Trait
Death of bone due to decreased blood supply
Clinical name: Avascular necrosis
A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
Summary
- Also called
- Aseptic bone necrosis, Aseptic necrosis, Bone infarction, Ischaemic bone necrosis, Ischemic bone necrosis, Osteochondronecrosis, Osteonecrosis
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Death of bone due to decreased blood supply, and the rest of your genome, with one test.
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Get my Genome Test53 genes linked to Death of bone due to decreased blood supply
Changes in these genes cause rare conditions in which Death of bone due to decreased blood supply is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 1 condition |
| NDC1NDC1 transmembrane nucleoporin | Always | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Very often (80–99%) | In 1 condition |
| GBA1glucosylceramidase beta 1 | Very often (80–99%) | In 3 conditions |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Very often (80–99%) | In 1 condition |
| SCARB2scavenger receptor class B member 2 | Very often (80–99%) | In 1 condition |
| SH3PXD2BSH3 and PX domains 2B | Very often (80–99%) | In 1 condition |
| HBBhemoglobin subunit beta | Often (30–79%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Sometimes (5–29%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Sometimes (5–29%) | In 1 condition |
| ELP1elongator acetyltransferase complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| FASFas cell surface death receptor | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| HPGD15-hydroxyprostaglandin dehydrogenase | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 1 condition |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| MAN2B1mannosidase alpha class 2B member 1 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NTRK1neurotrophic receptor tyrosine kinase 1 | Sometimes (5–29%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Sometimes (5–29%) | In 1 condition |
| SLCO2A1solute carrier organic anion transporter family member 2A1 | Sometimes (5–29%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Sometimes (5–29%) | In 1 condition |
| TERCtelomerase RNA component | Sometimes (5–29%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Sometimes (5–29%) | In 2 conditions |
| TINF2TERF1 interacting nuclear factor 2 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
Show 13 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Sometimes (5–29%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Sometimes (5–29%) | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Sometimes (5–29%) | In 1 condition |
| ATRXATRX chromatin remodeler | Rarely (1–4%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Rarely (1–4%) | In 1 condition |
| CDH23cadherin related 23 | Rarely (1–4%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Rarely (1–4%) | In 1 condition |
| TP53tumor protein p53 | Rarely (1–4%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Rarely (1–4%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Rarely (1–4%) | In 1 condition |
| ARSBarylsulfatase B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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