Trait
Chest pain
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
Summary
- Also called
- Thoracic pain
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Chest pain, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test143 genes linked to Chest pain
Changes in these genes cause rare conditions in which Chest pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| EMDemerin | Always | In 1 condition |
| POPDC2popeye domain cAMP effector 2 | Always | In 1 condition |
| SOX17SRY-box transcription factor 17 | Always | In 1 condition |
| CALRcalreticulin | Very often (80–99%) | In 1 condition |
| JAK2Janus kinase 2 | Very often (80–99%) | In 2 conditions |
| MPLMPL proto-oncogene, thrombopoietin receptor | Very often (80–99%) | In 2 conditions |
| SH2B3SH2B adaptor protein 3 | Very often (80–99%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 1 condition |
| TSC1TSC complex subunit 1 | Very often (80–99%) | In 1 condition |
| TSC2TSC complex subunit 2 | Very often (80–99%) | In 1 condition |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 1 condition |
| ACTA2actin alpha 2, smooth muscle | Often (30–79%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Often (30–79%) | In 1 condition |
| BTNL2butyrophilin like 2 | Often (30–79%) | In 2 conditions |
| CDH2cadherin 2 | Often (30–79%) | In 1 condition |
| CFTRCF transmembrane conductance regulator | Often (30–79%) | In 1 condition |
| COL3A1collagen type III alpha 1 chain | Often (30–79%) | In 1 condition |
| COL4A5collagen type IV alpha 5 chain | Often (30–79%) | In 1 condition |
| COL4A6collagen type IV alpha 6 chain | Often (30–79%) | In 1 condition |
| CRLF1cytokine receptor like factor 1 | Often (30–79%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Often (30–79%) | In 1 condition |
| DLEC1DLEC1 cilia and flagella associated protein | Often (30–79%) | In 1 condition |
| DLSTdihydrolipoamide S-succinyltransferase | Often (30–79%) | In 1 condition |
| DNMT3ADNA methyltransferase 3 alpha | Often (30–79%) | In 1 condition |
| DPM3dolichyl-phosphate mannosyltransferase subunit 3, regulatory | Often (30–79%) | In 1 condition |
| EFEMP2EGF-like fibulin extracellular matrix protein 2 | Often (30–79%) | In 1 condition |
| ELNelastin | Often (30–79%) | In 1 condition |
| EPAS1endothelial PAS domain protein 1 | Often (30–79%) | In 1 condition |
| ERBB2erb-b2 receptor tyrosine kinase 2 | Often (30–79%) | In 1 condition |
| FBN1fibrillin 1 | Often (30–79%) | In 1 condition |
| FHfumarate hydratase | Often (30–79%) | In 1 condition |
| FOXE3forkhead box E3 | Often (30–79%) | In 1 condition |
| GATA4GATA binding protein 4 | Often (30–79%) | In 1 condition |
| GATA5GATA binding protein 5 | Often (30–79%) | In 1 condition |
| GATA6GATA binding protein 6 | Often (30–79%) | In 1 condition |
| GJA5gap junction protein alpha 5 | Often (30–79%) | In 1 condition |
| HBBhemoglobin subunit beta | Often (30–79%) | In 1 condition |
| HEY2hes related family bHLH transcription factor with YRPW motif 2 | Often (30–79%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Often (30–79%) | In 1 condition |
Show 103 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| HLA-DPA1major histocompatibility complex, class II, DP alpha 1 | Often (30–79%) | In 1 condition |
| HLA-DPB1major histocompatibility complex, class II, DP beta 1 | Often (30–79%) | In 1 condition |
| HLA-DQA1major histocompatibility complex, class II, DQ alpha 1 | Often (30–79%) | In 1 condition |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Often (30–79%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Often (30–79%) | In 3 conditions |
| IL12Binterleukin 12B | Often (30–79%) | In 1 condition |
| KCNA5potassium voltage-gated channel subfamily A member 5 | Often (30–79%) | In 1 condition |
| KCNE1potassium voltage-gated channel subfamily E regulatory subunit 1 | Often (30–79%) | In 1 condition |
| KCNE2potassium voltage-gated channel subfamily E regulatory subunit 2 | Often (30–79%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Often (30–79%) | In 1 condition |
| KCNJ3potassium inwardly rectifying channel subfamily J member 3 | Often (30–79%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Often (30–79%) | In 1 condition |
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Often (30–79%) | In 1 condition |
| KIF1Bkinesin family member 1B | Often (30–79%) | In 1 condition |
| LAMP2lysosome associated membrane protein 2 | Often (30–79%) | In 1 condition |
| LOXlysyl oxidase | Often (30–79%) | In 1 condition |
| MAT2Amethionine adenosyltransferase 2A | Often (30–79%) | In 1 condition |
| MAXMYC associated transcriptional regulator X | Often (30–79%) | In 1 condition |
| MDH2malate dehydrogenase 2 | Often (30–79%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Often (30–79%) | In 3 conditions |
| MFAP5microfibril associated protein 5 | Often (30–79%) | In 1 condition |
| MLXMAX dimerization protein MLX | Often (30–79%) | In 1 condition |
| MYH11myosin heavy chain 11 | Often (30–79%) | In 2 conditions |
