Trait
Decreased activity of gonads
Clinical name: Hypogonadism
A decreased functionality of the gonad.
Reference genomeGRCh38hg38
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Read the genes linked to Decreased activity of gonads, and the rest of your genome, with one test.
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Get my Genome Test171 genes linked to Decreased activity of gonads
Changes in these genes cause rare conditions in which Decreased activity of gonads is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ALG1ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | Always | In 1 condition |
| BBS12Bardet-Biedl syndrome 12 | Always | In 2 conditions |
| BBS2Bardet-Biedl syndrome 2 | Always | In 2 conditions |
| BBS5Bardet-Biedl syndrome 5 | Always | In 2 conditions |
| BBS7Bardet-Biedl syndrome 7 | Always | In 2 conditions |
| DCAF17DDB1 and CUL4 associated factor 17 | Always | In 2 conditions |
| FANCBFA complementation group B | Always | In 2 conditions |
| FEZF1FEZ family zinc finger 1 | Always | In 1 condition |
| HAMPhepcidin antimicrobial peptide | Always | In 2 conditions |
| IFT74intraflagellar transport 74 | Always | In 2 conditions |
| LZTFL1leucine zipper transcription factor like 1 | Always | In 2 conditions |
| MDM2MDM2 proto-oncogene | Always | In 1 condition |
| PNPLA6patatin like domain 6, lysophospholipase | Always | In 3 conditions |
| SLC30A7solute carrier family 30 member 7 | Always | In 1 condition |
| STEAP3STEAP3 metalloreductase | Always | In 2 conditions |
| TP53tumor protein p53 | Always | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Very often (80–99%) | In 1 condition |
| ALX4ALX homeobox 4 | Very often (80–99%) | In 1 condition |
| ANK1ankyrin 1 | Very often (80–99%) | In 1 condition |
| CAMKMTcalmodulin-lysine N-methyltransferase | Very often (80–99%) | In 1 condition |
| CDH23cadherin related 23 | Very often (80–99%) | In 2 conditions |
| CDKN1Ccyclin dependent kinase inhibitor 1C | Very often (80–99%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Very often (80–99%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Very often (80–99%) | In 3 conditions |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Very often (80–99%) | In 2 conditions |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Very often (80–99%) | In 2 conditions |
| ERCC5ERCC excision repair 5, endonuclease | Very often (80–99%) | In 2 conditions |
| FMR1fragile X messenger ribonucleoprotein 1 | Very often (80–99%) | In 1 condition |
| LMNAlamin A/C | Very often (80–99%) | In 1 condition |
| MEN1menin 1 | Very often (80–99%) | In 1 condition |
| PEX1peroxisomal biogenesis factor 1 | Very often (80–99%) | In 1 condition |
| PEX6peroxisomal biogenesis factor 6 | Very often (80–99%) | In 1 condition |
| PHF6PHD finger protein 6 | Very often (80–99%) | In 1 condition |
| POLEDNA polymerase epsilon, catalytic subunit | Very often (80–99%) | In 1 condition |
| PPM1Bprotein phosphatase, Mg2+/Mn2+ dependent 1B | Very often (80–99%) | In 1 condition |
| PREPLprolyl endopeptidase like | Very often (80–99%) | In 1 condition |
| RNF216ring finger protein 216 | Very often (80–99%) | In 1 condition |
| SIL1SIL1 nucleotide exchange factor | Very often (80–99%) | In 1 condition |
| SIM1SIM bHLH transcription factor 1 | Very often (80–99%) | In 1 condition |
| SLC3A1solute carrier family 3 member 1 | Very often (80–99%) | In 1 condition |
Show 131 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1 | Very often (80–99%) | In 1 condition |
| TTC8tetratricopeptide repeat domain 8 | Very often (80–99%) | In 2 conditions |
| WRNWRN RecQ like helicase | Very often (80–99%) | In 2 conditions |
| XPAXPA, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Very often (80–99%) | In 1 condition |
| ZBTB20zinc finger and BTB domain containing 20 | Very often (80–99%) | In 1 condition |
| AIREautoimmune regulator | Often (30–79%) | In 2 conditions |
| ARL6ARF like GTPase 6 | Often (30–79%) | In 2 conditions |
| BBIP1BBSome interacting protein 1 | Often (30–79%) | In 1 condition |
| BBS1Bardet-Biedl syndrome 1 | Often (30–79%) | In 2 conditions |
| BBS10Bardet-Biedl syndrome 10 | Often (30–79%) | In 2 conditions |
| BBS4Bardet-Biedl syndrome 4 | Often (30–79%) | In 2 conditions |
