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Trait
Colon cancer
Summary
Colon cancerHP:0003003
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Read the genes linked to Colon cancer, and the rest of your genome, with one test.
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Get my Genome Test60 genes linked to Colon cancer
Changes in these genes cause rare conditions in which Colon cancer is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| APCAPC regulator of Wnt signaling pathway | Very often (80–99%) | In 6 conditions |
| BMPR1Abone morphogenetic protein receptor type 1A | Often (30–79%) | In 3 conditions |
| EPCAMepithelial cell adhesion molecule | Often (30–79%) | In 2 conditions |
| GREM1gremlin 1, DAN family BMP antagonist | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 2 conditions |
| MLH1mutL homolog 1 | Often (30–79%) | In 2 conditions |
| MSH2mutS homolog 2 | Often (30–79%) | In 3 conditions |
| MSH3mutS homolog 3 | Often (30–79%) | In 1 condition |
| MSH6mutS homolog 6 | Often (30–79%) | In 2 conditions |
| MUTYHmutY DNA glycosylase | Often (30–79%) | In 1 condition |
| NTHL1nth like DNA glycosylase 1 | Often (30–79%) | In 2 conditions |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 2 conditions |
| PMS1PMS1 homolog 1, mismatch repair system component | Often (30–79%) | In 1 condition |
| PMS2PMS1 homolog 2, mismatch repair system component | Often (30–79%) | In 2 conditions |
| TGFBR2transforming growth factor beta receptor 2 | Often (30–79%) | In 1 condition |
| AXIN2axin 2 | Sometimes (5–29%) | In 3 conditions |
| BRCA1BRCA1 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Sometimes (5–29%) | In 1 condition |
| BUB1BUB1 mitotic checkpoint serine/threonine kinase | Sometimes (5–29%) | In 2 conditions |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Sometimes (5–29%) | In 2 conditions |
| BUB3BUB3 mitotic checkpoint protein | Sometimes (5–29%) | In 1 condition |
| C1Scomplement C1s | Sometimes (5–29%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Sometimes (5–29%) | In 2 conditions |
| CEP57centrosomal protein 57 | Sometimes (5–29%) | In 1 condition |
| FOXE1forkhead box E1 | Sometimes (5–29%) | In 1 condition |
| HABP2hyaluronan binding protein 2 | Sometimes (5–29%) | In 1 condition |
| MBD4methyl-CpG binding domain 4, DNA glycosylase | Sometimes (5–29%) | In 1 condition |
| MINPP1multiple inositol-polyphosphate phosphatase 1 | Sometimes (5–29%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Sometimes (5–29%) | In 1 condition |
| PALLDpalladin, cytoskeletal associated protein | Sometimes (5–29%) | In 1 condition |
| RABL3RAB, member of RAS oncogene family like 3 | Sometimes (5–29%) | In 1 condition |
| RPS19ribosomal protein S19 | Sometimes (5–29%) | In 1 condition |
| SMAD4SMAD family member 4 | Sometimes (5–29%) | In 2 conditions |
| TP53tumor protein p53 | Sometimes (5–29%) | In 4 conditions |
| TRIP13thyroid hormone receptor interactor 13 | Sometimes (5–29%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Rarely (1–4%) | In 1 condition |
| FLCNfolliculin | Rarely (1–4%) | In 2 conditions |
| MDM2MDM2 proto-oncogene | Rarely (1–4%) | In 1 condition |
| NF1neurofibromin 1 | Rarely (1–4%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Not recorded | In 1 condition |
Show 20 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| AURKAaurora kinase A | Not recorded | In 1 condition |
| BAXBCL2 associated X, apoptosis regulator | Not recorded | In 1 condition |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Not recorded | In 1 condition |
| CCND1cyclin D1 | Not recorded | In 1 condition |
| CTNNB1catenin beta 1 | Not recorded | In 1 condition |
| DCCDCC netrin 1 receptor | Not recorded | In 1 condition |
| DLC1DLC1 Rho GTPase activating protein | Not recorded | In 1 condition |
| EP300EP300 lysine acetyltransferase | Not recorded | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Not recorded | In 1 condition |
| MCCMCC regulator of Wnt signaling pathway | Not recorded | In 1 condition |
| MLH3mutL homolog 3 | Not recorded | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Not recorded | In 1 condition |
| PDGFRLplatelet derived growth factor receptor like | Not recorded | In 1 condition |
| PLA2G2Aphospholipase A2 group IIA | Not recorded | In 1 condition |
| PTPN12protein tyrosine phosphatase non-receptor type 12 | Not recorded | In 1 condition |
| PTPRJprotein tyrosine phosphatase receptor type J | Not recorded | In 1 condition |
| RAD54BRAD54 homolog B | Not recorded | In 1 condition |
| SMAD7SMAD family member 7 | Not recorded | In 1 condition |
| SRCSRC proto-oncogene, non-receptor tyrosine kinase | Not recorded | In 1 condition |
| TLR2toll like receptor 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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