Požymis
Lack of feeling, emotion, interest
Klinikinis pavadinimas: Apathy
Apathy is a quantitative reduction of interest, motivation and the initiation and persistence of goal-directed behavior, where often the accompanying emotions, thoughts, and social interactions are also diminished. The individual is typically non-reactive to provocations, positive or negative, and appears to not care. Distinguished from lethargy which involves lack of physical or mental energy.
Santrauka
- Taip pat vadinama
- Lack of feeling, emotion, interest, motivation, initiation, State of indifference
- Kūno sistema
- Abnormality of the nervous system
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
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Įsigyti savo Genome Test94 genų susiję su Lack of feeling, emotion, interest
Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Lack of feeling, emotion, interest. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| APOEapolipoprotein E | Visada | 1 ligoje |
| GFAPglial fibrillary acidic protein | Visada | 1 ligoje |
| LAMB1laminin subunit beta 1 | Visada | 1 ligoje |
| PLP1proteolipid protein 1 | Visada | 1 ligoje |
| PSEN2presenilin 2 | Visada | 1 ligoje |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Visada | 1 ligoje |
| SCO2synthesis of cytochrome C oxidase 2 | Visada | 1 ligoje |
| VPS13Avacuolar protein sorting 13 homolog A | Visada | 2 ligose |
| DCTN1dynactin subunit 1 | Labai dažnai (80–99%) | 2 ligose |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Labai dažnai (80–99%) | 1 ligoje |
| ACAT1acetyl-CoA acetyltransferase 1 | Dažnai (30–79%) | 1 ligoje |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Dažnai (30–79%) | 2 ligose |
| CDONcell adhesion associated, oncogene regulated | Dažnai (30–79%) | 4 ligose |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Dažnai (30–79%) | 1 ligoje |
| COQ2coenzyme Q2, polyprenyltransferase | Dažnai (30–79%) | 2 ligose |
| CRIPTOcripto, EGF-CFC family member | Dažnai (30–79%) | 4 ligose |
| DISP1dispatched RND transporter family member 1 | Dažnai (30–79%) | 4 ligose |
| DLL1delta like canonical Notch ligand 1 | Dažnai (30–79%) | 4 ligose |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Dažnai (30–79%) | 1 ligoje |
| FGF8fibroblast growth factor 8 | Dažnai (30–79%) | 4 ligose |
| FGFR1fibroblast growth factor receptor 1 | Dažnai (30–79%) | 2 ligose |
| FOXH1forkhead box H1 | Dažnai (30–79%) | 4 ligose |
| FUSFUS RNA binding protein | Dažnai (30–79%) | 1 ligoje |
| GAS1growth arrest specific 1 | Dažnai (30–79%) | 4 ligose |
| GDAP2ganglioside induced differentiation associated protein 2 | Dažnai (30–79%) | 1 ligoje |
| GLI2GLI family zinc finger 2 | Dažnai (30–79%) | 4 ligose |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Dažnai (30–79%) | 2 ligose |
| HTRA2HtrA serine peptidase 2 | Dažnai (30–79%) | 1 ligoje |
| HTThuntingtin | Dažnai (30–79%) | 1 ligoje |
| LRRK2leucine rich repeat kinase 2 | Dažnai (30–79%) | 2 ligose |
| MAPTmicrotubule associated protein tau | Dažnai (30–79%) | 6 ligose |
| MRPL39mitochondrial ribosomal protein L39 | Dažnai (30–79%) | 1 ligoje |
| NODALnodal growth differentiation factor | Dažnai (30–79%) | 4 ligose |
| NOTCH3notch receptor 3 | Dažnai (30–79%) | 1 ligoje |
| PARK7Parkinsonism associated deglycase | Dažnai (30–79%) | 1 ligoje |
| PINK1PTEN induced kinase 1 | Dažnai (30–79%) | 1 ligoje |
| PLCH1phospholipase C eta 1 | Dažnai (30–79%) | 1 ligoje |
| PODXLpodocalyxin like | Dažnai (30–79%) | 1 ligoje |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Dažnai (30–79%) | 1 ligoje |
| PRKNparkin RBR E3 ubiquitin protein ligase | Dažnai (30–79%) | 1 ligoje |
Rodyti dar 54 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| PRNPprion protein (Kanno blood group) | Dažnai (30–79%) | 2 ligose |
