Trait
Pins and needles feeling
Clinical name: Paresthesia
Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause.
Summary
- Also called
- Tingling, Paresthesias
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test127 genes linked to Pins and needles feeling
Changes in these genes cause rare conditions in which Pins and needles feeling is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| LAMB1laminin subunit beta 1 | Always | In 1 condition |
| RAB32RAB32, member RAS oncogene family | Always | In 1 condition |
| APPamyloid beta precursor protein | Very often (80–99%) | In 2 conditions |
| CALRcalreticulin | Very often (80–99%) | In 1 condition |
| CASRcalcium sensing receptor | Very often (80–99%) | In 2 conditions |
| CTDP1CTD phosphatase 1 | Very often (80–99%) | In 1 condition |
| GNA11G protein subunit alpha 11 | Very often (80–99%) | In 2 conditions |
| JAK2Janus kinase 2 | Very often (80–99%) | In 3 conditions |
| LIFRLIF receptor subunit alpha | Very often (80–99%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Very often (80–99%) | In 2 conditions |
| SERPING1serpin family G member 1 | Very often (80–99%) | In 1 condition |
| SH2B3SH2B adaptor protein 3 | Very often (80–99%) | In 1 condition |
| SLC19A2solute carrier family 19 member 2 | Very often (80–99%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Often (30–79%) | In 1 condition |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Often (30–79%) | In 2 conditions |
| CCM2CCM2 scaffold protein | Often (30–79%) | In 1 condition |
| GBE11,4-alpha-glucan branching enzyme 1 | Often (30–79%) | In 1 condition |
| GPR101G protein-coupled receptor 101 | Often (30–79%) | In 1 condition |
| KRIT1KRIT1 ankyrin repeat containing | Often (30–79%) | In 1 condition |
| KRT14keratin 14 | Often (30–79%) | In 1 condition |
| KRT5keratin 5 | Often (30–79%) | In 1 condition |
| LIG3DNA ligase 3 | Often (30–79%) | In 1 condition |
| LITAFlipopolysaccharide induced TNF factor | Often (30–79%) | In 1 condition |
| MFN2mitofusin 2 | Often (30–79%) | In 2 conditions |
| OPA3outer mitochondrial membrane lipid metabolism regulator OPA3 | Often (30–79%) | In 1 condition |
| PDCD10programmed cell death 10 | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 2 conditions |
| PMP22peripheral myelin protein 22 | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 2 conditions |
| PRNPprion protein (Kanno blood group) | Often (30–79%) | In 1 condition |
| PRRT2proline rich transmembrane protein 2 | Often (30–79%) | In 2 conditions |
| RRM1ribonucleotide reductase catalytic subunit M1 | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Often (30–79%) | In 1 condition |
| SCYL1SCY1 like pseudokinase 1 | Often (30–79%) | In 2 conditions |
| SEPTIN9septin 9 | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 3 conditions |
Show 87 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| THPOthrombopoietin | Often (30–79%) | In 1 condition |
| TK2thymidine kinase 2 | Often (30–79%) | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Often (30–79%) | In 1 condition |
| TRIM32tripartite motif containing 32 | Often (30–79%) | In 1 condition |
| TYMPthymidine phosphorylase | Often (30–79%) | In 1 condition |
| ATMATM serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| ATXN1ataxin 1 | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CBLIFcobalamin binding intrinsic factor | Sometimes (5–29%) | In 2 conditions |
| CCND1cyclin D1 | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Sometimes (5–29%) | In 1 condition |
| COQ6coenzyme Q6, monooxygenase | Sometimes (5–29%) | In 1 condition |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Sometimes (5–29%) | In 1 condition |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Sometimes (5–29%) | In 1 condition |
| GNA14G protein subunit alpha 14 | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 4 conditions |
| GRIN2Aglutamate ionotropic receptor NMDA type subunit 2A | Sometimes (5–29%) | In 1 condition |
| HINT1histidine triad nucleotide binding protein 1 | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 2 conditions |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Sometimes (5–29%) | In 2 conditions |
| HPDL4-hydroxyphenylpyruvate dioxygenase like | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| KIF5Akinesin family member 5A | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| MEN1menin 1 | Sometimes (5–29%) | In 1 condition |
| MLH1mutL homolog 1 | Sometimes (5–29%) | In 1 condition |
| MSH2mutS homolog 2 | Sometimes (5–29%) | In 1 condition |
| MSH6mutS homolog 6 | Sometimes (5–29%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Sometimes (5–29%) | In 1 condition |
| NAGAalpha-N-acetylgalactosaminidase | Sometimes (5–29%) | In 1 condition |
| NEFLneurofilament light chain | Sometimes (5–29%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Sometimes (5–29%) | In 1 condition |
| NPATnuclear protein, coactivator of histone transcription | Sometimes (5–29%) | In 1 condition |
| NPRL2NPR2 like, GATOR1 complex subunit | Sometimes (5–29%) | In 1 condition |
| NPRL3NPR3 like, GATOR1 complex subunit | Sometimes (5–29%) | In 1 condition |
| P4HA2prolyl 4-hydroxylase subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PMS1PMS1 homolog 1, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 1 condition |
| RPS20ribosomal protein S20 | Sometimes (5–29%) | In 1 condition |
| SBF2SET binding factor 2 | Sometimes (5–29%) | In 1 condition |
| SCN3Asodium voltage-gated channel alpha subunit 3 | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 1 condition |
| SEMA4Asemaphorin 4A | Sometimes (5–29%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Sometimes (5–29%) | In 1 condition |
| SRPX2sushi repeat containing protein X-linked 2 | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| STX16syntaxin 16 | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| VCPvalosin containing protein | Sometimes (5–29%) | In 1 condition |
| VWA1von Willebrand factor A domain containing 1 | Sometimes (5–29%) | In 1 condition |
| YY1YY1 transcription factor | Sometimes (5–29%) | In 1 condition |
| CLCNKBchloride voltage-gated channel Kb | Rarely (1–4%) | In 1 condition |
| GATA1GATA binding protein 1 | Rarely (1–4%) | In 1 condition |
| SLC12A3solute carrier family 12 member 3 | Rarely (1–4%) | In 2 conditions |
| TRAPPC2trafficking protein particle complex subunit 2 | Rarely (1–4%) | In 1 condition |
| URODuroporphyrinogen decarboxylase | Rarely (1–4%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Rarely (1–4%) | In 1 condition |
| ALADaminolevulinate dehydratase | Not recorded | In 1 condition |
| ATL1atlastin GTPase 1 | Not recorded | In 1 condition |
| CUBNcubilin | Not recorded | In 1 condition |
| GLAgalactosidase alpha | Not recorded | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Not recorded | In 1 condition |
| HMBShydroxymethylbilane synthase | Not recorded | In 1 condition |
| KCNJ1potassium inwardly rectifying channel subfamily J member 1 | Not recorded | In 1 condition |
| MTHFRmethylenetetrahydrofolate reductase | Not recorded | In 1 condition |
| NAGLUN-acetyl-alpha-glucosaminidase | Not recorded | In 1 condition |
| SLC12A1solute carrier family 12 member 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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