Trait
Back pain
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
Summary
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test68 genes linked to Back pain
Changes in these genes cause rare conditions in which Back pain is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FHL1four and a half LIM domains 1 | Always | In 2 conditions |
| RAB32RAB32, member RAS oncogene family | Always | In 1 condition |
| TRAPPC2trafficking protein particle complex subunit 2 | Always | In 2 conditions |
| VCPvalosin containing protein | Always | In 2 conditions |
| ATP7BATPase copper transporting beta | Very often (80–99%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Very often (80–99%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Very often (80–99%) | In 1 condition |
| PALLDpalladin, cytoskeletal associated protein | Very often (80–99%) | In 1 condition |
| RABL3RAB, member of RAS oncogene family like 3 | Very often (80–99%) | In 1 condition |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 1 condition |
| CLCN7Cl-/H+ antiporter 7 | Often (30–79%) | In 1 condition |
| DLL3delta like canonical Notch ligand 3 | Often (30–79%) | In 1 condition |
| EMDemerin | Often (30–79%) | In 1 condition |
| FLNCfilamin C | Often (30–79%) | In 1 condition |
| HGDhomogentisate 1,2-dioxygenase | Often (30–79%) | In 1 condition |
| HMBShydroxymethylbilane synthase | Often (30–79%) | In 1 condition |
| HTRA1HtrA serine peptidase 1 | Often (30–79%) | In 1 condition |
| LMNAlamin A/C | Often (30–79%) | In 2 conditions |
| LMX1BLIM homeobox transcription factor 1 beta | Often (30–79%) | In 2 conditions |
| MESP2mesoderm posterior bHLH transcription factor 2 | Often (30–79%) | In 1 condition |
| NKX3-2NK3 homeobox 2 | Often (30–79%) | In 1 condition |
| PLEKHM1pleckstrin homology and RUN domain containing M1 | Often (30–79%) | In 1 condition |
| POLR3GLRNA polymerase III subunit GL | Often (30–79%) | In 1 condition |
| PPOXprotoporphyrinogen oxidase | Often (30–79%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Often (30–79%) | In 1 condition |
| SYNE2spectrin repeat containing nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Often (30–79%) | In 1 condition |
| TMEM43transmembrane protein 43 | Often (30–79%) | In 1 condition |
| TNXBtenascin XB | Often (30–79%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Sometimes (5–29%) | In 1 condition |
| ALG8ALG8 alpha-1,3-glucosyltransferase | Sometimes (5–29%) | In 1 condition |
| CCND1cyclin D1 | Sometimes (5–29%) | In 1 condition |
| CD46CD46 molecule | Sometimes (5–29%) | In 1 condition |
| CFHcomplement factor H | Sometimes (5–29%) | In 1 condition |
| CFIcomplement factor I | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
Show 28 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CPOXcoproporphyrinogen oxidase | Sometimes (5–29%) | In 1 condition |
| FLI1Fli-1 proto-oncogene, ETS transcription factor | Sometimes (5–29%) | In 1 condition |
| HELLPARHELLP associated long non-coding RNA | Sometimes (5–29%) | In 1 condition |
| LRP5LDL receptor related protein 5 | Sometimes (5–29%) | In 1 condition |
| PRKCSHPRKCSH beta subunit of glucosidase II | Sometimes (5–29%) | In 2 conditions |
| RASA1RAS p21 protein activator 1 | Sometimes (5–29%) | In 1 condition |
| SEC63SEC63 protein translocation regulator | Sometimes (5–29%) | In 1 condition |
| SFRP4secreted frizzled related protein 4 | Sometimes (5–29%) | In 1 condition |
| SLC22A12solute carrier family 22 member 12 | Sometimes (5–29%) | In 1 condition |
| SLC2A9solute carrier family 2 member 9 | Sometimes (5–29%) | In 1 condition |
| TBX18T-box transcription factor 18 | Sometimes (5–29%) | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Sometimes (5–29%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Rarely (1–4%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Rarely (1–4%) | In 1 condition |
| MATN3matrilin 3 | Rarely (1–4%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Rarely (1–4%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Rarely (1–4%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Rarely (1–4%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Rarely (1–4%) | In 1 condition |
| SMARCE1SWI/SNF related BAF chromatin remodeling complex subunit E1 | Rarely (1–4%) | In 1 condition |
| SMOsmoothened, frizzled class receptor | Rarely (1–4%) | In 1 condition |
| SPTBN1spectrin beta, non-erythrocytic 1 | Rarely (1–4%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Rarely (1–4%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Rarely (1–4%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Rarely (1–4%) | In 1 condition |
| CAPN3calpain 3 | Not recorded | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Not recorded | In 1 condition |
| VANGL1VANGL planar cell polarity protein 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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