| PTCH1patched 1 | Dažnai (30–79%) | 4 ligose |
| SHHsonic hedgehog signaling molecule | Dažnai (30–79%) | 4 ligose |
| SIX3SIX homeobox 3 | Dažnai (30–79%) | 4 ligose |
| SLC2A3solute carrier family 2 member 3 | Dažnai (30–79%) | 1 ligoje |
| SMC1Astructural maintenance of chromosomes 1A | Dažnai (30–79%) | 1 ligoje |
| SNCAsynuclein alpha | Dažnai (30–79%) | 2 ligose |
| SQSTM1sequestosome 1 | Dažnai (30–79%) | 3 ligose |
| STAG2STAG2 cohesin complex component | Dažnai (30–79%) | 2 ligose |
| STILSTIL centriolar assembly protein | Dažnai (30–79%) | 4 ligose |
| SYNJ1synaptojanin 1 | Dažnai (30–79%) | 1 ligoje |
| TARDBPTAR DNA binding protein | Dažnai (30–79%) | 2 ligose |
| TBK1TANK binding kinase 1 | Dažnai (30–79%) | 2 ligose |
| TGIF1TGFB induced factor homeobox 1 | Dažnai (30–79%) | 4 ligose |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Dažnai (30–79%) | 1 ligoje |
| TSFMTs translation elongation factor, mitochondrial | Dažnai (30–79%) | 1 ligoje |
| UCHL1ubiquitin C-terminal hydrolase L1 | Dažnai (30–79%) | 1 ligoje |
| VCPvalosin containing protein | Dažnai (30–79%) | 2 ligose |
| VPS13Cvacuolar protein sorting 13 homolog C | Dažnai (30–79%) | 2 ligose |
| ZIC2Zic family zinc finger 2 | Dažnai (30–79%) | 4 ligose |
| ALADaminolevulinate dehydratase | Kartais (5–29%) | 1 ligoje |
| ATP13A2ATPase cation transporting 13A2 | Kartais (5–29%) | 1 ligoje |
| ATXN10ataxin 10 | Kartais (5–29%) | 1 ligoje |
| CHD2chromodomain helicase DNA binding protein 2 | Kartais (5–29%) | 1 ligoje |
| CHMP2Bcharged multivesicular body protein 2B | Kartais (5–29%) | 2 ligose |
| CPceruloplasmin | Kartais (5–29%) | 1 ligoje |
| CUX2cut like homeobox 2 | Kartais (5–29%) | 1 ligoje |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Kartais (5–29%) | 1 ligoje |
| DNM1dynamin 1 | Kartais (5–29%) | 1 ligoje |
| EHMT1euchromatic histone lysine methyltransferase 1 | Kartais (5–29%) | 2 ligose |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Kartais (5–29%) | 1 ligoje |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Kartais (5–29%) | 1 ligoje |
| GBA1glucosylceramidase beta 1 | Kartais (5–29%) | 2 ligose |
| GIGYF2GRB10 interacting GYF protein 2 | Kartais (5–29%) | 1 ligoje |
| GRNgranulin precursor | Kartais (5–29%) | 2 ligose |
| HTRA1HtrA serine peptidase 1 | Kartais (5–29%) | 1 ligoje |
| MAPK10mitogen-activated protein kinase 10 | Kartais (5–29%) | 1 ligoje |
| PSEN1presenilin 1 | Kartais (5–29%) | 3 ligose |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Kartais (5–29%) | 1 ligoje |
| TMEM106Btransmembrane protein 106B | Kartais (5–29%) | 1 ligoje |
| TREM2triggering receptor expressed on myeloid cells 2 | Kartais (5–29%) | 1 ligoje |
| TREX1three prime repair exonuclease 1 | Kartais (5–29%) | 1 ligoje |
| VPS35VPS35 retromer complex component | Kartais (5–29%) | 1 ligoje |
| BMP6bone morphogenetic protein 6 | Retai (1–4 %) | 1 ligoje |
| HFEhomeostatic iron regulator | Retai (1–4 %) | 1 ligoje |
| PDGFBplatelet derived growth factor subunit B | Retai (1–4 %) | 1 ligoje |
| C9orf72C9orf72-SMCR8 complex subunit | Neužfiksuota | 1 ligoje |
| DNMT1DNA methyltransferase 1 | Neužfiksuota | 1 ligoje |
| GM2Aganglioside GM2 activator | Neužfiksuota | 1 ligoje |
| HEXAhexosaminidase subunit alpha | Neužfiksuota | 1 ligoje |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Neužfiksuota | 1 ligoje |
| JPH3junctophilin 3 | Neužfiksuota | 1 ligoje |
| SPASTspastin | Neužfiksuota | 1 ligoje |
| TMEM240transmembrane protein 240 | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
Platesni požymiai
Iš kur tai žinoma
- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.16-c6eea6bf.
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