Trait
Decreased immune function
Clinical name: Immunodeficiency
Failure of the immune system to protect the body adequately from infection, due to the absence or insufficiency of some component process or substance.
Summary
- Also called
- Immune deficiency
- Body system
- Abnormality of the immune system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Decreased immune function, and the rest of your genome, with one test.
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Get my Genome Test173 genes linked to Decreased immune function
Changes in these genes cause rare conditions in which Decreased immune function is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AK2adenylate kinase 2 | Always | In 1 condition |
| AP3D1adaptor related protein complex 3 subunit delta 1 | Always | In 1 condition |
| ARPC5actin related protein 2/3 complex subunit 5 | Always | In 1 condition |
| CARD11caspase recruitment domain family member 11 | Always | In 1 condition |
| CD3ECD3 epsilon subunit of T-cell receptor complex | Always | In 1 condition |
| CORO1Acoronin 1A | Always | In 1 condition |
| DCLRE1BDNA cross-link repair 1B | Always | In 1 condition |
| DCLRE1CDNA cross-link repair 1C | Always | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Always | In 1 condition |
| GATA2GATA binding protein 2 | Always | In 1 condition |
| GUK1guanylate kinase 1 | Always | In 1 condition |
| HYOU1hypoxia up-regulated 1 | Always | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Always | In 2 conditions |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| LCKLCK proto-oncogene, Src family tyrosine kinase | Always | In 1 condition |
| LCP2lymphocyte cytosolic protein 2 | Always | In 1 condition |
| MALT1MALT1 paracaspase | Always | In 1 condition |
| MAN2B2mannosidase alpha class 2B member 2 | Always | In 1 condition |
| MCM10minichromosome maintenance 10 replication initiation factor | Always | In 1 condition |
| NHEJ1non-homologous end joining factor 1 | Always | In 2 conditions |
| PTCRApre T cell antigen receptor alpha | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 2 conditions |
| RAG2recombination activating 2 | Always | In 1 condition |
| RNF31ring finger protein 31 | Always | In 1 condition |
| SIK3SIK family kinase 3 | Always | In 1 condition |
| SLC19A1solute carrier family 19 member 1 | Always | In 1 condition |
| STAT1signal transducer and activator of transcription 1 | Always | In 3 conditions |
| STIM1stromal interaction molecule 1 | Always | In 1 condition |
| STK4serine/threonine kinase 4 | Always | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Very often (80–99%) | In 1 condition |
| ACTBactin beta | Very often (80–99%) | In 1 condition |
| AGLamylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase | Very often (80–99%) | In 1 condition |
| ANTXR2ANTXR cell adhesion molecule 2 | Very often (80–99%) | In 1 condition |
| ARVCFARVCF delta catenin family member | Very often (80–99%) | In 1 condition |
| ATMATM serine/threonine kinase | Very often (80–99%) | In 1 condition |
| BLNKB cell linker | Very often (80–99%) | In 1 condition |
| BTKBruton tyrosine kinase | Very often (80–99%) | In 1 condition |
| CD79ACD79a molecule | Very often (80–99%) | In 1 condition |
| CD79BCD79b molecule | Very often (80–99%) | In 1 condition |
Show 133 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDCA7cell division cycle associated 7 | Very often (80–99%) | In 1 condition |
| COMTcatechol-O-methyltransferase | Very often (80–99%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Very often (80–99%) | In 2 conditions |
| DNMT3BDNA methyltransferase 3 beta | Very often (80–99%) | In 2 conditions |
| FOXN1forkhead box N1 | Very often (80–99%) | In 1 condition |
| GP1BBglycoprotein Ib platelet subunit beta | Very often (80–99%) | In 1 condition |
| HELLShelicase, lymphoid specific | Very often (80–99%) | In 1 condition |
| HIRAhistone cell cycle regulator | Very often (80–99%) | In 1 condition |
| IGHMimmunoglobulin heavy constant mu | Very often (80–99%) | In 1 condition |
| IGLL1immunoglobulin lambda like polypeptide 1 | Very often (80–99%) | In 1 condition |
| IL12RB1interleukin 12 receptor subunit beta 1 | Very often (80–99%) | In 2 conditions |
| IRAK4interleukin 1 receptor associated kinase 4 | Very often (80–99%) | In 2 conditions |
