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Gene

TP53

tumor protein p53

Summary

Cytogenetic location
17p13.1
Coordinates
Chromosome 17: 7,668,421–7,687,490 (GRCh38)
Exons
11 exons across 19.1 kb
Protein
393 amino acids
Inheritance
Autosomal dominant
Also known as
p53, LFS1
MANE Select transcript
ENST00000269305.9NM_000546.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Kidney Cancer

    • Primary or metastatic malignant neoplasm involving the kidney.

      • 1 GenCC submitter rates it definitive or strong

  • Li-Fraumeni Syndrome

    • Autosomal dominant

      A TP53-related cancer predisposition syndrome with early-onset sarcomas, breast cancer, brain tumours, adrenocortical carcinoma and leukaemia.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list
      What knowing changes

      Whole-body MRI surveillance, minimized radiation exposure, adrenocortical cancer screening, cascade testing, prenatal/preimplantation genetic diagnosis

  • Malignant Endocrine Neoplasm

    • A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma.

      • 1 GenCC submitter rates it definitive or strong

  • Urinary and Renal System Tumour

    • Urinary System Neoplasm

      A benign or malignant, primary or metastatic neoplasm involving the urinary system.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How TP53 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
  • Variants with a page
Chromosome 17, with a bracket where TP53 sits. TP53 and 70 genes near it on chromosome 17, from 7,177,956 to 8,177,955.Chromosome 1717p13.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.37.2 Mb7.4 Mb7.6 Mb7.8 Mb8 MbASGR1: 7,172,427–7,179,666, reverse strandASGR1DLG4: 7,187,187–7,219,836, reverse strandDLG4ACADVL: 7,217,125–7,225,273, forward strandDVL2: 7,225,338–7,234,538, reverse strandPHF23: 7,235,029–7,239,722, reverse strandGABARAP: 7,240,008–7,242,486, reverse strand: 7,240,427–7,244,635, reverse strandCTDNEP1: 7,243,583–7,252,841, reverse strand: 7,246,829–7,262,089, reverse strandELP5: 7,250,818–7,260,165, forward strandELP5CLDN7: 7,257,359–7,264,016, reverse strandCLDN7SLC2A4: 7,281,664–7,289,241, forward strandYBX2: 7,288,253–7,294,750, reverse strandYBX2EIF5A: 7,306,944–7,312,506, forward strandGPS2: 7,309,470–7,315,564, reverse strand: 7,312,661–7,319,174, reverse strandNEURL4: 7,315,628–7,329,393, reverse strandNEURL4ACAP1: 7,332,960–7,351,478, forward strandKCTD11: 7,351,889–7,354,944, forward strandKCTD11TMEM95: 7,355,123–7,357,219, forward strandTMEM95TNK1: 7,380,534–7,389,779, forward strandTNK1PLSCR3: 7,389,727–7,397,054, reverse strandPLSCR3TMEM256-PLSCR3: 7,389,734–7,404,097, reverse strandTMEM256: 7,402,774–7,404,138, reverse strandNLGN2: 7,404,684–7,419,860, forward strandSPEM1: 7,420,323–7,421,637, forward strandSPEM2: 7,425,563–7,427,568, forward strandSPEM3: 7,428,857–7,432,820, forward strand: 7,428,861–7,436,278, forward strandTMEM102: 7,435,344–7,437,679, forward strandFGF11: 7,438,128–7,444,937, forward strandFGF11CHRNB1: 7,445,004–7,457,710, forward strandCHRNB1ZBTB4: 7,459,366–7,484,278, reverse strandZBTB4SLC35G6: 7,481,446–7,483,496, forward strandSLC35G6POLR2A: 7,484,366–7,514,616, forward strandPOLR2ATNFSF12: 7,548,508–7,557,890, forward strandTNFSF12-TNFSF13: 7,549,099–7,561,601, forward strandTNFSF13: 7,558,251–7,561,660, forward strandSENP3: 7,561,867–7,571,969, forward strandSENP3-EIF4A1: 7,563,287–7,578,715, forward strandEIF4A1: 7,572,718–7,579,007, forward strandCD68: 7,579,380–7,582,515, forward strandMPDU1: 7,583,214–7,594,419, forward strandSOX15: 7,588,178–7,590,101, reverse strandSOX15FXR2: 7,591,230–7,614,916, reverse strandFXR2SHBG: 7,613,946–7,633,469, forward strandSHBGSAT2: 7,626,234–7,627,879, reverse strandSAT2ATP1B2: 7,646,627–7,657,771, forward strandATP1B2TP53: 7,668,421–7,687,490, reverse strandTP53WRAP53: 7,686,071–7,703,505, forward strandWRAP53EFNB3: 7,705,172–7,711,372, forward strandEFNB3DNAH2: 7,717,728–7,833,742, forward strandDNAH2KDM6B: 7,834,193–7,854,808, forward strandKDM6BTMEM88: 7,855,057–7,856,114, forward strandTMEM88NAA38: 7,856,681–7,885,238, reverse strandNAA38CYB5D1: 7,857,696–7,862,282, forward strandCYB5D1CHD3: 7,884,787–7,912,760, forward strandCHD3RNF227: 7,913,238–7,916,377, reverse strandKCNAB3: 7,920,956–7,929,856, reverse strandKCNAB3: 7,925,931–7,930,622, reverse strandTRAPPC1: 7,930,345–7,932,123, reverse strandTRAPPC1CNTROB: 7,932,101–7,949,953, forward strandGUCY2D: 8,002,615–8,020,342, forward strandGUCY2DALOX15B: 8,039,011–8,049,134, forward strandALOX15BALOX12B: 8,068,594–8,087,716, reverse strandALOX12BALOXE3: 8,095,900–8,119,047, reverse strandALOXE3HES7: 8,120,592–8,124,114, reverse strandHES7PER1: 8,140,467–8,156,506, reverse strandPER1: 8,150,816–8,162,975, reverse strandVAMP2: 8,159,149–8,163,584, reverse strandVAMP2TMEM107: 8,172,440–8,176,408, reverse strandTMEM107Diagram of TP53: 11 exons on the reverse strand of chromosome 17Exon 11: 2 known disease-causing sitesExon 10: 34 known disease-causing sitesExon 9: 24 known disease-causing sitesExon 8: 87 known disease-causing sitesExon 7: 72 known disease-causing sitesExon 6: 65 known disease-causing sitesExon 5: 118 known disease-causing sitesExon 4: 115 known disease-causing sitesExon 3: 10 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 11: 7,668,421–7,669,690, 1,270 bases. 2 variants with a page in exon 11. List themExon 10: 7,670,609–7,670,715, 107 bases. 13 variants with a page in exon 10. List themExon 9: 7,673,535–7,673,608, 74 bases. 4 variants with a page in exon 9. List themExon 8: 7,673,701–7,673,837, 137 bases. 25 variants with a page in exon 8. List themExon 7: 7,674,181–7,674,290, 110 bases. 20 variants with a page in exon 7. List themExon 6: 7,674,859–7,674,971, 113 bases. 18 variants with a page in exon 6. List themExon 5: 7,675,053–7,675,236, 184 bases. 39 variants with a page in exon 5. List themExon 4: 7,675,994–7,676,272, 279 bases. 23 variants with a page in exon 4. List themExon 3: 7,676,382–7,676,403, 22 bases. 1 variant with a page in exon 3. List themExon 2: 7,676,521–7,676,622, 102 bases. 1 variant with a page in exon 2. List themExon 1: 7,687,377–7,687,490, 114 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 19.1 kb; 1,182 of those bases code for the protein.

