Trait

Psychotic episodes

Periods of time during which an individual experiences significant disturbances in their thoughts, perceptions, emotions, and behavior, resulting in a loss of touch with reality. These episodes are hallmark features of psychotic disorders such as schizophrenia, schizoaffective disorder, and certain forms of bipolar disorder.

HPO HP:0000725

Body system: Abnormality of the nervous system

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18 genes linked to Psychotic episodes

Changes in these genes cause rare conditions in which Psychotic episodes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
MTHFRmethylenetetrahydrofolate reductase	Often (30–79%)	In 1 condition
PITRM1pitrilysin metallopeptidase 1	Often (30–79%)	In 1 condition
ARMC5armadillo repeat containing 5	Sometimes (5–29%)	In 1 condition
ATRXATRX chromatin remodeler	Sometimes (5–29%)	In 1 condition
BRAFB-Raf proto-oncogene, serine/threonine kinase	Sometimes (5–29%)	In 1 condition
CDH23cadherin related 23	Sometimes (5–29%)	In 1 condition
GNASGNAS complex locus	Sometimes (5–29%)	In 1 condition
KDM1Alysine demethylase 1A	Sometimes (5–29%)	In 1 condition
NR3C1nuclear receptor subfamily 3 group C member 1	Sometimes (5–29%)	In 1 condition
PARK7Parkinsonism associated deglycase	Sometimes (5–29%)	In 1 condition
SLC7A7solute carrier family 7 member 7	Sometimes (5–29%)	In 1 condition
TP53tumor protein p53	Sometimes (5–29%)	In 1 condition
USP48ubiquitin specific peptidase 48	Sometimes (5–29%)	In 1 condition
USP8ubiquitin specific peptidase 8	Sometimes (5–29%)	In 1 condition
NAGSN-acetylglutamate synthase	Rarely (1–4%)	In 1 condition
SNORD118small nucleolar RNA, C/D box 118	Rarely (1–4%)	In 1 condition
ATP13A2ATPase cation transporting 13A2	Not recorded	In 1 condition
HMBShydroxymethylbilane synthase	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal psychotic pattern

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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