Trait
Testicular degeneration
Clinical name: Testicular atrophy
Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility.
Summary
- Body system
- Abnormality of the genitourinary system
Reference genomeGRCh38hg38
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Get my Genome Test16 genes linked to Testicular degeneration
Changes in these genes cause rare conditions in which Testicular degeneration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FGD1FYVE, RhoGEF and PH domain containing 1 | Always | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Always | In 1 condition |
| FSHBfollicle stimulating hormone subunit beta | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| ARandrogen receptor | Sometimes (5–29%) | In 2 conditions |
| BMP6bone morphogenetic protein 6 | Sometimes (5–29%) | In 1 condition |
| HFEhomeostatic iron regulator | Sometimes (5–29%) | In 2 conditions |
| SMSspermine synthase | Sometimes (5–29%) | In 1 condition |
| TEX11testis expressed 11 | Sometimes (5–29%) | In 1 condition |
| ANOS1anosmin 1 | Not recorded | In 1 condition |
| BMP2bone morphogenetic protein 2 | Not recorded | In 1 condition |
| DMPKDM1 protein kinase | Not recorded | In 1 condition |
| HPRT1hypoxanthine phosphoribosyltransferase 1 | Not recorded | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Not recorded | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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