Trait
Swollen lymph nodes
Clinical name: Lymphadenopathy
Enlargement (swelling) of a lymph node.
Summary
- Also called
- Lymph node hyperplasia
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Swollen lymph nodes, and the rest of your genome, with one test.
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Get my Genome Test236 genes linked to Swollen lymph nodes
Changes in these genes cause rare conditions in which Swollen lymph nodes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CASP10caspase 10 | Always | In 2 conditions |
| CASP8caspase 8 | Always | In 1 condition |
| CD70CD70 molecule | Always | In 1 condition |
| CTNNBL1catenin beta like 1 | Always | In 1 condition |
| CYBC1cytochrome b-245 chaperone 1 | Always | In 1 condition |
| HMOX1heme oxygenase 1 | Always | In 1 condition |
| IKZF2IKAROS family zinc finger 2 | Always | In 1 condition |
| IL2RAinterleukin 2 receptor subunit alpha | Always | In 2 conditions |
| IL6STinterleukin 6 cytokine family signal transducer | Always | In 1 condition |
| IRF8interferon regulatory factor 8 | Always | In 2 conditions |
| ITKIL2 inducible T cell kinase | Always | In 1 condition |
| ITPR3inositol 1,4,5-trisphosphate receptor type 3 | Always | In 1 condition |
| LATlinker for activation of T cells | Always | In 1 condition |
| MAGT1magnesium transporter 1 | Always | In 1 condition |
| MCTS1MCTS1 re-initiation and release factor | Always | In 1 condition |
| NBNnibrin | Always | In 1 condition |
| NCKAP1LNCK associated protein 1 like | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 3 conditions |
| PLD4phospholipase D family member 4 | Always | In 1 condition |
| POLD3DNA polymerase delta 3, accessory subunit | Always | In 1 condition |
| PRKCDprotein kinase C delta | Always | In 1 condition |
| PSMG2proteasome assembly chaperone 2 | Always | In 1 condition |
| RASGRP1RAS guanyl releasing protein 1 | Always | In 1 condition |
| RC3H1ring finger and CCCH-type domains 1 | Always | In 1 condition |
| SHARPINSHANK associated RH domain interactor | Always | In 1 condition |
| SLC29A3solute carrier family 29 member 3 | Always | In 2 conditions |
| STXBP2syntaxin binding protein 2 | Always | In 2 conditions |
| TET2tet methylcytosine dioxygenase 2 | Always | In 4 conditions |
| TPP2tripeptidyl peptidase 2 | Always | In 2 conditions |
| TRACT cell receptor alpha constant | Always | In 1 condition |
| TRAF3TNF receptor associated factor 3 | Always | In 1 condition |
| UNGuracil DNA glycosylase | Always | In 1 condition |
| ZAP70zeta chain of T cell receptor associated protein kinase 70 | Always | In 2 conditions |
| ADAadenosine deaminase | Very often (80–99%) | In 1 condition |
| ATMATM serine/threonine kinase | Very often (80–99%) | In 1 condition |
| BCL2BCL2 apoptosis regulator | Very often (80–99%) | In 1 condition |
| BCL6BCL6 transcription repressor | Very often (80–99%) | In 1 condition |
| CCND1cyclin D1 | Very often (80–99%) | In 2 conditions |
| CD28CD28 molecule | Very often (80–99%) | In 2 conditions |
| CHD7chromodomain helicase DNA binding protein 7 | Very often (80–99%) | In 1 condition |
Show 196 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CLCN7Cl-/H+ antiporter 7 | Very often (80–99%) | In 1 condition |
| CTLA4cytotoxic T-lymphocyte associated protein 4 | Very often (80–99%) | In 5 conditions |
| DCLRE1CDNA cross-link repair 1C | Very often (80–99%) | In 2 conditions |
| EIF2AK4eukaryotic translation initiation factor 2 alpha kinase 4 | Very often (80–99%) | In 1 condition |
| EWSR1EWS RNA binding protein 1 | Very often (80–99%) | In 1 condition |
| FASFas cell surface death receptor | Very often (80–99%) | In 2 conditions |
