoje
ALG12ALG12 alpha-1,6-mannosyltransferase	Kartais (5–29%)	2 ligose
ASPHaspartate beta-hydroxylase	Kartais (5–29%)	1 ligoje
BRCC3BRCA1/BRCA2-containing complex subunit 3	Kartais (5–29%)	1 ligoje
BUB1BUB1 mitotic checkpoint serine/threonine kinase	Kartais (5–29%)	1 ligoje
BUB1BBUB1 mitotic checkpoint serine/threonine kinase B	Kartais (5–29%)	2 ligose
BUB3BUB3 mitotic checkpoint protein	Kartais (5–29%)	1 ligoje
CEP57centrosomal protein 57	Kartais (5–29%)	1 ligoje
COG8component of oligomeric golgi complex 8	Kartais (5–29%)	1 ligoje
CRELD1CRELD disulfide isomerase 1	Kartais (5–29%)	1 ligoje
DLK1delta like non-canonical Notch ligand 1	Kartais (5–29%)	3 ligose
FREM2FRAS1 related extracellular matrix 2	Kartais (5–29%)	1 ligoje
HMGA2high mobility group AT-hook 2	Kartais (5–29%)	1 ligoje
INSRinsulin receptor	Kartais (5–29%)	2 ligose
KIF11kinesin family member 11	Kartais (5–29%)	1 ligoje
LEMD3LEM domain containing 3	Kartais (5–29%)	1 ligoje
LMBRD2LMBR1 domain containing 2	Kartais (5–29%)	1 ligoje
LMX1BLIM homeobox transcription factor 1 beta	Kartais (5–29%)	1 ligoje
MAN1B1mannosidase alpha class 1B member 1	Kartais (5–29%)	2 ligose
MEG3maternally expressed 3	Kartais (5–29%)	3 ligose
PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)	Kartais (5–29%)	1 ligoje
PPP1CBprotein phosphatase 1 catalytic subunit beta	Kartais (5–29%)	1 ligoje
PPP1R15Bprotein phosphatase 1 regulatory subunit 15B	Kartais (5–29%)	1 ligoje
PTENphosphatase and tensin homolog	Kartais (5–29%)	1 ligoje
RAI1retinoic acid induced 1	Kartais (5–29%)	1 ligoje
RNF125ring finger protein 125	Kartais (5–29%)	1 ligoje
RTL1retrotransposon Gag like 1	Kartais (5–29%)	3 ligose
SATB2SATB homeobox 2	Kartais (5–29%)	1 ligoje
SETBP1SET binding protein 1	Kartais (5–29%)	1 ligoje
SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2	Kartais (5–29%)	1 ligoje
SMG9SMG9 nonsense mediated mRNA decay factor	Kartais (5–29%)	1 ligoje
STXBP1syntaxin binding protein 1	Kartais (5–29%)	1 ligoje
TBX1T-box transcription factor 1	Kartais (5–29%)	1 ligoje
TOGARAM1TOG array regulator of axonemal microtubules 1	Kartais (5–29%)	1 ligoje
TONSLtonsoku like, DNA repair protein	Kartais (5–29%)	1 ligoje
TRIP13thyroid hormone receptor interactor 13	Kartais (5–29%)	1 ligoje
WBP11WW domain binding protein 11	Kartais (5–29%)	1 ligoje
ACY1aminoacylase 1	Retai (1–4 %)	1 ligoje
EPG5ectopic P-granules 5 autophagy tethering factor	Retai (1–4 %)	1 ligoje
AVParginine vasopressin	Neužfiksuota	1 ligoje
COG7component of oligomeric golgi complex 7	Neužfiksuota	1 ligoje
DONSONDNA replication fork stabilization factor DONSON	Neužfiksuota	1 ligoje
FGFR1fibroblast growth factor receptor 1	Neužfiksuota	1 ligoje
FRAS1Fraser extracellular matrix complex subunit 1	Neužfiksuota	1 ligoje
FUCA1alpha-L-fucosidase 1	Neužfiksuota	1 ligoje
GDF5growth differentiation factor 5	Neužfiksuota	1 ligoje
HDAC4histone deacetylase 4	Neužfiksuota	1 ligoje
IDUAalpha-L-iduronidase	Neužfiksuota	1 ligoje
KMT2Alysine methyltransferase 2A	Neužfiksuota	1 ligoje
NANSN-acetylneuraminate synthase	Neužfiksuota	1 ligoje
PAM16presequence translocase associated motor 16	Neužfiksuota	1 ligoje
SIN3ASIN3 transcription regulator family member A	Neužfiksuota	1 ligoje
SKIC3SKI3 subunit of superkiller complex	Neužfiksuota	1 ligoje
SMARCA4SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4	Neužfiksuota	1 ligoje
SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1	Neužfiksuota	1 ligoje
STAMBPSTAM binding protein	Neužfiksuota	1 ligoje
TBL1XR1TBL1X/Y related 1	Neužfiksuota	1 ligoje
ZNF341zinc finger protein 341	Neužfiksuota	1 ligoje

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

Platesni požymiai

Abnormal of nasal shape

Iš kur tai žinoma

Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
Duomenų leidimas 2026.10.16-c6eea6bf.

Vienas testas. Atsakymai visam gyvenimui.