Trait
Chronic fatigue
Subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer.
Summary
- Also called
- Chronic extreme exhaustion
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
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Get my Genome Test27 genes linked to Chronic fatigue
Changes in these genes cause rare conditions in which Chronic fatigue is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AEBP1AE binding protein 1 | Always | In 1 condition |
| GUK1guanylate kinase 1 | Always | In 1 condition |
| NLRP3NLR family pyrin domain containing 3 | Always | In 1 condition |
| PSAPprosaposin | Always | In 1 condition |
| SLC13A1solute carrier family 13 member 1 | Always | In 1 condition |
| TGFBR1transforming growth factor beta receptor 1 | Always | In 1 condition |
| BRCA1BRCA1 DNA repair associated | Very often (80–99%) | In 1 condition |
| BRCA2BRCA2 DNA repair associated | Very often (80–99%) | In 1 condition |
| CDKN2Acyclin dependent kinase inhibitor 2A | Very often (80–99%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Very often (80–99%) | In 1 condition |
| PALB2partner and localizer of BRCA2 | Very often (80–99%) | In 1 condition |
| PALLDpalladin, cytoskeletal associated protein | Very often (80–99%) | In 1 condition |
| RABL3RAB, member of RAS oncogene family like 3 | Very often (80–99%) | In 1 condition |
| SMAD4SMAD family member 4 | Very often (80–99%) | In 1 condition |
| TP53tumor protein p53 | Very often (80–99%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Often (30–79%) | In 1 condition |
| EIF2AK4eukaryotic translation initiation factor 2 alpha kinase 4 | Often (30–79%) | In 1 condition |
| MC2Rmelanocortin 2 receptor | Often (30–79%) | In 1 condition |
| MDM4MDM4 regulator of p53 | Often (30–79%) | In 1 condition |
| MRAPmelanocortin 2 receptor accessory protein | Often (30–79%) | In 1 condition |
| NNTnicotinamide nucleotide transhydrogenase | Often (30–79%) | In 1 condition |
| SMAD2SMAD family member 2 | Often (30–79%) | In 1 condition |
| SMAD3SMAD family member 3 | Often (30–79%) | In 2 conditions |
| STARsteroidogenic acute regulatory protein | Often (30–79%) | In 1 condition |
| TFR2transferrin receptor 2 | Often (30–79%) | In 1 condition |
| TXNRD2thioredoxin reductase 2 | Often (30–79%) | In 1 condition |
| IVNS1ABPinfluenza virus NS1A binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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