Skip to content
Use your HSA or FSA funds

Trait

Megakaryocyte nucleus hyperlobulation

The presence of megakaryocytes in the bone marrow whose nuclei are more lobulated than expected for the size of the nucleus.

HPO HP:0031388

Summary

Body system
Abnormality of blood and blood-forming tissues

6 genes linked to Megakaryocyte nucleus hyperlobulation

Changes in these genes cause rare conditions in which Megakaryocyte nucleus hyperlobulation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CALRcalreticulinVery often (80–99%)In 1 condition
JAK2Janus kinase 2Very often (80–99%)In 1 condition
MPLMPL proto-oncogene, thrombopoietin receptorVery often (80–99%)In 1 condition
SH2B3SH2B adaptor protein 3Very often (80–99%)In 1 condition
TET2tet methylcytosine dioxygenase 2Very often (80–99%)In 1 condition
TP53tumor protein p53Very often (80–99%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal megakaryocyte morphology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test