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Gene

ALOX12B

arachidonate 12-lipoxygenase, 12R type

Summary

Cytogenetic location
17p13.1
Coordinates
Chromosome 17: 8,072,636–8,087,716 (GRCh38)
Exons
15 exons across 15.1 kb
Protein
701 amino acids
Also known as
12R-LOX
MANE Select transcript
ENST00000647874.1NM_001139.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Inherited Ichthyoses

    • Autosomal recessive congenital ichthyosisAutosomal recessive

      A group of recessive ichthyoses, including harlequin ichthyosis and lamellar ichthyosis, usually present at birth, often with a collodion membrane.

      • 4 GenCC submitters rate it definitive or strong
      Actionability

      Early diagnosis guides neonatal care, emollient and keratolytic regimens, and heat-intolerance precautions.

How ALOX12B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where ALOX12B sits. ALOX12B and 43 genes near it on chromosome 17, from 7,580,176 to 8,580,175.Chromosome 1717p13.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.37.6 Mb7.8 Mb8 Mb8.2 Mb8.4 MbCD68: 7,579,380–7,582,515, forward strandMPDU1: 7,583,214–7,594,419, forward strandSOX15: 7,588,178–7,590,101, reverse strandSOX15FXR2: 7,591,230–7,614,916, reverse strandFXR2SHBG: 7,613,946–7,633,469, forward strandSHBGSAT2: 7,626,234–7,627,879, reverse strandSAT2ATP1B2: 7,646,627–7,657,771, forward strandATP1B2TP53: 7,661,779–7,687,546, reverse strandTP53WRAP53: 7,686,071–7,703,505, forward strandWRAP53EFNB3: 7,705,172–7,711,372, forward strandEFNB3DNAH2: 7,717,728–7,833,742, forward strandDNAH2KDM6B: 7,834,193–7,854,808, forward strandKDM6BTMEM88: 7,855,057–7,856,114, forward strandTMEM88NAA38: 7,856,681–7,885,238, reverse strandNAA38CYB5D1: 7,857,696–7,862,282, forward strandCYB5D1CHD3: 7,884,787–7,912,760, forward strandRNF227: 7,913,238–7,916,377, reverse strandKCNAB3: 7,920,956–7,929,856, reverse strandKCNAB3: 7,925,931–7,930,622, reverse strandTRAPPC1: 7,930,345–7,932,123, reverse strandTRAPPC1CNTROB: 7,932,101–7,949,953, forward strandCNTROBGUCY2D: 8,002,615–8,020,342, forward strandGUCY2DALOX15B: 8,039,011–8,049,134, forward strandALOX15BALOX12B: 8,072,636–8,087,716, reverse strandALOX12BALOXE3: 8,095,900–8,119,047, reverse strandALOXE3HES7: 8,120,592–8,124,114, reverse strandHES7PER1: 8,140,467–8,156,506, reverse strandPER1: 8,150,816–8,162,975, reverse strandVAMP2: 8,159,149–8,163,584, reverse strandVAMP2TMEM107: 8,172,440–8,176,408, reverse strandBORCS6: 8,188,345–8,190,180, reverse strandBORCS6AURKB: 8,204,335–8,210,638, reverse strandAURKBCTC1: 8,224,815–8,248,075, reverse strandCTC1PFAS: 8,247,618–8,271,150, forward strandPFASSLC25A35: 8,287,762–8,295,410, reverse strandSLC25A35RANGRF: 8,288,631–8,290,092, forward strandRANGRFARHGEF15: 8,310,222–8,323,203, forward strandARHGEF15ODF4: 8,339,840–8,346,048, forward strandODF4KRABD2: 8,356,902–8,376,738, reverse strandKRABD2: 8,368,638–8,383,187, reverse strandRPL26: 8,377,500–8,384,062, reverse strandRNF222: 8,390,702–8,397,827, reverse strandRNF222NDEL1: 8,408,528–8,501,107, forward strandNDEL1MYH10: 8,474,205–8,632,303, reverse strandMYH10Diagram of ALOX12B: 15 exons on the reverse strand of chromosome 17Exon 14: 4 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 12: 4 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 9: 7 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 6 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 15: 8,072,636–8,072,950, 315 basesExon 14: 8,073,148–8,073,318, 171 basesExon 13: 8,073,657–8,073,757, 101 basesExon 12: 8,075,595–8,075,716, 122 basesExon 11: 8,076,175–8,076,344, 170 basesExon 10: 8,076,657–8,076,743, 87 basesExon 9: 8,076,990–8,077,193, 204 basesExon 8: 8,079,396–8,079,539, 144 basesExon 7: 8,079,769–8,079,941, 173 basesExon 6: 8,080,235–8,080,338, 104 basesExon 5: 8,080,658–8,080,780, 123 basesExon 4: 8,080,884–8,080,976, 93 basesExon 3: 8,081,106–8,081,187, 82 basesExon 2: 8,086,016–8,086,220, 205 basesExon 1: 8,087,296–8,087,716, 421 bases15141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 15.1 kb; 2,106 of those bases code for the protein.

Sequencing ALOX12B

43

positions in ALOX12B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 15.1 kb of ALOX12B, introns included, not only the 2.5 kb of exons.

Genes linked to the same conditions

Traits linked to ALOX12B

The Human Phenotype Ontology lists these as features of the rare conditions ALOX12B can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ALOX12B gene: arachidonate 12-lipoxygenase, 12R type. Retrieved 17 October 2026, from https://dantelabs.com/genes/alox12b

Vancouver

Dante Labs. ALOX12B gene: arachidonate 12-lipoxygenase, 12R type [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/alox12b

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