Trait
Acute blood cancer
Clinical name: Acute leukemia
A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).
Summary
- Also called
- Acute leukaemia, Acute leukemias
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test21 genes linked to Acute blood cancer
Changes in these genes cause rare conditions in which Acute blood cancer is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GATA2GATA binding protein 2 | Very often (80–99%) | In 1 condition |
| JAK2Janus kinase 2 | Very often (80–99%) | In 2 conditions |
| LIG4DNA ligase 4 | Often (30–79%) | In 1 condition |
| ATRXATRX chromatin remodeler | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| DYNC2LI1dynein cytoplasmic 2 light intermediate chain 1 | Sometimes (5–29%) | In 1 condition |
| EVCEvC ciliary complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| EVC2EvC ciliary complex subunit 2 | Sometimes (5–29%) | In 1 condition |
| GLI1GLI family zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Sometimes (5–29%) | In 1 condition |
| NBNnibrin | Sometimes (5–29%) | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Sometimes (5–29%) | In 1 condition |
| PRKACAprotein kinase cAMP-activated catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PRKACBprotein kinase cAMP-activated catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| SH2B3SH2B adaptor protein 3 | Sometimes (5–29%) | In 1 condition |
| STSsteroid sulfatase | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TP53tumor protein p53 | Sometimes (5–29%) | In 2 conditions |
| TREM2triggering receptor expressed on myeloid cells 2 | Sometimes (5–29%) | In 1 condition |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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