Trait
Lack of feeling, emotion, interest
Clinical name: Apathy
Apathy is a quantitative reduction of interest, motivation and the initiation and persistence of goal-directed behavior, where often the accompanying emotions, thoughts, and social interactions are also diminished. The individual is typically non-reactive to provocations, positive or negative, and appears to not care. Distinguished from lethargy which involves lack of physical or mental energy.
Summary
- Also called
- Lack of feeling, emotion, interest, motivation, initiation, State of indifference
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Lack of feeling, emotion, interest, and the rest of your genome, with one test.
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Get my Genome Test94 genes linked to Lack of feeling, emotion, interest
Changes in these genes cause rare conditions in which Lack of feeling, emotion, interest is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APOEapolipoprotein E | Always | In 1 condition |
| GFAPglial fibrillary acidic protein | Always | In 1 condition |
| LAMB1laminin subunit beta 1 | Always | In 1 condition |
| PLP1proteolipid protein 1 | Always | In 1 condition |
| PSEN2presenilin 2 | Always | In 1 condition |
| PSMD12proteasome 26S subunit, non-ATPase 12 | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
| VPS13Avacuolar protein sorting 13 homolog A | Always | In 2 conditions |
| DCTN1dynactin subunit 1 | Very often (80–99%) | In 2 conditions |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Very often (80–99%) | In 1 condition |
| ACAT1acetyl-CoA acetyltransferase 1 | Often (30–79%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Often (30–79%) | In 2 conditions |
| CDONcell adhesion associated, oncogene regulated | Often (30–79%) | In 4 conditions |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 1 condition |
| COQ2coenzyme Q2, polyprenyltransferase | Often (30–79%) | In 2 conditions |
| CRIPTOcripto, EGF-CFC family member | Often (30–79%) | In 4 conditions |
| DISP1dispatched RND transporter family member 1 | Often (30–79%) | In 4 conditions |
| DLL1delta like canonical Notch ligand 1 | Often (30–79%) | In 4 conditions |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Often (30–79%) | In 1 condition |
| FGF8fibroblast growth factor 8 | Often (30–79%) | In 4 conditions |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 2 conditions |
| FOXH1forkhead box H1 | Often (30–79%) | In 4 conditions |
| FUSFUS RNA binding protein | Often (30–79%) | In 1 condition |
| GAS1growth arrest specific 1 | Often (30–79%) | In 4 conditions |
| GDAP2ganglioside induced differentiation associated protein 2 | Often (30–79%) | In 1 condition |
| GLI2GLI family zinc finger 2 | Often (30–79%) | In 4 conditions |
| HMGCL3-hydroxy-3-methylglutaryl-CoA lyase | Often (30–79%) | In 2 conditions |
| HTRA2HtrA serine peptidase 2 | Often (30–79%) | In 1 condition |
| HTThuntingtin | Often (30–79%) | In 1 condition |
| LRRK2leucine rich repeat kinase 2 | Often (30–79%) | In 2 conditions |
| MAPTmicrotubule associated protein tau | Often (30–79%) | In 6 conditions |
| MRPL39mitochondrial ribosomal protein L39 | Often (30–79%) | In 1 condition |
| NODALnodal growth differentiation factor | Often (30–79%) | In 4 conditions |
| NOTCH3notch receptor 3 | Often (30–79%) | In 1 condition |
| PARK7Parkinsonism associated deglycase | Often (30–79%) | In 1 condition |
| PINK1PTEN induced kinase 1 | Often (30–79%) | In 1 condition |
| PLCH1phospholipase C eta 1 | Often (30–79%) | In 1 condition |
| PODXLpodocalyxin like | Often (30–79%) | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Often (30–79%) | In 1 condition |
| PRKNparkin RBR E3 ubiquitin protein ligase | Often (30–79%) | In 1 condition |