| MYH7myosin heavy chain 7 | Often (30–79%) | In 1 condition |
| MYL4myosin light chain 4 | Often (30–79%) | In 1 condition |
| MYLKmyosin light chain kinase | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Often (30–79%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Often (30–79%) | In 1 condition |
| NKX2-6NK2 homeobox 6 | Often (30–79%) | In 1 condition |
| NOS1nitric oxide synthase 1 | Often (30–79%) | In 1 condition |
| NPPAnatriuretic peptide A | Often (30–79%) | In 1 condition |
| NUP155nucleoporin 155 | Often (30–79%) | In 1 condition |
| PIGAphosphatidylinositol glycan anchor biosynthesis class A | Often (30–79%) | In 1 condition |
| PITX2paired like homeodomain 2 | Often (30–79%) | In 1 condition |
| PPOXprotoporphyrinogen oxidase | Often (30–79%) | In 1 condition |
| PRKG1protein kinase cGMP-dependent 1 | Often (30–79%) | In 1 condition |
| PRTN3proteinase 3 | Often (30–79%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Often (30–79%) | In 1 condition |
| RETret proto-oncogene | Often (30–79%) | In 3 conditions |
| RNF6ring finger protein 6 | Often (30–79%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Often (30–79%) | In 1 condition |
| SCN2Bsodium voltage-gated channel beta subunit 2 | Often (30–79%) | In 1 condition |
| SCN3Bsodium voltage-gated channel beta subunit 3 | Often (30–79%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Often (30–79%) | In 3 conditions |
| SCN4Bsodium voltage-gated channel beta subunit 4 | Often (30–79%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Often (30–79%) | In 1 condition |
| SCNN1Asodium channel epithelial 1 subunit alpha | Often (30–79%) | In 1 condition |
| SCNN1Bsodium channel epithelial 1 subunit beta | Often (30–79%) | In 1 condition |
| SCNN1Gsodium channel epithelial 1 subunit gamma | Often (30–79%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF2succinate dehydrogenase complex assembly factor 2 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 2 conditions |
| SDHCsuccinate dehydrogenase complex subunit C | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 2 conditions |
| SLC25A11solute carrier family 25 member 11 | Often (30–79%) | In 1 condition |
| SLC34A2solute carrier family 34 member 2 | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 1 condition |
| SMAD4SMAD family member 4 | Often (30–79%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Often (30–79%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Often (30–79%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Often (30–79%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 2 conditions |
| THPOthrombopoietin | Often (30–79%) | In 1 condition |
| THSD4thrombospondin type 1 domain containing 4 | Often (30–79%) | In 1 condition |
| TMEM127transmembrane protein 127 | Often (30–79%) | In 1 condition |
| TTNtitin | Often (30–79%) | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Often (30–79%) | In 2 conditions |
| WWOXWW domain containing oxidoreductase | Often (30–79%) | In 1 condition |
| ACTC1actin alpha cardiac muscle 1 | Sometimes (5–29%) | In 1 condition |
| ADAMTS19ADAM metallopeptidase with thrombospondin type 1 motif 19 | Sometimes (5–29%) | In 1 condition |
| APCAPC regulator of Wnt signaling pathway | Sometimes (5–29%) | In 1 condition |
| CAV3caveolin 3 | Sometimes (5–29%) | In 1 condition |
| CD4CD4 molecule | Sometimes (5–29%) | In 1 condition |
| CTNNB1catenin beta 1 | Sometimes (5–29%) | In 1 condition |
| DBHdopamine beta-hydroxylase | Sometimes (5–29%) | In 1 condition |
| DSG2desmoglein 2 | Sometimes (5–29%) | In 1 condition |
| GNASGNAS complex locus | Sometimes (5–29%) | In 3 conditions |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Sometimes (5–29%) | In 1 condition |
| MYL2myosin light chain 2 | Sometimes (5–29%) | In 1 condition |
| NDC1NDC1 transmembrane nucleoporin | Sometimes (5–29%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Sometimes (5–29%) | In 1 condition |
| PRKAG2protein kinase AMP-activated non-catalytic subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STX16syntaxin 16 | Sometimes (5–29%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| EXT1exostosin glycosyltransferase 1 | Rarely (1–4%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Rarely (1–4%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Rarely (1–4%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Rarely (1–4%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Rarely (1–4%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Rarely (1–4%) | In 1 condition |
| ENGendoglin | Not recorded | In 1 condition |
| MEF2Amyocyte enhancer factor 2A | Not recorded | In 1 condition |
| MYBPC3myosin binding protein C3 | Not recorded | In 1 condition |
| PLNphospholamban | Not recorded | In 1 condition |
| PPA2inorganic pyrophosphatase 2 | Not recorded | In 1 condition |
| TMEM43transmembrane protein 43 | Not recorded | In 1 condition |
| TNNC1troponin C1, slow skeletal and cardiac type | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks