Trait

Constitutional symptom

A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.

HPO HP:0025142

Reference genomeGRCh38hg38

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9 genes linked to Constitutional symptom

Changes in these genes cause rare conditions in which Constitutional symptom is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ASXL1ASXL transcriptional regulator 1	Often (30–79%)	In 1 condition
BAP1BRCA1 associated deubiquitinase 1	Often (30–79%)	In 1 condition
CALRcalreticulin	Often (30–79%)	In 1 condition
CBLCbl proto-oncogene	Often (30–79%)	In 1 condition
JAK2Janus kinase 2	Often (30–79%)	In 1 condition
MPLMPL proto-oncogene, thrombopoietin receptor	Often (30–79%)	In 1 condition
RUNX1RUNX family transcription factor 1	Often (30–79%)	In 1 condition
SRSF2serine and arginine rich splicing factor 2	Often (30–79%)	In 1 condition
TET2tet methylcytosine dioxygenase 2	Often (30–79%)	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

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Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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