Trait
Thin skin
Reduction in thickness of the skin, generally associated with a loss of suppleness and elasticity of the skin.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test93 genes linked to Thin skin
Changes in these genes cause rare conditions in which Thin skin is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CHUKcomponent of inhibitor of nuclear factor kappa B kinase complex | Always | In 1 condition |
| IFT140intraflagellar transport 140 | Always | In 1 condition |
| POLR3ARNA polymerase III subunit A | Always | In 2 conditions |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Always | In 2 conditions |
| PYCR1pyrroline-5-carboxylate reductase 1 | Always | In 3 conditions |
| UBE3Bubiquitin protein ligase E3B | Always | In 1 condition |
| ZMPSTE24zinc metallopeptidase STE24 | Always | In 2 conditions |
| ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2 | Very often (80–99%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Very often (80–99%) | In 1 condition |
| B4GALT7beta-1,4-galactosyltransferase 7 | Very often (80–99%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Very often (80–99%) | In 3 conditions |
| COL1A2collagen type I alpha 2 chain | Very often (80–99%) | In 4 conditions |
| COL3A1collagen type III alpha 1 chain | Very often (80–99%) | In 2 conditions |
| DDB2damage specific DNA binding protein 2 | Very often (80–99%) | In 1 condition |
| EDARectodysplasin A receptor | Very often (80–99%) | In 1 condition |
| EDARADDEDAR associated via death domain | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 1 condition |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Very often (80–99%) | In 1 condition |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 1 condition |
| FLNAfilamin A | Very often (80–99%) | In 2 conditions |
| GORABgolgin, RAB6 interacting | Very often (80–99%) | In 1 condition |
| KDF1keratinocyte differentiation factor 1 | Very often (80–99%) | In 1 condition |
| KRT2keratin 2 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 4 conditions |
| LRP6LDL receptor related protein 6 | Very often (80–99%) | In 1 condition |
| NFIXnuclear factor I X | Very often (80–99%) | In 1 condition |
| PEPDpeptidase D | Very often (80–99%) | In 1 condition |
| SLC39A13solute carrier family 39 member 13 | Very often (80–99%) | In 2 conditions |
| SMARCAD1SNF2 related chromatin remodeling ATPase with DExD box 1 | Very often (80–99%) | In 1 condition |
| TP63tumor protein p63 | Very often (80–99%) | In 3 conditions |
| TRAF6TNF receptor associated factor 6 | Very often (80–99%) | In 1 condition |
| XPAXPA, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| ARF1ARF GTPase 1 | Often (30–79%) | In 1 condition |
| ARFGEF2ARF guanine nucleotide exchange factor 2 | Often (30–79%) | In 1 condition |
| ATRXATRX chromatin remodeler | Often (30–79%) | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 1 condition |
| C1Rcomplement C1r | Often (30–79%) | In 2 conditions |
Show 53 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| C1Scomplement C1s | Often (30–79%) | In 1 condition |
| CAV1caveolin 1 | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 1 condition |
| COL7A1collagen type VII alpha 1 chain | Often (30–79%) | In 1 condition |
| DDR2discoidin domain receptor tyrosine kinase 2 | Often (30–79%) | In 1 condition |
| EMILIN1elastin microfibril interfacer 1 | Often (30–79%) | In 1 condition |
| ERMARDER membrane associated RNA degradation | Often (30–79%) | In 1 condition |
| MAP1Bmicrotubule associated protein 1B | Often (30–79%) | In 1 condition |
| NEDD4LNEDD4 like E3 ubiquitin protein ligase | Often (30–79%) | In 1 condition |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Often (30–79%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Often (30–79%) | In 2 conditions |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| PPARGperoxisome proliferator activated receptor gamma | Often (30–79%) | In 1 condition |
| PRKD1protein kinase D1 | Often (30–79%) | In 1 condition |
| PROCprotein C, inactivator of coagulation factors Va and VIIIa | Often (30–79%) | In 1 condition |
| PROS1protein S | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RECQLRecQ like helicase | Often (30–79%) | In 1 condition |
| SLC2A10solute carrier family 2 member 10 | Often (30–79%) | In 2 conditions |
| SOX18SRY-box transcription factor 18 | Often (30–79%) | In 1 condition |
| TMTC3transmembrane O-mannosyltransferase targeting cadherins 3 | Often (30–79%) | In 1 condition |
| TNXBtenascin XB | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TSHZ3teashirt zinc finger homeobox 3 | Often (30–79%) | In 1 condition |
| TWIST2twist family bHLH transcription factor 2 | Often (30–79%) | In 2 conditions |
| USP48ubiquitin specific peptidase 48 | Often (30–79%) | In 1 condition |
| USP8ubiquitin specific peptidase 8 | Often (30–79%) | In 2 conditions |
| ABL1ABL proto-oncogene 1, non-receptor tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| ADNPactivity dependent neuroprotector homeobox | Sometimes (5–29%) | In 1 condition |
| DHX30DExH-box helicase 30 | Sometimes (5–29%) | In 1 condition |
| EFEMP1EGF-like fibulin extracellular matrix protein 1 | Sometimes (5–29%) | In 1 condition |
| IPO8importin 8 | Sometimes (5–29%) | In 1 condition |
| MTAPmethylthioadenosine phosphorylase | Sometimes (5–29%) | In 1 condition |
| PPP1CBprotein phosphatase 1 catalytic subunit beta | Sometimes (5–29%) | In 1 condition |
| SMAD2SMAD family member 2 | Sometimes (5–29%) | In 1 condition |
| SMAD3SMAD family member 3 | Sometimes (5–29%) | In 1 condition |
| TGFB2transforming growth factor beta 2 | Sometimes (5–29%) | In 1 condition |
| TGFB3transforming growth factor beta 3 | Sometimes (5–29%) | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| WNT10AWnt family member 10A | Sometimes (5–29%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Not recorded | In 1 condition |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Not recorded | In 1 condition |
| CTC1CST telomere replication complex component 1 | Not recorded | In 1 condition |
| EDAectodysplasin A | Not recorded | In 1 condition |
| GNASGNAS complex locus | Not recorded | In 1 condition |
| LIFRLIF receptor subunit alpha | Not recorded | In 1 condition |
| ORC1origin recognition complex subunit 1 | Not recorded | In 1 condition |
| PDE11Aphosphodiesterase 11A | Not recorded | In 1 condition |
| PLOD1procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Not recorded | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Not recorded | In 1 condition |
| SATB2SATB homeobox 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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