| JMJD1Cjumonji domain containing 1C | Very often (80–99%) | In 1 condition |
| LAMTOR2late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 | Very often (80–99%) | In 2 conditions |
| LIG4DNA ligase 4 | Very often (80–99%) | In 1 condition |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Very often (80–99%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Very often (80–99%) | In 2 conditions |
| MAN2B1mannosidase alpha class 2B member 1 | Very often (80–99%) | In 2 conditions |
| MYD88MYD88 innate immune signal transduction adaptor | Very often (80–99%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Very often (80–99%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Very often (80–99%) | In 2 conditions |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Very often (80–99%) | In 2 conditions |
| POLEDNA polymerase epsilon, catalytic subunit | Very often (80–99%) | In 2 conditions |
| RAB27ARAB27A, member RAS oncogene family | Very often (80–99%) | In 1 condition |
| RAC2Rac family small GTPase 2 | Very often (80–99%) | In 1 condition |
| RNF168ring finger protein 168 | Very often (80–99%) | In 2 conditions |
| RREB1ras responsive element binding protein 1 | Very often (80–99%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Very often (80–99%) | In 2 conditions |
| SEC24CSEC24 homolog C, COPII component | Very often (80–99%) | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Very often (80–99%) | In 2 conditions |
| SKIC3SKI3 subunit of superkiller complex | Very often (80–99%) | In 1 condition |
| SPI1Spi-1 proto-oncogene | Very often (80–99%) | In 1 condition |
| TBX1T-box transcription factor 1 | Very often (80–99%) | In 1 condition |
| TCF3transcription factor 3 | Very often (80–99%) | In 1 condition |
| TERCtelomerase RNA component | Very often (80–99%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Very often (80–99%) | In 1 condition |
| TINF2TERF1 interacting nuclear factor 2 | Very often (80–99%) | In 1 condition |
| UFD1ubiquitin recognition factor in ER associated degradation 1 | Very often (80–99%) | In 1 condition |
| UHRF1ubiquitin like with PHD and ring finger domains 1 | Very often (80–99%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Very often (80–99%) | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Very often (80–99%) | In 3 conditions |
| ZBTB24zinc finger and BTB domain containing 24 | Very often (80–99%) | In 2 conditions |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| AFG2AAAA ATPase AFG2A | Often (30–79%) | In 2 conditions |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 2 conditions |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| CCDC47coiled-coil domain containing 47 | Often (30–79%) | In 1 condition |
| CD28CD28 molecule | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
| CHD1chromodomain helicase DNA binding protein 1 | Often (30–79%) | In 2 conditions |
| CPLX1complexin 1 | Often (30–79%) | In 1 condition |
| CTBP1C-terminal binding protein 1 | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 2 conditions |
| FGFRL1fibroblast growth factor receptor like 1 | Often (30–79%) | In 1 condition |
| LETM1leucine zipper and EF-hand containing transmembrane protein 1 | Often (30–79%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Often (30–79%) | In 1 condition |
| MMUTmethylmalonyl-CoA mutase | Often (30–79%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Often (30–79%) | In 1 condition |
| NSD2nuclear receptor binding SET domain protein 2 | Often (30–79%) | In 1 condition |
| PI4KAphosphatidylinositol 4-kinase alpha | Often (30–79%) | In 2 conditions |
| RNU6ATACRNA, U6atac small nuclear | Often (30–79%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Often (30–79%) | In 1 condition |
| TOP2BDNA topoisomerase II beta | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TTC7Atetratricopeptide repeat domain 7A | Often (30–79%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 1 condition |
| ALG1ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Sometimes (5–29%) | In 1 condition |
| CDC42cell division cycle 42 | Sometimes (5–29%) | In 2 conditions |
| CRKLCRK like proto-oncogene, adaptor protein | Sometimes (5–29%) | In 1 condition |
| CUL4Bcullin 4B | Sometimes (5–29%) | In 1 condition |
