Trait
Fluid accumulation in lower limbs
Clinical name: Pedal edema
An abnormal accumulation of excess fluid in the lower extremity resulting in swelling of the feet and extending upward to the lower leg.
Summary
- Also called
- Lower leg swelling, Edema of the lower limbs, Leg edema, Leg oedema, Oedema of the lower limbs, Pedal oedema, Peripheral edema of lower extremity, Peripheral oedema of lower extremity
- Body system
- Abnormality of limbsLaboratory abnormality
Reference genomeGRCh38hg38
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Read the genes linked to Fluid accumulation in lower limbs, and the rest of your genome, with one test.
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Get my Genome Test53 genes linked to Fluid accumulation in lower limbs
Changes in these genes cause rare conditions in which Fluid accumulation in lower limbs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP7BATPase copper transporting beta | Always | In 1 condition |
| FIBPFGF1 intracellular binding protein | Always | In 1 condition |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| TIE1tyrosine kinase with immunoglobulin like and EGF like domains 1 | Always | In 1 condition |
| FN1fibronectin 1 | Very often (80–99%) | In 1 condition |
| ALBalbumin | Often (30–79%) | In 1 condition |
| EIF2AK4eukaryotic translation initiation factor 2 alpha kinase 4 | Often (30–79%) | In 1 condition |
| EPHB4EPH receptor B4 | Often (30–79%) | In 1 condition |
| FLT4fms related receptor tyrosine kinase 4 | Often (30–79%) | In 1 condition |
| GJC2gap junction protein gamma 2 | Often (30–79%) | In 1 condition |
| VEGFCvascular endothelial growth factor C | Often (30–79%) | In 1 condition |
| ZNHIT3zinc finger HIT-type containing 3 | Often (30–79%) | In 1 condition |
| ACTC1actin alpha cardiac muscle 1 | Sometimes (5–29%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| AP1S3adaptor related protein complex 1 subunit sigma 3 | Sometimes (5–29%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| CITED2Cbp/p300 interacting transactivator with ED-rich tail 2 | Sometimes (5–29%) | In 1 condition |
| GATA4GATA binding protein 4 | Sometimes (5–29%) | In 1 condition |
| GATA6GATA binding protein 6 | Sometimes (5–29%) | In 1 condition |
| IKBKGinhibitor of nuclear factor kappa B kinase regulatory subunit gamma | Sometimes (5–29%) | In 1 condition |
| IL36RNinterleukin 36 receptor antagonist | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Sometimes (5–29%) | In 1 condition |
| MAGEL2MAGE family member L2 | Sometimes (5–29%) | In 3 conditions |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| MYH6myosin heavy chain 6 | Sometimes (5–29%) | In 1 condition |
| MYH7myosin heavy chain 7 | Sometimes (5–29%) | In 1 condition |
| NDNnecdin, MAGE family member | Sometimes (5–29%) | In 3 conditions |
| NFKBIANFKB inhibitor alpha | Sometimes (5–29%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Sometimes (5–29%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Sometimes (5–29%) | In 1 condition |
| OCA2OCA2 melanosomal transmembrane protein | Sometimes (5–29%) | In 3 conditions |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| PRKCSHPRKCSH beta subunit of glucosidase II | Sometimes (5–29%) | In 1 condition |
| SCN10Asodium voltage-gated channel alpha subunit 10 | Sometimes (5–29%) | In 1 condition |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Sometimes (5–29%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Sometimes (5–29%) | In 1 condition |
| SEC63SEC63 protein translocation regulator | Sometimes (5–29%) | In 1 condition |
Show 13 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SNRPNsmall nuclear ribonucleoprotein polypeptide N | Sometimes (5–29%) | In 3 conditions |
| TBX20T-box transcription factor 20 | Sometimes (5–29%) | In 1 condition |
| TLL1tolloid like 1 | Sometimes (5–29%) | In 1 condition |
| TNXBtenascin XB | Sometimes (5–29%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Sometimes (5–29%) | In 1 condition |
| ATRXATRX chromatin remodeler | Rarely (1–4%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Rarely (1–4%) | In 1 condition |
| CDH23cadherin related 23 | Rarely (1–4%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Rarely (1–4%) | In 1 condition |
| TP53tumor protein p53 | Rarely (1–4%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Rarely (1–4%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Rarely (1–4%) | In 1 condition |
| MKKSMKKS centrosomal shuttling protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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