Trait

Astrocytoma

Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma.

HPO HP:0009592

Body system: Abnormality of the nervous system Abnormal tissue mass

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25 genes linked to Astrocytoma

Changes in these genes cause rare conditions in which Astrocytoma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
MLH1mutL homolog 1	Very often (80–99%)	In 1 condition
FGFR1fibroblast growth factor receptor 1	Often (30–79%)	In 1 condition
MSH3mutS homolog 3	Often (30–79%)	In 2 conditions
MSH6mutS homolog 6	Often (30–79%)	In 1 condition
PMS2PMS1 homolog 2, mismatch repair system component	Often (30–79%)	In 1 condition
APCAPC regulator of Wnt signaling pathway	Sometimes (5–29%)	In 3 conditions
BRCA2BRCA2 DNA repair associated	Sometimes (5–29%)	In 1 condition
CDKN2Acyclin dependent kinase inhibitor 2A	Sometimes (5–29%)	In 2 conditions
CHEK2checkpoint kinase 2	Sometimes (5–29%)	In 1 condition
IDH1isocitrate dehydrogenase (NADP(+)) 1	Sometimes (5–29%)	In 2 conditions
IDH2isocitrate dehydrogenase (NADP(+)) 2	Sometimes (5–29%)	In 1 condition
MDM2MDM2 proto-oncogene	Sometimes (5–29%)	In 1 condition
TP53tumor protein p53	Sometimes (5–29%)	In 2 conditions
APC2APC regulator of Wnt signaling pathway 2	Rarely (1–4%)	In 1 condition
CCM2CCM2 scaffold protein	Rarely (1–4%)	In 1 condition
KRIT1KRIT1 ankyrin repeat containing	Rarely (1–4%)	In 1 condition
NF1neurofibromin 1	Rarely (1–4%)	In 1 condition
NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Rarely (1–4%)	In 2 conditions
NSD1nuclear receptor binding SET domain protein 1	Rarely (1–4%)	In 1 condition
PDCD10programmed cell death 10	Rarely (1–4%)	In 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Rarely (1–4%)	In 1 condition
ERBB2erb-b2 receptor tyrosine kinase 2	Not recorded	In 1 condition
IFNGinterferon gamma	Not recorded	In 1 condition
TSC1TSC complex subunit 1	Not recorded	In 1 condition
TSC2TSC complex subunit 2	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal astrocyte morphology Glioma

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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