Trait
Wide nose
Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae.
Summary
- Also called
- Broad nose, Increased breadth of nose, Increased nasal breadth, Increased nasal width, Increased width of nose
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
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Get my Genome Test137 genes linked to Wide nose
Changes in these genes cause rare conditions in which Wide nose is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ARID2AT-rich interaction domain 2 | Always | In 1 condition |
| CCNQcyclin Q | Always | In 1 condition |
| CDH11cadherin 11 | Always | In 1 condition |
| CHD8chromodomain helicase DNA binding protein 8 | Always | In 1 condition |
| GPC4glypican 4 | Always | In 1 condition |
| GRIP1glutamate receptor interacting protein 1 | Always | In 1 condition |
| INTS11integrator complex subunit 11 | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| KDM6Alysine demethylase 6A | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| KMT2Dlysine methyltransferase 2D | Always | In 1 condition |
| LARP7La ribonucleoprotein 7, transcriptional regulator | Always | In 2 conditions |
| LRRC7leucine rich repeat containing 7 | Always | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Always | In 2 conditions |
| PPFIA3PPFI scaffold protein A3 | Always | In 1 condition |
| PRRX1paired related homeobox 1 | Always | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Always | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Always | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Always | In 1 condition |
| TAF4TATA-box binding protein associated factor 4 | Always | In 1 condition |
| UBR5ubiquitin protein ligase E3 component n-recognin 5 | Always | In 1 condition |
| VPS33AVPS33A core subunit of CORVET and HOPS complexes | Always | In 1 condition |
| VPS53VPS53 subunit of GARP complex | Always | In 1 condition |
| WLSWnt ligand secretion mediator | Always | In 1 condition |
| ACTBactin beta | Very often (80–99%) | In 1 condition |
| ACTG1actin gamma 1 | Very often (80–99%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 1 condition |
| CKAP2Lcytoskeleton associated protein 2L | Very often (80–99%) | In 1 condition |
| CLCF1cardiotrophin like cytokine factor 1 | Very often (80–99%) | In 1 condition |
| CRLF1cytokine receptor like factor 1 | Very often (80–99%) | In 2 conditions |
| DVL1dishevelled segment polarity protein 1 | Very often (80–99%) | In 1 condition |
| DVL3dishevelled segment polarity protein 3 | Very often (80–99%) | In 1 condition |
| ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2 | Very often (80–99%) | In 1 condition |
| FZD2frizzled class receptor 2 | Very often (80–99%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Very often (80–99%) | In 1 condition |
| KAT6Blysine acetyltransferase 6B | Very often (80–99%) | In 2 conditions |
| MGPmatrix Gla protein | Very often (80–99%) | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Very often (80–99%) | In 1 condition |
| SEC23ASEC23 homolog A, COPII component | Very often (80–99%) | In 1 condition |
| TCTN3tectonic family member 3 | Very often (80–99%) | In 1 condition |
Show 97 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TMCO1transmembrane and coiled-coil domains 1 | Very often (80–99%) | In 2 conditions |
| TRIM37tripartite motif containing 37 | Very often (80–99%) | In 1 condition |
| WNT5AWnt family member 5A | Very often (80–99%) | In 1 condition |
| YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon | Very often (80–99%) | In 1 condition |
| ACBD6acyl-CoA binding domain containing 6 | Often (30–79%) | In 1 condition |
| ARID1AAT-rich interaction domain 1A | Often (30–79%) | In 1 condition |
| ATP6V1B2ATPase H+ transporting V1 subunit B2 | Often (30–79%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Often (30–79%) | In 1 condition |
| COX7Bcytochrome c oxidase subunit 7B | Often (30–79%) | In 1 condition |
| DPF2double PHD fingers 2 | Often (30–79%) | In 1 condition |
| DYNC2H1dynein cytoplasmic 2 heavy chain 1 | Often (30–79%) | In 1 condition |
| DYNC2I1dynein 2 intermediate chain 1 | Often (30–79%) | In 1 condition |
| DYNC2I2dynein 2 intermediate chain 2 | Often (30–79%) | In 1 condition |
| FHL1four and a half LIM domains 1 | Often (30–79%) | In 1 condition |
| GON4Lgon-4 like | Often (30–79%) | In 1 condition |
| HCCSholocytochrome c synthase | Often (30–79%) | In 1 condition |
| IFT80intraflagellar transport 80 | Often (30–79%) | In 1 condition |
| IL11RAinterleukin 11 receptor subunit alpha | Often (30–79%) | In 1 condition |
| KATNB1katanin regulatory subunit B1 | Often (30–79%) | In 1 condition |
| KCNH1potassium voltage-gated channel subfamily H member 1 | Often (30–79%) | In 3 conditions |
| KCNN3potassium calcium-activated channel subfamily N member 3 | Often (30–79%) | In 1 condition |
| KICS2KICSTOR subunit 2 | Often (30–79%) | In 1 condition |
| MEGF8multiple EGF like domains 8 | Often (30–79%) | In 1 condition |
| NDE1nudE neurodevelopment protein 1 | Often (30–79%) | In 1 condition |
| NDUFB11NADH:ubiquinone oxidoreductase subunit B11 | Often (30–79%) | In 1 condition |
