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Gene

SDHA

succinate dehydrogenase complex flavoprotein subunit A

Summary

Cytogenetic location
5p15.33
Coordinates
Chromosome 5: 218,320–257,082 (GRCh38)
Exons
15 exons across 38.8 kb
Protein
664 amino acids
Inheritance
Autosomal dominant
Also known as
FP, SDHF
Previous symbols
SDH2
MANE Select transcript
ENST00000264932.11NM_004168.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hereditary Pheochromocytoma and Paraganglioma

    • Hereditary pheochromocytoma-paragangliomaAutosomal dominant

      A group of syndromes (PPGL types 1-7, TMEM127- and MAX-related) in which variants in SDHB, SDHD, SDHC, SDHA, SDHAF2, MAX or TMEM127 raise the risk of pheochromocytoma and paraganglioma.

      • ClinGen rates the link definitive
      • 6 GenCC submitters rate it definitive or strong
      What knowing changes

      Regular blood or urine metanephrine testing and periodic whole-body MRI help find tumours early, before they cause blood-pressure crises; relatives can be offered testing.

  • Malignant Endocrine Neoplasm

    • A malignant neoplasm affecting the endocrine glands. Representative examples include thyroid gland carcinoma, parathyroid gland carcinoma, pituitary gland carcinoma, and adrenal cortex carcinoma.

      • 5 GenCC submitters rate it definitive or strong

  • Urinary and Renal System Tumour

    • Urinary System Neoplasm

      A benign or malignant, primary or metastatic neoplasm involving the urinary system.

      • 5 GenCC submitters rate it definitive or strong

Broader groupings

  • Leigh Syndrome

    • One of 69 genes linked to it

      A progressive neurological disease defined by specific neuropathological features associating brainstem and basal ganglia lesions.

      • ClinGen rates the link moderate

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How SDHA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where SDHA sits. SDHA and 12 genes near it on chromosome 5, from 1 to 737,700.Chromosome 55p15.33p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.30.1 Mb0.2 Mb0.3 Mb0.4 Mb0.5 Mb0.6 Mb0.7 MbPLEKHG4B: 92,001–189,972, forward strandPLEKHG4BLRRC14B: 191,451–196,334, forward strandLRRC14BCCDC127: 196,868–218,162, reverse strandCCDC127: 218,298–314,955, forward strandSDHA: 218,320–257,082, forward strandSDHAPDCD6: 271,452–314,978, forward strandPDCD6PDCD6-AHRR: 271,670–438,291, forward strandPDCD6-AHRRAHRR: 320,682–438,307, forward strandAHRREXOC3: 442,522–471,939, forward strandEXOC3SLC9A3: 470,456–524,450, reverse strandSLC9A3CEP72: 612,305–667,703, forward strandCEP72TPPP: 658,850–693,997, reverse strandTPPPZDHHC11B: 710,355–784,729, reverse strandZDHHC11BDiagram of SDHA: 15 exons on the forward strand of chromosome 5Exon 1: 14 known disease-causing sitesExon 2: 13 known disease-causing sitesExon 3: 21 known disease-causing sitesExon 4: 18 known disease-causing sitesExon 5: 18 known disease-causing sitesExon 6: 16 known disease-causing sitesExon 7: 12 known disease-causing sitesExon 8: 30 known disease-causing sitesExon 9: 18 known disease-causing sitesExon 10: 25 known disease-causing sitesExon 11: 12 known disease-causing sitesExon 12: 16 known disease-causing sitesExon 13: 23 known disease-causing sitesExon 14: 14 known disease-causing sitesExon 1: 218,320–218,418, 99 basesExon 2: 223,482–223,568, 87 basesExon 3: 224,360–224,521, 162 basesExon 4: 225,419–225,562, 144 basesExon 5: 225,883–226,047, 165 basesExon 6: 228,185–228,333, 149 basesExon 7: 230,876–231,000, 125 basesExon 8: 233,477–233,645, 169 basesExon 9: 235,144–235,339, 196 basesExon 10: 236,428–236,599, 172 basesExon 11: 240,358–240,476, 119 basesExon 12: 250,992–251,103, 112 basesExon 13: 251,338–251,468, 131 basesExon 14: 254,393–254,506, 114 basesExon 15: 256,334–257,082, 749 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 38.8 kb; 1,995 of those bases code for the protein.

How a genome test reads SDHA

306

positions in SDHA where ClinVar classes a change as pathogenic or likely pathogenic

306 of them (100%) fall in regions short reads find hard.

  • Low mappability (110 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (306 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 38.8 kb of SDHA, introns included, not only the 2.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SDHA gene: succinate dehydrogenase complex flavoprotein subunit A. Retrieved 17 October 2026, from https://dantelabs.com/genes/sdha

Vancouver

Dante Labs. SDHA gene: succinate dehydrogenase complex flavoprotein subunit A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/sdha

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