| LMNB2lamin B2 | Sometimes (5–29%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Sometimes (5–29%) | In 1 condition |
| MEIS2Meis homeobox 2 | Sometimes (5–29%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Sometimes (5–29%) | In 1 condition |
| SLC46A1solute carrier family 46 member 1 | Sometimes (5–29%) | In 1 condition |
| TBK1TANK binding kinase 1 | Sometimes (5–29%) | In 1 condition |
| TICAM1TIR domain containing adaptor molecule 1 | Sometimes (5–29%) | In 1 condition |
| TLR3toll like receptor 3 | Sometimes (5–29%) | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Sometimes (5–29%) | In 1 condition |
| UNC93B1unc-93B1 regulator of TLR signaling | Sometimes (5–29%) | In 1 condition |
| ZNF699zinc finger protein 699 | Sometimes (5–29%) | In 1 condition |
| AMNamnion associated transmembrane protein | Rarely (1–4%) | In 1 condition |
| CUBNcubilin | Rarely (1–4%) | In 1 condition |
| DNAJC21DnaJ heat shock protein family (Hsp40) member C21 | Rarely (1–4%) | In 1 condition |
| EFL1elongation factor like GTPase 1 | Rarely (1–4%) | In 1 condition |
| SBDSSBDS ribosome maturation factor | Rarely (1–4%) | In 1 condition |
| AICDAactivation induced cytidine deaminase | Not recorded | In 1 condition |
| BCL10BCL10 immune signaling adaptor | Not recorded | In 1 condition |
| CARD9caspase recruitment domain family member 9 | Not recorded | In 1 condition |
| CD247CD247 molecule | Not recorded | In 1 condition |
| CD3GCD3 gamma subunit of T-cell receptor complex | Not recorded | In 1 condition |
| CD40CD40 molecule | Not recorded | In 1 condition |
| CD40LGCD40 ligand | Not recorded | In 1 condition |
| CTPS1CTP synthase 1 | Not recorded | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Not recorded | In 1 condition |
| CYBBcytochrome b-245 beta chain | Not recorded | In 1 condition |
| EPG5ectopic P-granules 5 autophagy tethering factor | Not recorded | In 1 condition |
| FCGR3AFc gamma receptor IIIa | Not recorded | In 1 condition |
| ICOSinducible T cell costimulator | Not recorded | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Not recorded | In 1 condition |
| IFNGR2interferon gamma receptor 2 | Not recorded | In 1 condition |
| IKBKBinhibitor of nuclear factor kappa B kinase subunit beta | Not recorded | In 1 condition |
| IL12Binterleukin 12B | Not recorded | In 1 condition |
| IL21Rinterleukin 21 receptor | Not recorded | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Not recorded | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Not recorded | In 1 condition |
| IRF7interferon regulatory factor 7 | Not recorded | In 1 condition |
| IRF8interferon regulatory factor 8 | Not recorded | In 2 conditions |
| ISG15ISG15 ubiquitin like modifier | Not recorded | In 1 condition |
| IVNS1ABPinfluenza virus NS1A binding protein | Not recorded | In 1 condition |
| LATlinker for activation of T cells | Not recorded | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Not recorded | In 1 condition |
| MAGT1magnesium transporter 1 | Not recorded | In 1 condition |
| MYCMYC proto-oncogene, bHLH transcription factor | Not recorded | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Not recorded | In 1 condition |
| NCF2neutrophil cytosolic factor 2 | Not recorded | In 1 condition |
| NFE2L2NFE2 like bZIP transcription factor 2 | Not recorded | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Not recorded | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Not recorded | In 1 condition |
| PGM3phosphoglucomutase 3 | Not recorded | In 1 condition |
| PRPS1phosphoribosyl pyrophosphate synthetase 1 | Not recorded | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Not recorded | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Not recorded | In 1 condition |
| SH2D1ASH2 domain containing 1A | Not recorded | In 1 condition |
| SP110SP110 nuclear body protein | Not recorded | In 1 condition |
| TFRCtransferrin receptor | Not recorded | In 1 condition |
| TNFRSF4TNF receptor superfamily member 4 | Not recorded | In 1 condition |
| TYK2tyrosine kinase 2 | Not recorded | In 1 condition |
| UNC119unc-119 lipid binding chaperone | Not recorded | In 1 condition |
| UNGuracil DNA glycosylase | Not recorded | In 1 condition |
| XRCC4X-ray repair cross complementing 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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