| BBS9Bardet-Biedl syndrome 9 | Often (30–79%) | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Often (30–79%) | In 2 conditions |
| CEP19centrosomal protein 19 | Often (30–79%) | In 1 condition |
| CEP290centrosomal protein 290 | Often (30–79%) | In 1 condition |
| CFAP418cilia and flagella associated protein 418 | Often (30–79%) | In 1 condition |
| CHRNGcholinergic receptor nicotinic gamma subunit | Often (30–79%) | In 1 condition |
| CTNNB1catenin beta 1 | Often (30–79%) | In 1 condition |
| ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit | Often (30–79%) | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Often (30–79%) | In 1 condition |
| HJVhemojuvelin BMP co-receptor | Often (30–79%) | In 1 condition |
| IFT172intraflagellar transport 172 | Often (30–79%) | In 1 condition |
| IFT27intraflagellar transport 27 | Often (30–79%) | In 2 conditions |
| IGF1insulin like growth factor 1 | Often (30–79%) | In 1 condition |
| MAGEL2MAGE family member L2 | Often (30–79%) | In 2 conditions |
| MKKSMKKS centrosomal shuttling protein | Often (30–79%) | In 1 condition |
| MKS1MKS transition zone complex subunit 1 | Often (30–79%) | In 1 condition |
| MYH3myosin heavy chain 3 | Often (30–79%) | In 1 condition |
| NECTIN1nectin cell adhesion molecule 1 | Often (30–79%) | In 1 condition |
| NPHP1nephrocystin 1 | Often (30–79%) | In 1 condition |
| SCAPERS-phase cyclin A associated protein in the ER | Often (30–79%) | In 1 condition |
| SCLT1sodium channel and clathrin linker 1 | Often (30–79%) | In 1 condition |
| SDCCAG8SHH signaling and ciliogenesis regulator SDCCAG8 | Often (30–79%) | In 2 conditions |
| SEMA3Asemaphorin 3A | Often (30–79%) | In 1 condition |
| SOX10SRY-box transcription factor 10 | Often (30–79%) | In 2 conditions |
| TRIM32tripartite motif containing 32 | Often (30–79%) | In 2 conditions |
| USP7ubiquitin specific peptidase 7 | Often (30–79%) | In 1 condition |
| WDPCPWD repeat containing planar cell polarity effector | Often (30–79%) | In 1 condition |
| AMACRalpha-methylacyl-CoA racemase | Sometimes (5–29%) | In 1 condition |
| ANAPC1anaphase promoting complex subunit 1 | Sometimes (5–29%) | In 1 condition |
| ANTXR1ANTXR cell adhesion molecule 1 | Sometimes (5–29%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Sometimes (5–29%) | In 1 condition |
| ATP5F1DATP synthase F1 subunit delta | Sometimes (5–29%) | In 1 condition |
| ATP5F1EATP synthase F1 subunit epsilon | Sometimes (5–29%) | In 1 condition |
| ATP5MKATP synthase membrane subunit k | Sometimes (5–29%) | In 1 condition |
| ATP5POATP synthase peripheral stalk subunit OSCP | Sometimes (5–29%) | In 1 condition |
| ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 | Sometimes (5–29%) | In 1 condition |
| BCL11ABCL11 transcription factor A | Sometimes (5–29%) | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Sometimes (5–29%) | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Sometimes (5–29%) | In 1 condition |
| CASZ1castor zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| CISD2CDGSH iron sulfur domain 2 | Sometimes (5–29%) | In 1 condition |
| CUL4Bcullin 4B | Sometimes (5–29%) | In 2 conditions |
| FAAP100FA core complex associated protein 100 | Sometimes (5–29%) | In 1 condition |
| FANCAFA complementation group A | Sometimes (5–29%) | In 1 condition |
| FANCCFA complementation group C | Sometimes (5–29%) | In 1 condition |
| FANCD2FA complementation group D2 | Sometimes (5–29%) | In 1 condition |
| FANCEFA complementation group E | Sometimes (5–29%) | In 1 condition |
| FANCFFA complementation group F | Sometimes (5–29%) | In 1 condition |
| FANCGFA complementation group G | Sometimes (5–29%) | In 1 condition |
| FANCIFA complementation group I | Sometimes (5–29%) | In 1 condition |
| FANCLFA complementation group L | Sometimes (5–29%) | In 1 condition |
| FANCMFA complementation group M | Sometimes (5–29%) | In 1 condition |
| GABRDgamma-aminobutyric acid type A receptor subunit delta | Sometimes (5–29%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Sometimes (5–29%) | In 1 condition |
| IER3IP1immediate early response 3 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| IFT54intraflagellar transport 54 | Sometimes (5–29%) | In 1 condition |
| KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2 | Sometimes (5–29%) | In 1 condition |
| LUZP1leucine zipper protein 1 | Sometimes (5–29%) | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Sometimes (5–29%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Sometimes (5–29%) | In 1 condition |
| MMP23Bmatrix metallopeptidase 23B | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Sometimes (5–29%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Sometimes (5–29%) | In 1 condition |
| PDE4Dphosphodiesterase 4D | Sometimes (5–29%) | In 1 condition |
| PDPNpodoplanin | Sometimes (5–29%) | In 1 condition |
| PHGDHphosphoglycerate dehydrogenase | Sometimes (5–29%) | In 1 condition |
| PRDM16PR/SET domain 16 | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 2 conditions |
| PRKCZprotein kinase C zeta | Sometimes (5–29%) | In 1 condition |
| PTDSS1phosphatidylserine synthase 1 | Sometimes (5–29%) | In 1 condition |
| PTPN11protein tyrosine phosphatase non-receptor type 11 | Sometimes (5–29%) | In 1 condition |
| RAD51RAD51 recombinase | Sometimes (5–29%) | In 1 condition |
| RAD51CRAD51 paralog C | Sometimes (5–29%) | In 1 condition |
| RELREL proto-oncogene, NF-kB subunit | Sometimes (5–29%) | In 1 condition |
| REREarginine-glutamic acid dipeptide repeats | Sometimes (5–29%) | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Sometimes (5–29%) | In 1 condition |
| SKISKI proto-oncogene | Sometimes (5–29%) | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Sometimes (5–29%) | In 1 condition |
| SLX4SLX4 structure-specific endonuclease subunit | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 1 condition |
| SNAP29synaptosome associated protein 29 | Sometimes (5–29%) | In 1 condition |
| SPENspen family transcriptional repressor | Sometimes (5–29%) | In 1 condition |
| STSsteroid sulfatase | Sometimes (5–29%) | In 1 condition |
| STUB1STIP1 homology and U-box containing protein 1 | Sometimes (5–29%) | In 2 conditions |
| TGFB1transforming growth factor beta 1 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Sometimes (5–29%) | In 1 condition |
| UBE4Bubiquitination factor E4B | Sometimes (5–29%) | In 1 condition |
| VPS4Avacuolar protein sorting 4 homolog A | Sometimes (5–29%) | In 1 condition |
| WFS1wolframin ER transmembrane glycoprotein | Sometimes (5–29%) | In 1 condition |
| XPO1exportin 1 | Sometimes (5–29%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Sometimes (5–29%) | In 1 condition |
| DNM1Ldynamin 1L | Rarely (1–4%) | In 1 condition |
| HBBhemoglobin subunit beta | Rarely (1–4%) | In 1 condition |
| MYT1Lmyelin transcription factor 1 like | Rarely (1–4%) | In 1 condition |
| OPA1OPA1 mitochondrial dynamin like GTPase | Rarely (1–4%) | In 1 condition |
| PPIBpeptidylprolyl isomerase B | Rarely (1–4%) | In 1 condition |
| ABCD1ATP binding cassette subfamily D member 1 | Not recorded | In 1 condition |
| ARandrogen receptor | Not recorded | In 1 condition |
| ARSLarylsulfatase L | Not recorded | In 1 condition |
| ATRXATRX chromatin remodeler | Not recorded | In 1 condition |
| CCDC28Bcoiled-coil domain containing 28B | Not recorded | In 1 condition |
| CNBPCCHC-type zinc finger nucleic acid binding protein | Not recorded | In 1 condition |
| DMPKDM1 protein kinase | Not recorded | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Not recorded | In 1 condition |
| FGF17fibroblast growth factor 17 | Not recorded | In 1 condition |
| FSHBfollicle stimulating hormone subunit beta | Not recorded | In 1 condition |
| GNASGNAS complex locus | Not recorded | In 2 conditions |
| HDAC8histone deacetylase 8 | Not recorded | In 1 condition |
| IL17RDinterleukin 17 receptor D | Not recorded | In 1 condition |
| LEPleptin | Not recorded | In 1 condition |
| PROP1PROP paired-like homeobox 1 | Not recorded | In 1 condition |
| RECQL4RecQ like helicase 4 | Not recorded | In 1 condition |
| SGPL1sphingosine-1-phosphate lyase 1 | Not recorded | In 1 condition |
| SLC39A4solute carrier family 39 member 4 | Not recorded | In 1 condition |
| TGFB2transforming growth factor beta 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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From $449Free shipping · Results in 6–8 weeks