How a genome test reads TP53

596

positions in TP53 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 19.1 kb of TP53, introns included, not only the 2.5 kb of exons.

Variants with a page (162)

The TP53 variants with a page here, most review stars first. Each page describes ClinVar's public record of the variant, never a result.

VariantHGVS c.Exon or intronPosition (GRCh38)ClinVar classificationReview status
A138Pc.412G>CExon 57,675,200Likely pathogenic3 stars out of 4 reviewed by expert panel
A138Vc.413C>TExon 57,675,199Likely pathogenic3 stars out of 4 reviewed by expert panel
A161_Y163delinsDc.482_487delExon 57,675,124Likely pathogenic3 stars out of 4 reviewed by expert panel
A347Dc.1040C>AExon 107,670,669Pathogenic3 stars out of 4 reviewed by expert panel
c.-29+1G>TIntron 17,687,376Likely pathogenic3 stars out of 4 reviewed by expert panel
c.97-1G>AIntron 37,676,273Pathogenic3 stars out of 4 reviewed by expert panel
c.375+5G>AIntron 47,675,989Likely pathogenic3 stars out of 4 reviewed by expert panel
c.919+1G>AIntron 87,673,700Pathogenic3 stars out of 4 reviewed by expert panel
c.993+1delIntron 97,673,533Likely pathogenic3 stars out of 4 reviewed by expert panel
C124Xc.372C>AExon 47,675,997Pathogenic3 stars out of 4 reviewed by expert panel

See all 162 TP53 variants →

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TP53 gene: tumor protein p53. Retrieved 16 October 2026, from https://dantelabs.com/genes/tp53

Vancouver

Dante Labs. TP53 gene: tumor protein p53 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tp53

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