Trait
Abnormal tissue mass
Clinical name: Neoplasm
An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumor).
Summary
- Also called
- Cancer, Neoplasia, Oncological abnormality, Tumor, Tumour
Reference genomeGRCh38hg38
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Get my Genome Test124 genes linked to Abnormal tissue mass
Changes in these genes cause rare conditions in which Abnormal tissue mass is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| PAN2poly(A) specific ribonuclease subunit PAN2 | Always | In 1 condition |
| RAB32RAB32, member RAS oncogene family | Always | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Very often (80–99%) | In 2 conditions |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 2 conditions |
| BRD4bromodomain containing 4 | Very often (80–99%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Very often (80–99%) | In 1 condition |
| CHEK2checkpoint kinase 2 | Very often (80–99%) | In 1 condition |
| CTR9CTR9 component of Paf1/RNA polymerase II complex | Very often (80–99%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Very often (80–99%) | In 1 condition |
| GPC3glypican 3 | Very often (80–99%) | In 2 conditions |
| H19H19 imprinted maternally expressed transcript | Very often (80–99%) | In 1 condition |
| MDM2MDM2 proto-oncogene | Very often (80–99%) | In 1 condition |
| NUTM1NUT midline carcinoma family member 1 | Very often (80–99%) | In 1 condition |
| POU6F2POU class 6 homeobox 2 | Very often (80–99%) | In 1 condition |
| PTCH1patched 1 | Very often (80–99%) | In 1 condition |
| PTCH2patched 2 | Very often (80–99%) | In 1 condition |
| RESTRE1 silencing transcription factor | Very often (80–99%) | In 1 condition |
| SUFUSUFU negative regulator of hedgehog signaling | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 2 conditions |
| TRIM28tripartite motif containing 28 | Very often (80–99%) | In 1 condition |
| TRIP13thyroid hormone receptor interactor 13 | Very often (80–99%) | In 2 conditions |
| WT1WT1 transcription factor | Very often (80–99%) | In 1 condition |
| ACDACD shelterin complex subunit and telomerase recruitment factor | Often (30–79%) | In 2 conditions |
| ATMATM serine/threonine kinase | Often (30–79%) | In 1 condition |
| BCRBCR activator of RhoGEF and GTPase | Often (30–79%) | In 1 condition |
| BLMBLM RecQ like helicase | Often (30–79%) | In 1 condition |
| BRIP1BRCA1 interacting DNA helicase 1 | Often (30–79%) | In 1 condition |
| CRKLCRK like proto-oncogene, adaptor protein | Often (30–79%) | In 1 condition |
| CTC1CST telomere replication complex component 1 | Often (30–79%) | In 1 condition |
| DKC1dyskerin pseudouridine synthase 1 | Often (30–79%) | In 2 conditions |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Often (30–79%) | In 2 conditions |
| FAAP100FA core complex associated protein 100 | Often (30–79%) | In 1 condition |
| FANCAFA complementation group A | Often (30–79%) | In 1 condition |
| FANCBFA complementation group B | Often (30–79%) | In 1 condition |
| FANCCFA complementation group C | Often (30–79%) | In 1 condition |
| FANCD2FA complementation group D2 | Often (30–79%) | In 1 condition |
| FANCEFA complementation group E | Often (30–79%) | In 1 condition |
| FANCFFA complementation group F | Often (30–79%) | In 1 condition |
| FANCGFA complementation group G | Often (30–79%) | In 1 condition |
| FANCIFA complementation group I | Often (30–79%) | In 1 condition |
Show 84 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| FANCLFA complementation group L | Often (30–79%) | In 1 condition |
| FANCMFA complementation group M | Often (30–79%) | In 1 condition |
| MAD2L2mitotic arrest deficient 2 like 2 | Often (30–79%) | In 1 condition |
| MAPK1mitogen-activated protein kinase 1 | Often (30–79%) | In 1 condition |
| NBNnibrin | Often (30–79%) | In 1 condition |
| NHP2NHP2 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NOP10NOP10 ribonucleoprotein | Often (30–79%) | In 1 condition |
| NPM1nucleophosmin 1 | Often (30–79%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Often (30–79%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Often (30–79%) | In 2 conditions |
| PTENphosphatase and tensin homolog | Often (30–79%) | In 2 conditions |
| RAD51RAD51 recombinase | Often (30–79%) | In 1 condition |
| RAD51CRAD51 paralog C | Often (30–79%) | In 1 condition |
| RFWD3ring finger and WD repeat domain 3 | Often (30–79%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Often (30–79%) | In 2 conditions |
| SLX4SLX4 structure-specific endonuclease subunit | Often (30–79%) | In 1 condition |
| TERCtelomerase RNA component | Often (30–79%) | In 2 conditions |
| TERTtelomerase reverse transcriptase | Often (30–79%) | In 2 conditions |
| TINF2TERF1 interacting nuclear factor 2 | Often (30–79%) | In 2 conditions |
| TYMSthymidylate synthetase | Often (30–79%) | In 1 condition |
