Trait
Increased circulating ACTH level
An abnormal increased in the concentration of corticotropin, also known as adrenocorticotropic hormone (ACTH), in the blood.
Summary
- Also called
- High blood corticotropin levels, Increased plasma ACTH
- Body system
- Abnormality of the endocrine system
Reference genomeGRCh38hg38
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Get my Genome Test19 genes linked to Increased circulating ACTH level
Changes in these genes cause rare conditions in which Increased circulating ACTH level is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| MC2Rmelanocortin 2 receptor | Always | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Always | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Always | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Always | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Always | In 3 conditions |
| CYP11A1cytochrome P450 family 11 subfamily A member 1 | Very often (80–99%) | In 2 conditions |
| AAASaladin WD repeat nucleoporin | Often (30–79%) | In 1 condition |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 2 conditions |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
| CYP11B1cytochrome P450 family 11 subfamily B member 1 | Often (30–79%) | In 1 condition |
| GMPPAGDP-mannose pyrophosphorylase A | Often (30–79%) | In 1 condition |
| PORcytochrome p450 oxidoreductase | Often (30–79%) | In 3 conditions |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TRAPPC11trafficking protein particle complex subunit 11 | Often (30–79%) | In 1 condition |
| USP48ubiquitin specific peptidase 48 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 2 conditions |
| AIPAHR interacting HSP90 co-chaperone | Not recorded | In 1 condition |
| GNASGNAS complex locus | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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