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Gene

TRIM28

tripartite motif containing 28

Summary

Cytogenetic location
19q13.43
Coordinates
Chromosome 19: 58,544,064–58,550,715 (GRCh38)
Exons
17 exons across 6.7 kb
Protein
835 amino acids
Also known as
TIF1B, KAP1, TF1B, RNF96, PPP1R157, KAP-1, TIF1-beta, TIF1beta
MANE Select transcript
ENST00000253024.10NM_005762.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Kidney Cancer

    • Primary or metastatic malignant neoplasm involving the kidney.

      • 1 GenCC submitter rates it definitive or strong

  • Urinary and Renal System Tumour

    • Urinary System Neoplasm

      A benign or malignant, primary or metastatic neoplasm involving the urinary system.

      • 1 GenCC submitter rates it definitive or strong

How TRIM28 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where TRIM28 sits. TRIM28 and 25 genes near it on chromosome 19, from 58,047,390 to 59,047,389.Chromosome 1919q13.43p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4358.2 Mb58.4 Mb58.6 Mb58.8 Mb59 MbZSCAN1: 58,034,002–58,054,631, forward strandZSCAN1ZNF135: 58,059,238–58,086,310, forward strandZNF135ZSCAN18: 58,083,318–58,118,427, reverse strandZSCAN18ZNF329: 58,126,248–58,155,110, reverse strandZNF329ZNF274: 58,183,029–58,215,964, forward strandZNF274ZNF544: 58,228,594–58,278,375, forward strandZNF544: 58,228,914–58,315,183, forward strandZNF8: 58,278,949–58,302,791, forward strandZNF8ERVK3-1: 58,305,347–58,316,812, forward strandERVK3-1ZSCAN22: 58,326,994–58,342,346, forward strandA1BG: 58,345,178–58,353,502, reverse strandA1BGZNF497: 58,354,357–58,362,848, reverse strandZNF837: 58,367,614–58,381,054, reverse strandZNF837RPS5: 58,380,570–58,394,810, forward strandRPS5RNF225: 58,395,656–58,397,079, forward strandRNF225ZNF584: 58,401,504–58,431,736, forward strandZNF584ZNF132: 58,432,814–58,440,172, reverse strandZNF324B: 58,450,369–58,459,868, forward strandZNF324BZNF324: 58,467,052–58,475,436, forward strandZNF324ZNF446: 58,474,017–58,483,992, forward strandZNF446SLC27A5: 58,479,512–58,512,413, reverse strandSLC27A5ZBTB45: 58,513,530–58,538,911, reverse strandTRIM28: 58,544,064–58,550,715, forward strandTRIM28CHMP2A: 58,551,452–58,555,129, reverse strandCHMP2AUBE2M: 58,555,709–58,558,986, reverse strandUBE2MMZF1: 58,561,915–58,573,603, reverse strandMZF1Diagram of TRIM28: 17 exons on the forward strand of chromosome 19Exon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 1: 58,544,064–58,545,097, 1,034 basesExon 2: 58,545,425–58,545,537, 113 basesExon 3: 58,545,764–58,545,896, 133 basesExon 4: 58,547,376–58,547,511, 136 basesExon 5: 58,547,597–58,547,713, 117 basesExon 6: 58,547,792–58,547,906, 115 basesExon 7: 58,548,034–58,548,180, 147 basesExon 8: 58,548,294–58,548,408, 115 basesExon 9: 58,548,486–58,548,592, 107 basesExon 10: 58,548,740–58,548,776, 37 basesExon 11: 58,548,862–58,548,910, 49 basesExon 12: 58,548,988–58,549,240, 253 basesExon 13: 58,549,331–58,549,650, 320 basesExon 14: 58,549,737–58,549,860, 124 basesExon 15: 58,549,949–58,550,035, 87 basesExon 16: 58,550,147–58,550,284, 138 basesExon 17: 58,550,377–58,550,715, 339 bases1246810121416175′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.4 kb of the gene's 6.7 kb; 2,508 of those bases code for the protein.

Sequencing TRIM28

5Low

How hard TRIM28 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats4.1%
  • GC content45%
  • Reference coverage0%

4

positions in TRIM28 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6.7 kb of TRIM28, introns included, not only the 3.4 kb of exons.

Genes linked to the same conditions

Traits linked to TRIM28

The Human Phenotype Ontology lists these as features of the rare conditions TRIM28 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). TRIM28 gene: tripartite motif containing 28. Retrieved 18 October 2026, from https://dantelabs.com/genes/trim28

Vancouver

Dante Labs. TRIM28 gene: tripartite motif containing 28 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/trim28

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