Trait
Basal cell carcinoma
The presence of a basal cell carcinoma of the skin.
Summary
- Also called
- Basal cell carcinomas, Basal cell epithelioma, Basal cell nevus, Basalioma
Reference genomeGRCh38hg38
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Get my Genome Test59 genes linked to Basal cell carcinoma
Changes in these genes cause rare conditions in which Basal cell carcinoma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| SUFUSUFU negative regulator of hedgehog signaling | Always | In 2 conditions |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| PTCH1patched 1 | Very often (80–99%) | In 4 conditions |
| DICER1dicer 1, ribonuclease III | Often (30–79%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Often (30–79%) | In 2 conditions |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Often (30–79%) | In 2 conditions |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Often (30–79%) | In 2 conditions |
| ERCC5ERCC excision repair 5, endonuclease | Often (30–79%) | In 1 condition |
| KEAP1kelch like ECH associated protein 1 | Often (30–79%) | In 1 condition |
| POLHDNA polymerase eta | Often (30–79%) | In 2 conditions |
| PTCH2patched 2 | Often (30–79%) | In 2 conditions |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Often (30–79%) | In 1 condition |
| ATMATM serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BMPR1Abone morphogenetic protein receptor type 1A | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Sometimes (5–29%) | In 1 condition |
| CIB1calcium and integrin binding 1 | Sometimes (5–29%) | In 1 condition |
| CYLDCYLD lysine 63 deubiquitinase | Sometimes (5–29%) | In 2 conditions |
| EPCAMepithelial cell adhesion molecule | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Sometimes (5–29%) | In 2 conditions |
| KRASKRas proto-oncogene, GTPase | Sometimes (5–29%) | In 2 conditions |
| MC1Rmelanocortin 1 receptor | Sometimes (5–29%) | In 1 condition |
| MLH1mutL homolog 1 | Sometimes (5–29%) | In 3 conditions |
| MSH2mutS homolog 2 | Sometimes (5–29%) | In 2 conditions |
| MSH6mutS homolog 6 | Sometimes (5–29%) | In 1 condition |
| MUTYHmutY DNA glycosylase | Sometimes (5–29%) | In 1 condition |
| NPATnuclear protein, coactivator of histone transcription | Sometimes (5–29%) | In 1 condition |
| NTHL1nth like DNA glycosylase 1 | Sometimes (5–29%) | In 2 conditions |
| OCA2OCA2 melanosomal transmembrane protein | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PMS1PMS1 homolog 1, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Sometimes (5–29%) | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| RECQL4RecQ like helicase 4 | Sometimes (5–29%) | In 2 conditions |
| RPS19ribosomal protein S19 | Sometimes (5–29%) | In 1 condition |
| RPS20ribosomal protein S20 | Sometimes (5–29%) | In 1 condition |
| SEMA4Asemaphorin 4A | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
Show 19 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| TYMSthymidylate synthetase | Sometimes (5–29%) | In 1 condition |
| TYRtyrosinase | Sometimes (5–29%) | In 2 conditions |
| WNT10AWnt family member 10A | Sometimes (5–29%) | In 2 conditions |
| AAGABalpha and gamma adaptin binding protein | Rarely (1–4%) | In 1 condition |
| ANAPC1anaphase promoting complex subunit 1 | Rarely (1–4%) | In 1 condition |
| CASP10caspase 10 | Rarely (1–4%) | In 1 condition |
| COL14A1collagen type XIV alpha 1 chain | Rarely (1–4%) | In 1 condition |
| FASFas cell surface death receptor | Rarely (1–4%) | In 1 condition |
| FASLGFas ligand | Rarely (1–4%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Rarely (1–4%) | In 1 condition |
| COL17A1collagen type XVII alpha 1 chain | Not recorded | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Not recorded | In 4 conditions |
| DDB2damage specific DNA binding protein 2 | Not recorded | In 1 condition |
| MMP1matrix metallopeptidase 1 | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| RASA1RAS p21 protein activator 1 | Not recorded | In 1 condition |
| SMOsmoothened, frizzled class receptor | Not recorded | In 1 condition |
| TMC6transmembrane channel like 6 | Not recorded | In 1 condition |
| TP53tumor protein p53 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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