Trait
Breakdown of bone
Clinical name: Osteolysis
Osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.
Summary
- Also called
- Increased bone resorption, Osteolytic defects of bones
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test74 genes linked to Breakdown of bone
Changes in these genes cause rare conditions in which Breakdown of bone is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BANF1barrier to autointegration nuclear assembly factor 1 | Always | In 1 condition |
| CHEK2checkpoint kinase 2 | Very often (80–99%) | In 1 condition |
| ELMO2engulfment and cell motility 2 | Very often (80–99%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Very often (80–99%) | In 2 conditions |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Very often (80–99%) | In 2 conditions |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Very often (80–99%) | In 2 conditions |
| IL1RNinterleukin 1 receptor antagonist | Very often (80–99%) | In 1 condition |
| KIF1Akinesin family member 1A | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 2 conditions |
| MAFBMAF bZIP transcription factor B | Very often (80–99%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Very often (80–99%) | In 1 condition |
| MMP14matrix metallopeptidase 14 | Very often (80–99%) | In 1 condition |
| MMP2matrix metallopeptidase 2 | Very often (80–99%) | In 1 condition |
| NOTCH2notch receptor 2 | Very often (80–99%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Very often (80–99%) | In 1 condition |
| RB1RB transcriptional corepressor 1 | Very often (80–99%) | In 1 condition |
| RETREG1reticulophagy regulator 1 | Very often (80–99%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Very often (80–99%) | In 1 condition |
| SCN9Asodium voltage-gated channel alpha subunit 9 | Very often (80–99%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 1 condition |
| VDRvitamin D receptor | Very often (80–99%) | In 1 condition |
| WNK1WNK lysine deficient protein kinase 1 | Very often (80–99%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Very often (80–99%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Very often (80–99%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CCN2cellular communication network factor 2 | Often (30–79%) | In 1 condition |
| CCND1cyclin D1 | Often (30–79%) | In 1 condition |
| CCR6C-C motif chemokine receptor 6 | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 1 condition |
| HNRNPA1heterogeneous nuclear ribonucleoprotein A1 | Often (30–79%) | In 1 condition |
| HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B1 | Often (30–79%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Often (30–79%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Often (30–79%) | In 1 condition |
| TNFRSF11ATNF receptor superfamily member 11a | Often (30–79%) | In 2 conditions |
| VCPvalosin containing protein | Often (30–79%) | In 1 condition |
Show 34 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| ANTXR2ANTXR cell adhesion molecule 2 | Sometimes (5–29%) | In 2 conditions |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Sometimes (5–29%) | In 1 condition |
| ATP7AATPase copper transporting alpha | Sometimes (5–29%) | In 1 condition |
| BUB1BUB1 mitotic checkpoint serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Sometimes (5–29%) | In 1 condition |
| BUB3BUB3 mitotic checkpoint protein | Sometimes (5–29%) | In 1 condition |
| CBLCbl proto-oncogene | Sometimes (5–29%) | In 1 condition |
| CDKN1Bcyclin dependent kinase inhibitor 1B | Sometimes (5–29%) | In 1 condition |
| CDKN2Bcyclin dependent kinase inhibitor 2B | Sometimes (5–29%) | In 1 condition |
| CEP57centrosomal protein 57 | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| CTSCcathepsin C | Sometimes (5–29%) | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| GJB2gap junction protein beta 2 | Sometimes (5–29%) | In 1 condition |
| GNPTABN-acetylglucosamine-1-phosphate transferase subunits alpha and beta | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Sometimes (5–29%) | In 1 condition |
| MEN1menin 1 | Sometimes (5–29%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| NOTCH3notch receptor 3 | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| PERPp53 apoptosis effector related to PMP22 | Sometimes (5–29%) | In 1 condition |
| PIGLphosphatidylinositol glycan anchor biosynthesis class L | Sometimes (5–29%) | In 1 condition |
| RUNX1RUNX family transcription factor 1 | Sometimes (5–29%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Sometimes (5–29%) | In 1 condition |
| SRSF2serine and arginine rich splicing factor 2 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TRIP13thyroid hormone receptor interactor 13 | Sometimes (5–29%) | In 1 condition |
| TRPV3transient receptor potential cation channel subfamily V member 3 | Sometimes (5–29%) | In 1 condition |
| GATA1GATA binding protein 1 | Rarely (1–4%) | In 1 condition |
| URODuroporphyrinogen decarboxylase | Rarely (1–4%) | In 1 condition |
| UROSuroporphyrinogen III synthase | Rarely (1–4%) | In 2 conditions |
| SQSTM1sequestosome 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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