| NOTCH2notch receptor 2 | Often (30–79%) | In 2 conditions |
| OTUD6BOTU deubiquitinase 6B | Often (30–79%) | In 1 condition |
| PHGDHphosphoglycerate dehydrogenase | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Often (30–79%) | In 1 condition |
| QRICH1glutamine rich 1 | Often (30–79%) | In 1 condition |
| RAB23RAB23, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RELNreelin | Often (30–79%) | In 1 condition |
| RNF2ring finger protein 2 | Often (30–79%) | In 1 condition |
| RPS6KA3ribosomal protein S6 kinase A3 | Often (30–79%) | In 3 conditions |
| SETD1ASET domain containing 1A, histone lysine methyltransferase | Often (30–79%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Often (30–79%) | In 2 conditions |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 1 condition |
| WDR35WD repeat domain 35 | Often (30–79%) | In 1 condition |
| ADAMTS18ADAM metallopeptidase with thrombospondin type 1 motif 18 | Sometimes (5–29%) | In 1 condition |
| ALG12ALG12 alpha-1,6-mannosyltransferase | Sometimes (5–29%) | In 2 conditions |
| ASPHaspartate beta-hydroxylase | Sometimes (5–29%) | In 1 condition |
| BRCC3BRCA1/BRCA2-containing complex subunit 3 | Sometimes (5–29%) | In 1 condition |
| BUB1BUB1 mitotic checkpoint serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Sometimes (5–29%) | In 2 conditions |
| BUB3BUB3 mitotic checkpoint protein | Sometimes (5–29%) | In 1 condition |
| CEP57centrosomal protein 57 | Sometimes (5–29%) | In 1 condition |
| COG8component of oligomeric golgi complex 8 | Sometimes (5–29%) | In 1 condition |
| CRELD1CRELD disulfide isomerase 1 | Sometimes (5–29%) | In 1 condition |
| DLK1delta like non-canonical Notch ligand 1 | Sometimes (5–29%) | In 3 conditions |
| FREM2FRAS1 related extracellular matrix 2 | Sometimes (5–29%) | In 1 condition |
| HMGA2high mobility group AT-hook 2 | Sometimes (5–29%) | In 1 condition |
| INSRinsulin receptor | Sometimes (5–29%) | In 2 conditions |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| LEMD3LEM domain containing 3 | Sometimes (5–29%) | In 1 condition |
| LMBRD2LMBR1 domain containing 2 | Sometimes (5–29%) | In 1 condition |
| LMX1BLIM homeobox transcription factor 1 beta | Sometimes (5–29%) | In 1 condition |
| MAN1B1mannosidase alpha class 1B member 1 | Sometimes (5–29%) | In 2 conditions |
| MEG3maternally expressed 3 | Sometimes (5–29%) | In 3 conditions |
| PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group) | Sometimes (5–29%) | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| PTENphosphatase and tensin homolog | Sometimes (5–29%) | In 1 condition |
| RAI1retinoic acid induced 1 | Sometimes (5–29%) | In 1 condition |
| RNF125ring finger protein 125 | Sometimes (5–29%) | In 1 condition |
| RTL1retrotransposon Gag like 1 | Sometimes (5–29%) | In 3 conditions |
| SATB2SATB homeobox 2 | Sometimes (5–29%) | In 1 condition |
| SETBP1SET binding protein 1 | Sometimes (5–29%) | In 1 condition |
| SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 | Sometimes (5–29%) | In 1 condition |
| SMG9SMG9 nonsense mediated mRNA decay factor | Sometimes (5–29%) | In 1 condition |
| STXBP1syntaxin binding protein 1 | Sometimes (5–29%) | In 1 condition |
| TBX1T-box transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| TOGARAM1TOG array regulator of axonemal microtubules 1 | Sometimes (5–29%) | In 1 condition |
| TONSLtonsoku like, DNA repair protein | Sometimes (5–29%) | In 1 condition |
| TRIP13thyroid hormone receptor interactor 13 | Sometimes (5–29%) | In 1 condition |
| WBP11WW domain binding protein 11 | Sometimes (5–29%) | In 1 condition |
| ACY1aminoacylase 1 | Rarely (1–4%) | In 1 condition |
| EPG5ectopic P-granules 5 autophagy tethering factor | Rarely (1–4%) | In 1 condition |
| AVParginine vasopressin | Not recorded | In 1 condition |
| COG7component of oligomeric golgi complex 7 | Not recorded | In 1 condition |
| DONSONDNA replication fork stabilization factor DONSON | Not recorded | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Not recorded | In 1 condition |
| FRAS1Fraser extracellular matrix complex subunit 1 | Not recorded | In 1 condition |
| FUCA1alpha-L-fucosidase 1 | Not recorded | In 1 condition |
| GDF5growth differentiation factor 5 | Not recorded | In 1 condition |
| HDAC4histone deacetylase 4 | Not recorded | In 1 condition |
| IDUAalpha-L-iduronidase | Not recorded | In 1 condition |
| KMT2Alysine methyltransferase 2A | Not recorded | In 1 condition |
| NANSN-acetylneuraminate synthase | Not recorded | In 1 condition |
| PAM16presequence translocase associated motor 16 | Not recorded | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Not recorded | In 1 condition |
| SKIC3SKI3 subunit of superkiller complex | Not recorded | In 1 condition |
| SMARCA4SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 | Not recorded | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Not recorded | In 1 condition |
| STAMBPSTAM binding protein | Not recorded | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Not recorded | In 1 condition |
| ZNF341zinc finger protein 341 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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