| FASLGFas ligand | Very often (80–99%) | In 1 condition |
| GINS1GINS complex subunit 1 | Very often (80–99%) | In 1 condition |
| HLA-DRB1major histocompatibility complex, class II, DR beta 1 | Very often (80–99%) | In 4 conditions |
| IGHimmunoglobulin heavy locus | Very often (80–99%) | In 3 conditions |
| IL2RGinterleukin 2 receptor subunit gamma | Very often (80–99%) | In 1 condition |
| IL7Rinterleukin 7 receptor | Very often (80–99%) | In 3 conditions |
| MVKmevalonate kinase | Very often (80–99%) | In 3 conditions |
| NUDCD3NudC domain containing 3 | Very often (80–99%) | In 1 condition |
| OSTM1osteoclastogenesis associated transmembrane protein 1 | Very often (80–99%) | In 1 condition |
| PSMB10proteasome 20S subunit beta 10 | Very often (80–99%) | In 1 condition |
| RAG1recombination activating 1 | Very often (80–99%) | In 2 conditions |
| RAG2recombination activating 2 | Very often (80–99%) | In 2 conditions |
| RIPK1receptor interacting serine/threonine kinase 1 | Very often (80–99%) | In 1 condition |
| RMRPRNA component of mitochondrial RNA processing endoribonuclease | Very often (80–99%) | In 1 condition |
| SNX10sorting nexin 10 | Very often (80–99%) | In 1 condition |
| TCIRG1T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 | Very often (80–99%) | In 1 condition |
| TNFRSF1BTNF receptor superfamily member 1B | Very often (80–99%) | In 2 conditions |
| TNFSF11TNF superfamily member 11 | Very often (80–99%) | In 1 condition |
| WT1WT1 transcription factor | Very often (80–99%) | In 2 conditions |
| ADA2adenosine deaminase 2 | Often (30–79%) | In 1 condition |
| ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3 | Often (30–79%) | In 1 condition |
| AICDAactivation induced cytidine deaminase | Often (30–79%) | In 1 condition |
| ALKALK receptor tyrosine kinase | Often (30–79%) | In 1 condition |
| ASXL1ASXL transcriptional regulator 1 | Often (30–79%) | In 2 conditions |
| BRCA1BRCA1 DNA repair associated | Often (30–79%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Often (30–79%) | In 2 conditions |
| CBLCbl proto-oncogene | Often (30–79%) | In 1 condition |
| CCBE1collagen and calcium binding EGF domains 1 | Often (30–79%) | In 1 condition |
| CD27CD27 molecule | Often (30–79%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Often (30–79%) | In 1 condition |
| ELANEelastase, neutrophil expressed | Often (30–79%) | In 1 condition |
| FAT4FAT atypical cadherin 4 | Often (30–79%) | In 1 condition |
| FCHO1FCH and mu domain containing endocytic adaptor 1 | Often (30–79%) | In 1 condition |
| HACE1HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 | Often (30–79%) | In 1 condition |
| IL6interleukin 6 | Often (30–79%) | In 1 condition |
| IRAK1interleukin 1 receptor associated kinase 1 | Often (30–79%) | In 2 conditions |
| ISG15ISG15 ubiquitin like modifier | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| LACC1laccase domain multifunctional purine nucleosidase 1 | Often (30–79%) | In 1 condition |
| LIN28Blin-28 RNA binding posttranscriptional regulator B | Often (30–79%) | In 1 condition |
| LMO1LIM domain only 1 | Often (30–79%) | In 1 condition |
| MAP2K1mitogen-activated protein kinase kinase 1 | Often (30–79%) | In 1 condition |
| MIFmacrophage migration inhibitory factor | Often (30–79%) | In 1 condition |
| MYCNMYCN proto-oncogene, bHLH transcription factor | Often (30–79%) | In 1 condition |
| NLRP12NLR family pyrin domain containing 12 | Often (30–79%) | In 1 condition |
| NRASNRAS proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| OTULINOTU deubiquitinase with linear linkage specificity | Often (30–79%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Often (30–79%) | In 1 condition |
