Trait

Enlarged adrenal glands

Clinical name: Adrenal hyperplasia

Enlargement of the adrenal gland.

HPO HP:0008221

Body system: Abnormality of the endocrine system

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22 genes linked to Enlarged adrenal glands

Changes in these genes cause rare conditions in which Enlarged adrenal glands is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AIREautoimmune regulator	Very often (80–99%)	In 1 condition
KCNJ5potassium inwardly rectifying channel subfamily J member 5	Very often (80–99%)	In 2 conditions
ATRXATRX chromatin remodeler	Often (30–79%)	In 1 condition
BRAFB-Raf proto-oncogene, serine/threonine kinase	Often (30–79%)	In 1 condition
CDH23cadherin related 23	Often (30–79%)	In 1 condition
CYP11B1cytochrome P450 family 11 subfamily B member 1	Often (30–79%)	In 2 conditions
CYP11B2cytochrome P450 family 11 subfamily B member 2	Often (30–79%)	In 1 condition
NR3C1nuclear receptor subfamily 3 group C member 1	Often (30–79%)	In 2 conditions
PORcytochrome p450 oxidoreductase	Often (30–79%)	In 1 condition
TP53tumor protein p53	Often (30–79%)	In 1 condition
USP48ubiquitin specific peptidase 48	Often (30–79%)	In 1 condition
USP8ubiquitin specific peptidase 8	Often (30–79%)	In 1 condition
CLCN2chloride voltage-gated channel 2	Sometimes (5–29%)	In 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2	Rarely (1–4%)	In 1 condition
CACNA1Dcalcium voltage-gated channel subunit alpha1 D	Rarely (1–4%)	In 1 condition
TBC1D24TBC1 domain family member 24	Rarely (1–4%)	In 1 condition
CYP17A1cytochrome P450 family 17 subfamily A member 1	Not recorded	In 1 condition
CYP21A2cytochrome P450 family 21 subfamily A member 2	Not recorded	In 1 condition
GNASGNAS complex locus	Not recorded	In 1 condition
HSD3B2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Not recorded	In 1 condition
PDE8Bphosphodiesterase 8B	Not recorded	In 1 condition
PRKACAprotein kinase cAMP-activated catalytic subunit alpha	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal adrenal morphology

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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