Show 54 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 2 conditions |
| PTCH1patched 1 | Often (30–79%) | In 4 conditions |
| SHHsonic hedgehog signaling molecule | Often (30–79%) | In 4 conditions |
| SIX3SIX homeobox 3 | Often (30–79%) | In 4 conditions |
| SLC2A3solute carrier family 2 member 3 | Often (30–79%) | In 1 condition |
| SMC1Astructural maintenance of chromosomes 1A | Often (30–79%) | In 1 condition |
| SNCAsynuclein alpha | Often (30–79%) | In 2 conditions |
| SQSTM1sequestosome 1 | Often (30–79%) | In 3 conditions |
| STAG2STAG2 cohesin complex component | Often (30–79%) | In 2 conditions |
| STILSTIL centriolar assembly protein | Often (30–79%) | In 4 conditions |
| SYNJ1synaptojanin 1 | Often (30–79%) | In 1 condition |
| TARDBPTAR DNA binding protein | Often (30–79%) | In 2 conditions |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 2 conditions |
| TGIF1TGFB induced factor homeobox 1 | Often (30–79%) | In 4 conditions |
| TRANK1tetratricopeptide repeat and ankyrin repeat containing 1 | Often (30–79%) | In 1 condition |
| TSFMTs translation elongation factor, mitochondrial | Often (30–79%) | In 1 condition |
| UCHL1ubiquitin C-terminal hydrolase L1 | Often (30–79%) | In 1 condition |
| VCPvalosin containing protein | Often (30–79%) | In 2 conditions |
| VPS13Cvacuolar protein sorting 13 homolog C | Often (30–79%) | In 2 conditions |
| ZIC2Zic family zinc finger 2 | Often (30–79%) | In 4 conditions |
| ALADaminolevulinate dehydratase | Sometimes (5–29%) | In 1 condition |
| ATP13A2ATPase cation transporting 13A2 | Sometimes (5–29%) | In 1 condition |
| ATXN10ataxin 10 | Sometimes (5–29%) | In 1 condition |
| CHD2chromodomain helicase DNA binding protein 2 | Sometimes (5–29%) | In 1 condition |
| CHMP2Bcharged multivesicular body protein 2B | Sometimes (5–29%) | In 2 conditions |
| CPceruloplasmin | Sometimes (5–29%) | In 1 condition |
| CUX2cut like homeobox 2 | Sometimes (5–29%) | In 1 condition |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Sometimes (5–29%) | In 1 condition |
| DNM1dynamin 1 | Sometimes (5–29%) | In 1 condition |
| EHMT1euchromatic histone lysine methyltransferase 1 | Sometimes (5–29%) | In 2 conditions |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Sometimes (5–29%) | In 1 condition |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Sometimes (5–29%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Sometimes (5–29%) | In 2 conditions |
| GIGYF2GRB10 interacting GYF protein 2 | Sometimes (5–29%) | In 1 condition |
| GRNgranulin precursor | Sometimes (5–29%) | In 2 conditions |
| HTRA1HtrA serine peptidase 1 | Sometimes (5–29%) | In 1 condition |
| MAPK10mitogen-activated protein kinase 10 | Sometimes (5–29%) | In 1 condition |
| PSEN1presenilin 1 | Sometimes (5–29%) | In 3 conditions |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Sometimes (5–29%) | In 1 condition |
| TMEM106Btransmembrane protein 106B | Sometimes (5–29%) | In 1 condition |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| VPS35VPS35 retromer complex component | Sometimes (5–29%) | In 1 condition |
| BMP6bone morphogenetic protein 6 | Rarely (1–4%) | In 1 condition |
| HFEhomeostatic iron regulator | Rarely (1–4%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Rarely (1–4%) | In 1 condition |
| C9orf72C9orf72-SMCR8 complex subunit | Not recorded | In 1 condition |
| DNMT1DNA methyltransferase 1 | Not recorded | In 1 condition |
| GM2Aganglioside GM2 activator | Not recorded | In 1 condition |
| HEXAhexosaminidase subunit alpha | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| JPH3junctophilin 3 | Not recorded | In 1 condition |
| SPASTspastin | Not recorded | In 1 condition |
| TMEM240transmembrane protein 240 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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