| PALLDpalladin, cytoskeletal associated protein | Often (30–79%) | In 1 condition |
| PHOX2Bpaired like homeobox 2B | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 2 conditions |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Often (30–79%) | In 1 condition |
| PRF1perforin 1 | Often (30–79%) | In 2 conditions |
| PSMB8proteasome 20S subunit beta 8 | Often (30–79%) | In 1 condition |
| PSTPIP1proline-serine-threonine phosphatase interacting protein 1 | Often (30–79%) | In 1 condition |
| RAB27ARAB27A, member RAS oncogene family | Often (30–79%) | In 1 condition |
| RABL3RAB, member of RAS oncogene family like 3 | Often (30–79%) | In 1 condition |
| RBCK1RANBP2-type and C3HC4-type zinc finger containing 1 | Often (30–79%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Often (30–79%) | In 2 conditions |
| RUNX1RUNX family transcription factor 1 | Often (30–79%) | In 1 condition |
| SAT1spermidine/spermine N1-acetyltransferase 1 | Often (30–79%) | In 1 condition |
| SMAD4SMAD family member 4 | Often (30–79%) | In 1 condition |
| SPP1secreted phosphoprotein 1 | Often (30–79%) | In 2 conditions |
| SRSF2serine and arginine rich splicing factor 2 | Often (30–79%) | In 2 conditions |
| STAT1signal transducer and activator of transcription 1 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 4 conditions |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| STX11syntaxin 11 | Often (30–79%) | In 2 conditions |
| SYKspleen associated tyrosine kinase | Often (30–79%) | In 1 condition |
| TBK1TANK binding kinase 1 | Often (30–79%) | In 1 condition |
| TLR8toll like receptor 8 | Often (30–79%) | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Often (30–79%) | In 1 condition |
| TP53tumor protein p53 | Often (30–79%) | In 1 condition |
| TSC1TSC complex subunit 1 | Often (30–79%) | In 1 condition |
| TSC2TSC complex subunit 2 | Often (30–79%) | In 1 condition |
| UNC13Dunc-13 homolog D | Often (30–79%) | In 1 condition |
| WDR1WD repeat domain 1 | Often (30–79%) | In 1 condition |
| YARS1tyrosyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| ZNFX1zinc finger NFX1-type containing 1 | Often (30–79%) | In 1 condition |
| ANKRD55ankyrin repeat domain 55 | Sometimes (5–29%) | In 1 condition |
| BANK1B cell scaffold protein with ankyrin repeats 1 | Sometimes (5–29%) | In 1 condition |
| BAP1BRCA1 associated deubiquitinase 1 | Sometimes (5–29%) | In 1 condition |
| BCL10BCL10 immune signaling adaptor | Sometimes (5–29%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| BIRC3baculoviral IAP repeat containing 3 | Sometimes (5–29%) | In 1 condition |
| BLKBLK proto-oncogene, Src family tyrosine kinase | Sometimes (5–29%) | In 1 condition |
| BTNL2butyrophilin like 2 | Sometimes (5–29%) | In 1 condition |
| C4Acomplement C4A (Chido/Rodgers blood group) | Sometimes (5–29%) | In 2 conditions |
| C4Bcomplement C4B (Chido/Rodgers blood group) | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| CCR1C-C motif chemokine receptor 1 | Sometimes (5–29%) | In 1 condition |
| CD247CD247 molecule | Sometimes (5–29%) | In 1 condition |
| CR2complement C3d receptor 2 | Sometimes (5–29%) | In 2 conditions |
| CTR9CTR9 component of Paf1/RNA polymerase II complex | Sometimes (5–29%) | In 1 condition |
| DIS3L2DIS3 like 3'-5' exoribonuclease 2 | Sometimes (5–29%) | In 1 condition |
| DLEC1DLEC1 cilia and flagella associated protein | Sometimes (5–29%) | In 1 condition |
| DNASE1deoxyribonuclease 1 | Sometimes (5–29%) | In 1 condition |
| DNASE1L3deoxyribonuclease 1L3 | Sometimes (5–29%) | In 1 condition |
| ERAP1endoplasmic reticulum aminopeptidase 1 | Sometimes (5–29%) | In 1 condition |
| ERBB2erb-b2 receptor tyrosine kinase 2 | Sometimes (5–29%) | In 1 condition |
