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Gene

DLG4

discs large MAGUK scaffold protein 4

Summary

Cytogenetic location
17p13.1
Coordinates
Chromosome 17: 7,187,187–7,217,627 (GRCh38)
Exons
20 exons across 30.4 kb
Protein
724 amino acids
Also known as
PSD-95, PSD95, SAP90, SAP-90
MANE Select transcript
ENST00000399506.9NM_001321075.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How DLG4 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 17, with a bracket where DLG4 sits. DLG4 and 62 genes near it on chromosome 17, from 6,702,407 to 7,702,406.Chromosome 1717p13.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.36.8 Mb7 Mb7.2 Mb7.4 Mb7.6 MbSLC13A5: 6,684,715–6,713,377, reverse strandSLC13A5XAF1: 6,755,375–6,775,647, forward strandXAF1FBXO39: 6,776,210–6,797,101, forward strandFBXO39TEKT1: 6,789,133–6,831,761, reverse strandTEKT1ALOX12: 6,996,049–7,010,754, forward strandRNASEK: 7,012,412–7,014,535, forward strandRNASEK-C17orf49: 7,012,635–7,017,520, forward strandBACC1: 7,014,480–7,017,544, forward strandBACC1BCL6B: 7,023,050–7,030,290, forward strandBCL6BSLC16A13: 7,035,981–7,041,031, forward strandSLC16A13SLC16A11: 7,041,605–7,044,092, reverse strandSLC16A11CLEC10A: 7,074,537–7,081,166, reverse strandCLEC10AASGR2: 7,100,166–7,116,603, reverse strandASGR2ASGR1: 7,172,427–7,179,666, reverse strandASGR1DLG4: 7,187,187–7,217,627, reverse strandDLG4ACADVL: 7,217,125–7,225,273, forward strandACADVLDVL2: 7,225,338–7,234,538, reverse strandDVL2PHF23: 7,235,029–7,239,722, reverse strandPHF23GABARAP: 7,240,008–7,242,486, reverse strand: 7,240,427–7,244,635, reverse strandCTDNEP1: 7,243,583–7,252,841, reverse strand: 7,246,829–7,262,089, reverse strandELP5: 7,250,818–7,260,165, forward strandCLDN7: 7,257,359–7,264,016, reverse strandSLC2A4: 7,281,664–7,289,241, forward strandYBX2: 7,288,253–7,294,750, reverse strandYBX2EIF5A: 7,306,944–7,312,506, forward strandEIF5AGPS2: 7,309,470–7,315,564, reverse strandGPS2: 7,312,661–7,319,174, reverse strandNEURL4: 7,315,628–7,329,393, reverse strandACAP1: 7,332,960–7,351,478, forward strandKCTD11: 7,351,889–7,354,944, forward strandTMEM95: 7,355,123–7,357,219, forward strandTNK1: 7,380,534–7,389,779, forward strandTNK1PLSCR3: 7,389,727–7,397,054, reverse strandPLSCR3TMEM256-PLSCR3: 7,389,734–7,404,097, reverse strandTMEM256: 7,402,774–7,404,138, reverse strandTMEM256NLGN2: 7,404,684–7,419,860, forward strandSPEM1: 7,420,323–7,421,637, forward strandSPEM2: 7,425,563–7,427,568, forward strandSPEM3: 7,428,857–7,432,820, forward strand: 7,428,861–7,436,278, forward strandTMEM102: 7,435,344–7,437,679, forward strandFGF11: 7,438,128–7,444,937, forward strandCHRNB1: 7,445,004–7,457,710, forward strandZBTB4: 7,459,366–7,484,278, reverse strandZBTB4SLC35G6: 7,481,446–7,483,496, forward strandSLC35G6POLR2A: 7,484,366–7,514,616, forward strandPOLR2ATNFSF12: 7,548,508–7,557,890, forward strandTNFSF12TNFSF12-TNFSF13: 7,549,099–7,561,601, forward strandTNFSF12-TNFSF13TNFSF13: 7,558,251–7,561,660, forward strandTNFSF13SENP3: 7,561,867–7,571,969, forward strandSENP3SENP3-EIF4A1: 7,563,287–7,578,715, forward strandEIF4A1: 7,572,718–7,579,007, forward strandCD68: 7,579,380–7,582,515, forward strandMPDU1: 7,583,214–7,594,419, forward strandSOX15: 7,588,178–7,590,101, reverse strandFXR2: 7,591,230–7,614,916, reverse strandSHBG: 7,613,946–7,633,469, forward strandSHBGSAT2: 7,626,234–7,627,879, reverse strandSAT2ATP1B2: 7,646,627–7,657,771, forward strandATP1B2TP53: 7,661,779–7,687,546, reverse strandTP53WRAP53: 7,686,071–7,703,505, forward strandWRAP53Diagram of DLG4: 20 exons on the reverse strand of chromosome 17Exon 20: 2 known disease-causing sitesExon 18: 4 known disease-causing sitesExon 17: 7 known disease-causing sitesExon 16: 2 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 13: 5 known disease-causing sitesExon 12: 6 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 9: 12 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 1 known disease-causing siteExon 3: 3 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 20: 7,187,187–7,190,814, 3,628 basesExon 19: 7,191,267–7,191,358, 92 basesExon 18: 7,191,893–7,192,002, 110 basesExon 17: 7,192,945–7,193,117, 173 basesExon 16: 7,193,483–7,193,584, 102 basesExon 15: 7,193,667–7,193,714, 48 basesExon 14: 7,193,844–7,193,871, 28 basesExon 13: 7,193,964–7,194,000, 37 basesExon 12: 7,194,319–7,194,495, 177 basesExon 11: 7,196,220–7,196,334, 115 basesExon 10: 7,196,473–7,196,575, 103 basesExon 9: 7,196,757–7,197,052, 296 basesExon 8: 7,202,903–7,203,047, 145 basesExon 7: 7,203,193–7,203,329, 137 basesExon 6: 7,203,424–7,203,593, 170 basesExon 5: 7,203,692–7,203,816, 125 basesExon 4: 7,204,008–7,204,067, 60 basesExon 3: 7,204,199–7,204,252, 54 basesExon 2: 7,208,174–7,208,239, 66 basesExon 1: 7,217,118–7,217,627, 510 bases201510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.2 kb of the gene's 30.4 kb; 2,175 of those bases code for the protein.

    How a genome test reads DLG4

    82

    positions in DLG4 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 30.4 kb of DLG4, introns included, not only the 6.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). DLG4 gene: discs large MAGUK scaffold protein 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/dlg4

    Vancouver

    Dante Labs. DLG4 gene: discs large MAGUK scaffold protein 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/dlg4

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