Trait

Kidney cancer

Clinical name: Renal neoplasm

The presence of a neoplasm of the kidney.

HPO HP:0009726

Also called: Renal tumors, Neoplasia of the kidneys, Renal tumours
Body system: Abnormality of the genitourinary system Abnormal tissue mass

This page as data

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library(jsonlite)

url <- "https://dantelabs.com/traits/renal-neoplasm.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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29 genes linked to Kidney cancer

Changes in these genes cause rare conditions in which Kidney cancer is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LMNAlamin A/C	Often (30–79%)	In 1 condition
B3GALT6beta-1,3-galactosyltransferase 6	Sometimes (5–29%)	In 1 condition
EPCAMepithelial cell adhesion molecule	Sometimes (5–29%)	In 1 condition
KRASKRas proto-oncogene, GTPase	Sometimes (5–29%)	In 1 condition
MLH1mutL homolog 1	Sometimes (5–29%)	In 1 condition
MSH2mutS homolog 2	Sometimes (5–29%)	In 1 condition
MSH6mutS homolog 6	Sometimes (5–29%)	In 1 condition
PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Sometimes (5–29%)	In 1 condition
PMS1PMS1 homolog 1, mismatch repair system component	Sometimes (5–29%)	In 1 condition
PMS2PMS1 homolog 2, mismatch repair system component	Sometimes (5–29%)	In 1 condition
TGFBR2transforming growth factor beta receptor 2	Sometimes (5–29%)	In 1 condition
TSC1TSC complex subunit 1	Sometimes (5–29%)	In 1 condition
TSC2TSC complex subunit 2	Sometimes (5–29%)	In 1 condition
WRNWRN RecQ like helicase	Sometimes (5–29%)	In 1 condition
CDKN2Acyclin dependent kinase inhibitor 2A	Rarely (1–4%)	In 1 condition
CHEK2checkpoint kinase 2	Rarely (1–4%)	In 2 conditions
MDM2MDM2 proto-oncogene	Rarely (1–4%)	In 1 condition
TP53tumor protein p53	Rarely (1–4%)	In 1 condition
ATMATM serine/threonine kinase	Not recorded	In 1 condition
BMPR1Abone morphogenetic protein receptor type 1A	Not recorded	In 1 condition
BRCA2BRCA2 DNA repair associated	Not recorded	In 1 condition
FLCNfolliculin	Not recorded	In 1 condition
KLLNkillin, p53 regulated DNA replication inhibitor	Not recorded	In 1 condition
MUTYHmutY DNA glycosylase	Not recorded	In 1 condition
NPATnuclear protein, coactivator of histone transcription	Not recorded	In 1 condition
POLD1DNA polymerase delta 1, catalytic subunit	Not recorded	In 1 condition
POLEDNA polymerase epsilon, catalytic subunit	Not recorded	In 1 condition
RPS20ribosomal protein S20	Not recorded	In 1 condition
SEMA4Asemaphorin 4A	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of the kidney Urinary tract neoplasm

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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