| ETS1ETS proto-oncogene 1, transcription factor | Sometimes (5–29%) | In 1 condition |
| FCGR2BFc gamma receptor IIb | Sometimes (5–29%) | In 1 condition |
| FCGR3BFc gamma receptor IIIb | Sometimes (5–29%) | In 1 condition |
| FIP1L1factor interacting with PAPOLA and CPSF1 | Sometimes (5–29%) | In 1 condition |
| FOXN1forkhead box N1 | Sometimes (5–29%) | In 1 condition |
| FOXP1forkhead box P1 | Sometimes (5–29%) | In 1 condition |
| FOXP3forkhead box P3 | Sometimes (5–29%) | In 2 conditions |
| GATA2GATA binding protein 2 | Sometimes (5–29%) | In 1 condition |
| GPC3glypican 3 | Sometimes (5–29%) | In 1 condition |
| H19H19 imprinted maternally expressed transcript | Sometimes (5–29%) | In 1 condition |
| HLA-Bmajor histocompatibility complex, class I, B | Sometimes (5–29%) | In 1 condition |
| IFNGR1interferon gamma receptor 1 | Sometimes (5–29%) | In 2 conditions |
| IGHG1immunoglobulin heavy constant gamma 1 (G1m marker) | Sometimes (5–29%) | In 1 condition |
| IL10interleukin 10 | Sometimes (5–29%) | In 2 conditions |
| IL12Ainterleukin 12A | Sometimes (5–29%) | In 1 condition |
| IL12A-AS1IL12A antisense RNA 1 | Sometimes (5–29%) | In 1 condition |
| IL23Rinterleukin 23 receptor | Sometimes (5–29%) | In 1 condition |
| IL2RBinterleukin 2 receptor subunit beta | Sometimes (5–29%) | In 2 conditions |
| IRF2BP2interferon regulatory factor 2 binding protein 2 | Sometimes (5–29%) | In 1 condition |
| IRF4interferon regulatory factor 4 | Sometimes (5–29%) | In 1 condition |
| IRF5interferon regulatory factor 5 | Sometimes (5–29%) | In 1 condition |
| ITGAMintegrin subunit alpha M | Sometimes (5–29%) | In 1 condition |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 1 condition |
| JAZF1JAZF zinc finger 1 | Sometimes (5–29%) | In 1 condition |
| KIAA0319LKIAA0319 like | Sometimes (5–29%) | In 1 condition |
| KITKIT proto-oncogene, receptor tyrosine kinase | Sometimes (5–29%) | In 2 conditions |
| KLRC4killer cell lectin like receptor C4 | Sometimes (5–29%) | In 1 condition |
| LCATlecithin-cholesterol acyltransferase | Sometimes (5–29%) | In 1 condition |
| LIG4DNA ligase 4 | Sometimes (5–29%) | In 1 condition |
| LRBALPS responsive beige-like anchor protein | Sometimes (5–29%) | In 1 condition |
| LYSTlysosomal trafficking regulator | Sometimes (5–29%) | In 2 conditions |
| MALT1MALT1 paracaspase | Sometimes (5–29%) | In 1 condition |
| MECP2methyl-CpG binding protein 2 | Sometimes (5–29%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Sometimes (5–29%) | In 2 conditions |
| MPLMPL proto-oncogene, thrombopoietin receptor | Sometimes (5–29%) | In 1 condition |
| MYD88MYD88 innate immune signal transduction adaptor | Sometimes (5–29%) | In 1 condition |
| NABP1nucleic acid binding protein 1 | Sometimes (5–29%) | In 1 condition |
| NOD2nucleotide binding oligomerization domain containing 2 | Sometimes (5–29%) | In 1 condition |
| NPM1nucleophosmin 1 | Sometimes (5–29%) | In 1 condition |
| NUMA1nuclear mitotic apparatus protein 1 | Sometimes (5–29%) | In 1 condition |
| PDCD1programmed cell death 1 | Sometimes (5–29%) | In 1 condition |
| PMLPML nuclear body scaffold | Sometimes (5–29%) | In 1 condition |
| POU6F2POU class 6 homeobox 2 | Sometimes (5–29%) | In 1 condition |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Sometimes (5–29%) | In 1 condition |
| PTPN2protein tyrosine phosphatase non-receptor type 2 | Sometimes (5–29%) | In 1 condition |
| PTPN22protein tyrosine phosphatase non-receptor type 22 | Sometimes (5–29%) | In 2 conditions |
| PXKPX domain containing serine/threonine kinase like | Sometimes (5–29%) | In 1 condition |
| RARAretinoic acid receptor alpha | Sometimes (5–29%) | In 1 condition |
