Trait
Erythromelalgia
Recurrent episodes of redness, burning pain, and warmth of the extremities following exposure to heat or exercise with symptoms predominantly involving the feet.
Summary
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test10 genes linked to Erythromelalgia
Changes in these genes cause rare conditions in which Erythromelalgia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SCN10Asodium voltage-gated channel alpha subunit 10 | Very often (80–99%) | In 1 condition |
| SCN11Asodium voltage-gated channel alpha subunit 11 | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 2 conditions |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 2 conditions |
| MPLMPL proto-oncogene, thrombopoietin receptor | Sometimes (5–29%) | In 1 condition |
| SH2B3SH2B adaptor protein 3 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TP53tumor protein p53 | Sometimes (5–29%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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