Trait
Nephroblastoma
The presence of a nephroblastoma, which is a neoplasm of the kidney that primarily affects children.
Summary
- Also called
- Wilms tumor, Wilms tumour
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test48 genes linked to Nephroblastoma
Changes in these genes cause rare conditions in which Nephroblastoma is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DICER1dicer 1, ribonuclease III | Always | In 2 conditions |
| TRIM28tripartite motif containing 28 | Always | In 2 conditions |
| TRIP13thyroid hormone receptor interactor 13 | Always | In 3 conditions |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 3 conditions |
| CTR9CTR9 component of Paf1/RNA polymerase II complex | Very often (80–99%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Very often (80–99%) | In 3 conditions |
| GPC3glypican 3 | Very often (80–99%) | In 4 conditions |
| H19H19 imprinted maternally expressed transcript | Very often (80–99%) | In 3 conditions |
| POU6F2POU class 6 homeobox 2 | Very often (80–99%) | In 2 conditions |
| RESTRE1 silencing transcription factor | Very often (80–99%) | In 2 conditions |
| WT1WT1 transcription factor | Very often (80–99%) | In 8 conditions |
| PALB2partner and localizer of BRCA2 | Often (30–79%) | In 1 condition |
| PAX6paired box 6 | Often (30–79%) | In 1 condition |
| ALX4ALX homeobox 4 | Sometimes (5–29%) | In 1 condition |
| BUB1BUB1 mitotic checkpoint serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Sometimes (5–29%) | In 2 conditions |
| BUB3BUB3 mitotic checkpoint protein | Sometimes (5–29%) | In 1 condition |
| CEP57centrosomal protein 57 | Sometimes (5–29%) | In 1 condition |
| EXT2exostosin glycosyltransferase 2 | Sometimes (5–29%) | In 1 condition |
| FIBPFGF1 intracellular binding protein | Sometimes (5–29%) | In 2 conditions |
| GPC4glypican 4 | Sometimes (5–29%) | In 2 conditions |
| HDAC4histone deacetylase 4 | Sometimes (5–29%) | In 1 condition |
| IGF2insulin like growth factor 2 | Sometimes (5–29%) | In 4 conditions |
| KCNQ1OT1KCNQ1 opposite strand/antisense transcript 1 | Sometimes (5–29%) | In 2 conditions |
| PHF21APHD finger protein 21A | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 4 conditions |
| PTCH1patched 1 | Sometimes (5–29%) | In 1 condition |
| TRIM37tripartite motif containing 37 | Sometimes (5–29%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Rarely (1–4%) | In 1 condition |
| BLMBLM RecQ like helicase | Rarely (1–4%) | In 1 condition |
| C1Scomplement C1s | Rarely (1–4%) | In 1 condition |
| CDC73cell division cycle 73 | Rarely (1–4%) | In 3 conditions |
| DHX37DEAH-box helicase 37 | Rarely (1–4%) | In 1 condition |
| GATA4GATA binding protein 4 | Rarely (1–4%) | In 1 condition |
| HRASHRas proto-oncogene, GTPase | Rarely (1–4%) | In 1 condition |
| MAP3K1mitogen-activated protein kinase kinase kinase 1 | Rarely (1–4%) | In 1 condition |
| NR0B1nuclear receptor subfamily 0 group B member 1 | Rarely (1–4%) | In 1 condition |
| NR5A1nuclear receptor subfamily 5 group A member 1 | Rarely (1–4%) | In 1 condition |
| SETBP1SET binding protein 1 | Rarely (1–4%) | In 1 condition |
| SOX9SRY-box transcription factor 9 | Rarely (1–4%) | In 1 condition |
Show 8 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SPRED1sprouty related EVH1 domain containing 1 | Rarely (1–4%) | In 1 condition |
| SRYsex determining region Y | Rarely (1–4%) | In 1 condition |
| VAMP7vesicle associated membrane protein 7 | Rarely (1–4%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Rarely (1–4%) | In 1 condition |
| ZFPM2zinc finger protein, FOG family member 2 | Rarely (1–4%) | In 1 condition |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Not recorded | In 1 condition |
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Not recorded | In 1 condition |
| TP53tumor protein p53 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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