| RESTRE1 silencing transcription factor | Sometimes (5–29%) | In 1 condition |
| RNF6ring finger protein 6 | Sometimes (5–29%) | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Sometimes (5–29%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Sometimes (5–29%) | In 1 condition |
| SDHCsuccinate dehydrogenase complex subunit C | Sometimes (5–29%) | In 1 condition |
| SOCS1suppressor of cytokine signaling 1 | Sometimes (5–29%) | In 1 condition |
| STAT3signal transducer and activator of transcription 3 | Sometimes (5–29%) | In 1 condition |
| STAT5Bsignal transducer and activator of transcription 5B | Sometimes (5–29%) | In 1 condition |
| TBL1XR1TBL1X/Y related 1 | Sometimes (5–29%) | In 1 condition |
| TGFBR2transforming growth factor beta receptor 2 | Sometimes (5–29%) | In 1 condition |
| TLR4toll like receptor 4 | Sometimes (5–29%) | In 1 condition |
| TLR7toll like receptor 7 | Sometimes (5–29%) | In 1 condition |
| TNFAIP3TNF alpha induced protein 3 | Sometimes (5–29%) | In 1 condition |
| TNFSF4TNF superfamily member 4 | Sometimes (5–29%) | In 1 condition |
| TNIP1TNFAIP3 interacting protein 1 | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| TRIM28tripartite motif containing 28 | Sometimes (5–29%) | In 1 condition |
| TRIP13thyroid hormone receptor interactor 13 | Sometimes (5–29%) | In 1 condition |
| UBAC2UBA domain containing 2 | Sometimes (5–29%) | In 1 condition |
| UBE2L3ubiquitin conjugating enzyme E2 L3 | Sometimes (5–29%) | In 1 condition |
| WWOXWW domain containing oxidoreductase | Sometimes (5–29%) | In 1 condition |
| ZBTB16zinc finger and BTB domain containing 16 | Sometimes (5–29%) | In 1 condition |
| ASAH1N-acylsphingosine amidohydrolase 1 | Rarely (1–4%) | In 1 condition |
| COL1A1collagen type I alpha 1 chain | Rarely (1–4%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Rarely (1–4%) | In 1 condition |
| ACP5acid phosphatase 5, tartrate resistant | Not recorded | In 1 condition |
| ARPC1Bactin related protein 2/3 complex subunit 1B | Not recorded | In 1 condition |
| CARD9caspase recruitment domain family member 9 | Not recorded | In 1 condition |
| CD19CD19 molecule | Not recorded | In 1 condition |
| CYBAcytochrome b-245 alpha chain | Not recorded | In 1 condition |
| CYBBcytochrome b-245 beta chain | Not recorded | In 1 condition |
| ICOSinducible T cell costimulator | Not recorded | In 2 conditions |
| MCM4minichromosome maintenance complex component 4 | Not recorded | In 1 condition |
| NCF1neutrophil cytosolic factor 1 | Not recorded | In 1 condition |
| NCF2neutrophil cytosolic factor 2 | Not recorded | In 1 condition |
| POMPproteasome maturation protein | Not recorded | In 1 condition |
| PSMB4proteasome 20S subunit beta 4 | Not recorded | In 1 condition |
| SH2D1ASH2 domain containing 1A | Not recorded | In 1 condition |
| SMPD1sphingomyelin phosphodiesterase 1 | Not recorded | In 1 condition |
| TNFRSF13BTNF receptor superfamily member 13B | Not recorded | In 1 condition |
| TNFRSF13CTNF receptor superfamily member 13C | Not recorded | In 1 condition |
| XIAPX-linked inhibitor of apoptosis | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
- Swollen lymph nodes in center of chest36 genes
- Follicular hyperplasia16 genes
- Generalized swelling of lymph nodes14 genes
- Swollen lymph nodes in the neck14 genes
- Chronic noninfectious lymphadenopathy9 genes
- Axillary lymphadenopathy6 genes
- Inguinal lymphadenopathy6 genes
- Hilar lymph node enlargement1 gene
- Paratracheal lymphadenopathy1 gene
- Submandibular lymph node enlargement1 gene
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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