| UBE2Tubiquitin conjugating enzyme E2 T | Often (30–79%) | In 1 condition |
| USB1U6 snRNA biogenesis phosphodiesterase 1 | Often (30–79%) | In 1 condition |
| WRAP53WD repeat containing antisense to TP53 | Often (30–79%) | In 1 condition |
| XRCC2X-ray repair cross complementing 2 | Often (30–79%) | In 1 condition |
| AKT1AKT serine/threonine kinase 1 | Sometimes (5–29%) | In 1 condition |
| BTKBruton tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| BUB1BUB1 mitotic checkpoint serine/threonine kinase | Sometimes (5–29%) | In 1 condition |
| BUB1BBUB1 mitotic checkpoint serine/threonine kinase B | Sometimes (5–29%) | In 1 condition |
| BUB3BUB3 mitotic checkpoint protein | Sometimes (5–29%) | In 1 condition |
| CARD14caspase recruitment domain family member 14 | Sometimes (5–29%) | In 1 condition |
| CEP57centrosomal protein 57 | Sometimes (5–29%) | In 1 condition |
| COQ6coenzyme Q6, monooxygenase | Sometimes (5–29%) | In 1 condition |
| CREBBPCREB binding lysine acetyltransferase | Sometimes (5–29%) | In 2 conditions |
| DCLRE1CDNA cross-link repair 1C | Sometimes (5–29%) | In 1 condition |
| DDB2damage specific DNA binding protein 2 | Sometimes (5–29%) | In 1 condition |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 1 condition |
| ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit | Sometimes (5–29%) | In 2 conditions |
| ERCC5ERCC excision repair 5, endonuclease | Sometimes (5–29%) | In 1 condition |
| FLCNfolliculin | Sometimes (5–29%) | In 1 condition |
| GPC4glypican 4 | Sometimes (5–29%) | In 1 condition |
| IDH1isocitrate dehydrogenase (NADP(+)) 1 | Sometimes (5–29%) | In 1 condition |
| IDH2isocitrate dehydrogenase (NADP(+)) 2 | Sometimes (5–29%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 1 condition |
| NAB2NGFI-A binding protein 2 | Sometimes (5–29%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Sometimes (5–29%) | In 1 condition |
| PCNAproliferating cell nuclear antigen | Sometimes (5–29%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Sometimes (5–29%) | In 1 condition |
| PNPpurine nucleoside phosphorylase | Sometimes (5–29%) | In 1 condition |
| PRDM10PR/SET domain 10 | Sometimes (5–29%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Sometimes (5–29%) | In 1 condition |
| PTPN6protein tyrosine phosphatase non-receptor type 6 | Sometimes (5–29%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Sometimes (5–29%) | In 1 condition |
| STAT6signal transducer and activator of transcription 6 | Sometimes (5–29%) | In 1 condition |
| STK11serine/threonine kinase 11 | Sometimes (5–29%) | In 1 condition |
| USP9Xubiquitin specific peptidase 9 X-linked | Sometimes (5–29%) | In 1 condition |
| WASWASP actin nucleation promoting factor | Sometimes (5–29%) | In 1 condition |
| WRNWRN RecQ like helicase | Sometimes (5–29%) | In 1 condition |
| XPAXPA, DNA damage recognition and repair factor | Sometimes (5–29%) | In 1 condition |
| XPCXPC complex subunit, DNA damage recognition and repair factor | Sometimes (5–29%) | In 1 condition |
| APC2APC regulator of Wnt signaling pathway 2 | Rarely (1–4%) | In 1 condition |
| BCHEbutyrylcholinesterase | Rarely (1–4%) | In 1 condition |
| NSD1nuclear receptor binding SET domain protein 1 | Rarely (1–4%) | In 1 condition |
| ARandrogen receptor | Not recorded | In 1 condition |
| BPTFbromodomain PHD finger transcription factor | Not recorded | In 1 condition |
| CD19CD19 molecule | Not recorded | In 1 condition |
| CR2complement C3d receptor 2 | Not recorded | In 1 condition |
| CYLDCYLD lysine 63 deubiquitinase | Not recorded | In 1 condition |
| CYP2D6cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) | Not recorded | In 1 condition |
| EP300EP300 lysine acetyltransferase | Not recorded | In 1 condition |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Not recorded | In 1 condition |
| FGFR3fibroblast growth factor receptor 3 | Not recorded | In 1 condition |
| GNASGNAS complex locus | Not recorded | In 1 condition |
| ICOSinducible T cell costimulator | Not recorded | In 1 condition |
| IL6interleukin 6 | Not recorded | In 1 condition |
| KIF1Bkinesin family member 1B | Not recorded | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Not recorded | In 1 condition |
| MAXMYC associated transcriptional regulator X | Not recorded | In 1 condition |
| RETret proto-oncogene | Not recorded | In 1 condition |
| SDHAF2succinate dehydrogenase complex assembly factor 2 | Not recorded | In 1 condition |
| TMEM127transmembrane protein 127 | Not recorded | In 1 condition |
| TNFRSF13BTNF receptor superfamily member 13B | Not recorded | In 1 condition |
| TNFRSF13CTNF receptor superfamily member 13C | Not recorded | In 1 condition |
| VHLvon Hippel-Lindau tumor suppressor | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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